DR info

Clinical trials : 39 / Drugs : 42 - (DrugBank : 32) / Drug target genes : 47 - Drug target pathways : 67

Mitochondrial disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
21	Mitochondrial disease	-
6	Parkinson disease	47.000
13	Multiple sclerosis/Neuromyelitis optica	45.191
96	Crohn disease	38.649
46	Malignant rheumatoid arthritis	38.546
2	Amyotrophic lateral sclerosis	37.014
97	Ulcerative colitis	35.709
8	Huntington disease	29.787
206	Fragile X syndrome	26.505
70	Spinal stenosis	22.774
5	Progressive supranuclear palsy	20.283
17	Multiple system atrophy	19.334
205	Fragile X syndrome related disease	19.141
22	Moyamoya disease	18.096
78	Hypopituitarism	17.395
18	Spinocerebellar degeneration	17.258
156	Rett syndrome	17.097
3	Spinal muscular atrophy	16.352
152	PCDH19 related syndrome	16.000
84	Sarcoidosis	14.550
201	Angelman syndrome	14.534
34	Neurofibromatosis	14.360
145	West syndrome	12.981
298	Hereditary pancreatitis	12.846
231	Alpha-1-antitrypsin deficiency	12.605
158	Tuberous sclerosis	12.605
272	Fibrodysplasia ossificans progressiva	11.941
193	Prader-Willi syndrome	11.898
98	Eosinophilic gastrointestinal disease	11.770
155	Acquired aphasia with convulsive disorder	11.269
140	Dorabe syndrome	11.059
296	Biliary atresia	10.248
75	Cushing disease	10.118
299	Cystic fibrosis	9.921
144	Lennox-Gastaut syndrome	9.914
36	Epidermolysis bullosa	8.893
113	Muscular dystrophy	7.384
226	Interstitial cystitis with Hunners ulcer	7.181
265	Lipodystrophy	6.139
236	Pseudohypoparathyroidism	6.064
179	Williams syndrome	5.676
4	Primary lateral sclerosis	5.170
294	Congenital diaphragmatic hernia	5.000
63	Idiopathic thrombocytopenic purpura	4.634
246	Methylmalonic acidemia	4.486
107	Juvenile idiopathic arthritis	4.357
215	Tetralogy of Fallot	4.312
171	Wilson disease	3.000
323	Aromatic L-amino acid decarboxylase deficiency	3.000
51	Scleroderma	2.824
49	Systemic lupus erythematosus	2.818
271	Ankylosing spondylitis	2.657
65	Primary immunodeficiency	2.451
85	Idiopathic interstitial pneumonia	2.385
212	Tricuspid atresia	2.170
203	22q11.2 deletion syndrome	2.128
127	Frontotemporal lobar degeneration	2.085
337	Homocystinuria	2.000
282	Congenital dyserythropoietic anemia	2.000
254	Porphyria	1.708
187	Kabuki syndrome	1.362
225	Congenital nephrogenic diabetes insipidus	1.277
118	Myelomeningocele	1.245
169	Menkes disease	1.128
170	Occipital horn syndrome	1.128
86	Pulmonary arterial hypertension	1.080
251	Urea cycle disorder	1.043
71	Idiopathic osteonecrosis of the femoral head	1.043
11	Myasthenia gravis	1.028