DR info

Clinical trials : 267 / Drugs : 241 - (DrugBank : 77) / Drug target genes : 68 - Drug target pathways : 180

Systemic amyloidosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
28	Systemic amyloidosis	-
46	Malignant rheumatoid arthritis	32.822
51	Scleroderma	26.066
85	Idiopathic interstitial pneumonia	25.587
34	Neurofibromatosis	22.759
2	Amyotrophic lateral sclerosis	20.774
13	Multiple sclerosis/Neuromyelitis optica	19.622
49	Systemic lupus erythematosus	17.943
56	Behcet disease	16.296
26	HTLV-1-associated myelopathy	15.825
42	Polyarteritis nodosa	15.357
65	Primary immunodeficiency	14.795
96	Crohn disease	13.610
6	Parkinson disease	13.337
38	Stevens-Johnson syndrome	13.265
11	Myasthenia gravis	12.256
228	Bronchiolitis obliterans	12.050
331	Idiopathic multicentric castleman disease	11.300
127	Frontotemporal lobar degeneration	10.800
86	Pulmonary arterial hypertension	10.560
93	Primary biliary cholangitis	10.509
60	Aplastic anemia	9.487
266	Familial mediterranean fever	9.036
113	Muscular dystrophy	8.903
58	Hypertrophic cardiomyopathy	8.849
107	Juvenile idiopathic arthritis	8.505
227	Osler disease	8.461
53	Sjogren syndrome	8.280
61	Autoimmune hemolytic anemia	7.989
210	Single Ventricle	7.795
164	Oculocutaneous albinism	7.512
283	Acquired pure red cell aplasia	7.435
97	Ulcerative colitis	7.267
285	Fanconi anemia	7.084
36	Epidermolysis bullosa	6.957
226	Interstitial cystitis with Hunners ulcer	6.909
162	Pemphigoid	6.673
41	Giant cell arteritis	6.673
62	Paroxysmal nocturnal hemoglobinuria	6.635
284	Diamond-Blackfan anemia	6.417
35	Pemphigus	6.417
45	Eosinophilic granulomatosis with Polyangiitis	6.229
39	Toxic epidermal necrolysis	6.083
151	Rasmussen encephalitis	6.000
234	Peroxisomal disease (except Adrenoleukodystrophy)	5.657
20	Adrenoleukodystrophy	5.372
19	Lysosomal storage disease	5.208
16	Crow-Fukase syndrome	5.000
302	Leber hereditary optic neuropathy	5.000
95	Autoimmune hepatitis	4.909
222	Primary nephrotic syndrome	4.785
224	Purpura nephritis	4.719
66	IgA nephropathy	4.714
286	Hereditary sideroblastic anemia	4.636
50	Dermatomyositis	4.636
84	Sarcoidosis	4.216
168	Ehlers-Danlos syndrome	4.182
8	Huntington disease	4.176
40	Takayasu arteritis	4.025
70	Spinal stenosis	3.967
89	Lymphangioleiomyomatosis	3.818
300	IgG4-related disease	3.663
269	Pyogenic arthritis	3.663
256	Muscle glycogenosis	3.484
64	Thrombotic thrombocytopenic purpura	3.480
326	Osteopetrosis	3.480
299	Cystic fibrosis	3.409
55	Relapsing polychondritis	3.273
298	Hereditary pancreatitis	3.116
57	Idiopathic dilated cardiomyopathy	2.946
63	Idiopathic thrombocytopenic purpura	2.782
1	Spinal and bulbar muscular atrophy	2.689
158	Tuberous sclerosis	2.577
10	Charcot-Marie-Tooth disease	2.479
25	Progressive multifocal leukoencephalopathy	2.390
160	Congenital ichthyosis	2.364
14	Chronic inflammatory demyelinating polyneuropathy	2.304
87	Pulmonary veno-occlusive disease	2.284
274	Osteogenesis Imperfecta	2.029
169	Menkes disease	1.912
170	Occipital horn syndrome	1.912
67	Polycystic kidney disease	1.895
114	Non-dystrophic myotonia syndrome	1.662
288	Autoimmune acquired coagulation factor deficiency	1.662
15	Inclusion body myositis	1.609
193	Prader-Willi syndrome	1.601
94	Primary sclerosing cholangitis	1.595
231	Alpha-1-antitrypsin deficiency	1.481
43	Microscopic polyangiitis	1.316
280	Huge arteriovenous malformation with cervicofacial or limb lesion	1.316
90	Retinitis pigmentosa	1.213
144	Lennox-Gastaut syndrome	1.213
118	Myelomeningocele	1.210
22	Moyamoya disease	1.204
5	Progressive supranuclear palsy	1.049
106	Cryopyrin-associated periodic syndrome	1.030
251	Urea cycle disorder	1.030
235	Hypoparathyroidism	1.030
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000