DR info

Clinical trials : 5 / Drugs : 13 - (DrugBank : 6) / Drug target genes : 13 - Drug target pathways : 25

Primary lateral sclerosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
4	Primary lateral sclerosis	-
6	Parkinson disease	19.000
2	Amyotrophic lateral sclerosis	12.118
13	Multiple sclerosis/Neuromyelitis optica	12.020
17	Multiple system atrophy	11.161
8	Huntington disease	6.975
206	Fragile X syndrome	6.140
5	Progressive supranuclear palsy	5.992
215	Tetralogy of Fallot	5.427
21	Mitochondrial disease	5.170
90	Retinitis pigmentosa	5.133
3	Spinal muscular atrophy	5.068
70	Spinal stenosis	4.909
46	Malignant rheumatoid arthritis	4.494
78	Hypopituitarism	4.211
309	Progressive myoclonus epilepsy	4.000
113	Muscular dystrophy	3.996
96	Crohn disease	3.589
12	Congenital myasthenic syndrome	3.368
7	Corticobasal degeneration	3.363
127	Frontotemporal lobar degeneration	3.353
11	Myasthenia gravis	3.267
201	Angelman syndrome	3.014
323	Aromatic L-amino acid decarboxylase deficiency	3.000
97	Ulcerative colitis	2.795
203	22q11.2 deletion syndrome	2.632
164	Oculocutaneous albinism	2.619
74	Prolactin secreting pituitary adenoma	2.467
140	Dorabe syndrome	2.408
156	Rett syndrome	2.215
205	Fragile X syndrome related disease	2.053
14	Chronic inflammatory demyelinating polyneuropathy	1.895
18	Spinocerebellar degeneration	1.725
299	Cystic fibrosis	1.508
254	Porphyria	1.507
85	Idiopathic interstitial pneumonia	1.502
49	Systemic lupus erythematosus	1.477
212	Tricuspid atresia	1.421
118	Myelomeningocele	1.421
169	Menkes disease	1.316
170	Occipital horn syndrome	1.316
280	Huge arteriovenous malformation with cervicofacial or limb lesion	1.015