DR info

Clinical trials : 4,356 / Drugs : 2,567 - (DrugBank : 415) / Drug target genes : 192 - Drug target pathways : 228

Malignant rheumatoid arthritis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
46	Malignant rheumatoid arthritis	-
13	Multiple sclerosis/Neuromyelitis optica	103.510
96	Crohn disease	95.936
97	Ulcerative colitis	82.158
6	Parkinson disease	70.881
49	Systemic lupus erythematosus	70.556
2	Amyotrophic lateral sclerosis	69.225
70	Spinal stenosis	50.084
51	Scleroderma	49.603
8	Huntington disease	48.417
65	Primary immunodeficiency	46.486
84	Sarcoidosis	46.346
107	Juvenile idiopathic arthritis	42.012
85	Idiopathic interstitial pneumonia	40.269
271	Ankylosing spondylitis	39.235
36	Epidermolysis bullosa	38.959
21	Mitochondrial disease	38.546
34	Neurofibromatosis	38.221
53	Sjogren syndrome	35.799
56	Behcet disease	34.212
113	Muscular dystrophy	34.049
299	Cystic fibrosis	33.684
50	Dermatomyositis	33.229
28	Systemic amyloidosis	32.822
298	Hereditary pancreatitis	32.310
11	Myasthenia gravis	31.738
158	Tuberous sclerosis	31.451
93	Primary biliary cholangitis	31.451
226	Interstitial cystitis with Hunners ulcer	29.531
41	Giant cell arteritis	29.436
206	Fragile X syndrome	29.053
22	Moyamoya disease	28.000
17	Multiple system atrophy	27.900
60	Aplastic anemia	27.190
162	Pemphigoid	26.036
42	Polyarteritis nodosa	26.000
40	Takayasu arteritis	25.000
78	Hypopituitarism	23.376
86	Pulmonary arterial hypertension	23.170
5	Progressive supranuclear palsy	23.064
66	IgA nephropathy	21.729
231	Alpha-1-antitrypsin deficiency	21.729
285	Fanconi anemia	21.396
205	Fragile X syndrome related disease	21.389
58	Hypertrophic cardiomyopathy	20.574
98	Eosinophilic gastrointestinal disease	20.466
145	West syndrome	20.016
222	Primary nephrotic syndrome	19.418
18	Spinocerebellar degeneration	19.023
63	Idiopathic thrombocytopenic purpura	19.023
95	Autoimmune hepatitis	19.000
19	Lysosomal storage disease	18.854
156	Rett syndrome	18.502
3	Spinal muscular atrophy	17.926
210	Single Ventricle	17.335
193	Prader-Willi syndrome	17.284
228	Bronchiolitis obliterans	16.897
164	Oculocutaneous albinism	16.484
283	Acquired pure red cell aplasia	16.142
152	PCDH19 related syndrome	16.000
265	Lipodystrophy	15.884
144	Lennox-Gastaut syndrome	15.511
296	Biliary atresia	15.390
35	Pemphigus	15.046
224	Purpura nephritis	15.000
256	Muscle glycogenosis	14.995
75	Cushing disease	14.969
140	Dorabe syndrome	14.640
45	Eosinophilic granulomatosis with Polyangiitis	14.376
44	Wegener granulomatosis	14.059
266	Familial mediterranean fever	14.000
26	HTLV-1-associated myelopathy	13.838
331	Idiopathic multicentric castleman disease	13.670
284	Diamond-Blackfan anemia	13.491
201	Angelman syndrome	13.491
61	Autoimmune hemolytic anemia	13.450
127	Frontotemporal lobar degeneration	13.277
38	Stevens-Johnson syndrome	13.137
300	IgG4-related disease	13.137
269	Pyogenic arthritis	13.137
55	Relapsing polychondritis	12.000
272	Fibrodysplasia ossificans progressiva	11.656
215	Tetralogy of Fallot	11.124
20	Adrenoleukodystrophy	10.614
43	Microscopic polyangiitis	10.397
234	Peroxisomal disease (except Adrenoleukodystrophy)	10.138
62	Paroxysmal nocturnal hemoglobinuria	9.686
288	Autoimmune acquired coagulation factor deficiency	9.643
160	Congenital ichthyosis	9.643
155	Acquired aphasia with convulsive disorder	9.448
326	Osteopetrosis	9.195
57	Idiopathic dilated cardiomyopathy	9.000
169	Menkes disease	9.000
170	Occipital horn syndrome	9.000
227	Osler disease	8.936
280	Huge arteriovenous malformation with cervicofacial or limb lesion	8.783
286	Hereditary sideroblastic anemia	8.000
94	Primary sclerosing cholangitis	7.866
64	Thrombotic thrombocytopenic purpura	7.767
236	Pseudohypoparathyroidism	7.511
10	Charcot-Marie-Tooth disease	7.443
274	Osteogenesis Imperfecta	7.297
168	Ehlers-Danlos syndrome	7.150
25	Progressive multifocal leukoencephalopathy	7.000
1	Spinal and bulbar muscular atrophy	6.469
37	Generalised pustular psoriasis	6.344
118	Myelomeningocele	6.158
270	Chronic recurrent multifocal osteomyelitis	6.000
151	Rasmussen encephalitis	6.000
83	Addison disease	6.000
76	Pituitary gonadotropin secretion hyperthyroidism	6.000
39	Toxic epidermal necrolysis	5.913
15	Inclusion body myositis	5.913
67	Polycystic kidney disease	5.048
157	Sturge-Weber syndrome	5.000
278	Huge lymphatic malformation with cervicofacial lesion	5.000
302	Leber hereditary optic neuropathy	5.000
294	Congenital diaphragmatic hernia	5.000
4	Primary lateral sclerosis	4.494
90	Retinitis pigmentosa	4.120
106	Cryopyrin-associated periodic syndrome	4.000
71	Idiopathic osteonecrosis of the femoral head	4.000
246	Methylmalonic acidemia	3.948
88	Chronic thromboembolic pulmonary hypertension	3.891
16	Crow-Fukase syndrome	3.217
81	Congenital adrenal hyperplasia	3.097
310	Congenital anomalies syndrome	3.000
229	Autoimmune pulmonary alveolar proteinosis	3.000
323	Aromatic L-amino acid decarboxylase deficiency	3.000
218	Alport syndrome	2.695
89	Lymphangioleiomyomatosis	2.614
167	Marfan syndrome	2.568
225	Congenital nephrogenic diabetes insipidus	2.387
87	Pulmonary veno-occlusive disease	2.262
251	Urea cycle disorder	2.262
91	Budd-Chiari syndrome	2.262
235	Hypoparathyroidism	2.262
202	Smith-Magenis syndrome	2.262
212	Tricuspid atresia	2.043
254	Porphyria	2.028
77	Growth hormone secreting pituitary adenoma	2.000
268	Nakajo-Nishimura syndrome	2.000
325	Hereditary autoinflammatory syndrome	2.000
337	Homocystinuria	2.000
195	Noonan syndrome	2.000
263	Cerebrotendinous xanthomatosis	2.000
257	Hepatic glycogenosis	2.000
282	Congenital dyserythropoietic anemia	2.000
120	Hereditary dystonia	2.000
203	22q11.2 deletion syndrome	1.873
179	Williams syndrome	1.826
211	Hypoplastic left heart syndrome	1.819
74	Prolactin secreting pituitary adenoma	1.655
149	Hemiconvulsion hemiplegia epilepsy syndrome	1.566
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy	1.524
47	Buerger disease	1.524
114	Non-dystrophic myotonia syndrome	1.486
14	Chronic inflammatory demyelinating polyneuropathy	1.391
187	Kabuki syndrome	1.341
171	Wilson disease	1.341
172	Hypophosphatasia	1.341
79	Homozygous familial hypercholesterolemia	1.032
301	Macular dystrophy	1.032
333	Hutchinson-Gilford syndrome	1.011
238	Vitamin D-resistant rickets	1.011
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
111	Congenital myopathy	1.000
108	TNF receptor-associated periodic syndrome	1.000
267	Hyper-IgD syndrome	1.000
317	Trifunctional protein deficiency	1.000
54	Adult still disease	1.000
191	Werner syndrome	1.000
68	Ossification of the ligamentum flavum	1.000
52	Mixed connective tissue disease	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000