DR info

Clinical trials : 993 / Drugs : 702 - (DrugBank : 184) / Drug target genes : 116 - Drug target pathways : 200

Systemic lupus erythematosus and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
49	Systemic lupus erythematosus	-
46	Malignant rheumatoid arthritis	70.556
13	Multiple sclerosis/Neuromyelitis optica	46.335
96	Crohn disease	40.532
65	Primary immunodeficiency	37.524
97	Ulcerative colitis	34.003
93	Primary biliary cholangitis	30.027
51	Scleroderma	29.731
56	Behcet disease	27.865
2	Amyotrophic lateral sclerosis	26.925
53	Sjogren syndrome	26.180
60	Aplastic anemia	22.307
50	Dermatomyositis	21.711
42	Polyarteritis nodosa	20.882
66	IgA nephropathy	20.839
85	Idiopathic interstitial pneumonia	20.325
11	Myasthenia gravis	20.020
40	Takayasu arteritis	19.869
41	Giant cell arteritis	18.833
285	Fanconi anemia	18.716
28	Systemic amyloidosis	17.943
107	Juvenile idiopathic arthritis	17.094
222	Primary nephrotic syndrome	16.573
26	HTLV-1-associated myelopathy	15.753
19	Lysosomal storage disease	15.449
271	Ankylosing spondylitis	14.940
113	Muscular dystrophy	14.774
162	Pemphigoid	14.770
283	Acquired pure red cell aplasia	14.472
284	Diamond-Blackfan anemia	13.713
35	Pemphigus	13.713
6	Parkinson disease	13.668
331	Idiopathic multicentric castleman disease	12.871
61	Autoimmune hemolytic anemia	12.371
84	Sarcoidosis	12.294
55	Relapsing polychondritis	12.000
37	Generalised pustular psoriasis	11.743
300	IgG4-related disease	11.464
299	Cystic fibrosis	11.365
62	Paroxysmal nocturnal hemoglobinuria	11.278
160	Congenital ichthyosis	11.271
95	Autoimmune hepatitis	10.768
266	Familial mediterranean fever	10.466
210	Single Ventricle	10.220
44	Wegener granulomatosis	9.906
269	Pyogenic arthritis	9.853
224	Purpura nephritis	9.853
45	Eosinophilic granulomatosis with Polyangiitis	9.801
86	Pulmonary arterial hypertension	9.600
20	Adrenoleukodystrophy	9.534
228	Bronchiolitis obliterans	8.914
63	Idiopathic thrombocytopenic purpura	8.905
164	Oculocutaneous albinism	8.718
234	Peroxisomal disease (except Adrenoleukodystrophy)	8.480
78	Hypopituitarism	8.124
34	Neurofibromatosis	8.004
286	Hereditary sideroblastic anemia	8.000
64	Thrombotic thrombocytopenic purpura	7.894
326	Osteopetrosis	7.894
39	Toxic epidermal necrolysis	7.493
256	Muscle glycogenosis	7.265
226	Interstitial cystitis with Hunners ulcer	6.377
43	Microscopic polyangiitis	6.039
151	Rasmussen encephalitis	6.000
83	Addison disease	6.000
36	Epidermolysis bullosa	5.961
158	Tuberous sclerosis	5.760
94	Primary sclerosing cholangitis	5.679
25	Progressive multifocal leukoencephalopathy	5.188
16	Crow-Fukase syndrome	5.000
302	Leber hereditary optic neuropathy	5.000
38	Stevens-Johnson syndrome	4.529
75	Cushing disease	4.492
8	Huntington disease	4.300
270	Chronic recurrent multifocal osteomyelitis	4.203
76	Pituitary gonadotropin secretion hyperthyroidism	4.203
227	Osler disease	3.954
127	Frontotemporal lobar degeneration	3.795
274	Osteogenesis Imperfecta	3.715
206	Fragile X syndrome	3.649
265	Lipodystrophy	3.580
18	Spinocerebellar degeneration	3.491
15	Inclusion body myositis	3.416
17	Multiple system atrophy	3.375
90	Retinitis pigmentosa	3.293
81	Congenital adrenal hyperplasia	3.158
3	Spinal muscular atrophy	3.124
21	Mitochondrial disease	2.818
58	Hypertrophic cardiomyopathy	2.778
251	Urea cycle disorder	2.270
91	Budd-Chiari syndrome	2.270
202	Smith-Magenis syndrome	2.270
205	Fragile X syndrome related disease	2.269
70	Spinal stenosis	2.259
14	Chronic inflammatory demyelinating polyneuropathy	2.211
215	Tetralogy of Fallot	2.211
77	Growth hormone secreting pituitary adenoma	2.000
268	Nakajo-Nishimura syndrome	2.000
325	Hereditary autoinflammatory syndrome	2.000
337	Homocystinuria	2.000
257	Hepatic glycogenosis	2.000
139	Congenital cerebral hypomyelination	2.000
120	Hereditary dystonia	2.000
203	22q11.2 deletion syndrome	1.927
5	Progressive supranuclear palsy	1.858
278	Huge lymphatic malformation with cervicofacial lesion	1.832
211	Hypoplastic left heart syndrome	1.832
159	Xeroderma pigmentosum	1.832
156	Rett syndrome	1.679
98	Eosinophilic gastrointestinal disease	1.552
288	Autoimmune acquired coagulation factor deficiency	1.547
218	Alport syndrome	1.539
4	Primary lateral sclerosis	1.477
225	Congenital nephrogenic diabetes insipidus	1.453
296	Biliary atresia	1.452
171	Wilson disease	1.345
229	Autoimmune pulmonary alveolar proteinosis	1.345
172	Hypophosphatasia	1.345
80	Resistance to thyroid hormone	1.345
88	Chronic thromboembolic pulmonary hypertension	1.328
298	Hereditary pancreatitis	1.298
67	Polycystic kidney disease	1.213
212	Tricuspid atresia	1.174
89	Lymphangioleiomyomatosis	1.105
145	West syndrome	1.105
79	Homozygous familial hypercholesterolemia	1.053
301	Macular dystrophy	1.053
57	Idiopathic dilated cardiomyopathy	1.053
106	Cryopyrin-associated periodic syndrome	1.018
333	Hutchinson-Gilford syndrome	1.018
235	Hypoparathyroidism	1.018
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
111	Congenital myopathy	1.000
54	Adult still disease	1.000
260	Sitosterolemia	1.000
52	Mixed connective tissue disease	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000