DR info

Clinical trials : 525 / Drugs : 565 - (DrugBank : 148) / Drug target genes : 114 - Drug target pathways : 217

Scleroderma and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
51	Scleroderma	-
46	Malignant rheumatoid arthritis	49.603
85	Idiopathic interstitial pneumonia	45.016
13	Multiple sclerosis/Neuromyelitis optica	44.136
49	Systemic lupus erythematosus	29.731
96	Crohn disease	29.342
28	Systemic amyloidosis	26.066
65	Primary immunodeficiency	25.644
50	Dermatomyositis	24.354
42	Polyarteritis nodosa	24.251
2	Amyotrophic lateral sclerosis	24.006
97	Ulcerative colitis	23.361
84	Sarcoidosis	23.344
228	Bronchiolitis obliterans	23.264
34	Neurofibromatosis	22.698
86	Pulmonary arterial hypertension	22.363
93	Primary biliary cholangitis	20.853
107	Juvenile idiopathic arthritis	20.677
6	Parkinson disease	20.573
41	Giant cell arteritis	20.280
56	Behcet disease	19.051
53	Sjogren syndrome	18.809
222	Primary nephrotic syndrome	18.802
11	Myasthenia gravis	17.548
271	Ankylosing spondylitis	17.402
226	Interstitial cystitis with Hunners ulcer	17.211
58	Hypertrophic cardiomyopathy	16.825
162	Pemphigoid	16.094
164	Oculocutaneous albinism	15.747
40	Takayasu arteritis	15.207
285	Fanconi anemia	14.513
283	Acquired pure red cell aplasia	14.474
331	Idiopathic multicentric castleman disease	14.159
284	Diamond-Blackfan anemia	13.718
38	Stevens-Johnson syndrome	13.182
45	Eosinophilic granulomatosis with Polyangiitis	12.832
44	Wegener granulomatosis	12.730
60	Aplastic anemia	12.451
35	Pemphigus	12.254
55	Relapsing polychondritis	12.000
256	Muscle glycogenosis	11.654
36	Epidermolysis bullosa	11.230
26	HTLV-1-associated myelopathy	11.097
70	Spinal stenosis	11.065
299	Cystic fibrosis	10.601
227	Osler disease	10.475
266	Familial mediterranean fever	10.468
89	Lymphangioleiomyomatosis	10.404
113	Muscular dystrophy	9.988
300	IgG4-related disease	9.855
298	Hereditary pancreatitis	9.751
66	IgA nephropathy	9.572
43	Microscopic polyangiitis	8.872
62	Paroxysmal nocturnal hemoglobinuria	8.617
269	Pyogenic arthritis	8.352
224	Purpura nephritis	8.352
210	Single Ventricle	8.089
95	Autoimmune hepatitis	8.048
286	Hereditary sideroblastic anemia	8.000
88	Chronic thromboembolic pulmonary hypertension	7.897
19	Lysosomal storage disease	7.547
61	Autoimmune hemolytic anemia	7.478
63	Idiopathic thrombocytopenic purpura	7.149
160	Congenital ichthyosis	7.139
20	Adrenoleukodystrophy	7.125
274	Osteogenesis Imperfecta	6.042
151	Rasmussen encephalitis	6.000
10	Charcot-Marie-Tooth disease	5.973
39	Toxic epidermal necrolysis	5.973
234	Peroxisomal disease (except Adrenoleukodystrophy)	5.522
64	Thrombotic thrombocytopenic purpura	5.376
326	Osteopetrosis	5.376
302	Leber hereditary optic neuropathy	5.000
294	Congenital diaphragmatic hernia	5.000
8	Huntington disease	4.314
47	Buerger disease	4.204
158	Tuberous sclerosis	4.191
168	Ehlers-Danlos syndrome	4.106
67	Polycystic kidney disease	3.945
90	Retinitis pigmentosa	3.901
1	Spinal and bulbar muscular atrophy	3.727
94	Primary sclerosing cholangitis	3.696
140	Dorabe syndrome	3.346
16	Crow-Fukase syndrome	3.228
211	Hypoplastic left heart syndrome	3.228
193	Prader-Willi syndrome	3.212
225	Congenital nephrogenic diabetes insipidus	3.202
156	Rett syndrome	2.946
265	Lipodystrophy	2.854
231	Alpha-1-antitrypsin deficiency	2.847
21	Mitochondrial disease	2.824
144	Lennox-Gastaut syndrome	2.745
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy	2.714
127	Frontotemporal lobar degeneration	2.581
78	Hypopituitarism	2.411
87	Pulmonary veno-occlusive disease	2.270
251	Urea cycle disorder	2.270
81	Congenital adrenal hyperplasia	2.212
288	Autoimmune acquired coagulation factor deficiency	2.212
98	Eosinophilic gastrointestinal disease	2.017
268	Nakajo-Nishimura syndrome	2.000
325	Hereditary autoinflammatory syndrome	2.000
337	Homocystinuria	2.000
282	Congenital dyserythropoietic anemia	2.000
280	Huge arteriovenous malformation with cervicofacial or limb lesion	1.928
7	Corticobasal degeneration	1.856
276	Achondroplasia	1.832
167	Marfan syndrome	1.685
272	Fibrodysplasia ossificans progressiva	1.630
114	Non-dystrophic myotonia syndrome	1.549
15	Inclusion body myositis	1.545
270	Chronic recurrent multifocal osteomyelitis	1.540
218	Alport syndrome	1.540
310	Congenital anomalies syndrome	1.345
172	Hypophosphatasia	1.345
25	Progressive multifocal leukoencephalopathy	1.331
75	Cushing disease	1.175
212	Tricuspid atresia	1.175
5	Progressive supranuclear palsy	1.141
74	Prolactin secreting pituitary adenoma	1.106
296	Biliary atresia	1.076
79	Homozygous familial hypercholesterolemia	1.053
106	Cryopyrin-associated periodic syndrome	1.018
235	Hypoparathyroidism	1.018
71	Idiopathic osteonecrosis of the femoral head	1.018
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
232	Carney complex	1.000
108	TNF receptor-associated periodic syndrome	1.000
267	Hyper-IgD syndrome	1.000
99	Chronic intestinal pseudo-obstruction	1.000
317	Trifunctional protein deficiency	1.000
54	Adult still disease	1.000
52	Mixed connective tissue disease	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000