DR info

Clinical trials : 2,307 / Drugs : 2,007 - (DrugBank : 349) / Drug target genes : 188 - Drug target pathways : 199

Parkinson disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
6	Parkinson disease	-
13	Multiple sclerosis/Neuromyelitis optica	139.526
2	Amyotrophic lateral sclerosis	85.629
97	Ulcerative colitis	79.226
46	Malignant rheumatoid arthritis	70.881
8	Huntington disease	64.162
96	Crohn disease	60.766
5	Progressive supranuclear palsy	60.082
17	Multiple system atrophy	56.028
206	Fragile X syndrome	50.607
70	Spinal stenosis	50.043
21	Mitochondrial disease	47.000
140	Dorabe syndrome	46.266
156	Rett syndrome	43.883
193	Prader-Willi syndrome	42.594
3	Spinal muscular atrophy	41.411
144	Lennox-Gastaut syndrome	38.939
86	Pulmonary arterial hypertension	38.700
296	Biliary atresia	38.150
298	Hereditary pancreatitis	36.742
18	Spinocerebellar degeneration	36.501
226	Interstitial cystitis with Hunners ulcer	36.228
84	Sarcoidosis	35.677
158	Tuberous sclerosis	35.000
299	Cystic fibrosis	33.579
36	Epidermolysis bullosa	31.194
113	Muscular dystrophy	29.859
231	Alpha-1-antitrypsin deficiency	29.724
127	Frontotemporal lobar degeneration	28.239
22	Moyamoya disease	28.000
34	Neurofibromatosis	26.227
85	Idiopathic interstitial pneumonia	24.240
145	West syndrome	23.394
98	Eosinophilic gastrointestinal disease	23.236
201	Angelman syndrome	22.000
90	Retinitis pigmentosa	21.490
78	Hypopituitarism	20.639
51	Scleroderma	20.573
107	Juvenile idiopathic arthritis	20.545
205	Fragile X syndrome related disease	19.669
58	Hypertrophic cardiomyopathy	19.292
272	Fibrodysplasia ossificans progressiva	19.011
4	Primary lateral sclerosis	19.000
152	PCDH19 related syndrome	16.000
75	Cushing disease	15.946
11	Myasthenia gravis	15.366
256	Muscle glycogenosis	14.982
65	Primary immunodeficiency	14.888
215	Tetralogy of Fallot	14.374
203	22q11.2 deletion syndrome	14.000
67	Polycystic kidney disease	13.821
49	Systemic lupus erythematosus	13.668
28	Systemic amyloidosis	13.337
19	Lysosomal storage disease	12.038
155	Acquired aphasia with convulsive disorder	11.826
222	Primary nephrotic syndrome	11.301
89	Lymphangioleiomyomatosis	11.273
63	Idiopathic thrombocytopenic purpura	11.051
233	Wolfram syndrome	11.000
26	HTLV-1-associated myelopathy	10.460
265	Lipodystrophy	10.370
66	IgA nephropathy	10.094
38	Stevens-Johnson syndrome	9.753
254	Porphyria	9.179
169	Menkes disease	9.000
170	Occipital horn syndrome	9.000
271	Ankylosing spondylitis	8.869
149	Hemiconvulsion hemiplegia epilepsy syndrome	8.696
50	Dermatomyositis	8.681
162	Pemphigoid	8.459
118	Myelomeningocele	8.000
53	Sjogren syndrome	7.821
164	Oculocutaneous albinism	7.286
57	Idiopathic dilated cardiomyopathy	7.149
179	Williams syndrome	7.149
102	Rubinstein-Taybi syndrome	7.000
283	Acquired pure red cell aplasia	6.973
45	Eosinophilic granulomatosis with Polyangiitis	6.973
288	Autoimmune acquired coagulation factor deficiency	6.973
81	Congenital adrenal hyperplasia	6.858
95	Autoimmune hepatitis	6.639
41	Giant cell arteritis	6.540
167	Marfan syndrome	6.468
225	Congenital nephrogenic diabetes insipidus	6.143
280	Huge arteriovenous malformation with cervicofacial or limb lesion	5.940
10	Charcot-Marie-Tooth disease	5.911
20	Adrenoleukodystrophy	5.822
224	Purpura nephritis	5.572
56	Behcet disease	5.269
236	Pseudohypoparathyroidism	5.266
285	Fanconi anemia	5.260
64	Thrombotic thrombocytopenic purpura	5.251
61	Autoimmune hemolytic anemia	5.200
42	Polyarteritis nodosa	5.025
157	Sturge-Weber syndrome	5.000
278	Huge lymphatic malformation with cervicofacial lesion	5.000
12	Congenital myasthenic syndrome	5.000
302	Leber hereditary optic neuropathy	5.000
294	Congenital diaphragmatic hernia	5.000
1	Spinal and bulbar muscular atrophy	4.978
228	Bronchiolitis obliterans	4.851
35	Pemphigus	4.836
227	Osler disease	4.648
60	Aplastic anemia	4.645
93	Primary biliary cholangitis	4.618
40	Takayasu arteritis	4.319
331	Idiopathic multicentric castleman disease	4.318
210	Single Ventricle	4.204
14	Chronic inflammatory demyelinating polyneuropathy	4.192
151	Rasmussen encephalitis	4.189
62	Paroxysmal nocturnal hemoglobinuria	4.103
168	Ehlers-Danlos syndrome	4.064
7	Corticobasal degeneration	4.064
309	Progressive myoclonus epilepsy	4.000
72	Pituitary ADH secretion disorder	4.000
246	Methylmalonic acidemia	3.945
284	Diamond-Blackfan anemia	3.936
274	Osteogenesis Imperfecta	3.630
39	Toxic epidermal necrolysis	3.360
74	Prolactin secreting pituitary adenoma	3.209
286	Hereditary sideroblastic anemia	3.175
55	Relapsing polychondritis	3.096
234	Peroxisomal disease (except Adrenoleukodystrophy)	3.096
171	Wilson disease	3.000
310	Congenital anomalies syndrome	3.000
229	Autoimmune pulmonary alveolar proteinosis	3.000
323	Aromatic L-amino acid decarboxylase deficiency	3.000
114	Non-dystrophic myotonia syndrome	2.882
88	Chronic thromboembolic pulmonary hypertension	2.872
218	Alport syndrome	2.695
300	IgG4-related disease	2.515
269	Pyogenic arthritis	2.515
326	Osteopetrosis	2.370
87	Pulmonary veno-occlusive disease	2.262
251	Urea cycle disorder	2.262
202	Smith-Magenis syndrome	2.262
160	Congenital ichthyosis	2.128
212	Tricuspid atresia	2.043
77	Growth hormone secreting pituitary adenoma	2.000
337	Homocystinuria	2.000
263	Cerebrotendinous xanthomatosis	2.000
257	Hepatic glycogenosis	2.000
282	Congenital dyserythropoietic anemia	2.000
307	Canavan disease	2.000
120	Hereditary dystonia	2.000
43	Microscopic polyangiitis	1.871
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy	1.524
15	Inclusion body myositis	1.509
230	Alveolar hypoventilation syndrome	1.485
94	Primary sclerosing cholangitis	1.414
187	Kabuki syndrome	1.340
44	Wegener granulomatosis	1.292
301	Macular dystrophy	1.032
333	Hutchinson-Gilford syndrome	1.011
91	Budd-Chiari syndrome	1.011
235	Hypoparathyroidism	1.011
71	Idiopathic osteonecrosis of the femoral head	1.011
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
111	Congenital myopathy	1.000
241	Hypertyrosinemia type I	1.000
52	Mixed connective tissue disease	1.000
290	Chronic nonspecific multiple ulcers of the small intestine	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000