DR info

Clinical trials : 500 / Drugs : 614 - (DrugBank : 119) / Drug target genes : 92 - Drug target pathways : 217

Primary immunodeficiency and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
65	Primary immunodeficiency	-
46	Malignant rheumatoid arthritis	46.486
13	Multiple sclerosis/Neuromyelitis optica	40.579
49	Systemic lupus erythematosus	37.524
2	Amyotrophic lateral sclerosis	34.238
96	Crohn disease	29.669
85	Idiopathic interstitial pneumonia	26.756
51	Scleroderma	25.644
93	Primary biliary cholangitis	25.630
60	Aplastic anemia	24.286
285	Fanconi anemia	21.991
331	Idiopathic multicentric castleman disease	21.505
56	Behcet disease	20.864
107	Juvenile idiopathic arthritis	20.306
26	HTLV-1-associated myelopathy	20.161
97	Ulcerative colitis	19.838
53	Sjogren syndrome	19.708
42	Polyarteritis nodosa	19.443
284	Diamond-Blackfan anemia	18.586
11	Myasthenia gravis	18.194
222	Primary nephrotic syndrome	16.466
41	Giant cell arteritis	16.459
34	Neurofibromatosis	15.896
299	Cystic fibrosis	15.282
50	Dermatomyositis	15.200
6	Parkinson disease	14.888
28	Systemic amyloidosis	14.795
19	Lysosomal storage disease	14.478
40	Takayasu arteritis	13.968
283	Acquired pure red cell aplasia	12.917
162	Pemphigoid	12.641
326	Osteopetrosis	12.522
35	Pemphigus	12.412
164	Oculocutaneous albinism	12.387
271	Ankylosing spondylitis	12.033
256	Muscle glycogenosis	11.961
113	Muscular dystrophy	11.576
228	Bronchiolitis obliterans	10.314
55	Relapsing polychondritis	10.195
269	Pyogenic arthritis	9.920
45	Eosinophilic granulomatosis with Polyangiitis	9.910
266	Familial mediterranean fever	8.931
62	Paroxysmal nocturnal hemoglobinuria	8.763
20	Adrenoleukodystrophy	8.450
86	Pulmonary arterial hypertension	8.281
84	Sarcoidosis	8.238
95	Autoimmune hepatitis	8.168
286	Hereditary sideroblastic anemia	8.000
64	Thrombotic thrombocytopenic purpura	7.983
61	Autoimmune hemolytic anemia	7.661
44	Wegener granulomatosis	7.543
233	Wolfram syndrome	7.527
63	Idiopathic thrombocytopenic purpura	7.522
160	Congenital ichthyosis	7.245
90	Retinitis pigmentosa	7.140
300	IgG4-related disease	7.037
102	Rubinstein-Taybi syndrome	7.000
66	IgA nephropathy	6.907
226	Interstitial cystitis with Hunners ulcer	6.874
58	Hypertrophic cardiomyopathy	6.406
274	Osteogenesis Imperfecta	6.107
39	Toxic epidermal necrolysis	6.012
151	Rasmussen encephalitis	6.000
38	Stevens-Johnson syndrome	5.760
234	Peroxisomal disease (except Adrenoleukodystrophy)	5.570
158	Tuberous sclerosis	5.166
302	Leber hereditary optic neuropathy	5.000
36	Epidermolysis bullosa	4.829
127	Frontotemporal lobar degeneration	4.720
210	Single Ventricle	4.664
3	Spinal muscular atrophy	4.606
224	Purpura nephritis	4.599
37	Generalised pustular psoriasis	4.545
265	Lipodystrophy	4.530
78	Hypopituitarism	4.436
89	Lymphangioleiomyomatosis	4.403
83	Addison disease	4.213
76	Pituitary gonadotropin secretion hyperthyroidism	4.213
5	Progressive supranuclear palsy	4.102
227	Osler disease	4.070
235	Hypoparathyroidism	4.000
71	Idiopathic osteonecrosis of the femoral head	4.000
43	Microscopic polyangiitis	3.772
323	Aromatic L-amino acid decarboxylase deficiency	3.000
94	Primary sclerosing cholangitis	2.923
270	Chronic recurrent multifocal osteomyelitis	2.726
21	Mitochondrial disease	2.451
15	Inclusion body myositis	2.424
251	Urea cycle disorder	2.275
215	Tetralogy of Fallot	2.267
206	Fragile X syndrome	2.250
81	Congenital adrenal hyperplasia	2.245
98	Eosinophilic gastrointestinal disease	2.133
77	Growth hormone secreting pituitary adenoma	2.000
268	Nakajo-Nishimura syndrome	2.000
325	Hereditary autoinflammatory syndrome	2.000
337	Homocystinuria	2.000
282	Congenital dyserythropoietic anemia	2.000
280	Huge arteriovenous malformation with cervicofacial or limb lesion	1.964
301	Macular dystrophy	1.877
16	Crow-Fukase syndrome	1.840
298	Hereditary pancreatitis	1.811
149	Hemiconvulsion hemiplegia epilepsy syndrome	1.667
70	Spinal stenosis	1.595
288	Autoimmune acquired coagulation factor deficiency	1.590
18	Spinocerebellar degeneration	1.549
225	Congenital nephrogenic diabetes insipidus	1.520
14	Chronic inflammatory demyelinating polyneuropathy	1.452
8	Huntington disease	1.405
229	Autoimmune pulmonary alveolar proteinosis	1.348
172	Hypophosphatasia	1.348
75	Cushing disease	1.273
118	Myelomeningocele	1.188
212	Tricuspid atresia	1.188
74	Prolactin secreting pituitary adenoma	1.133
22	Moyamoya disease	1.121
169	Menkes disease	1.067
170	Occipital horn syndrome	1.067
106	Cryopyrin-associated periodic syndrome	1.022
238	Vitamin D-resistant rickets	1.022
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
232	Carney complex	1.000
191	Werner syndrome	1.000
68	Ossification of the ligamentum flavum	1.000
52	Mixed connective tissue disease	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000