DR info

Clinical trials : 627 / Drugs : 443 - (DrugBank : 120) / Drug target genes : 99 - Drug target pathways : 212

Idiopathic interstitial pneumonia and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
85	Idiopathic interstitial pneumonia	-
51	Scleroderma	45.016
46	Malignant rheumatoid arthritis	40.269
13	Multiple sclerosis/Neuromyelitis optica	39.217
2	Amyotrophic lateral sclerosis	29.059
65	Primary immunodeficiency	26.756
228	Bronchiolitis obliterans	26.515
28	Systemic amyloidosis	25.587
6	Parkinson disease	24.240
34	Neurofibromatosis	21.476
331	Idiopathic multicentric castleman disease	21.383
26	HTLV-1-associated myelopathy	21.316
42	Polyarteritis nodosa	20.963
49	Systemic lupus erythematosus	20.325
96	Crohn disease	19.882
222	Primary nephrotic syndrome	19.374
89	Lymphangioleiomyomatosis	18.831
86	Pulmonary arterial hypertension	17.274
227	Osler disease	16.330
113	Muscular dystrophy	15.277
164	Oculocutaneous albinism	13.428
56	Behcet disease	12.907
127	Frontotemporal lobar degeneration	12.020
210	Single Ventricle	11.557
45	Eosinophilic granulomatosis with Polyangiitis	11.329
41	Giant cell arteritis	11.306
97	Ulcerative colitis	11.071
93	Primary biliary cholangitis	10.847
285	Fanconi anemia	9.740
58	Hypertrophic cardiomyopathy	9.724
60	Aplastic anemia	9.584
11	Myasthenia gravis	9.164
266	Familial mediterranean fever	8.905
66	IgA nephropathy	8.718
283	Acquired pure red cell aplasia	8.485
215	Tetralogy of Fallot	8.485
284	Diamond-Blackfan anemia	8.380
50	Dermatomyositis	7.906
39	Toxic epidermal necrolysis	7.512
5	Progressive supranuclear palsy	7.351
19	Lysosomal storage disease	7.115
162	Pemphigoid	7.079
38	Stevens-Johnson syndrome	7.003
224	Purpura nephritis	7.003
102	Rubinstein-Taybi syndrome	7.000
36	Epidermolysis bullosa	6.966
3	Spinal muscular atrophy	6.635
40	Takayasu arteritis	6.516
61	Autoimmune hemolytic anemia	6.516
8	Huntington disease	6.429
62	Paroxysmal nocturnal hemoglobinuria	6.344
90	Retinitis pigmentosa	6.169
20	Adrenoleukodystrophy	6.111
35	Pemphigus	6.111
274	Osteogenesis Imperfecta	6.078
151	Rasmussen encephalitis	6.000
226	Interstitial cystitis with Hunners ulcer	5.939
84	Sarcoidosis	5.838
57	Idiopathic dilated cardiomyopathy	5.554
234	Peroxisomal disease (except Adrenoleukodystrophy)	5.549
326	Osteopetrosis	5.420
88	Chronic thromboembolic pulmonary hypertension	5.172
70	Spinal stenosis	5.165
53	Sjogren syndrome	5.039
302	Leber hereditary optic neuropathy	5.000
211	Hypoplastic left heart syndrome	5.000
43	Microscopic polyangiitis	4.848
17	Multiple system atrophy	4.739
95	Autoimmune hepatitis	4.694
256	Muscle glycogenosis	4.692
233	Wolfram syndrome	4.635
286	Hereditary sideroblastic anemia	4.591
269	Pyogenic arthritis	4.568
107	Juvenile idiopathic arthritis	4.530
78	Hypopituitarism	4.331
64	Thrombotic thrombocytopenic purpura	4.323
55	Relapsing polychondritis	4.290
63	Idiopathic thrombocytopenic purpura	4.267
299	Cystic fibrosis	4.261
67	Polycystic kidney disease	4.053
87	Pulmonary veno-occlusive disease	4.000
280	Huge arteriovenous malformation with cervicofacial or limb lesion	3.747
18	Spinocerebellar degeneration	3.612
158	Tuberous sclerosis	3.579
278	Huge lymphatic malformation with cervicofacial lesion	3.232
160	Congenital ichthyosis	3.025
169	Menkes disease	2.890
170	Occipital horn syndrome	2.890
47	Buerger disease	2.721
44	Wegener granulomatosis	2.663
98	Eosinophilic gastrointestinal disease	2.614
21	Mitochondrial disease	2.385
91	Budd-Chiari syndrome	2.273
71	Idiopathic osteonecrosis of the femoral head	2.273
298	Hereditary pancreatitis	2.208
206	Fragile X syndrome	2.182
94	Primary sclerosing cholangitis	2.144
271	Ankylosing spondylitis	2.081
118	Myelomeningocele	2.081
282	Congenital dyserythropoietic anemia	2.000
203	22q11.2 deletion syndrome	1.948
301	Macular dystrophy	1.868
157	Sturge-Weber syndrome	1.836
276	Achondroplasia	1.836
16	Crow-Fukase syndrome	1.836
166	Pseudoxanthoma elasticum	1.836
294	Congenital diaphragmatic hernia	1.836
300	IgG4-related disease	1.835
205	Fragile X syndrome related disease	1.716
288	Autoimmune acquired coagulation factor deficiency	1.571
218	Alport syndrome	1.545
83	Addison disease	1.545
4	Primary lateral sclerosis	1.502
14	Chronic inflammatory demyelinating polyneuropathy	1.441
25	Progressive multifocal leukoencephalopathy	1.338
212	Tricuspid atresia	1.182
22	Moyamoya disease	1.100
156	Rett syndrome	1.086
149	Hemiconvulsion hemiplegia epilepsy syndrome	1.065
106	Cryopyrin-associated periodic syndrome	1.020
238	Vitamin D-resistant rickets	1.020
235	Hypoparathyroidism	1.020
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
111	Congenital myopathy	1.000
108	TNF receptor-associated periodic syndrome	1.000
267	Hyper-IgD syndrome	1.000
52	Mixed connective tissue disease	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000