DR info

Clinical trials : 2,442 / Drugs : 1,278 - (DrugBank : 248) / Drug target genes : 142 - Drug target pathways : 209

Crohn disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
96	Crohn disease	-
13	Multiple sclerosis/Neuromyelitis optica	108.041
46	Malignant rheumatoid arthritis	95.936
97	Ulcerative colitis	91.853
2	Amyotrophic lateral sclerosis	75.223
6	Parkinson disease	60.766
156	Rett syndrome	47.218
49	Systemic lupus erythematosus	40.532
70	Spinal stenosis	40.060
21	Mitochondrial disease	38.649
84	Sarcoidosis	33.784
8	Huntington disease	33.306
36	Epidermolysis bullosa	31.399
226	Interstitial cystitis with Hunners ulcer	31.172
298	Hereditary pancreatitis	31.090
113	Muscular dystrophy	30.186
65	Primary immunodeficiency	29.669
51	Scleroderma	29.342
50	Dermatomyositis	28.929
158	Tuberous sclerosis	28.111
22	Moyamoya disease	28.000
107	Juvenile idiopathic arthritis	27.297
11	Myasthenia gravis	24.516
17	Multiple system atrophy	24.407
206	Fragile X syndrome	23.956
53	Sjogren syndrome	23.645
19	Lysosomal storage disease	23.620
231	Alpha-1-antitrypsin deficiency	23.333
75	Cushing disease	22.933
98	Eosinophilic gastrointestinal disease	21.977
271	Ankylosing spondylitis	21.977
34	Neurofibromatosis	21.439
40	Takayasu arteritis	21.412
193	Prader-Willi syndrome	21.086
5	Progressive supranuclear palsy	21.066
78	Hypopituitarism	20.820
299	Cystic fibrosis	20.235
60	Aplastic anemia	20.222
85	Idiopathic interstitial pneumonia	19.882
41	Giant cell arteritis	19.841
205	Fragile X syndrome related disease	19.706
18	Spinocerebellar degeneration	19.185
162	Pemphigoid	18.390
93	Primary biliary cholangitis	17.535
95	Autoimmune hepatitis	17.154
140	Dorabe syndrome	17.086
144	Lennox-Gastaut syndrome	16.826
86	Pulmonary arterial hypertension	16.101
152	PCDH19 related syndrome	16.000
272	Fibrodysplasia ossificans progressiva	15.934
58	Hypertrophic cardiomyopathy	15.928
3	Spinal muscular atrophy	15.883
285	Fanconi anemia	15.488
56	Behcet disease	14.565
265	Lipodystrophy	14.463
296	Biliary atresia	14.400
63	Idiopathic thrombocytopenic purpura	14.400
283	Acquired pure red cell aplasia	14.392
45	Eosinophilic granulomatosis with Polyangiitis	14.392
145	West syndrome	14.007
66	IgA nephropathy	13.650
28	Systemic amyloidosis	13.610
284	Diamond-Blackfan anemia	13.527
222	Primary nephrotic syndrome	12.441
201	Angelman syndrome	12.052
35	Pemphigus	12.052
38	Stevens-Johnson syndrome	11.401
256	Muscle glycogenosis	11.260
44	Wegener granulomatosis	11.097
62	Paroxysmal nocturnal hemoglobinuria	11.097
164	Oculocutaneous albinism	10.437
42	Polyarteritis nodosa	10.432
55	Relapsing polychondritis	10.143
234	Peroxisomal disease (except Adrenoleukodystrophy)	10.143
269	Pyogenic arthritis	9.771
224	Purpura nephritis	9.771
215	Tetralogy of Fallot	9.668
160	Congenital ichthyosis	9.668
155	Acquired aphasia with convulsive disorder	9.511
20	Adrenoleukodystrophy	9.333
168	Ehlers-Danlos syndrome	9.000
57	Idiopathic dilated cardiomyopathy	9.000
169	Menkes disease	9.000
170	Occipital horn syndrome	9.000
127	Frontotemporal lobar degeneration	8.214
167	Marfan syndrome	8.148
286	Hereditary sideroblastic anemia	8.000
94	Primary sclerosing cholangitis	7.895
326	Osteopetrosis	7.788
228	Bronchiolitis obliterans	7.549
280	Huge arteriovenous malformation with cervicofacial or limb lesion	7.313
43	Microscopic polyangiitis	7.313
61	Autoimmune hemolytic anemia	7.243
288	Autoimmune acquired coagulation factor deficiency	7.002
300	IgG4-related disease	6.865
236	Pseudohypoparathyroidism	6.374
118	Myelomeningocele	6.161
151	Rasmussen encephalitis	6.000
274	Osteogenesis Imperfecta	5.958
10	Charcot-Marie-Tooth disease	5.922
39	Toxic epidermal necrolysis	5.922
67	Polycystic kidney disease	5.895
227	Osler disease	5.637
90	Retinitis pigmentosa	5.521
64	Thrombotic thrombocytopenic purpura	5.273
25	Progressive multifocal leukoencephalopathy	5.173
157	Sturge-Weber syndrome	5.000
278	Huge lymphatic malformation with cervicofacial lesion	5.000
302	Leber hereditary optic neuropathy	5.000
294	Congenital diaphragmatic hernia	5.000
1	Spinal and bulbar muscular atrophy	4.987
26	HTLV-1-associated myelopathy	4.376
37	Generalised pustular psoriasis	4.315
81	Congenital adrenal hyperplasia	4.205
83	Addison disease	4.191
246	Methylmalonic acidemia	3.966
4	Primary lateral sclerosis	3.589
210	Single Ventricle	3.534
171	Wilson disease	3.000
310	Congenital anomalies syndrome	3.000
229	Autoimmune pulmonary alveolar proteinosis	3.000
323	Aromatic L-amino acid decarboxylase deficiency	3.000
270	Chronic recurrent multifocal osteomyelitis	2.698
218	Alport syndrome	2.698
76	Pituitary gonadotropin secretion hyperthyroidism	2.698
15	Inclusion body myositis	2.354
251	Urea cycle disorder	2.263
91	Budd-Chiari syndrome	2.263
71	Idiopathic osteonecrosis of the femoral head	2.263
212	Tricuspid atresia	2.048
88	Chronic thromboembolic pulmonary hypertension	2.015
268	Nakajo-Nishimura syndrome	2.000
325	Hereditary autoinflammatory syndrome	2.000
337	Homocystinuria	2.000
195	Noonan syndrome	2.000
263	Cerebrotendinous xanthomatosis	2.000
257	Hepatic glycogenosis	2.000
282	Congenital dyserythropoietic anemia	2.000
203	22q11.2 deletion syndrome	1.881
16	Crow-Fukase syndrome	1.821
211	Hypoplastic left heart syndrome	1.821
159	Xeroderma pigmentosum	1.821
331	Idiopathic multicentric castleman disease	1.806
89	Lymphangioleiomyomatosis	1.500
114	Non-dystrophic myotonia syndrome	1.496
14	Chronic inflammatory demyelinating polyneuropathy	1.397
225	Congenital nephrogenic diabetes insipidus	1.371
172	Hypophosphatasia	1.341
74	Prolactin secreting pituitary adenoma	1.071
179	Williams syndrome	1.036
333	Hutchinson-Gilford syndrome	1.012
238	Vitamin D-resistant rickets	1.012
235	Hypoparathyroidism	1.012
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
232	Carney complex	1.000
111	Congenital myopathy	1.000
99	Chronic intestinal pseudo-obstruction	1.000
191	Werner syndrome	1.000
52	Mixed connective tissue disease	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000