13. Multiple sclerosis/Neuromyelitis optica Clinical trials / Disease details

Clinical trials : 3,340 / Drugs : 2,163 - (DrugBank : 383) / Drug target genes : 241 - Drug target pathways : 238

35 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2020-000644-55-DE (EUCTR)	22/04/2021	17/06/2020	Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's TyrosineKinase (BTK) Inhibitor Tolebru ...	A Phase 3, randomized, double-blind efficacy and safety study comparing SAR442168 to teriflunomide ( ...	Relapsing Multiple Sclerosis MedDRA version: 21.0;Level: PT;Classification code 10080700;Term: Relap ...	Product Code: SAR442168 INN or Proposed INN: Not available Other descriptive name: PRN2246 Trade Name: ...	Genzyme Corporation	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1200	Phase 3	United States;Serbia;Portugal;Slovakia;Greece;Spain;Ukraine;Russian Federation;Israel;Chile;Switzerl ...
2	NCT04742400 (ClinicalTrials.gov)	April 15, 2021	5/2/2021	Tolebrutinib, a Brain-penetrant Bruton s Tyrosine Kinase Inhibitor, for the Modulation of Chronicall ...	A Phase 2 Clinical Trial of Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for ...	Multiple Sclerosis	Drug: tolebrutinib 60mg;Drug: tolebrutinib 120mg	National Institute of Neurological Disorders and Stroke (NINDS)	NULL	Active, not recruiting	18 Years	N/A	All	11	Phase 2	United States
3	EUCTR2020-000647-30-PT (EUCTR)	26/02/2021	17/09/2020	Nonrelapsing secondary progressive multiple sclerosis (NRSPMS) study of Bruton tyrosine kinase (BTK) ...	A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in par ...	Non-relapsing Secondary Progressive Multiple Sclerosis MedDRA version: 21.1;Level: PT;Classification ...	Product Code: SAR442168 INN or Proposed INN: Not available Other descriptive name: PRN2246	Genzyme Corporation	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1700	Phase 3	United States;Belarus;Portugal;Greece;Spain;Ukraine;Russian Federation;Israel;Italy;India;France;Aus ...
4	EUCTR2020-000645-14-PT (EUCTR)	26/02/2021	23/11/2020	Primary progressive multiple sclerosis (PPMS) Study of Bruton's tyrosine kinase (BTK) inhibitor tole ...	A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in par ...	Primary Progressive Multiple Sclerosis MedDRA version: 21.1;Level: PT;Classification code 10063401;T ...	Product Code: SAR442168 INN or Proposed INN: Not available Other descriptive name: PRN2246	Genzyme Corporation	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1320	Phase 3	Belarus;Portugal;Serbia;United States;Estonia;Greece;Spain;Ukraine;Ireland;Israel;Chile;Russian Fede ...
5	JPRN-jRCT2021200035	22/02/2021	24/12/2020	Relapsing Forms of multiple sclerosis (RMS) study of Bruton's Tyrosine Kinase (BTK) inhibitor Tolebr ...	A Phase 3, randomized, double-blind efficacy and safety study comparing SAR442168 to teriflunomide ( ...	Relapsing Multiple Sclerosis	Drug: SAR442168 (Tolebrutinib) Pharmaceutical form: Tablet, Route of administration: Oral Drug: Placeb ...	Tanaka Tomoyuki	NULL	Not Recruiting	>= 18age old	<= 55age old	Both	900	Phase 3	Bulgaria;Canada;Czechia;Estonia;Spain;United States;Belarus;China;Finland;Germany;Italy;Lithuania;Po ...
6	EUCTR2020-000645-14-BE (EUCTR)	22/02/2021	29/10/2020	Primary progressive multiple sclerosis (PPMS) Study of Bruton's tyrosine kinase (BTK) inhibitor tole ...	A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in par ...	Primary Progressive Multiple Sclerosis MedDRA version: 21.1;Level: PT;Classification code 10063401;T ...	Product Code: SAR442168 INN or Proposed INN: Not available Other descriptive name: PRN2246	Genzyme Corporation	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1320	Phase 3	Portugal;Belarus;Serbia;United States;Estonia;Greece;Spain;Ukraine;Ireland;Russian Federation;Israel ...
7	EUCTR2020-000637-41-AT (EUCTR)	16/02/2021	09/09/2020	Relapsing Forms of multiple sclerosis (RMS) study of Bruton's TyrosineKinase (BTK) inhibitor Tolebru ...	A Phase 3, randomized, double-blind efficacy and safety study comparing SAR442168 to teriflunomide ( ...	Relapsing Multiple Sclerosis MedDRA version: 21.0;Level: PT;Classification code 10080700;Term: Relap ...	Product Code: SAR442168 INN or Proposed INN: Not available Other descriptive name: PRN2246 Trade Name: ...	Genzyme Corporation	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1200	Phase 3	United States;Belarus;Estonia;Taiwan;Hong Kong;Spain;Ukraine;Russian Federation;Italy;Denmark;China; ...
8	EUCTR2020-000645-14-NL (EUCTR)	12/02/2021	16/11/2020	Primary progressive multiple sclerosis (PPMS) Study of Bruton's tyrosine kinase (BTK) inhibitor tole ...	A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in par ...	Primary Progressive Multiple Sclerosis MedDRA version: 21.1;Level: PT;Classification code 10063401;T ...	Product Code: SAR442168 INN or Proposed INN: Not available Other descriptive name: PRN2246	Genzyme Corporation	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1320	Phase 3	Portugal;Belarus;Serbia;United States;Estonia;Greece;Spain;Ukraine;Ireland;Russian Federation;Israel ...
9	EUCTR2020-000645-14-DE (EUCTR)	28/01/2021	26/10/2020	Primary progressive multiple sclerosis (PPMS) Study of Bruton's tyrosinekinase (BTK) inhibitor toleb ...	A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in par ...	Primary Progressive Multiple Sclerosis MedDRA version: 21.1;Level: PT;Classification code 10063401;T ...	Product Code: SAR442168 INN or Proposed INN: Not available Other descriptive name: PRN2246	Genzyme Corporation	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1320	Phase 3	United States;Serbia;Portugal;Belarus;Estonia;Greece;Spain;Ukraine;Ireland;Russian Federation;Chile; ...
10	EUCTR2020-000647-30-NL (EUCTR)	23/12/2020	16/09/2020	Nonrelapsing secondary progressive multiple sclerosis (NRSPMS) study of Bruton tyrosine kinase (BTK) ...	A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in par ...	Non-relapsing Secondary Progressive Multiple Sclerosis MedDRA version: 21.1;Level: PT;Classification ...	Product Code: SAR442168 INN or Proposed INN: Not available Other descriptive name: PRN2246	Genzyme Corporation	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	1700	Phase 3	United States;Belarus;Portugal;Greece;Spain;Ukraine;Russian Federation;Israel;Italy;India;France;Aus ...

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