Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CDK4 [6] PI3K-Akt signaling pathway, Tight junction, T cell receptor signaling pathway, Pathways in cancer, Viral carcinogenesis, Small cell lung cancer D10688 Abemaciclib [1] 34
2 CDK6 [4] PI3K-Akt signaling pathway, Pathways in cancer, Viral carcinogenesis, Small cell lung cancer D10688 Abemaciclib [1] 34
3 CSF1R [6] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D11270 Pexidartinib [1] 34
4 CSF2RA [1] Pathways in cancer D05066 Molgramostim [3] 97, 229, 299
5 CSF2RA [1] Pathways in cancer D05712 Regramostim [1] 229
6 CSF2RA [1] Pathways in cancer D05803 Sargramostim [7] 6, 28, 60, 62, 96, 229, 285
7 CSF2RA [1] Pathways in cancer D09930 Mavrilimumab [2] 41, 46
8 CSF3R [2] PI3K-Akt signaling pathway, Pathways in cancer D03235 Filgrastim [34] 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
9 CSF3R [2] PI3K-Akt signaling pathway, Pathways in cancer D03247 Lenograstim [7] 2, 13, 16, 18, 19, 57, 65
10 CSF3R [2] PI3K-Akt signaling pathway, Pathways in cancer D06889 Pegfilgrastim [1] 60
11 NQO1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer D00564 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
12 NQO1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer D01280 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
13 NQO1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer D08682 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
14 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D00150 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224
15 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D00357 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
16 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D00400 Valsartan [7] 57, 58, 66, 75, 218, 222, 224
17 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D00522 Candesartan cilexetil [1] 67
18 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D00522 Candesartan [2] 58, 67
19 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D00523 Irbesartan [4] 66, 167, 168, 222
20 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D00626 Candesartan cilexetil [1] 67
21 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D00627 Telmisartan [2] 66, 67
22 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D02014 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224
23 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D08146 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
24 AGTR1 [5] Phospholipase D signaling pathway, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Pathways in cancer D11776 Sparsentan [3] 66, 218, 222
25 EDNRA [3] Vascular smooth muscle contraction, Renin secretion, Pathways in cancer D01227 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
26 EDNRA [3] Vascular smooth muscle contraction, Renin secretion, Pathways in cancer D07077 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211
27 EDNRA [3] Vascular smooth muscle contraction, Renin secretion, Pathways in cancer D07171 Sitaxentan [1] 86
28 EDNRA [3] Vascular smooth muscle contraction, Renin secretion, Pathways in cancer D07538 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
29 EDNRA [3] Vascular smooth muscle contraction, Renin secretion, Pathways in cancer D07741 Zibotentan [1] 51
30 EDNRA [3] Vascular smooth muscle contraction, Renin secretion, Pathways in cancer D10135 Macitentan [5] 51, 85, 86, 88, 210
31 EDNRA [3] Vascular smooth muscle contraction, Renin secretion, Pathways in cancer D11776 Sparsentan [3] 66, 218, 222
32 EDNRB [2] Relaxin signaling pathway, Pathways in cancer D01227 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
33 EDNRB [2] Relaxin signaling pathway, Pathways in cancer D07538 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
34 EDNRB [2] Relaxin signaling pathway, Pathways in cancer D10135 Macitentan [5] 51, 85, 86, 88, 210
35 EGFR [11] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D01977 Gefitinib [1] 75
36 EGFR [11] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D03455 Cetuximab [5] 34, 51, 86, 89, 331
37 EGFR [11] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D04023 Erlotinib [1] 94
38 EGFR [11] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D04024 Lapatinib [3] 34, 74, 75
39 EGFR [11] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D07907 Erlotinib [1] 94
40 EGFR [11] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08108 Lapatinib [3] 34, 74, 75
41 EGFR [11] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11251 Icotinib [1] 34
42 EGFR [11] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11772 Tesevatinib [1] 67
43 EPOR [2] PI3K-Akt signaling pathway, Pathways in cancer D03231 Erythropoietin [10] 2, 6, 13, 18, 22, 46, 47, 70, 95, 96
44 EPOR [2] PI3K-Akt signaling pathway, Pathways in cancer D09946 Peginesatide [1] 283
45 ERBB2 [6] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D04024 Lapatinib [3] 34, 74, 75
46 ERBB2 [6] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D08108 Lapatinib [3] 34, 74, 75
47 ERBB2 [6] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D11772 Tesevatinib [1] 67
48 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00105 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
49 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00185 Estriol [2] 13, 227
50 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00289 Danazol [5] 60, 63, 64, 65, 285
51 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00554 Ethinylestradiol [4] 13, 46, 49, 299
52 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00575 Mestranol [2] 46, 49
53 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00962 Clomifene [1] 74
54 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00966 Tamoxifen [4] 2, 86, 113, 227
55 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01161 Fulvestrant [2] 49, 86
56 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01413 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
57 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01413 Estradiol valerate [1] 65
58 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01617 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
59 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01953 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
60 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01986 Estriol [2] 13, 227
61 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D02217 Raloxifene [1] 46
62 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D02367 Desogestrel [1] 230
63 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D04061 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
64 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D04063 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
65 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D04064 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
66 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D04065 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
67 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D07726 Clomifene [1] 74
68 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D08409 Prasterone [6] 49, 53, 83, 86, 96, 113
69 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D08465 Raloxifene [1] 46
70 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D08559 Tamoxifen [4] 2, 86, 113, 227
71 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D11513 Estetrol [1] 53
72 ESR1 [4] Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D11514 Estetrol [1] 53
73 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D00105 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
74 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D00185 Estriol [2] 13, 227
75 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D00575 Mestranol [2] 46, 49
76 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D00962 Clomifene [1] 74
77 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D00966 Tamoxifen [4] 2, 86, 113, 227
78 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D01161 Fulvestrant [2] 49, 86
79 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D01413 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
80 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D01413 Estradiol valerate [1] 65
81 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D01617 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
82 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D01953 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
83 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D01986 Estriol [2] 13, 227
84 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D02217 Raloxifene [1] 46
85 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D04061 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
86 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D04063 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
87 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D04064 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
88 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D04065 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
89 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D07726 Clomifene [1] 74
90 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D08409 Prasterone [6] 49, 53, 83, 86, 96, 113
91 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D08465 Raloxifene [1] 46
92 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D08559 Tamoxifen [4] 2, 86, 113, 227
93 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D11513 Estetrol [1] 53
94 ESR2 [2] Prolactin signaling pathway, Pathways in cancer D11514 Estetrol [1] 53
95 F2 [4] Phospholipase D signaling pathway, Platelet activation, Regulation of actin cytoskeleton, Pathways in cancer D06410 Thrombomodulin Alfa [1] 85
96 F2 [4] Phospholipase D signaling pathway, Platelet activation, Regulation of actin cytoskeleton, Pathways in cancer D07144 Dabigatran etexilate [1] 51
97 F2 [4] Phospholipase D signaling pathway, Platelet activation, Regulation of actin cytoskeleton, Pathways in cancer D09707 Dabigatran [4] 51, 85, 91, 124
98 FGFR1 [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
99 FGFR1 [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D11589 Infigratinib [1] 276
100 FGFR3 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
101 FGFR3 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer D11589 Infigratinib [1] 276
102 FGFR2 [7] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D05338 Palifermin [5] 13, 36, 38, 39, 65
103 FGFR2 [7] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
104 FGFR2 [7] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D11589 Infigratinib [1] 276
105 FLT3 [4] Ras signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D06272 Sorafenib [2] 34, 86
106 FLT3 [4] Ras signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D06402 Sunitinib [2] 28, 34
107 FLT3 [4] Ras signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D08524 Sorafenib [2] 34, 86
108 FLT3 [4] Ras signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D08552 Sunitinib [2] 28, 34
109 FLT3 [4] Ras signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D11270 Pexidartinib [1] 34
110 FLT4 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D03218 Axitinib [1] 34
111 FLT4 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D06272 Sorafenib [2] 34, 86
112 FLT4 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D06402 Sunitinib [2] 28, 34
113 FLT4 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D08524 Sorafenib [2] 34, 86
114 FLT4 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D08552 Sunitinib [2] 28, 34
115 FLT4 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D08881 Cediranib [1] 34
116 FLT4 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
117 FLT4 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D11772 Tesevatinib [1] 67
118 ALK [2] Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09731 Crizotinib [1] 34
119 ALK [2] Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10866 Brigatinib [1] 34
120 MTOR [13] Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D00753 Sirolimus [41] 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
121 MTOR [13] Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D02714 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277
122 MTOR [13] Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D06068 Temsirolimus [4] 13, 34, 89, 331
123 ABL1 [3] Ras signaling pathway, Pathways in cancer, Viral myocarditis D01441 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
124 ABL1 [3] Ras signaling pathway, Pathways in cancer, Viral myocarditis D03252 Bosutinib [2] 2, 67
125 ABL1 [3] Ras signaling pathway, Pathways in cancer, Viral myocarditis D03658 Dasatinib [2] 51, 85
126 ABL1 [3] Ras signaling pathway, Pathways in cancer, Viral myocarditis D06414 Dasatinib [2] 51, 85
127 ABL1 [3] Ras signaling pathway, Pathways in cancer, Viral myocarditis D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
128 ABL1 [3] Ras signaling pathway, Pathways in cancer, Viral myocarditis D08953 Nilotinib [5] 6, 8, 34, 51, 86
129 ABL1 [3] Ras signaling pathway, Pathways in cancer, Viral myocarditis D09664 Saracatinib [3] 6, 89, 272
130 HDAC1 [4] Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis D06320 Vorinostat [3] 19, 75, 96
131 HDAC2 [4] Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis D06320 Vorinostat [3] 19, 75, 96
132 HMOX1 [2] Porphyrin metabolism, Pathways in cancer D05922 Stannsoporfin [1] 254
133 IFNA1 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
134 IFNA1 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
135 IFNA2 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
136 IFNA2 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
137 IFNA4 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
138 IFNA4 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
139 IFNA5 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
140 IFNA5 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
141 IFNA6 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
142 IFNA6 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
143 IFNA7 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
144 IFNA7 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
145 IFNA8 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
146 IFNA8 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
147 IFNA10 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
148 IFNA10 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
149 IFNA13 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
150 IFNA13 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
151 IFNA14 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
152 IFNA14 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
153 IFNA16 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
154 IFNA16 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
155 IFNA17 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
156 IFNA17 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
157 IFNA21 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09662 Rontalizumab [1] 49
158 IFNA21 [5] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis, Pathways in cancer D09668 Sifalimumab [1] 49
159 IFNAR1 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D00745 Interferon alfa-2a [1] 56
160 IFNAR1 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D00746 Interferon beta-1b [1] 13
161 IFNAR1 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D02745 Interferon alfa-2b [2] 25, 34
162 IFNAR1 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D03305 Interferon alfa [6] 13, 25, 26, 28, 56, 96
163 IFNAR1 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D04554 Interferon beta-1a [4] 13, 26, 96, 97
164 IFNAR1 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D10483 Peginterferon beta-1a [1] 13
165 IFNAR1 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D11082 Anifrolumab [2] 46, 49
166 IFNAR2 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D00745 Interferon alfa-2a [1] 56
167 IFNAR2 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D00746 Interferon beta-1b [1] 13
168 IFNAR2 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D02745 Interferon alfa-2b [2] 25, 34
169 IFNAR2 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D03305 Interferon alfa [6] 13, 25, 26, 28, 56, 96
170 IFNAR2 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D04554 Interferon beta-1a [4] 13, 26, 96, 97
171 IFNAR2 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D10483 Peginterferon beta-1a [1] 13
172 IFNAR2 [3] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Pathways in cancer D11082 Anifrolumab [2] 46, 49
173 IFNG [12] Proteasome, TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D04242 Fontolizumab [1] 46
174 IFNG [12] Proteasome, TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Systemic lupus erythematosus, Rheumatoid arthritis D11120 Emapalumab [2] 49, 107
175 IFNGR1 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D00747 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326
176 IFNGR2 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D00747 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326
177 IGF1R [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D03297 Mecasermin [6] 65, 78, 96, 168, 265, 299
178 IGF1R [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D04870 Mecasermin [6] 65, 78, 96, 168, 265, 299
179 IGF1R [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D09680 Teprotumumab [1] 51
180 IGF1R [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D09925 Linsitinib [1] 232
181 IL2RA [5] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
182 IL2RA [5] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer D03058 Basiliximab [6] 2, 50, 66, 97, 222, 228
183 IL2RA [5] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer D03639 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284
184 IL2RB [6] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer, Transcriptional misregulation in cancer D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
185 IL2RG [6] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer, Primary immunodeficiency D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
186 IL4 [5] PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Pathways in cancer D03117 Binetrakin [1] 46
187 IL4R [4] PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer D10354 Dupilumab [4] 51, 98, 160, 162
188 IL5 [3] Th1 and Th2 cell differentiation, T cell receptor signaling pathway, Pathways in cancer D04923 Mepolizumab [4] 44, 45, 98, 162
189 IL5 [3] Th1 and Th2 cell differentiation, T cell receptor signaling pathway, Pathways in cancer D08985 Reslizumab [2] 44, 98
190 IL5RA [1] Pathways in cancer D09874 Benralizumab [5] 44, 45, 98, 162, 299
191 IL6 [14] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Pertussis, Yersinia infection, Tuberculosis, Pathways in cancer, Transcriptional misregulation in cancer, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
192 IL6 [14] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Pertussis, Yersinia infection, Tuberculosis, Pathways in cancer, Transcriptional misregulation in cancer, Rheumatoid arthritis D08976 Pomalidomide [6] 28, 34, 51, 85, 227, 331
193 IL6 [14] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Pertussis, Yersinia infection, Tuberculosis, Pathways in cancer, Transcriptional misregulation in cancer, Rheumatoid arthritis D09669 Siltuximab [2] 28, 331
194 IL6 [14] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Pertussis, Yersinia infection, Tuberculosis, Pathways in cancer, Transcriptional misregulation in cancer, Rheumatoid arthritis D10080 Sirukumab [2] 41, 46
195 IL6R [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation, Pathways in cancer D02596 Tocilizumab [21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
196 IL6R [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation, Pathways in cancer D10161 Sarilumab [5] 41, 46, 84, 107, 271
197 IL6R [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation, Pathways in cancer D11079 Satralizumab [2] 11, 13
198 IL12A [8] Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Pertussis, Toxoplasmosis, Tuberculosis, Pathways in cancer D09214 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
199 IL12B [9] Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Pertussis, Toxoplasmosis, Tuberculosis, Pathways in cancer, Proteoglycans in cancer D09214 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
200 IL13 [2] Th1 and Th2 cell differentiation, Pathways in cancer D08857 Anrukinzumab [1] 97
201 IL13 [2] Th1 and Th2 cell differentiation, Pathways in cancer D09633 Lebrikizumab [1] 85
202 IL13 [2] Th1 and Th2 cell differentiation, Pathways in cancer D09979 Tralokinumab [2] 85, 97
203 AR [2] Pathways in cancer, Prostate cancer D00075 Testosterone [9] 1, 2, 3, 13, 60, 76, 78, 113, 265
204 AR [2] Pathways in cancer, Prostate cancer D00289 Danazol [5] 60, 63, 64, 65, 285
205 AR [2] Pathways in cancer, Prostate cancer D00444 Stanozolol [1] 60
206 AR [2] Pathways in cancer, Prostate cancer D00462 Oxandrolone [2] 211, 285
207 AR [2] Pathways in cancer, Prostate cancer D00586 Flutamide [1] 81
208 AR [2] Pathways in cancer, Prostate cancer D00955 Nandrolone decanoate [2] 60, 85
209 AR [2] Pathways in cancer, Prostate cancer D00957 Testosterone [9] 1, 2, 3, 13, 60, 76, 78, 113, 265
210 AR [2] Pathways in cancer, Prostate cancer D00958 Testosterone [9] 1, 2, 3, 13, 60, 76, 78, 113, 265
211 AR [2] Pathways in cancer, Prostate cancer D00958 Testosterone enanthate [2] 13, 113
212 AR [2] Pathways in cancer, Prostate cancer D00959 Testosterone [9] 1, 2, 3, 13, 60, 76, 78, 113, 265
213 AR [2] Pathways in cancer, Prostate cancer D00959 Testosterone propionate [1] 113
214 AR [2] Pathways in cancer, Prostate cancer D03338 Calusterone [3] 2, 46, 71
215 AR [2] Pathways in cancer, Prostate cancer D06085 Testosterone [9] 1, 2, 3, 13, 60, 76, 78, 113, 265
216 AR [2] Pathways in cancer, Prostate cancer D06087 Testosterone [9] 1, 2, 3, 13, 60, 76, 78, 113, 265
217 AR [2] Pathways in cancer, Prostate cancer D06087 Testosterone undecanoate [2] 13, 60
218 AR [2] Pathways in cancer, Prostate cancer D08250 Nandrolone [2] 60, 85
219 AR [2] Pathways in cancer, Prostate cancer D08409 Prasterone [6] 49, 53, 83, 86, 96, 113
220 AR [2] Pathways in cancer, Prostate cancer D08573 Testosterone decanoate [1] 113
221 AR [2] Pathways in cancer, Prostate cancer D08574 Testosterone phenylpropionate [1] 113
222 JAK1 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, Viral carcinogenesis, PD-L1 expression and PD-1 checkpoint pathway in cancer D09959 Ruxolitinib [1] 228
223 JAK1 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, Viral carcinogenesis, PD-L1 expression and PD-1 checkpoint pathway in cancer D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
224 JAK1 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, Viral carcinogenesis, PD-L1 expression and PD-1 checkpoint pathway in cancer D10308 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
225 JAK1 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, Viral carcinogenesis, PD-L1 expression and PD-1 checkpoint pathway in cancer D10653 Peficitinib [1] 46
226 JAK1 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, Viral carcinogenesis, PD-L1 expression and PD-1 checkpoint pathway in cancer D10871 Filgotinib [6] 46, 53, 96, 97, 222, 271
227 JAK1 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, Viral carcinogenesis, PD-L1 expression and PD-1 checkpoint pathway in cancer D10944 Itacitinib [5] 46, 51, 60, 97, 228
228 JAK1 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Pathways in cancer, Viral carcinogenesis, PD-L1 expression and PD-1 checkpoint pathway in cancer D10994 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271
229 JAK2 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09959 Ruxolitinib [1] 228
230 JAK2 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
231 JAK2 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10308 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
232 JAK2 [9] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10653 Peficitinib [1] 46
233 JAK3 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis, Primary immunodeficiency D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
234 JAK3 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer, Viral carcinogenesis, Primary immunodeficiency D10653 Peficitinib [1] 46
235 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D01441 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
236 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D03658 Dasatinib [2] 51, 85
237 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D06272 Sorafenib [2] 34, 86
238 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D06402 Sunitinib [2] 28, 34
239 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D06414 Dasatinib [2] 51, 85
240 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
241 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D08524 Sorafenib [2] 34, 86
242 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D08552 Sunitinib [2] 28, 34
243 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D08953 Nilotinib [5] 6, 8, 34, 51, 86
244 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D10229 Masitinib [6] 2, 5, 6, 13, 46, 96
245 KIT [5] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D11270 Pexidartinib [1] 34
246 MET [7] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Renal cell carcinoma D10062 Cabozantinib [1] 34
247 NFE2L2 [2] Protein processing in endoplasmic reticulum, Pathways in cancer D10964 Omaveloxolone [1] 18
248 NFKB1 [24] Ras signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Prostate cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D01146 Iguratimod [4] 46, 51, 53, 271
249 IL23A [5] Th17 cell differentiation, Pertussis, Tuberculosis, Pathways in cancer, Rheumatoid arthritis D09214 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
250 IL23A [5] Th17 cell differentiation, Pertussis, Tuberculosis, Pathways in cancer, Rheumatoid arthritis D10400 Tildrakizumab [2] 162, 271
251 IL23A [5] Th17 cell differentiation, Pertussis, Tuberculosis, Pathways in cancer, Rheumatoid arthritis D10438 Guselkumab [5] 37, 41, 51, 96, 97
252 IL23A [5] Th17 cell differentiation, Pertussis, Tuberculosis, Pathways in cancer, Rheumatoid arthritis D10912 Brazikumab [2] 96, 97
253 IL23A [5] Th17 cell differentiation, Pertussis, Tuberculosis, Pathways in cancer, Rheumatoid arthritis D11052 Risankizumab [4] 37, 96, 97, 271
254 IL23A [5] Th17 cell differentiation, Pertussis, Tuberculosis, Pathways in cancer, Rheumatoid arthritis D11123 Mirikizumab [3] 37, 96, 97
255 PDGFRA [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D01441 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
256 PDGFRA [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D06402 Sunitinib [2] 28, 34
257 PDGFRA [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
258 PDGFRA [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D08552 Sunitinib [2] 28, 34
259 PDGFRA [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D08953 Nilotinib [5] 6, 8, 34, 51, 86
260 PDGFRA [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
261 PDGFRB [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D03658 Dasatinib [2] 51, 85
262 PDGFRB [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D06272 Sorafenib [2] 34, 86
263 PDGFRB [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D06402 Sunitinib [2] 28, 34
264 PDGFRB [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D06414 Dasatinib [2] 51, 85
265 PDGFRB [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D08524 Sorafenib [2] 34, 86
266 PDGFRB [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D08552 Sunitinib [2] 28, 34
267 PDGFRB [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D08953 Nilotinib [5] 6, 8, 34, 51, 86
268 PDGFRB [7] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
269 PGF [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer D09574 Aflibercept [2] 90, 166
270 PIK3CA [32] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
271 PIK3CB [32] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
272 PIK3CD [32] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
273 PIK3CD [32] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11437 Parsaclisib [3] 35, 53, 61
274 PML [3] Ubiquitin mediated proteolysis, Pathways in cancer, Transcriptional misregulation in cancer D00094 Tretinoin [6] 2, 62, 63, 75, 94, 231
275 PPARG [5] PPAR signaling pathway, Thermogenesis, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer D00596 Rosiglitazone [5] 46, 75, 97, 222, 265
276 PPARG [5] PPAR signaling pathway, Thermogenesis, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer D00945 Pioglitazone [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
277 PPARG [5] PPAR signaling pathway, Thermogenesis, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer D08378 Pioglitazone [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
278 PPARG [5] PPAR signaling pathway, Thermogenesis, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer D08491 Rosiglitazone [5] 46, 75, 97, 222, 265
279 PPARG [5] PPAR signaling pathway, Thermogenesis, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer D11256 Seladelpar [2] 93, 94
280 PPARG [5] PPAR signaling pathway, Thermogenesis, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer D11603 Leriglitazone [1] 20
281 MAP2K1 [26] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09666 Selumetinib [1] 34
282 MAP2K1 [26] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10175 Trametinib [4] 2, 34, 279, 280
283 MAP2K1 [26] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10405 Cobimetinib [1] 280
284 MAP2K1 [26] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10604 Binimetinib [1] 34
285 MAP2K2 [23] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09666 Selumetinib [1] 34
286 MAP2K2 [23] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10175 Trametinib [4] 2, 34, 279, 280
287 MAP2K2 [23] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10405 Cobimetinib [1] 280
288 MAP2K2 [23] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10604 Binimetinib [1] 34
289 PTGER1 [1] Pathways in cancer D00180 Alprostadil [2] 51, 70
290 PTGER1 [1] Pathways in cancer D02705 Alprostadil [2] 51, 70
291 PTGER1 [1] Pathways in cancer D02722 Limaprost [1] 70
292 PTGER2 [2] Renin secretion, Pathways in cancer D00419 Misoprostol [3] 46, 70, 271
293 PTGER3 [2] Regulation of lipolysis in adipocytes, Pathways in cancer D00419 Misoprostol [3] 46, 70, 271
294 PTGER4 [2] Renin secretion, Pathways in cancer D00419 Misoprostol [3] 46, 70, 271
295 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00109 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
296 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00118 Naproxen [4] 13, 46, 107, 271
297 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00120 Sulindac [1] 206
298 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00126 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
299 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00130 Diflunisal [1] 28
300 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00132 Ketoprofen [1] 46
301 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00141 Indomethacin [3] 225, 271, 298
302 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00217 Acetaminophen [18] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
303 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00315 Etodolac [1] 46
304 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00330 Flurbiprofen [3] 13, 21, 46
305 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00428 Salsalate [1] 5
306 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00567 Celecoxib [10] 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
307 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00568 Rofecoxib [1] 46
308 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00813 Ketorolac [2] 70, 226
309 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00903 Diclofenac [5] 13, 34, 46, 78, 271
310 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00904 Diclofenac [5] 13, 34, 46, 78, 271
311 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D00969 Meloxicam [4] 46, 49, 271, 296
312 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01049 Nimesulide [1] 46
313 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01122 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
314 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01183 Tolfenamic acid [1] 5
315 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01475 Flurbiprofen [3] 13, 21, 46
316 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01545 Aceclofenac [1] 46
317 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D01565 Indomethacin [3] 225, 271, 298
318 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D02110 Indomethacin [3] 225, 271, 298
319 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D02290 Flurbiprofen [3] 13, 21, 46
320 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D02709 Valdecoxib [1] 46
321 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D03710 Etoricoxib [2] 46, 271
322 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D03714 Lumiracoxib [1] 46
323 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D03716 Parecoxib [2] 46, 271
324 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D04490 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
325 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D06606 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
326 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D07816 Diclofenac [5] 13, 34, 46, 78, 271
327 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D08104 Ketorolac [2] 70, 226
328 PTGS2 [8] VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Small cell lung cancer D08149 Loxoprofen [2] 46, 271
329 RAF1 [23] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Tuberculosis, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D06272 Sorafenib [2] 34, 86
330 RAF1 [23] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Tuberculosis, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08524 Sorafenib [2] 34, 86
331 RARA [3] Th17 cell differentiation, Pathways in cancer, Transcriptional misregulation in cancer D00094 Tretinoin [6] 2, 62, 63, 75, 94, 231
332 RARA [3] Th17 cell differentiation, Pathways in cancer, Transcriptional misregulation in cancer D00348 Isotretinoin [4] 36, 39, 159, 160
333 RARA [3] Th17 cell differentiation, Pathways in cancer, Transcriptional misregulation in cancer D01418 Tamibarotene [2] 26, 96
334 RARA [3] Th17 cell differentiation, Pathways in cancer, Transcriptional misregulation in cancer D02754 Acitretin [1] 37
335 RARA [3] Th17 cell differentiation, Pathways in cancer, Transcriptional misregulation in cancer D02815 Alitretinoin [1] 49
336 RARA [3] Th17 cell differentiation, Pathways in cancer, Transcriptional misregulation in cancer D04162 Fenretinide [1] 299
337 RARA [3] Th17 cell differentiation, Pathways in cancer, Transcriptional misregulation in cancer D06543 Vitamin A [3] 13, 53, 90
338 RARB [2] Pathways in cancer, Small cell lung cancer D00094 Tretinoin [6] 2, 62, 63, 75, 94, 231
339 RARB [2] Pathways in cancer, Small cell lung cancer D00348 Isotretinoin [4] 36, 39, 159, 160
340 RARB [2] Pathways in cancer, Small cell lung cancer D02754 Acitretin [1] 37
341 RARB [2] Pathways in cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
342 RARB [2] Pathways in cancer, Small cell lung cancer D04162 Fenretinide [1] 299
343 RARB [2] Pathways in cancer, Small cell lung cancer D06543 Vitamin A [3] 13, 53, 90
344 BCL2 [12] Platinum drug resistance, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Pathways in cancer, Prostate cancer, Small cell lung cancer D10679 Venetoclax [1] 28
345 RELA [24] Ras signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Toxoplasmosis, Tuberculosis, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Prostate cancer, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D12181 Edasalonexent [1] 113
346 RET [2] Pathways in cancer, Thyroid cancer D06272 Sorafenib [2] 34, 86
347 RET [2] Pathways in cancer, Thyroid cancer D06402 Sunitinib [2] 28, 34
348 RET [2] Pathways in cancer, Thyroid cancer D08524 Sorafenib [2] 34, 86
349 RET [2] Pathways in cancer, Thyroid cancer D08552 Sunitinib [2] 28, 34
350 ROCK1 [10] Sphingolipid signaling pathway, Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Shigellosis, Yersinia infection, Pathways in cancer, Proteoglycans in cancer D07941 Fasudil [4] 2, 5, 7, 51
351 RXRA [8] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin [1] 37
352 RXRA [8] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
353 RXRA [8] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene [2] 13, 75
354 RXRB [7] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin [1] 37
355 RXRB [7] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
356 RXRB [7] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene [2] 13, 75
357 RXRG [7] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin [1] 37
358 RXRG [7] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
359 RXRG [7] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene [2] 13, 75
360 SMO [2] Pathways in cancer, Proteoglycans in cancer D09992 Vismodegib [1] 85
361 SMO [2] Pathways in cancer, Proteoglycans in cancer D10671 Taladegib [1] 85
362 BRAF [11] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D06272 Sorafenib [2] 34, 86
363 BRAF [11] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D08524 Sorafenib [2] 34, 86
364 BRAF [11] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10064 Dabrafenib [1] 34
365 TGFB1 [9] TGF-beta signaling pathway, Th17 cell differentiation, Relaxin signaling pathway, Toxoplasmosis, Tuberculosis, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D09620 Fresolimumab [4] 51, 85, 222, 274
366 TGFB2 [7] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D09620 Fresolimumab [4] 51, 85, 222, 274
367 TGFB3 [6] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis, Pathways in cancer, Renal cell carcinoma, Rheumatoid arthritis D09620 Fresolimumab [4] 51, 85, 222, 274
368 VEGFA [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D05697 Ranibizumab [4] 34, 166, 227, 301
369 VEGFA [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D06409 Bevacizumab [9] 13, 34, 85, 86, 87, 89, 227, 280, 331
370 VEGFA [9] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D09574 Aflibercept [2] 90, 166
371 VEGFB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Relaxin signaling pathway, Pathways in cancer D09574 Aflibercept [2] 90, 166
372 CXCR4 [3] Viral protein interaction with cytokine and cytokine receptor, Regulation of actin cytoskeleton, Pathways in cancer D08971 Plerixafor [6] 19, 20, 51, 65, 285, 299
373 FGF23 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer D10913 Burosumab [1] 238
374 CASP9 [12] Platinum drug resistance, PI3K-Akt signaling pathway, VEGF signaling pathway, Thyroid hormone signaling pathway, Prion disease, Pathways of neurodegeneration - multiple diseases, Toxoplasmosis, Tuberculosis, Pathways in cancer, Prostate cancer, Small cell lung cancer, Viral myocarditis D11195 Rimiducid [6] 19, 60, 65, 284, 285, 326
375 ROCK2 [11] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer D07941 Fasudil [4] 2, 5, 7, 51
376 ROCK2 [11] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer D11815 Belumosudil [1] 51
377 KEAP1 [2] Ubiquitin mediated proteolysis, Pathways in cancer D03846 Dimethyl fumarate [5] 13, 49, 51, 86, 296