Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1Bosentan1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬12件: 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2Bosentan (Tracleer)1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 51 💬
3Bosentan 125 mg1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 51 💬
4Bosentan 62.5 mg1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 51 💬
5Bosentan administration1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
6Bosentan and dapagliflozin2件: Bosentan (Bosentan),
Dapagliflozin		3件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan),
Dapagliflozin 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 40, 41 💬
7Bosentan Dispersible Tablets1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
8Bosentan group1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 51 💬
9Bosentan monohydrat1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
10BOSENTAN MONOHYDRATE1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 51, 84, 86, 88 💬
11BOSENTAN MYLAN1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 41 💬
12Bosentan, Ambrisentan2件: Ambrisentan,
Bosentan (Bosentan)		3件: Bosentan (Bosentan, Bosentan hydrate),
Ambrisentan ,
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
13Duo-Therapy with Sildenafil + Bosentan2件: Bosentan (Bosentan),
Sildenafil		4件: Bosentan (Bosentan, Bosentan hydrate),
Sildenafil citrate ,
Bosentan (Bosentan),
Sildenafil 💬 		3件: EDNRA,
EDNRB,
PDE5A 💬 		10件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
14ERA and PDE-5I (Sildenafil, Tadalafil, Bosentan, Macitentan)4件: Bosentan (Bosentan),
Macitentan,
Sildenafil,
Tadalafil		6件: Bosentan (Bosentan, Bosentan hydrate),
Tadalafil ,
Sildenafil citrate ,
Bosentan (Bosentan),
Sildenafil ,
Macitentan 💬 		3件: EDNRA,
EDNRB,
PDE5A 💬 		10件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
15NIRS after bosentan administration1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 13 💬
16Other: Switch from Ambrisentan to Bosentan2件: Ambrisentan,
Bosentan (Bosentan)		3件: Bosentan (Bosentan, Bosentan hydrate),
Ambrisentan ,
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
17Sildenafil 20mg and Bosentan 62.5mg2件: Bosentan (Bosentan),
Sildenafil		4件: Bosentan (Bosentan, Bosentan hydrate),
Sildenafil citrate ,
Bosentan (Bosentan),
Sildenafil 💬 		3件: EDNRA,
EDNRB,
PDE5A 💬 		10件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 51, 86 💬
18Sildenafil singly or in association with Bosentan2件: Bosentan (Bosentan),
Sildenafil		4件: Bosentan (Bosentan, Bosentan hydrate),
Sildenafil citrate ,
Bosentan (Bosentan),
Sildenafil 💬 		3件: EDNRA,
EDNRB,
PDE5A 💬 		10件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
19TCD after bosentan administration1件: Bosentan (Bosentan)2件: Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 13 💬