Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1L-citrulline and metformin & L-citrulline
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 113 💬
2Metformin
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬23件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 84, 86, 97, 113, 127, 206, 218, 225, 265, 285, 298 💬
3Metformin + standard OF care
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 222 💬
4Metformin 1000 MG oral tablet
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 13 💬
5Metformin 500 MG oral tablet, UP TO 4 tablets A DAY
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 13 💬
6Metformin 500 MG TID oral tablet
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 97 💬
7Metformin 500MG
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 113 💬
8Metformin and clemastine IN combination
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 13 💬
9Metformin and metformin & L-citrulline
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 113 💬
10Metformin HCL
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 285 💬
11Metformin hydrochloride1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬5件: 81, 158, 265, 299, 301 💬
12Metformin hydrochloride 850 MG oral tablet1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 13 💬
13Metformin treatment
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 46 💬
14Metformin XR
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 67 💬
15Metformin/CP-690,550
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Metformin (Metformin hydrochloride)2件: Metformin hydrochloride (Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION),
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬1件: 46 💬
16Pioglitazone or metformin
(Metformin hydrochloride, METFORMIN HYDROCHLORIDE, METFORMIN HYDROCHLORIDE EXTENDED RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE 500MG, METFORMIN HYDROCHLORIDE ORAL SOLUTION)		1件: Pioglitazone2件: Pioglitazone hydrochloride ,
Pioglitazone 💬 		1件: NR1C3 💬 12件: AMPK signaling pathway, Efferocytosis, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬1件: 265 💬