Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. KEGG DRUG DrugBank 薬物名（臨床試験情報から抽出） KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Captopril 💬1件: Captopril (Captopril and Hydrochlorothiazide)1件: Captopril1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬2件: 17, 86 💬
2 Hydrochlorothiazide 💬
(Hydrochlorothiazide (JP18/USP/INN))		1件: Hydrochlorothiazide (Hydrochlorothiazide 100 Tab)2件: Esidrix; Hydrochlorothiazide1件: SLC12A3 💬 1件: 💬4件: 13, 67, 225, 235 💬
3 Lisinopril 💬1件: Lisinopril (Lisinopril with Hydrochlorothiazide)2件: Lisinopril; ZESTRIL1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬7件: 19, 46, 49, 66, 67, 113, 222 💬
4 Valsartan 💬1件: Valsartan (Valsartan and Hydrochlorothiazide)3件: Diovan; Entresto; Valsartan1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬7件: 57, 58, 66, 75, 218, 222, 224 💬
5 Spironolactone 💬1件: Spironolactone (Spironolactone and Hydrochlorothiazide)1件: Spironolactone1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
6 Irbesartan 💬1件: Irbesartan (Irbesartan/hydrochlorothiazide Teva)2件: Aprovel; IRBESARTAN1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬4件: 66, 167, 168, 222 💬
7 Candesartan cilexetil 💬1件: Candesartan cilexetil (Candesartan Cilexetil-Hydrochlorothiazide)1件: CANDESARTAN1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 67 💬
8 Telmisartan 💬1件: Telmisartan (Telmisartan and Hydrochlorothiazide 80 mg/25 mg)1件: Telmisartan1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬2件: 66, 67 💬
9 Bisoprolol 💬1件: Bisoprolol (Bisoprolol Fumarate Hydrochlorothiazide)2件: BISOPROLOL; Bisoprolol Fumarate1件: ADRB1 💬 11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 58, 67, 86, 113 💬
10 Metoprolol 💬1件: Metoprolol (Metoprolol Tartrate and Hydrochlorothiazide 100 mg-50 mg)2件: Metoprolol; METOPROLOL SUCCINATE1件: ADRB1 💬 11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 17, 57, 58, 113, 193, 226 💬
11 Quinapril 💬1件: Quinapril (Quinapril HCL and Hydrochlorothiazide)1件: Accuretic1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬1件: 19 💬
12 Amiloride 💬1件: Amiloride (Amiloride Hydrochloride and Hydrochlorothiazide)3件: Amiloride; Amiloride Hydrochloride; Midamor3件: SCNN1A,
SCNN1B,
SCNN1G 💬 		2件: Aldosterone-regulated sodium reabsorption, Taste transduction 💬4件: 13, 67, 225, 299 💬
13 Amlodipine 💬1件: Amlodipine (Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide)1件: Amlodipine4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 67, 298 💬
14 Benazepril 💬1件: Benazepril (Benazepril and Hydrochlorothiazide)1件: Benazepril1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬4件: 49, 57, 218, 224 💬
15 Enalapril 💬1件: Enalapril (Enalapril Maleate and Hydrochlorothiazide)2件: Enalapril; Enalapril Maleate1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬6件: 19, 46, 66, 113, 210, 222 💬
16 Hydralazine 💬1件: Hydralazine (Hydralazine HCl and Hydrochlorothiazide)1件: Hydralazine1件: AOC3 💬 5件: Glycine, serine and threonine metabolism, Metabolic pathways, Phenylalanine metabolism, Tyrosine metabolism, beta-Alanine metabolism 💬1件: 67 💬
17 Lisinopril 💬1件: Lisinopril (Lisinopril with Hydrochlorothiazide)2件: Lisinopril; ZESTRIL1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬7件: 19, 46, 49, 66, 67, 113, 222 💬
18 Losartan 💬1件: Losartan (Losartan Potassium and Hydrochlorothiazide)3件: Cozaar; Losartan; LOSARTAN POTASSIUM1件: AGTR1 💬 16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬17件: 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
19 Moexipril 💬1件: Moexipril (Moexipril hydrochloride/hydrochlorothiazide)1件: Moexipril1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬1件: 93 💬
20 Propranolol 💬1件: Propranolol (Propranolol Hydrochloride and Hydrochlorothiazide)2件: Propanolol; Propranolol3件: ADRB1,
ADRB2,
ADRB3 💬 		12件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 6, 158, 167, 227, 278, 296 💬