Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Alcoholism 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
2 Alcoholism 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
3 Aldosterone synthesis and secretion 💬
1件: MC2R 💬 Corticotropin 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
4 Aldosterone synthesis and secretion 💬
1件: MC2R 💬 Corticotropin, repository 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
5 Alzheimer disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
6 Alzheimer disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
7 Amphetamine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
8 Amphetamine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
9 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
10 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
11 Calcium signaling pathway 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
12 Calcium signaling pathway 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
13 cAMP signaling pathway 💬
2件: CRHR1, CRHR2 💬 Corticorelin 💬 Corticorelin 2件: 75, 205 💬
14 cAMP signaling pathway 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
15 cAMP signaling pathway 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
16 cAMP signaling pathway 💬
1件: MC2R 💬 Corticotropin 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
17 cAMP signaling pathway 💬
1件: MC2R 💬 Corticotropin, repository 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
18 Circadian entrainment 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
19 Circadian entrainment 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
20 Cocaine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
21 Cocaine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
22 Cortisol synthesis and secretion 💬
1件: MC2R 💬 Corticotropin 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
23 Cortisol synthesis and secretion 💬
1件: MC2R 💬 Corticotropin, repository 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
24 Cushing syndrome 💬
2件: CRHR1, CRHR2 💬 Corticorelin 💬 Corticorelin 2件: 75, 205 💬
25 Cushing syndrome 💬
1件: MC2R 💬 Corticotropin 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
26 Cushing syndrome 💬
1件: MC2R 💬 Corticotropin, repository 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
27 Dopaminergic synapse 💬
2件: GRIN2A, GRIN2B 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
28 Dopaminergic synapse 💬
2件: GRIN2A, GRIN2B 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
29 GABAergic synapse 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬
30 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
31 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
32 Hormone signaling 💬
2件: CRHR1, CRHR2 💬 Corticorelin 💬 Corticorelin 2件: 75, 205 💬
33 Hormone signaling 💬
1件: MC2R 💬 Corticotropin 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
34 Hormone signaling 💬
1件: MC2R 💬 Corticotropin, repository 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
35 Huntington disease 💬
2件: GRIN1, GRIN2B 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
36 Huntington disease 💬
2件: GRIN1, GRIN2B 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
37 Long-term depression 💬
1件: CRHR1 💬 Corticorelin 💬 Corticorelin 2件: 75, 205 💬
38 Long-term potentiation 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
39 Long-term potentiation 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
40 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬
41 Neuroactive ligand signaling 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬
42 Neuroactive ligand signaling 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
43 Neuroactive ligand signaling 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
44 Neuroactive ligand-receptor interaction 💬
2件: CRHR1, CRHR2 💬 Corticorelin 💬 Corticorelin 2件: 75, 205 💬
45 Neuroactive ligand-receptor interaction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬
46 Neuroactive ligand-receptor interaction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
47 Neuroactive ligand-receptor interaction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
48 Neuroactive ligand-receptor interaction 💬
1件: MC2R 💬 Corticotropin 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
49 Neuroactive ligand-receptor interaction 💬
1件: MC2R 💬 Corticotropin, repository 💬 Corticotropin 11件: 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
50 Neuroactive ligand-receptor interaction 💬
1件: NR3C1 💬 Prednisone 💬 Prednisone 54件:  2 , 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬
51 Nicotine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬
52 Nicotine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
53 Nicotine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
54 Pathways of neurodegeneration - multiple diseases 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
55 Pathways of neurodegeneration - multiple diseases 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
56 Prion disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
57 Prion disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
58 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
59 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
60 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
61 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
62 Retrograde endocannabinoid signaling 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬
63 Serotonergic synapse 💬
3件: GABRB, GABRB, GABRB 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬
64 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
65 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
66 Systemic lupus erythematosus 💬
2件: GRIN2A, GRIN2B 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
67 Systemic lupus erythematosus 💬
2件: GRIN2A, GRIN2B 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
68 Taste transduction 💬
6件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬