Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Osteoclast differentiation 💬
 1件: BTK 💬 Acalabrutinib 💬 Acalabrutinib 2件: 46, 61 💬
2 Osteoclast differentiation 💬
 1件: BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib 2件: 46, 61 💬
3 Osteoclast differentiation 💬
 1件: BTK 💬 Branebrutinib 💬 Branebrutinib 3件: 46, 49, 53 💬
4 Osteoclast differentiation 💬
 1件: BTK 💬 Elsubrutinib 💬 Elsubrutinib 1件: 49 💬
5 Osteoclast differentiation 💬
 1件: BTK 💬 Evobrutinib 💬 Evobrutinib 3件: 13, 46, 49 💬
6 Osteoclast differentiation 💬
 1件: BTK 💬 Fenebrutinib 💬 Fenebrutinib 1件: 13 💬
7 Osteoclast differentiation 💬
 1件: BTK 💬 Ibrutinib 💬 Ibrutinib 3件: 28, 60, 61 💬
8 Osteoclast differentiation 💬
 1件: BTK 💬 Orelabrutinib 💬 Orelabrutinib 4件: 13, 49, 61, 63 💬
9 Osteoclast differentiation 💬
 1件: BTK 💬 Pirtobrutinib 💬 Pirtobrutinib 1件: 13 💬
10 Osteoclast differentiation 💬
 1件: BTK 💬 Remibrutinib 💬 Remibrutinib 3件: 11, 13, 53 💬
11 Osteoclast differentiation 💬
 1件: BTK 💬 Rilzabrutinib 💬 Rilzabrutinib 5件: 35, 61, 63, 222, 300 💬
12 Osteoclast differentiation 💬
 1件: BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib 2件: 46, 53 💬
13 Osteoclast differentiation 💬
 1件: BTK 💬 Tirabrutinib 💬 Tirabrutinib 2件: 46, 53 💬
14 Osteoclast differentiation 💬
 1件: BTK 💬 Tolebrutinib 💬 Tolebrutinib 2件: 11, 13 💬
15 Osteoclast differentiation 💬
 1件: BTK 💬 Zanubrutinib 💬 Zanubrutinib 6件: 13, 61, 63, 222, 300, 331 💬
16 Osteoclast differentiation 💬
 1件: CALCR 💬 Elcatonin 💬 Elcatonin 1件: 70 💬
17 Osteoclast differentiation 💬
 1件: CSF1R 💬 Axatilimab 💬 Axatilimab 1件: 85 💬
18 Osteoclast differentiation 💬
 1件: CSF1R 💬 Sunitinib malate 💬 Sunitinib 2件: 28, 34 💬
19 Osteoclast differentiation 💬
 1件: CSF1R 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
20 Osteoclast differentiation 💬
 2件: FYN, LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
21 Osteoclast differentiation 💬
 2件: FYN, LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
22 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Anifrolumab 💬 Anifrolumab 5件: 46, 49, 50, 51, 53 💬
23 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Interferon beta 💬 Human interferon beta 5件: 13, 20, 50, 96, 97 💬
24 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Interferon alfa 💬 Interferon alfa 2件: 25, 56 💬
25 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Interferon alfa-2a 💬 Interferon alfa-2a 1件: 56 💬
26 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Interferon alfa-2b 💬 Interferon alfa-2b 1件: 25 💬
27 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Interferon beta-1a 💬 Interferon beta-1a 3件: 13, 96, 97 💬
28 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Interferon beta-1b 💬 Interferon beta-1b 1件: 13 💬
29 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Peginterferon alfa-2a 💬 Peginterferon alfa-2a 1件: 222 💬
30 Osteoclast differentiation 💬
 2件: IFNAR1, IFNAR2 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a 1件: 13 💬
31 Osteoclast differentiation 💬
 1件: IFNB 💬 Dazukibart 💬 Dazukibart 1件: 50 💬
32 Osteoclast differentiation 💬
 1件: IFNG 💬 Emapalumab 💬 Emapalumab 5件: 49, 54, 60, 65, 107 💬
33 Osteoclast differentiation 💬
 1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
34 Osteoclast differentiation 💬
 2件: IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
35 Osteoclast differentiation 💬
 1件: IL1A 💬 Bermekimab 💬 Bermekimab 1件: 51 💬
36 Osteoclast differentiation 💬
 2件: IL1A, IL1B 💬 Lutikizumab 💬 Lutikizumab 3件: 46, 96, 97 💬
37 Osteoclast differentiation 💬
 2件: IL1A, IL1B 💬 Rilonacept 💬 Rilonacept 5件: 51, 84, 106, 107, 266 💬
38 Osteoclast differentiation 💬
 3件: IL1A, IL1B, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
39 Osteoclast differentiation 💬
 1件: IL1B 💬 Canakinumab 💬 Canakinumab 11件: 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
40 Osteoclast differentiation 💬
 1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
41 Osteoclast differentiation 💬
 1件: IL1R1 💬 Anakinra 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
42 Osteoclast differentiation 💬
 1件: JAK1 💬 Abrocitinib 💬 Abrocitinib 2件: 39, 84 💬
43 Osteoclast differentiation 💬
 1件: JAK1 💬 Baricitinib 💬 Baricitinib 21件:  2 , 13, 40, 41, 46, 49, 50, 51, 53, 54, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
44 Osteoclast differentiation 💬
 1件: JAK1 💬 Filgotinib 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
45 Osteoclast differentiation 💬
 1件: JAK1 💬 Itacitinib 💬 Itacitinib 4件: 46, 51, 97, 228 💬
46 Osteoclast differentiation 💬
 1件: JAK1 💬 Itacitinib adipate 💬 Itacitinib 4件: 46, 51, 97, 228 💬
47 Osteoclast differentiation 💬
 1件: JAK1 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
48 Osteoclast differentiation 💬
 1件: JAK1 💬 Ruxolitinib 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
49 Osteoclast differentiation 💬
 1件: JAK1 💬 Ruxolitinib phosphate 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
50 Osteoclast differentiation 💬
 1件: JAK1 💬 Upadacitinib 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
51 Osteoclast differentiation 💬
 1件: JAK1 💬 Upadacitinib tartrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
52 Osteoclast differentiation 💬
 1件: JAK1 💬 Upadacitinib hydrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
53 Osteoclast differentiation 💬
 2件: JAK1, SYK 💬 Gusacitinib 💬 Gusacitinib 1件: 49 💬
54 Osteoclast differentiation 💬
 2件: JAK1, TYK2 💬 Delgocitinib 💬 Delgocitinib 1件: 50 💬
55 Osteoclast differentiation 💬
 2件: JAK1, TYK2 💬 Filgotinib maleate 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
56 Osteoclast differentiation 💬
 2件: JAK1, TYK2 💬 Tofacitinib citrate 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
57 Osteoclast differentiation 💬
 2件: JAK1, TYK2 💬 Tofacitinib 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
58 Osteoclast differentiation 💬
 1件: LILR 💬 Daxdilimab 💬 Daxdilimab 2件: 49, 50 💬
59 Osteoclast differentiation 💬
 1件: MAP2K1 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
60 Osteoclast differentiation 💬
 1件: MAP2K1 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
61 Osteoclast differentiation 💬
 1件: MAP2K1 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
62 Osteoclast differentiation 💬
 1件: MAP2K1 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
63 Osteoclast differentiation 💬
 1件: MAP2K1 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
64 Osteoclast differentiation 💬
 1件: MAP2K1 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
65 Osteoclast differentiation 💬
 1件: MAP2K1 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
66 Osteoclast differentiation 💬
 1件: MAP2K1 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
67 Osteoclast differentiation 💬
 1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
68 Osteoclast differentiation 💬
 1件: NR1C3 💬 Bocidelpar 💬 Bocidelpar 1件: 113 💬
69 Osteoclast differentiation 💬
 1件: NR1C3 💬 Bocidelpar sulfate 💬 Bocidelpar 1件: 113 💬
70 Osteoclast differentiation 💬
 1件: NR1C3 💬 Leriglitazone 💬 Leriglitazone 1件: 20 💬
71 Osteoclast differentiation 💬
 1件: NR1C3 💬 Pioglitazone hydrochloride 💬 Pioglitazone 17件:  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 220, 229, 265, 298, 299 💬
72 Osteoclast differentiation 💬
 1件: NR1C3 💬 Pioglitazone 💬 Pioglitazone 17件:  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 220, 229, 265, 298, 299 💬
73 Osteoclast differentiation 💬
 1件: NR1C3 💬 Rosiglitazone maleate 💬 Rosiglitazone 6件: 46, 75, 77, 97, 222, 265 💬
74 Osteoclast differentiation 💬
 1件: NR1C3 💬 Rosiglitazone 💬 Rosiglitazone 6件: 46, 75, 77, 97, 222, 265 💬
75 Osteoclast differentiation 💬
 1件: NR1C3 💬 Saroglitazar 💬 Saroglitazar 1件: 93 💬
76 Osteoclast differentiation 💬
 1件: NR1C3 💬 Saroglitazar magnesium 💬 Saroglitazar 1件: 93 💬
77 Osteoclast differentiation 💬
 1件: NR1C3 💬 Seladelpar 💬 Seladelpar 2件: 93, 94 💬
78 Osteoclast differentiation 💬
 1件: NR1C3 💬 Seladelpar lysine 💬 Seladelpar 2件: 93, 94 💬
79 Osteoclast differentiation 💬
 4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
80 Osteoclast differentiation 💬
 4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
81 Osteoclast differentiation 💬
 1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
82 Osteoclast differentiation 💬
 1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
83 Osteoclast differentiation 💬
 1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
84 Osteoclast differentiation 💬
 2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
85 Osteoclast differentiation 💬
 3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
86 Osteoclast differentiation 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
87 Osteoclast differentiation 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
88 Osteoclast differentiation 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
89 Osteoclast differentiation 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Cyclosporine 💬 Cyclosporine 42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
90 Osteoclast differentiation 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
91 Osteoclast differentiation 💬
 1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
92 Osteoclast differentiation 💬
 1件: SYK 💬 Fostamatinib 💬 Fostamatinib 5件: 46, 49, 61, 63, 66 💬
93 Osteoclast differentiation 💬
 1件: SYK 💬 Fostamatinib disodium 💬 Fostamatinib 5件: 46, 49, 61, 63, 66 💬
94 Osteoclast differentiation 💬
 2件: TGFB1, TGFB2 💬 Fresolimumab 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
95 Osteoclast differentiation 💬
 1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
96 Osteoclast differentiation 💬
 1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
97 Osteoclast differentiation 💬
 1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
98 Osteoclast differentiation 💬
 1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
99 Osteoclast differentiation 💬
 1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
100 Osteoclast differentiation 💬
 1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
101 Osteoclast differentiation 💬
 1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
102 Osteoclast differentiation 💬
 1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
103 Osteoclast differentiation 💬
 1件: TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
104 Osteoclast differentiation 💬
 1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
105 Osteoclast differentiation 💬
 1件: TNFSF11 💬 Denosumab 💬 Denosumab 10件: 46, 50, 70, 75, 77, 93, 95, 96, 274, 299 💬
106 Osteoclast differentiation 💬
 1件: TYK2 💬 Deucravacitinib 💬 Deucravacitinib 9件: 36, 37, 49, 53, 84, 96, 97, 160, 269 💬
107 Osteoclast differentiation 💬
 1件: TYK2 💬 Zasocitinib 💬 Zasocitinib 2件: 96, 97 💬