Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. KEGG DRUG DrugBank Drug (Description in trials) KEGG GENES KEGG PATHWAY Disease ID
1 Blarcamesine 💬[1] Blarcamesine[2] Anavex2-73; Blarcamesine[6] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5,
SIGMAR1 💬 		[15] Alzheimer disease, Amyotrophic lateral sclerosis, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 6, 156 💬
2 Blarcamesine hydrochloride 💬[1] Blarcamesine[2] Anavex2-73; Blarcamesine[6] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5,
SIGMAR1 💬 		[15] Alzheimer disease, Amyotrophic lateral sclerosis, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 6, 156 💬
3 Cannabidiol 💬[1] Cannabidiol[1] Cannabidiol[2] CNR1,
CNR2 💬 		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[18] 6, 8, 13, 19, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 271 💬
4 Daunorubicin 💬[1] Dextromethorphan[2] Dextromethorphan; Dextromethorphan hydrobromide--[9] 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
5 Dextromethorphan 💬[1] Dextromethorphan[2] Dextromethorphan; Dextromethorphan hydrobromide[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[9] 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
6 Dextromethorphan hydrobromide 💬[1] Dextromethorphan[2] Dextromethorphan; Dextromethorphan hydrobromide[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[9] 6, 8, 13, 21, 46, 85, 96, 97, 156 💬
7 Donepezil 💬[1] Donepezil[2] Donepezil; Donepezil hydrochloride[1] ACHE 💬 [3] Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬[8] 5, 6, 13, 46, 124, 127, 156, 206 💬
8 Donepezil hydrochloride 💬[1] Donepezil[2] Donepezil; Donepezil hydrochloride[1] ACHE 💬 [3] Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬[8] 5, 6, 13, 46, 124, 127, 156, 206 💬
9 Esketamine 💬[1] Esketamine[3] Esketamine; Esketamine hydrochloride; Ketamine[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[7] 2, 4, 6, 70, 96, 97, 156 💬
10 Esketamine hydrochloride 💬[1] Esketamine[3] Esketamine; Esketamine hydrochloride; Ketamine[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[7] 2, 4, 6, 70, 96, 97, 156 💬
11 Fingolimod 💬[1] Fingolimod[2] Fingolimod; Fingolimod hydrochloride[1] S1PR1 💬 [4] Efferocytosis, FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[3] 13, 14, 156 💬
12 Fingolimod hydrochloride 💬[1] Fingolimod[2] Fingolimod; Fingolimod hydrochloride[1] S1PR1 💬 [4] Efferocytosis, FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[3] 13, 14, 156 💬
13 Fingolimod lauryl sulfate 💬[1] Fingolimod[2] Fingolimod; Fingolimod hydrochloride[1] S1PR1 💬 [4] Efferocytosis, FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[3] 13, 14, 156 💬
14 Glatiramer acetate 💬[1] Glatiramer[1] Glatiramer acetate[20] MHC1,
MHC1,
MHC1,
MHC1,
MHC1,
MHC1,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2,
MHC2 💬 		[32] Allograft rejection, Antigen processing and presentation, Asthma, Autoimmune thyroid disease, Cell adhesion molecules, Cellular senescence, Endocytosis, Epstein-Barr virus infection, Graft-versus-host disease, Hematopoietic cell lineage, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Inflammatory bowel disease, Influenza A, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Phagosome, Rheumatoid arthritis, Staphylococcus aureus infection, Systemic lupus erythematosus, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Viral carcinogenesis, Viral myocarditis 💬[3] 13, 96, 156 💬
15 Insulin human 💬[1] Insulin human[1] Human insulin[1] INSR 💬 [23] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Hormone signaling, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 156 💬
16 Ketamine 💬[1] Ketamine[3] Ketamine; Ketamine hydrochloride; Nmda[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[6] 6, 13, 70, 113, 156, 215 💬
17 Ketamine hydrochloride 💬[1] Ketamine[3] Ketamine; Ketamine hydrochloride; Nmda[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[21] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[6] 6, 13, 70, 113, 156, 215 💬
18 Lovastatin 💬[1] Lovastatin[1] Lovastatin[1] HMGCR 💬 [3] AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬[11] 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
19 Risperidone 💬[1] Risperidone[1] Risperidone[2] DRD2,
HTR2 💬 		[13] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[3] 8, 156, 187 💬
20 Sarizotan hydrochloride 💬[1] Sarizotan[2] Sarizotan; Sarizotan hydrochloride[2] DRD2,
HTR1 💬 		[12] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[2] 6, 156 💬
21 Sodium butyrate 💬[1] Butyric Acid[4] Butanoic acid; Butyrate; Butyric acid; Sodium butyrate--[3] 46, 97, 222 💬
22 Somatropin 💬[1] Somatotropin[7] Growth hormone; Human growth hormone; Recombinant human growth hormone; Rhgh; Somatotropin; Somatropin; Somatropina[1] GHR 💬 [6] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, Hormone signaling, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[26] 2, 3, 19, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
23 Topiramate 💬[1] Topiramate[1] Topiramate[36] CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRB,
GABRB,
GABRB,
GABRD,
GABRE,
GABRG,
GABRG,
GABRG,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬 		[53] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 6, 140, 144, 156, 193 💬
24 Triheptanoin 💬[1] Triheptanoin[1] Triheptanoin--[10] 2, 8, 65, 149, 156, 248, 256, 257, 317, 324 💬
25 Trofinetide 💬[1] Trofinetide[1] Trofinetide--[1] 156 💬
26 Vatiquinone 💬[1] Vatiquinone[2] Alpha-tocotrienol quinone; Vatiquinone--[3] 18, 21, 156 💬