Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. KEGG DRUG DrugBank Drug (Description in trials) KEGG GENES KEGG PATHWAY Disease ID
1 Abatacept 💬[1] Abatacept[1] Abatacept[2] CD80,
CD86 💬 		[14] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecule (CAM) interaction, Graft-versus-host disease, IgSF CAM signaling, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[28] 2, 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 223, 271, 284, 285, 300 💬
2 Abetimus sodium 💬[1] Abetimus[2] Abetimus; ABETIMUS SODIUM--[2] 49, 223 💬
3 Adomiparin 💬[1] Enoxaparin[2] Enoxaparin; Enoxaparin Sodium[1] SERPINC1 💬 [1] Complement and coagulation cascades 💬[6] 46, 48, 71, 222, 223, 327 💬
4 Alendronate sodium 💬[1] Alendronic acid[3] Alendronate; Alendronate sodium; ALENDRONIC ACID[1] FDPS 💬 [3] Human T-cell leukemia virus 1 infection, Influenza A, Terpenoid backbone biosynthesis 💬[5] 19, 46, 223, 274, 299 💬
5 Alendronic acid 💬[1] Alendronic acid[3] Alendronate; Alendronate sodium; ALENDRONIC ACID[1] FDPS 💬 [3] Human T-cell leukemia virus 1 infection, Influenza A, Terpenoid backbone biosynthesis 💬[5] 19, 46, 223, 274, 299 💬
6 Alfacalcidol 💬[1] Alfacalcidol[1] Alfacalcidol[1] VDR 💬 [5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[10] 41, 46, 49, 50, 96, 107, 222, 223, 235, 238 💬
7 Aliskiren 💬[1] Aliskiren[1] Aliskiren[1] REN 💬 [3] Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[4] 66, 167, 222, 223 💬
8 Aliskiren fumarate 💬[1] Aliskiren[1] Aliskiren[1] REN 💬 [3] Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[4] 66, 167, 222, 223 💬
9 Amoxicillin 💬[1] Amoxicillin[2] Amoxicilina; Amoxicillin--[9] 6, 46, 63, 94, 96, 97, 222, 223, 299 💬
10 Amoxicillin 💬[1] Amoxicillin[2] Amoxicilina; Amoxicillin--[9] 6, 46, 63, 94, 96, 97, 222, 223, 299 💬
11 Amoxicillin sodium 💬[1] Amoxicillin[2] Amoxicilina; Amoxicillin--[9] 6, 46, 63, 94, 96, 97, 222, 223, 299 💬
12 Apixaban 💬[1] Apixaban[1] Apixaban[1] F10 💬 [1] Complement and coagulation cascades 💬[6] 48, 96, 97, 222, 223, 279 💬
13 Arginine 💬[1] Arginine[1] Arginine--[16] 2, 21, 46, 57, 58, 67, 72, 96, 97, 98, 113, 210, 223, 225, 251, 299 💬
14 Arginine hydrochloride 💬[1] Arginine[1] Arginine--[16] 2, 21, 46, 57, 58, 67, 72, 96, 97, 98, 113, 210, 223, 225, 251, 299 💬
15 Arginine hydrochloride 💬[1] Arginine[1] Arginine--[16] 2, 21, 46, 57, 58, 67, 72, 96, 97, 98, 113, 210, 223, 225, 251, 299 💬
16 Avacopan 💬[1] Avacopan[1] Avacopan[1] C5AR1 💬 [6] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Staphylococcus aureus infection 💬[4] 43, 44, 66, 223 💬
17 Azathioprine 💬[1] Azathioprine[2] AZATHIOPRINE; Azatioprina--[26] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 55, 57, 63, 65, 66, 84, 85, 93, 94, 95, 96, 97, 162, 223, 300 💬
18 Azathioprine sodium 💬[1] Azathioprine[2] AZATHIOPRINE; Azatioprina--[26] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 55, 57, 63, 65, 66, 84, 85, 93, 94, 95, 96, 97, 162, 223, 300 💬
19 Belimumab 💬[1] Belimumab[1] Belimumab[1] TNFSF13B 💬 [4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[17] 11, 13, 43, 44, 46, 48, 49, 50, 51, 53, 63, 66, 95, 222, 223, 296, 300 💬
20 Bortezomib 💬[1] Bortezomib[1] Bortezomib[1] PSMB5 💬 [8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[19] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 172, 222, 223, 228, 256, 283, 288, 331 💬
21 Budesonide 💬[1] Budesonide[1] BUDESONIDE[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[10] 66, 93, 94, 95, 96, 97, 98, 223, 228, 299 💬
22 Calcitriol 💬[1] Calcitriol[1] Calcitriol[1] VDR 💬 [5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[11] 18, 37, 46, 49, 66, 96, 158, 223, 235, 238, 326 💬
23 Chlorambucil 💬[1] Chlorambucil[1] Chlorambucil--[2] 222, 223 💬
24 Clarithromycin 💬[1] Clarithromycin[1] Clarithromycin--[10] 6, 46, 63, 84, 96, 97, 222, 223, 228, 299 💬
25 Cyclophosphamide 💬[1] Cyclophosphamide[5] Ciclofosfamida; CICLOFOSFAMIDE; Cyclophosphamid; Cyclophosphamide; CYCLOPHOSPHAMIDE MONOHYDRATE--[50] 11, 13, 14, 16, 19, 20, 26, 28, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 62, 63, 65, 66, 84, 93, 96, 162, 164, 172, 205, 221, 222, 223, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331 💬
26 Cyclophosphamide 💬[1] Cyclophosphamide[5] Ciclofosfamida; CICLOFOSFAMIDE; Cyclophosphamid; Cyclophosphamide; CYCLOPHOSPHAMIDE MONOHYDRATE--[50] 11, 13, 14, 16, 19, 20, 26, 28, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 62, 63, 65, 66, 84, 93, 96, 162, 164, 172, 205, 221, 222, 223, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331 💬
27 Cyclosporine 💬[1] Cyclosporine[7] CICLOSPORIN; CICLOSPORINA; Ciclosporine; Cyclosporin; Cyclosporin A; Cyclosporine; Cyclosporine A[5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[39] 11, 14, 19, 20, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 61, 62, 63, 64, 65, 67, 90, 95, 97, 107, 118, 162, 164, 222, 223, 226, 228, 234, 283, 284, 285, 302 💬
28 Dalteparin sodium 💬[1] Dalteparin[2] Dalteparin; Dalteparin Sodium[1] SERPINC1 💬 [1] Complement and coagulation cascades 💬[3] 222, 223, 327 💬
29 Danicopan 💬[1] Danicopan[2] ACH-0144471; Danicopan[1] CFD 💬 [3] Complement and coagulation cascades, Coronavirus disease, Staphylococcus aureus infection 💬[2] 62, 223 💬
30 Daratumumab 💬[1] Daratumumab[1] Daratumumab[1] CD38 💬 [6] Calcium signaling pathway, Hematopoietic cell lineage, Nicotinate and nicotinamide metabolism, Oxytocin signaling pathway, Pancreatic secretion, Salivary secretion 💬[13] 13, 16, 28, 39, 46, 48, 49, 60, 63, 222, 223, 288, 331 💬
31 Denosumab 💬[1] Denosumab[1] Denosumab[1] TNFSF11 💬 [8] Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬[11] 46, 50, 70, 75, 77, 93, 95, 96, 223, 274, 299 💬
32 Desmopressin 💬[1] Desmopressin[2] DESMOPRESSIN; Desmopressin acetate[2] AVPR2,
F8 💬 		[5] Complement and coagulation cascades, Hormone signaling, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[8] 6, 22, 64, 72, 75, 223, 225, 288 💬
33 Desmopressin acetate 💬[1] Desmopressin[2] Desmopressin; Desmopressin acetate[2] AVPR2,
F8 💬 		[5] Complement and coagulation cascades, Hormone signaling, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[8] 6, 22, 64, 72, 75, 223, 225, 288 💬
34 Dexamethasone 💬[1] Dexamethasone[4] Dexametasone; Dexamethason; Dexamethasone; Dexamethasone sodium phosphate[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[29] 13, 14, 16, 19, 28, 35, 46, 53, 63, 64, 65, 70, 71, 74, 75, 81, 84, 90, 96, 97, 162, 222, 223, 235, 257, 283, 296, 299, 331 💬
35 Dexamethasone phosphate 💬[1] Dexamethasone[4] Dexametasone; Dexamethason; DEXAMETHASONE; Dexamethasone sodium phosphate[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[29] 13, 14, 16, 19, 28, 35, 46, 53, 63, 64, 65, 70, 71, 74, 75, 81, 84, 90, 96, 97, 162, 222, 223, 235, 257, 283, 296, 299, 331 💬
36 Dexamethasone sodium phosphate 💬[1] Dexamethasone[4] Dexametasone; Dexamethason; Dexamethasone; Dexamethasone sodium phosphate[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[29] 13, 14, 16, 19, 28, 35, 46, 53, 63, 64, 65, 70, 71, 74, 75, 81, 84, 90, 96, 97, 162, 222, 223, 235, 257, 283, 296, 299, 331 💬
37 Eculizumab 💬[1] Eculizumab[1] ECULIZUMAB[1] C5 💬 [11] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[8] 11, 13, 14, 61, 62, 109, 221, 223 💬
38 Elbasvir 💬[1] Elbasvir[1] Elbasvir--[1] 223 💬
39 Empagliflozin 💬[1] Empagliflozin[1] Empagliflozin--[17] 28, 46, 57, 58, 65, 67, 72, 77, 86, 96, 97, 113, 222, 223, 257, 298, 299 💬
40 Enalapril 💬[1] Enalapril[2] Enalapril; Enalapril Maleate[1] ACE 💬 [6] Chagas disease, Coronavirus disease, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[10] 13, 19, 46, 57, 66, 113, 210, 222, 223, 279 💬
41 Enalapril maleate 💬[1] Enalapril[2] Enalapril; Enalapril Maleate[1] ACE 💬 [6] Chagas disease, Coronavirus disease, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[10] 13, 19, 46, 57, 66, 113, 210, 222, 223, 279 💬
42 Enoxaparin sodium 💬[1] Enoxaparin[2] ENOXAPARIN; Enoxaparin Sodium[1] SERPINC1 💬 [1] Complement and coagulation cascades 💬[6] 46, 48, 71, 222, 223, 327 💬
43 Entecavir 💬[1] Entecavir[1] Entecavir--[8] 46, 56, 96, 97, 107, 222, 223, 271 💬
44 Entecavir 💬[1] Entecavir[1] Entecavir--[8] 46, 56, 96, 97, 107, 222, 223, 271 💬
45 Finerenone 💬[1] Finerenone[1] Finerenone[1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[5] 66, 218, 222, 223, 224 💬
46 Fludarabine 💬[1] Fludarabine[3] FLUDARABINA; Fludarabine; Fludarabine Phosphate[1] RRM1 💬 [4] Drug metabolism - other enzymes, Glutathione metabolism, Purine metabolism, Pyrimidine metabolism 💬[30] 11, 13, 14, 16, 19, 28, 34, 35, 36, 44, 46, 49, 50, 51, 60, 61, 62, 63, 65, 85, 96, 107, 164, 222, 223, 283, 284, 285, 286, 326 💬
47 Fludarabine phosphate 💬[1] Fludarabine[3] FLUDARABINA; Fludarabine; Fludarabine phosphate[1] RRM1 💬 [4] Drug metabolism - other enzymes, Glutathione metabolism, Purine metabolism, Pyrimidine metabolism 💬[30] 11, 13, 14, 16, 19, 28, 34, 35, 36, 44, 46, 49, 50, 51, 60, 61, 62, 63, 65, 85, 96, 107, 164, 222, 223, 283, 284, 285, 286, 326 💬
48 Frexalimab 💬[1] Frexalimab[1] Frexalimab[1] CD40LG 💬 [14] Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecule (CAM) interaction, Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Lipid and atherosclerosis, Malaria, NF-kappa B signaling pathway, Primary immunodeficiency, Systemic lupus erythematosus, T cell receptor signaling pathway, Toxoplasmosis, Viral myocarditis 💬[3] 13, 222, 223 💬
49 Grazoprevir 💬[1] Grazoprevir[1] Grazoprevir--[1] 223 💬
50 Grazoprevir 💬[1] Grazoprevir[1] Grazoprevir--[1] 223 💬
51 Hydroxychloroquine 💬[1] Hydroxychloroquine[2] Hydroxychloroquine; HYDROXYCHLOROQUINE SULFATE--[29] 6, 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 89, 90, 96, 97, 107, 218, 222, 223, 224, 234, 254, 271, 298, 299 💬
52 Hydroxychloroquine sulfate 💬[1] Hydroxychloroquine[2] Hydroxychloroquine; HYDROXYCHLOROQUINE SULFATE--[29] 6, 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 89, 90, 96, 97, 107, 218, 222, 223, 224, 234, 254, 271, 298, 299 💬
53 Infliximab 💬[1] Infliximab[2] INFLIXIMAB; Infliximab-Dyyb[1] TNF 💬 [66] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 162, 164, 223, 269, 270, 271 💬
54 Iptacopan 💬[1] Iptacopan[1] Iptacopan[1] CFB 💬 [3] Complement and coagulation cascades, Coronavirus disease, Staphylococcus aureus infection 💬[8] 11, 61, 62, 63, 66, 109, 222, 223 💬
55 Iptacopan hydrochloride 💬[1] Iptacopan[1] Iptacopan[1] CFB 💬 [3] Complement and coagulation cascades, Coronavirus disease, Staphylococcus aureus infection 💬[8] 11, 61, 62, 63, 66, 109, 222, 223 💬
56 Irbesartan 💬[1] Irbesartan[1] Irbesartan[1] AGTR1 💬 [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[6] 57, 66, 167, 168, 222, 223 💬
57 Lamivudine 💬[1] Lamivudine[1] Lamivudine--[10] 2, 26, 42, 46, 49, 135, 156, 223, 265, 325 💬
58 Lansoprazole 💬[1] Lansoprazole[1] Lansoprazole[2] ATP4A,
ATP4B 💬 		[3] Collecting duct acid secretion, Gastric acid secretion, Oxidative phosphorylation 💬[8] 63, 71, 85, 98, 166, 222, 223, 299 💬
59 Leflunomide 💬[1] Leflunomide[2] Leflunomide; Leflunomidum[1] DHODH 💬 [1] Pyrimidine metabolism 💬[14] 11, 40, 46, 49, 53, 54, 66, 107, 162, 223, 224, 270, 271, 300 💬
60 Lisinopril 💬[1] Lisinopril[1] Lisinopril[1] ACE 💬 [6] Chagas disease, Coronavirus disease, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[9] 19, 46, 49, 57, 66, 67, 113, 222, 223 💬
61 Lisinopril 💬[1] Lisinopril[1] Lisinopril[1] ACE 💬 [6] Chagas disease, Coronavirus disease, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[9] 19, 46, 49, 57, 66, 67, 113, 222, 223 💬
62 Losartan 💬[1] Losartan[2] Losartan; LOSARTAN POTASSIUM[1] AGTR1 💬 [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[20] 17, 19, 36, 46, 57, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 223, 299 💬
63 Losartan potassium 💬[1] Losartan[2] Losartan; LOSARTAN POTASSIUM[1] AGTR1 💬 [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[20] 17, 19, 36, 46, 57, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 223, 299 💬
64 Methotrexate 💬[1] Methotrexate[5] Methotrexat; Methotrexate; METHOTREXATE SODIUM; Methylaminopterin; Metotrexato[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[41] 11, 13, 14, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 223, 240, 256, 270, 271, 284, 285, 286, 326, 331 💬
65 Methotrexate sodium 💬[1] Methotrexate[5] Methotrexat; Methotrexate; METHOTREXATE SODIUM; Methylaminopterin; Metotrexato[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[41] 11, 13, 14, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 223, 240, 256, 270, 271, 284, 285, 286, 326, 331 💬
66 Methylprednisolone 💬[1] Methylprednisolone[3] Methylprednisolon; METHYLPREDNISOLONE; METHYLPREDNISOLONE ACETATE[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[51] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 111, 127, 145, 162, 164, 211, 222, 223, 224, 271, 283, 284, 285, 296, 300 💬
67 Methylprednisolone acetate 💬[1] Methylprednisolone[3] Methylprednisolon; Methylprednisolone; METHYLPREDNISOLONE ACETATE[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[51] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 111, 127, 145, 162, 164, 211, 222, 223, 224, 271, 283, 284, 285, 296, 300 💬
68 Mezagitamab 💬[1] Mezagitamab[1] Mezagitamab[1] CD38 💬 [6] Calcium signaling pathway, Hematopoietic cell lineage, Nicotinate and nicotinamide metabolism, Oxytocin signaling pathway, Pancreatic secretion, Salivary secretion 💬[3] 63, 66, 223 💬
69 Mycophenolate mofetil 💬[1] Mycophenolate mofetil[1] Mycophenolate Mofetil[2] IMPDH1,
IMPDH2 💬 		[2] Drug metabolism - other enzymes, Purine metabolism 💬[38] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 57, 60, 61, 62, 63, 65, 66, 93, 95, 96, 118, 162, 164, 222, 223, 224, 226, 234, 283, 284, 285, 300 💬
70 Mycophenolate mofetil hydrochloride 💬[1] Mycophenolate mofetil[1] MYCOPHENOLATE MOFETIL[2] IMPDH1,
IMPDH2 💬 		[2] Drug metabolism - other enzymes, Purine metabolism 💬[38] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 57, 60, 61, 62, 63, 65, 66, 93, 95, 96, 118, 162, 164, 222, 223, 224, 226, 234, 283, 284, 285, 300 💬
71 Mycophenolate sodium 💬[1] Mycophenolic acid[5] Acido Micofenolico; MICOFENOLICO ACIDO; Mycophenolate; Mycophenolate sodium; MYCOPHENOLIC ACID[2] IMPDH1,
IMPDH2 💬 		[2] Drug metabolism - other enzymes, Purine metabolism 💬[11] 11, 43, 49, 51, 53, 60, 66, 96, 222, 223, 228 💬
72 Mycophenolic acid 💬[1] Mycophenolic acid[5] Acido Micofenolico; MICOFENOLICO ACIDO; Mycophenolate; Mycophenolate sodium; MYCOPHENOLIC ACID[2] IMPDH1,
IMPDH2 💬 		[2] Drug metabolism - other enzymes, Purine metabolism 💬[11] 11, 43, 49, 51, 53, 60, 66, 96, 222, 223, 228 💬
73 Narsoplimab 💬[1] Narsoplimab[1] Narsoplimab[1] MASP2 💬 [3] Complement and coagulation cascades, Coronavirus disease, Staphylococcus aureus infection 💬[3] 66, 222, 223 💬
74 Obinutuzumab 💬[1] Obinutuzumab[1] OBINUTUZUMAB[1] MS4A1 💬 [1] Hematopoietic cell lineage 💬[6] 43, 44, 49, 63, 222, 223 💬
75 Ofatumumab 💬[1] Ofatumumab[2] HuMax-CD20; OFATUMUMAB[1] MS4A1 💬 [1] Hematopoietic cell lineage 💬[6] 11, 13, 35, 46, 222, 223 💬
76 Olmesartan 💬[1] Olmesartan[2] Olmesartan; Olmesartan medoxomil[1] AGTR1 💬 [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 57, 223 💬
77 Olmesartan medoxomil 💬[1] Olmesartan[2] Olmesartan; Olmesartan medoxomil[1] AGTR1 💬 [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 57, 223 💬
78 Pegcetacoplan 💬[1] Pegcetacoplan[1] Pegcetacoplan[1] C3 💬 [18] Alcoholic liver disease, Chagas disease, Complement and coagulation cascades, Coronavirus disease, Herpes simplex virus 1 infection, Integrin signaling, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Phagocytosis, Shigellosis, Staphylococcus aureus infection, Systemic lupus erythematosus, Tuberculosis, Viral carcinogenesis 💬[4] 2, 61, 62, 223 💬
79 Pentoxifylline 💬[1] Pentoxifylline[1] Pentoxifylline--[13] 6, 26, 46, 56, 84, 93, 96, 97, 113, 222, 223, 296, 298 💬
80 Pioglitazone 💬[1] Pioglitazone[1] Pioglitazone[1] PPARG 💬 [12] AMPK signaling pathway, Efferocytosis, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 223, 229, 265, 298, 299 💬
81 Pioglitazone hydrochloride 💬[1] Pioglitazone[1] Pioglitazone[1] PPARG 💬 [12] AMPK signaling pathway, Efferocytosis, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 223, 229, 265, 298, 299 💬
82 Potassium 💬[1] Potassium[1] Potassium--[17] 36, 46, 57, 58, 66, 67, 88, 93, 94, 97, 98, 115, 167, 179, 215, 223, 235 💬
83 Potassium citrate 💬[1] Potassium citrate[1] Potassium citrate--[1] 223 💬
84 Prednisolone 💬[1] Prednisolone[3] Prednisolona; Prednisolone; Prednisolonum[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[48] 3, 11, 13, 14, 18, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 54, 56, 57, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 111, 113, 145, 162, 222, 223, 251, 269, 271, 296, 299, 300 💬
85 Prednisolone acetate 💬[1] Prednisolone acetate[1] PREDNISOLONE ACETATE[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[2] 222, 223 💬
86 Prednisone 💬[1] Prednisone[2] PREDNISONA; PREDNISONE[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[58] 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 48, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 127, 145, 162, 164, 205, 222, 223, 224, 228, 251, 269, 283, 284, 285, 288, 299, 300, 303, 307, 331 💬
87 Probucol 💬[1] Probucol[1] Probucol--[4] 21, 66, 79, 223 💬
88 Ramipril 💬[1] Ramipril[1] Ramipril[1] ACE 💬 [6] Chagas disease, Coronavirus disease, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[10] 46, 49, 57, 66, 67, 113, 218, 222, 223, 257 💬
89 Rilzabrutinib 💬[1] Rilzabrutinib[1] Rilzabrutinib[1] BTK 💬 [7] B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬[6] 35, 61, 63, 222, 223, 300 💬
90 Rituximab 💬[1] Rituximab[1] RITUXIMAB[1] MS4A1 💬 [1] Hematopoietic cell lineage 💬[54] 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 48, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 88, 93, 94, 96, 97, 162, 172, 222, 223, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
91 Saquinavir 💬[1] Saquinavir[1] Saquinavir--[4] 86, 222, 223, 265 💬
92 Saquinavir mesylate 💬[1] Saquinavir[1] Saquinavir--[4] 86, 222, 223, 265 💬
93 Simvastatin 💬[1] Simvastatin[2] SIMVASTATIN; Simvastatine[1] HMGCR 💬 [3] AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬[22] 6, 13, 15, 34, 46, 49, 51, 57, 66, 79, 86, 89, 94, 158, 160, 162, 195, 223, 265, 298, 299, 310 💬
94 Sirolimus 💬[1] Sirolimus[2] Rapamycin; SIROLIMUS[1] MTOR 💬 [52] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, Integrated stress response (ISR) signaling pathway, Integrin signaling, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, Lysosome biogenesis, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[46] 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 54, 57, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 97, 98, 111, 127, 137, 157, 158, 192, 222, 223, 227, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
95 Sparsentan 💬[1] Sparsentan[1] Sparsentan[2] AGTR1,
EDNRA 💬 		[18] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 66, 218, 222, 223 💬
96 Spironolactone 💬[1] Spironolactone[1] Spironolactone[1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[12] 46, 57, 58, 67, 86, 113, 210, 214, 218, 222, 223, 225 💬
97 Sulfamethoxazole 💬[1] Sulfamethoxazole[2] Sulfamethoxazole; Sulphamethoxazole--[8] 35, 44, 49, 61, 85, 223, 296, 299 💬
98 Tacrolimus 💬[1] Tacrolimus[1] Tacrolimus[5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
99 Tacrolimus 💬[1] Tacrolimus[1] TACROLIMUS[5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
100 Tocilizumab 💬[1] Tocilizumab[2] BAT1806; Tocilizumab[1] IL6R 💬 [11] Coronavirus disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[26] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 65, 86, 107, 149, 153, 223, 266, 271, 298, 331 💬
101 Valsartan 💬[1] Valsartan[1] Valsartan[1] AGTR1 💬 [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[11] 28, 57, 58, 66, 75, 86, 210, 218, 222, 223, 224 💬
102 Zigakibart 💬[1] Zigakibart[1] Zigakibart[1] TNFSF13 💬 [3] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis 💬[2] 66, 223 💬
103 Zinc chloride 💬[1] Zinc chloride[1] Zinc chloride--[1] 223 💬