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KEGG DRUG

DrugBank

Drug (Description in trials)

KEGG GENES

KEGG PATHWAY

Disease ID

Methotrexate 💬

[1] Methotrexate

[6] Methotrexat; METHOTREXATE; METHOTREXATE SODIUM; Metoject; Metotrexato; Méthotrexate

[2] DHFR,
DHFR2 💬

[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One c ...

[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

Sulfasalazine 💬

[1] Sulfasalazine

[3] Salazosulfapyridine; Salicylazosulfapyridine; SULFASALAZINE

[6] 46, 86, 94, 107, 270, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
86	Pulmonary arterial hypertension
94	Primary sclerosing cholangitis
107	Juvenile idiopathic arthritis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis

Etanercept

Name	Other Names
Etanercept	Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)

💬

[1] Etanercept

[4] Benepali; ENBREL; Erelzi; Etanercept

[2] LTA,
TNF 💬

[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African ...

[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬

Disease ID	Name
15	Inclusion body myositis
28	Systemic amyloidosis
35	Pemphigus
38	Stevens-Johnson syndrome
39	Toxic epidermal necrolysis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
53	Sjogren syndrome
56	Behcet disease
60	Aplastic anemia
85	Idiopathic interstitial pneumonia
107	Juvenile idiopathic arthritis
228	Bronchiolitis obliterans
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
285	Fanconi anemia

Leflunomide 💬

[1] Leflunomide

[3] Arava; Leflunomide; Leflunomidum

[1] DHODH 💬

[3] Biosynthesis of cofactors, Metabolic pathways, Pyrimidine metabolism 💬

[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis
40	Takayasu arteritis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
53	Sjogren syndrome
66	IgA nephropathy
107	Juvenile idiopathic arthritis
162	Pemphigoid
224	Purpura nephritis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
300	IgG4-related disease

Zoledronic acid 💬

[1] Zoledronic acid

[4] Aclasta; Zoledronate; Zoledronic acid; Zometa

[1] FDPS 💬

[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone bio ...

[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬

Disease ID	Name
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
17	Multiple system atrophy
46	Malignant rheumatoid arthritis
65	Primary immunodeficiency
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
270	Chronic recurrent multifocal osteomyelitis
274	Osteogenesis Imperfecta
299	Cystic fibrosis
333	Hutchinson-Gilford syndrome

Adalimumab

Name

Other Names

Adalimumab

Adalimumab (USAN/INN)
Adalimumab (genetical recombination) (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 1] (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 2] (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 3] (JAN)
Adalimumab-adaz
Adalimumab-adbm
Adalimumab-afzb
Adalimumab-atto
Adalimumab-bwwd
Adalimumab-fkjp
Humira (TN)
Abrilada (TN)
Amjevita (TN)
Cyltezo (TN)
Hadlima (TN)
Hyrimoz (TN)

💬

[1] Adalimumab

[7] ADALIMUMAB; Amgevita; Cyltezo; Hulio; HUMIRA; Hyrimoz; Imraldi

[1] TNF 💬

[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African ...

[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬

Disease ID	Name
19	Lysosomal storage disease
37	Generalised pustular psoriasis
40	Takayasu arteritis
41	Giant cell arteritis
46	Malignant rheumatoid arthritis
56	Behcet disease
84	Sarcoidosis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
160	Congenital ichthyosis
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
226	Interstitial cystitis with Hunners ulcer
269	Pyogenic arthritis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis

Infliximab

Name	Other Names
Infliximab	Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)

💬

[1] Infliximab

[6] Flixabi; INFLECTRA; INFLIXIMAB; Remicade; Remsima; Zessly

[1] TNF 💬

[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African ...

[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 1 ...

Disease ID	Name
35	Pemphigus
37	Generalised pustular psoriasis
38	Stevens-Johnson syndrome
39	Toxic epidermal necrolysis
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
55	Relapsing polychondritis
56	Behcet disease
65	Primary immunodeficiency
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
98	Eosinophilic gastrointestinal disease
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
269	Pyogenic arthritis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis

Golimumab 💬

[1] Golimumab

[2] Golimumab; Simponi

[1] TNF 💬

[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African ...

[8] 46, 56, 84, 96, 97, 107, 270, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
56	Behcet disease
84	Sarcoidosis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis

Pamidronic acid 💬

[1] Pamidronic acid

[1] Pamidronate

[1] FDPS 💬

[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone bio ...

[3] 270, 271, 274 💬

Zoledronic acid 💬

[1] Zoledronic acid

[4] ACLASTA; Zoledronate; Zoledronic acid; Zometa

[1] FDPS 💬

[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone bio ...

[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬

Disease ID	Name
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
17	Multiple system atrophy
46	Malignant rheumatoid arthritis
65	Primary immunodeficiency
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
270	Chronic recurrent multifocal osteomyelitis
274	Osteogenesis Imperfecta
299	Cystic fibrosis
333	Hutchinson-Gilford syndrome

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