Drug Description in Trials / DrugBank / KEGG DRUG

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No.

KEGG DRUG

DrugBank

Drug (Description in trials)

KEGG GENES

KEGG PATHWAY

Disease ID

1

Ibuprofen 💬
(Ibuprofen (JP18/USP/INN))

[1] Ibuprofen (Crane Safety Ibuprofen)

[2] IBUPROFEN; IBUPROFEN 200MG

[2] PTGS1,
PTGS2 💬

[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬

[7] 13, 46, 65, 107, 113, 271, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
46	Malignant rheumatoid arthritis
65	Primary immunodeficiency
107	Juvenile idiopathic arthritis
113	Muscular dystrophy
271	Ankylosing spondylitis
299	Cystic fibrosis

2

Diphenhydramine 💬

[1] Diphenhydramine (dg health Ibuprofen pm)

[2] Diphenhydramine; Diphenhydramine hydrochloride

[1] HRH1 💬

[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬

[8] 11, 13, 49, 51, 70, 86, 222, 256 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
49	Systemic lupus erythematosus
51	Scleroderma
70	Spinal stenosis
86	Pulmonary arterial hypertension
222	Primary nephrotic syndrome
256	Muscle glycogenosis

3

Famotidine 💬

[1] Famotidine (Ibuprofen and famotidine)

[2] FAMOTIDINA; Famotidine

[1] HRH2 💬

[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬

[6] 6, 46, 61, 86, 98, 107 💬

4

[1] Oxycodone (Oxycodone hydrochloride and Ibuprofen)

[2] OXYCODONE; OXYCODONE HYDROCHLORIDE

[3] OPRD1,
OPRK1,
OPRM1 💬

[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬

[5] 6, 13, 70, 226, 298 💬

5

Pseudoephedrine 💬

[1] Pseudoephedrine (Equate Ibuprofen Cold and Sinus)

[1] Pseudoephedrine

[9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬

Name	Full Name
ADRA1A	adrenoceptor alpha 1A
ADRA1B	adrenoceptor alpha 1B
ADRA1D	adrenoceptor alpha 1D
ADRA2A	adrenoceptor alpha 2A
ADRA2B	adrenoceptor alpha 2B
ADRA2C	adrenoceptor alpha 2C
ADRB1	adrenoceptor beta 1
ADRB2	adrenoceptor beta 2
ADRB3	adrenoceptor beta 3

[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬

[1] 17 💬