Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adrenergic signaling in cardiomyocytes 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Adrenergic signaling in cardiomyocytes × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 1. Adrenergic signaling in cardiomyocytes × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
2	Adrenergic signaling in cardiomyocytes 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Adrenergic signaling in cardiomyocytes × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 1. Adrenergic signaling in cardiomyocytes × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
3	Adrenergic signaling in cardiomyocytes 💬	[5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S SCN5A sodium voltage-gated channel alpha subunit 5	Topiramate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 3. Adrenergic signaling in cardiomyocytes × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
4	Alcoholism 💬	[1] DDC 💬 Alcoholism × Name Full Name DDC dopa decarboxylase	Carbidopa 💬 Alcoholism × Name Other Names Carbidopa Carbidopa (USP) Carbidopa hydrate (JP18) Lodosyn (TN) LODOSYN CARBIDOPA CARBIDOPA TABLETS, 25 MG	Carbidopa	[5]  6 , 13, 17, 140, 201 💬 4. Alcoholism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 140 Dorabe syndrome;Dravet syndrome; 201 Angelman syndrome;
5	Alcoholism 💬	[2] DRD1, DRD2 💬 Alcoholism × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2	Levodopa 💬 Alcoholism × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 5. Alcoholism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
6	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Aldosterone synthesis and secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 6. Aldosterone synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
7	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Aldosterone synthesis and secretion × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 7. Aldosterone synthesis and secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
8	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Aldosterone synthesis and secretion × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 7. Aldosterone synthesis and secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
9	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Alzheimer disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Alzheimer disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 9. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
10	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Alzheimer disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Alzheimer disease × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 10. Alzheimer disease × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
11	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Alzheimer disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Alzheimer disease × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 10. Alzheimer disease × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
12	Amphetamine addiction 💬	[2] CACNA1C, CACNA1D 💬 Amphetamine addiction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil hydrochloride 💬 Amphetamine addiction × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 12. Amphetamine addiction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
13	Amphetamine addiction 💬	[2] CACNA1C, CACNA1D 💬 Amphetamine addiction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil 💬 Amphetamine addiction × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 12. Amphetamine addiction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
14	Amphetamine addiction 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Amphetamine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 14. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
15	Amphetamine addiction 💬	[1] DDC 💬 Amphetamine addiction × Name Full Name DDC dopa decarboxylase	Carbidopa 💬 Amphetamine addiction × Name Other Names Carbidopa Carbidopa (USP) Carbidopa hydrate (JP18) Lodosyn (TN) LODOSYN CARBIDOPA CARBIDOPA TABLETS, 25 MG	Carbidopa	[5]  6 , 13, 17, 140, 201 💬 15. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 140 Dorabe syndrome;Dravet syndrome; 201 Angelman syndrome;
16	Amphetamine addiction 💬	[1] DRD1 💬 Amphetamine addiction × Name Full Name DRD1 dopamine receptor D1	Levodopa 💬 Amphetamine addiction × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 16. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
17	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Amyotrophic lateral sclerosis × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 17. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
18	Amyotrophic lateral sclerosis 💬	[1] SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Fenfluramine hydrochloride 💬 Amyotrophic lateral sclerosis × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 18. Amyotrophic lateral sclerosis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
19	Amyotrophic lateral sclerosis 💬	[1] SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Fenfluramine 💬 Amyotrophic lateral sclerosis × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 18. Amyotrophic lateral sclerosis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
20	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 20. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
21	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 21. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
22	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 21. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
23	Axon guidance 💬	[1] TRPC5 💬 Axon guidance × Name Full Name TRPC5 transient receptor potential cation channel subfamily C member 5	Clemizole hydrochloride 💬 Axon guidance × Name Other Names Clemizole hydrochloride Clemizole hydrochloride (JAN/USAN) Allercur (TN) Reactrol (TN)	Clemizole	[2] 140, 144 💬 23. Axon guidance × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
24	Axon guidance 💬	[1] TRPC5 💬 Axon guidance × Name Full Name TRPC5 transient receptor potential cation channel subfamily C member 5	Clemizole 💬 Axon guidance × Name Other Names Clemizole Clemizole (USAN/INN)	Clemizole	[2] 140, 144 💬 23. Axon guidance × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
25	Bile secretion 💬	[1] CA2 💬 Bile secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Bile secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 25. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
26	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Calcium signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Calcium signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 26. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
27	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Calcium signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Calcium signaling pathway × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 27. Calcium signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
28	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Calcium signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Calcium signaling pathway × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 27. Calcium signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
29	Calcium signaling pathway 💬	[2] DRD1, DRD5 💬 Calcium signaling pathway × Name Full Name DRD1 dopamine receptor D1 DRD5 dopamine receptor D5	Levodopa 💬 Calcium signaling pathway × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 29. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
30	Calcium signaling pathway 💬	[1] HTR2 💬 Calcium signaling pathway × Name Full Name HTR2	Lorcaserin hydrochloride 💬 Calcium signaling pathway × Name Other Names Lorcaserin hydrochloride Lorcaserin hydrochloride (USAN) APD-356 Belviq (TN)	Lorcaserin	[1] 140 💬 30. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
31	Calcium signaling pathway 💬	[1] HTR2 💬 Calcium signaling pathway × Name Full Name HTR2	Lorcaserin hydrochloride hemihydrate 💬 Calcium signaling pathway × Name Other Names Lorcaserin hydrochloride hemihydrate Lorcaserin hydrochloride hemihydrate Belviq (TN)	Lorcaserin	[1] 140 💬 30. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
32	Calcium signaling pathway 💬	[2] HTR2, HTR2 💬 Calcium signaling pathway × Name Full Name HTR2 HTR2	Fenfluramine hydrochloride 💬 Calcium signaling pathway × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 32. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
33	Calcium signaling pathway 💬	[2] HTR2, HTR2 💬 Calcium signaling pathway × Name Full Name HTR2 HTR2	Fenfluramine 💬 Calcium signaling pathway × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 32. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
34	cAMP signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cAMP signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 cAMP signaling pathway × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 34. cAMP signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
35	cAMP signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cAMP signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 cAMP signaling pathway × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 34. cAMP signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
36	cAMP signaling pathway 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 cAMP signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 36. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
37	cAMP signaling pathway 💬	[3] DRD1, DRD2, DRD5 💬 cAMP signaling pathway × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2 DRD5 dopamine receptor D5	Levodopa 💬 cAMP signaling pathway × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 37. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
38	cAMP signaling pathway 💬	[2] GABBR, GABBR 💬 cAMP signaling pathway × Name Full Name GABBR GABBR	gamma-Aminobutyric acid 💬 cAMP signaling pathway × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 38. cAMP signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
39	cAMP signaling pathway 💬	[1] HTR1 💬 cAMP signaling pathway × Name Full Name HTR1	Fenfluramine hydrochloride 💬 cAMP signaling pathway × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 39. cAMP signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
40	cAMP signaling pathway 💬	[1] HTR1 💬 cAMP signaling pathway × Name Full Name HTR1	Fenfluramine 💬 cAMP signaling pathway × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 39. cAMP signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
41	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬 Carbohydrate digestion and absorption × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Carbohydrate digestion and absorption × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 41. Carbohydrate digestion and absorption × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
42	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬 Carbohydrate digestion and absorption × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil hydrochloride 💬 Carbohydrate digestion and absorption × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 42. Carbohydrate digestion and absorption × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
43	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬 Carbohydrate digestion and absorption × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil 💬 Carbohydrate digestion and absorption × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 42. Carbohydrate digestion and absorption × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
44	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cardiac muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cardiac muscle contraction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 44. Cardiac muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
45	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cardiac muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Cardiac muscle contraction × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 45. Cardiac muscle contraction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
46	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cardiac muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Cardiac muscle contraction × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 45. Cardiac muscle contraction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
47	Cellular senescence 💬	[1] CACNA1D 💬 Cellular senescence × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Cellular senescence × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 47. Cellular senescence × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
48	Cellular senescence 💬	[1] CACNA1D 💬 Cellular senescence × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil hydrochloride 💬 Cellular senescence × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 48. Cellular senescence × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
49	Cellular senescence 💬	[1] CACNA1D 💬 Cellular senescence × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil 💬 Cellular senescence × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 48. Cellular senescence × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
50	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cGMP-PKG signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 cGMP-PKG signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 50. cGMP-PKG signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
51	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cGMP-PKG signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 cGMP-PKG signaling pathway × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 51. cGMP-PKG signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
52	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cGMP-PKG signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 cGMP-PKG signaling pathway × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 51. cGMP-PKG signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
53	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Chemical carcinogenesis - receptor activation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 53. Chemical carcinogenesis - receptor activation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
54	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Chemical carcinogenesis - receptor activation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Chemical carcinogenesis - receptor activation × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 54. Chemical carcinogenesis - receptor activation × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
55	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Chemical carcinogenesis - receptor activation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Chemical carcinogenesis - receptor activation × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 54. Chemical carcinogenesis - receptor activation × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
56	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cholinergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cholinergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 56. Cholinergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
57	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cholinergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Cholinergic synapse × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 57. Cholinergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
58	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cholinergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Cholinergic synapse × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 57. Cholinergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
59	Circadian entrainment 💬	[2] CACNA1C, CACNA1D 💬 Circadian entrainment × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil hydrochloride 💬 Circadian entrainment × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 59. Circadian entrainment × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
60	Circadian entrainment 💬	[2] CACNA1C, CACNA1D 💬 Circadian entrainment × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil 💬 Circadian entrainment × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 59. Circadian entrainment × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
61	Circadian entrainment 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Circadian entrainment × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 61. Circadian entrainment × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
62	Cocaine addiction 💬	[1] DDC 💬 Cocaine addiction × Name Full Name DDC dopa decarboxylase	Carbidopa 💬 Cocaine addiction × Name Other Names Carbidopa Carbidopa (USP) Carbidopa hydrate (JP18) Lodosyn (TN) LODOSYN CARBIDOPA CARBIDOPA TABLETS, 25 MG	Carbidopa	[5]  6 , 13, 17, 140, 201 💬 62. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 140 Dorabe syndrome;Dravet syndrome; 201 Angelman syndrome;
63	Cocaine addiction 💬	[2] DRD1, DRD2 💬 Cocaine addiction × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2	Levodopa 💬 Cocaine addiction × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 63. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
64	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Cocaine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 64. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
65	Collecting duct acid secretion 💬	[1] CA2 💬 Collecting duct acid secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Collecting duct acid secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 65. Collecting duct acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
66	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cortisol synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cortisol synthesis and secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 66. Cortisol synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
67	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cortisol synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Cortisol synthesis and secretion × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 67. Cortisol synthesis and secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
68	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cortisol synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Cortisol synthesis and secretion × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 67. Cortisol synthesis and secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
69	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cushing syndrome × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cushing syndrome × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 69. Cushing syndrome × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
70	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cushing syndrome × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Cushing syndrome × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 70. Cushing syndrome × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
71	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cushing syndrome × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Cushing syndrome × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 70. Cushing syndrome × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
72	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Dilated cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Dilated cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 72. Dilated cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
73	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Dilated cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Dilated cardiomyopathy × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 73. Dilated cardiomyopathy × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
74	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Dilated cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Dilated cardiomyopathy × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 73. Dilated cardiomyopathy × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
75	Dopaminergic synapse 💬	[2] CACNA1C, CACNA1D 💬 Dopaminergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil hydrochloride 💬 Dopaminergic synapse × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 75. Dopaminergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
76	Dopaminergic synapse 💬	[2] CACNA1C, CACNA1D 💬 Dopaminergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil 💬 Dopaminergic synapse × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 75. Dopaminergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
77	Dopaminergic synapse 💬	[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Dopaminergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 SCN1A sodium voltage-gated channel alpha subunit 1	Topiramate 💬 Dopaminergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 77. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
78	Dopaminergic synapse 💬	[1] DDC 💬 Dopaminergic synapse × Name Full Name DDC dopa decarboxylase	Carbidopa 💬 Dopaminergic synapse × Name Other Names Carbidopa Carbidopa (USP) Carbidopa hydrate (JP18) Lodosyn (TN) LODOSYN CARBIDOPA CARBIDOPA TABLETS, 25 MG	Carbidopa	[5]  6 , 13, 17, 140, 201 💬 78. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 140 Dorabe syndrome;Dravet syndrome; 201 Angelman syndrome;
79	Dopaminergic synapse 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopaminergic synapse × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2 DRD3 dopamine receptor D3 DRD4 dopamine receptor D4 DRD5 dopamine receptor D5	Levodopa 💬 Dopaminergic synapse × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 79. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
80	Estrogen signaling pathway 💬	[2] GABBR, GABBR 💬 Estrogen signaling pathway × Name Full Name GABBR GABBR	gamma-Aminobutyric acid 💬 Estrogen signaling pathway × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 80. Estrogen signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
81	GABAergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GABAergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 GABAergic synapse × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 81. GABAergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
82	GABAergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GABAergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 GABAergic synapse × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 81. GABAergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
83	GABAergic synapse 💬	[20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Topiramate 💬 GABAergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 83. GABAergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
84	GABAergic synapse 💬	[18] GABBR, GABBR, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name GABBR GABBR GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	gamma-Aminobutyric acid 💬 GABAergic synapse × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 84. GABAergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
85	GABAergic synapse 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 GABAergic synapse × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 85. GABAergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
86	Gap junction 💬	[2] DRD1, DRD2 💬 Gap junction × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2	Levodopa 💬 Gap junction × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 86. Gap junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
87	Gap junction 💬	[1] HTR2 💬 Gap junction × Name Full Name HTR2	Lorcaserin hydrochloride 💬 Gap junction × Name Other Names Lorcaserin hydrochloride Lorcaserin hydrochloride (USAN) APD-356 Belviq (TN)	Lorcaserin	[1] 140 💬 87. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
88	Gap junction 💬	[1] HTR2 💬 Gap junction × Name Full Name HTR2	Lorcaserin hydrochloride hemihydrate 💬 Gap junction × Name Other Names Lorcaserin hydrochloride hemihydrate Lorcaserin hydrochloride hemihydrate Belviq (TN)	Lorcaserin	[1] 140 💬 87. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
89	Gap junction 💬	[2] HTR2, HTR2 💬 Gap junction × Name Full Name HTR2 HTR2	Fenfluramine hydrochloride 💬 Gap junction × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 89. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
90	Gap junction 💬	[2] HTR2, HTR2 💬 Gap junction × Name Full Name HTR2 HTR2	Fenfluramine 💬 Gap junction × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 89. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
91	Gastric acid secretion 💬	[1] CA2 💬 Gastric acid secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Gastric acid secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 91. Gastric acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
92	Glutamatergic synapse 💬	[2] CACNA1C, CACNA1D 💬 Glutamatergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil hydrochloride 💬 Glutamatergic synapse × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 92. Glutamatergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
93	Glutamatergic synapse 💬	[2] CACNA1C, CACNA1D 💬 Glutamatergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil 💬 Glutamatergic synapse × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 92. Glutamatergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
94	Glutamatergic synapse 💬	[11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Glutamatergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Glutamatergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 94. Glutamatergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
95	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 GnRH secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 95. GnRH secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
96	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 GnRH secretion × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 96. GnRH secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
97	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 GnRH secretion × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 96. GnRH secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
98	GnRH secretion 💬	[2] GABBR, GABBR 💬 GnRH secretion × Name Full Name GABBR GABBR	gamma-Aminobutyric acid 💬 GnRH secretion × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 98. GnRH secretion × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
99	GnRH secretion 💬	[1] TRPC5 💬 GnRH secretion × Name Full Name TRPC5 transient receptor potential cation channel subfamily C member 5	Clemizole hydrochloride 💬 GnRH secretion × Name Other Names Clemizole hydrochloride Clemizole hydrochloride (JAN/USAN) Allercur (TN) Reactrol (TN)	Clemizole	[2] 140, 144 💬 99. GnRH secretion × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
100	GnRH secretion 💬	[1] TRPC5 💬 GnRH secretion × Name Full Name TRPC5 transient receptor potential cation channel subfamily C member 5	Clemizole 💬 GnRH secretion × Name Other Names Clemizole Clemizole (USAN/INN)	Clemizole	[2] 140, 144 💬 99. GnRH secretion × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
101	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 GnRH signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 101. GnRH signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
102	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 GnRH signaling pathway × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 102. GnRH signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
103	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 GnRH signaling pathway × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 102. GnRH signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
104	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Growth hormone synthesis, secretion and action × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Growth hormone synthesis, secretion and action × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 104. Growth hormone synthesis, secretion and action × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
105	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Growth hormone synthesis, secretion and action × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Growth hormone synthesis, secretion and action × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 105. Growth hormone synthesis, secretion and action × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
106	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Growth hormone synthesis, secretion and action × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Growth hormone synthesis, secretion and action × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 105. Growth hormone synthesis, secretion and action × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
107	Hormone signaling 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Hormone signaling × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2 DRD3 dopamine receptor D3 DRD4 dopamine receptor D4 DRD5 dopamine receptor D5	Levodopa 💬 Hormone signaling × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 107. Hormone signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
108	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Huntington disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 108. Huntington disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
109	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Hypertrophic cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Hypertrophic cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 109. Hypertrophic cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
110	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Hypertrophic cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Hypertrophic cardiomyopathy × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 110. Hypertrophic cardiomyopathy × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
111	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Hypertrophic cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Hypertrophic cardiomyopathy × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 110. Hypertrophic cardiomyopathy × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
112	Inflammatory mediator regulation of TRP channels 💬	[1] HTR2 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2	Lorcaserin hydrochloride 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Lorcaserin hydrochloride Lorcaserin hydrochloride (USAN) APD-356 Belviq (TN)	Lorcaserin	[1] 140 💬 112. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
113	Inflammatory mediator regulation of TRP channels 💬	[1] HTR2 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2	Lorcaserin hydrochloride hemihydrate 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Lorcaserin hydrochloride hemihydrate Lorcaserin hydrochloride hemihydrate Belviq (TN)	Lorcaserin	[1] 140 💬 112. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
114	Inflammatory mediator regulation of TRP channels 💬	[2] HTR2, HTR2 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2 HTR2	Fenfluramine hydrochloride 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 114. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
115	Inflammatory mediator regulation of TRP channels 💬	[2] HTR2, HTR2 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2 HTR2	Fenfluramine 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 114. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
116	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Insulin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Insulin secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 116. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
117	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Insulin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Insulin secretion × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 117. Insulin secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
118	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Insulin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Insulin secretion × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 117. Insulin secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
119	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Long-term depression × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 119. Long-term depression × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
120	Long-term potentiation 💬	[1] CACNA1C 💬 Long-term potentiation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C	Verapamil hydrochloride 💬 Long-term potentiation × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 120. Long-term potentiation × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
121	Long-term potentiation 💬	[1] CACNA1C 💬 Long-term potentiation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C	Verapamil 💬 Long-term potentiation × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 120. Long-term potentiation × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
122	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Long-term potentiation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 122. Long-term potentiation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
123	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 MAPK signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 MAPK signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 123. MAPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
124	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 MAPK signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 MAPK signaling pathway × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 124. MAPK signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
125	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 MAPK signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 MAPK signaling pathway × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 124. MAPK signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
126	Morphine addiction 💬	[1] DRD1 💬 Morphine addiction × Name Full Name DRD1 dopamine receptor D1	Levodopa 💬 Morphine addiction × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 126. Morphine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
127	Morphine addiction 💬	[18] GABBR, GABBR, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABBR GABBR GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	gamma-Aminobutyric acid 💬 Morphine addiction × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 127. Morphine addiction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
128	Morphine addiction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Topiramate 💬 Morphine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 128. Morphine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
129	Morphine addiction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Morphine addiction × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 129. Morphine addiction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
130	Neuroactive ligand signaling 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Neuroactive ligand signaling × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2 DRD3 dopamine receptor D3 DRD4 dopamine receptor D4 DRD5 dopamine receptor D5	Levodopa 💬 Neuroactive ligand signaling × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 130. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
131	Neuroactive ligand signaling 💬	[18] GABBR, GABBR, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Neuroactive ligand signaling × Name Full Name GABBR GABBR GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	gamma-Aminobutyric acid 💬 Neuroactive ligand signaling × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 131. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
132	Neuroactive ligand signaling 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Neuroactive ligand signaling × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Neuroactive ligand signaling × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 132. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
133	Neuroactive ligand signaling 💬	[25] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand signaling × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Neuroactive ligand signaling × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 133. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
134	Neuroactive ligand signaling 💬	[4] HTR1, HTR2, HTR2, SLC6A4 💬 Neuroactive ligand signaling × Name Full Name HTR1 HTR2 HTR2 SLC6A4 solute carrier family 6 member 4	Fenfluramine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 134. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
135	Neuroactive ligand signaling 💬	[4] HTR1, HTR2, HTR2, SLC6A4 💬 Neuroactive ligand signaling × Name Full Name HTR1 HTR2 HTR2 SLC6A4 solute carrier family 6 member 4	Fenfluramine 💬 Neuroactive ligand signaling × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 134. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
136	Neuroactive ligand signaling 💬	[1] HTR2 💬 Neuroactive ligand signaling × Name Full Name HTR2	Lorcaserin hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Lorcaserin hydrochloride Lorcaserin hydrochloride (USAN) APD-356 Belviq (TN)	Lorcaserin	[1] 140 💬 136. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
137	Neuroactive ligand signaling 💬	[1] HTR2 💬 Neuroactive ligand signaling × Name Full Name HTR2	Lorcaserin hydrochloride hemihydrate 💬 Neuroactive ligand signaling × Name Other Names Lorcaserin hydrochloride hemihydrate Lorcaserin hydrochloride hemihydrate Belviq (TN)	Lorcaserin	[1] 140 💬 136. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
138	Neuroactive ligand-receptor interaction 💬	[2] CNR1, CNR2 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1 CNR2 cannabinoid receptor 2	Cannabidiol 💬 Neuroactive ligand-receptor interaction × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 138. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
139	Neuroactive ligand-receptor interaction 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2 DRD3 dopamine receptor D3 DRD4 dopamine receptor D4 DRD5 dopamine receptor D5	Levodopa 💬 Neuroactive ligand-receptor interaction × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 139. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
140	Neuroactive ligand-receptor interaction 💬	[18] GABBR, GABBR, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Neuroactive ligand-receptor interaction × Name Full Name GABBR GABBR GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	gamma-Aminobutyric acid 💬 Neuroactive ligand-receptor interaction × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 140. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
141	Neuroactive ligand-receptor interaction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Neuroactive ligand-receptor interaction × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 141. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
142	Neuroactive ligand-receptor interaction 💬	[25] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Neuroactive ligand-receptor interaction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 142. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
143	Neuroactive ligand-receptor interaction 💬	[3] HTR1, HTR2, HTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR1 HTR2 HTR2	Fenfluramine hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 143. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
144	Neuroactive ligand-receptor interaction 💬	[3] HTR1, HTR2, HTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR1 HTR2 HTR2	Fenfluramine 💬 Neuroactive ligand-receptor interaction × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 143. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
145	Neuroactive ligand-receptor interaction 💬	[1] HTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR2	Lorcaserin hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Lorcaserin hydrochloride Lorcaserin hydrochloride (USAN) APD-356 Belviq (TN)	Lorcaserin	[1] 140 💬 145. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
146	Neuroactive ligand-receptor interaction 💬	[1] HTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR2	Lorcaserin hydrochloride hemihydrate 💬 Neuroactive ligand-receptor interaction × Name Other Names Lorcaserin hydrochloride hemihydrate Lorcaserin hydrochloride hemihydrate Belviq (TN)	Lorcaserin	[1] 140 💬 145. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
147	Nicotine addiction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Nicotine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Nicotine addiction × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 147. Nicotine addiction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
148	Nicotine addiction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Nicotine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	gamma-Aminobutyric acid 💬 Nicotine addiction × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 148. Nicotine addiction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
149	Nicotine addiction 💬	[20] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Nicotine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 149. Nicotine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
150	Nitrogen metabolism 💬	[2] CA2, CA4 💬 Nitrogen metabolism × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Nitrogen metabolism × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 150. Nitrogen metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
151	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Oxytocin signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Oxytocin signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 151. Oxytocin signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
152	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Oxytocin signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Oxytocin signaling pathway × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 152. Oxytocin signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
153	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Oxytocin signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Oxytocin signaling pathway × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 152. Oxytocin signaling pathway × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
154	Pancreatic secretion 💬	[1] CA2 💬 Pancreatic secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Pancreatic secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 154. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
155	Parkinson disease 💬	[2] DRD1, DRD2 💬 Parkinson disease × Name Full Name DRD1 dopamine receptor D1 DRD2 dopamine receptor D2	Levodopa 💬 Parkinson disease × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 155. Parkinson disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
156	Pathways of neurodegeneration - multiple diseases 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 156. Pathways of neurodegeneration - multiple diseases × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
157	Pathways of neurodegeneration - multiple diseases 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 156. Pathways of neurodegeneration - multiple diseases × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
158	Pathways of neurodegeneration - multiple diseases 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 158. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
159	Pathways of neurodegeneration - multiple diseases 💬	[1] SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Fenfluramine hydrochloride 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 159. Pathways of neurodegeneration - multiple diseases × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
160	Pathways of neurodegeneration - multiple diseases 💬	[1] SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Fenfluramine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 159. Pathways of neurodegeneration - multiple diseases × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
161	Phenylalanine metabolism 💬	[1] DDC 💬 Phenylalanine metabolism × Name Full Name DDC dopa decarboxylase	Carbidopa 💬 Phenylalanine metabolism × Name Other Names Carbidopa Carbidopa (USP) Carbidopa hydrate (JP18) Lodosyn (TN) LODOSYN CARBIDOPA CARBIDOPA TABLETS, 25 MG	Carbidopa	[5]  6 , 13, 17, 140, 201 💬 161. Phenylalanine metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 140 Dorabe syndrome;Dravet syndrome; 201 Angelman syndrome;
162	Primary bile acid biosynthesis 💬	[1] CYP46A1 💬 Primary bile acid biosynthesis × Name Full Name CYP46A1 cytochrome P450 family 46 subfamily A member 1	Soticlestat 💬 Primary bile acid biosynthesis × Name Other Names Soticlestat Soticlestat (JAN/USAN/INN)	Soticlestat	[2] 140, 144 💬 162. Primary bile acid biosynthesis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
163	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Prion disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Prion disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 163. Prion disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
164	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Prion disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Prion disease × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 164. Prion disease × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
165	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Prion disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Prion disease × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 164. Prion disease × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
166	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬 Proximal tubule bicarbonate reclamation × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Proximal tubule bicarbonate reclamation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 166. Proximal tubule bicarbonate reclamation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
167	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Rap1 signaling pathway × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 167. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
168	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 dopamine receptor D2	Levodopa 💬 Rap1 signaling pathway × Name Other Names Levodopa Levodopa (JP18/USP/INN) Dopar (TN) INBRIJA	Levodopa	[6]  6 , 17, 90, 140, 164, 201 💬 168. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
169	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Renin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Renin secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 169. Renin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
170	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Renin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Renin secretion × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 170. Renin secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
171	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Renin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Renin secretion × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 170. Renin secretion × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
172	Retrograde endocannabinoid signaling 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Retrograde endocannabinoid signaling × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Retrograde endocannabinoid signaling × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 172. Retrograde endocannabinoid signaling × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
173	Retrograde endocannabinoid signaling 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Retrograde endocannabinoid signaling × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Retrograde endocannabinoid signaling × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 172. Retrograde endocannabinoid signaling × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
174	Retrograde endocannabinoid signaling 💬	[24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Retrograde endocannabinoid signaling × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 174. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
175	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Retrograde endocannabinoid signaling × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 175. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
176	Retrograde endocannabinoid signaling 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Retrograde endocannabinoid signaling × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	gamma-Aminobutyric acid 💬 Retrograde endocannabinoid signaling × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 176. Retrograde endocannabinoid signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
177	Retrograde endocannabinoid signaling 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Retrograde endocannabinoid signaling × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Retrograde endocannabinoid signaling × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 177. Retrograde endocannabinoid signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
178	Serotonergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Serotonergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Serotonergic synapse × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 178. Serotonergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
179	Serotonergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Serotonergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Serotonergic synapse × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 178. Serotonergic synapse × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
180	Serotonergic synapse 💬	[7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB, GABRB, GABRB 💬 Serotonergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRB GABRB GABRB	Topiramate 💬 Serotonergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 180. Serotonergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
181	Serotonergic synapse 💬	[1] DDC 💬 Serotonergic synapse × Name Full Name DDC dopa decarboxylase	Carbidopa 💬 Serotonergic synapse × Name Other Names Carbidopa Carbidopa (USP) Carbidopa hydrate (JP18) Lodosyn (TN) LODOSYN CARBIDOPA CARBIDOPA TABLETS, 25 MG	Carbidopa	[5]  6 , 13, 17, 140, 201 💬 181. Serotonergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 140 Dorabe syndrome;Dravet syndrome; 201 Angelman syndrome;
182	Serotonergic synapse 💬	[3] GABRB, GABRB, GABRB 💬 Serotonergic synapse × Name Full Name GABRB GABRB GABRB	Clobazam 💬 Serotonergic synapse × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 182. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
183	Serotonergic synapse 💬	[3] GABRB, GABRB, GABRB 💬 Serotonergic synapse × Name Full Name GABRB GABRB GABRB	gamma-Aminobutyric acid 💬 Serotonergic synapse × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 183. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
184	Serotonergic synapse 💬	[4] HTR1, HTR2, HTR2, SLC6A4 💬 Serotonergic synapse × Name Full Name HTR1 HTR2 HTR2 SLC6A4 solute carrier family 6 member 4	Fenfluramine hydrochloride 💬 Serotonergic synapse × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 184. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
185	Serotonergic synapse 💬	[4] HTR1, HTR2, HTR2, SLC6A4 💬 Serotonergic synapse × Name Full Name HTR1 HTR2 HTR2 SLC6A4 solute carrier family 6 member 4	Fenfluramine 💬 Serotonergic synapse × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 184. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
186	Serotonergic synapse 💬	[1] HTR2 💬 Serotonergic synapse × Name Full Name HTR2	Lorcaserin hydrochloride 💬 Serotonergic synapse × Name Other Names Lorcaserin hydrochloride Lorcaserin hydrochloride (USAN) APD-356 Belviq (TN)	Lorcaserin	[1] 140 💬 186. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
187	Serotonergic synapse 💬	[1] HTR2 💬 Serotonergic synapse × Name Full Name HTR2	Lorcaserin hydrochloride hemihydrate 💬 Serotonergic synapse × Name Other Names Lorcaserin hydrochloride hemihydrate Lorcaserin hydrochloride hemihydrate Belviq (TN)	Lorcaserin	[1] 140 💬 186. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
188	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Spinocerebellar ataxia × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 188. Spinocerebellar ataxia × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
189	Synaptic vesicle cycle 💬	[1] SLC6A4 💬 Synaptic vesicle cycle × Name Full Name SLC6A4 solute carrier family 6 member 4	Fenfluramine hydrochloride 💬 Synaptic vesicle cycle × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 189. Synaptic vesicle cycle × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
190	Synaptic vesicle cycle 💬	[1] SLC6A4 💬 Synaptic vesicle cycle × Name Full Name SLC6A4 solute carrier family 6 member 4	Fenfluramine 💬 Synaptic vesicle cycle × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 189. Synaptic vesicle cycle × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
191	Taste transduction 💬	[1] CACNA1C 💬 Taste transduction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C	Verapamil hydrochloride 💬 Taste transduction × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 191. Taste transduction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
192	Taste transduction 💬	[1] CACNA1C 💬 Taste transduction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C	Verapamil 💬 Taste transduction × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 191. Taste transduction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
193	Taste transduction 💬	[10] CACNA1C, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C GABRA GABRA GABRA GABRA GABRA GABRA SCN2A sodium voltage-gated channel alpha subunit 2 SCN3A sodium voltage-gated channel alpha subunit 3 SCN9A sodium voltage-gated channel alpha subunit 9	Topiramate 💬 Taste transduction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 193. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
194	Taste transduction 💬	[8] GABBR, GABBR, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA 💬 Taste transduction × Name Full Name GABBR GABBR GABRA GABRA GABRA GABRA GABRA GABRA	gamma-Aminobutyric acid 💬 Taste transduction × Name Other Names gamma-Aminobutyric acid gamma-Aminobutyric acid (JAN) Gammalon (TN)	gamma-Aminobutyric acid	[1] 140 💬 194. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome;
195	Taste transduction 💬	[6] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA 💬 Taste transduction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA	Clobazam 💬 Taste transduction × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 195. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
196	Taste transduction 💬	[1] HTR1 💬 Taste transduction × Name Full Name HTR1	Fenfluramine hydrochloride 💬 Taste transduction × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 196. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
197	Taste transduction 💬	[1] HTR1 💬 Taste transduction × Name Full Name HTR1	Fenfluramine 💬 Taste transduction × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 196. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
198	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Thermogenesis × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 198. Thermogenesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
199	Tight junction 💬	[1] CACNA1D 💬 Tight junction × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Tight junction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 199. Tight junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
200	Tight junction 💬	[1] CACNA1D 💬 Tight junction × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil hydrochloride 💬 Tight junction × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 200. Tight junction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
201	Tight junction 💬	[1] CACNA1D 💬 Tight junction × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil 💬 Tight junction × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 200. Tight junction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
202	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Transcriptional misregulation in cancer × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 202. Transcriptional misregulation in cancer × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
203	Tryptophan metabolism 💬	[1] DDC 💬 Tryptophan metabolism × Name Full Name DDC dopa decarboxylase	Carbidopa 💬 Tryptophan metabolism × Name Other Names Carbidopa Carbidopa (USP) Carbidopa hydrate (JP18) Lodosyn (TN) LODOSYN CARBIDOPA CARBIDOPA TABLETS, 25 MG	Carbidopa	[5]  6 , 13, 17, 140, 201 💬 203. Tryptophan metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 140 Dorabe syndrome;Dravet syndrome; 201 Angelman syndrome;
204	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬 Type II diabetes mellitus × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Type II diabetes mellitus × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 204. Type II diabetes mellitus × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
205	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬 Type II diabetes mellitus × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil hydrochloride 💬 Type II diabetes mellitus × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 205. Type II diabetes mellitus × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
206	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬 Type II diabetes mellitus × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Verapamil 💬 Type II diabetes mellitus × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 205. Type II diabetes mellitus × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
207	Tyrosine metabolism 💬	[1] DDC 💬 Tyrosine metabolism × Name Full Name DDC dopa decarboxylase	Carbidopa 💬 Tyrosine metabolism × Name Other Names Carbidopa Carbidopa (USP) Carbidopa hydrate (JP18) Lodosyn (TN) LODOSYN CARBIDOPA CARBIDOPA TABLETS, 25 MG	Carbidopa	[5]  6 , 13, 17, 140, 201 💬 207. Tyrosine metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 140 Dorabe syndrome;Dravet syndrome; 201 Angelman syndrome;
208	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Vascular smooth muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Vascular smooth muscle contraction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 208. Vascular smooth muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
209	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Vascular smooth muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil hydrochloride 💬 Vascular smooth muscle contraction × Name Other Names Verapamil hydrochloride Verapamil hydrochloride (JP18/USP) Calan (TN) Covera-hs (TN) Vasolan (TN) Verelan (TN) VERAPAMIL HCI VERAPAMIL HYDROCHLORIDE VERELAN VERELAN PM	Verapamil	[4] 58, 96, 140, 167 💬 209. Vascular smooth muscle contraction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;
210	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Vascular smooth muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Verapamil 💬 Vascular smooth muscle contraction × Name Other Names Verapamil Verapamil (USAN/INN)	Verapamil	[4] 58, 96, 140, 167 💬 209. Vascular smooth muscle contraction × Disease ID Name 58 Hypertrophic cardiomyopathy;HCM; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 167 Marfan syndrome;Loeys-Dietz syndrome;LDS;

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