Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Adrenergic signaling in cardiomyocytes 💬

[5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
CACNA1F	calcium voltage-gated channel subunit alpha1 F
CACNA1S	calcium voltage-gated channel subunit alpha1 S
SCN5A	sodium voltage-gated channel alpha subunit 5

Topiramate 💬

[6] 6 , 97, 140, 144, 156, 193 💬

2

Adrenergic signaling in cardiomyocytes 💬

[1] KCNQ1 💬

[2] 2 , 144 💬

3

Adrenergic signaling in cardiomyocytes 💬

[1] SCN5A 💬

Lamotrigine 💬

[5] 13, 34, 38, 114, 144 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
114	Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;
144	Lennox-Gastaut syndrome;

4

Adrenergic signaling in cardiomyocytes 💬

[1] SCN5A 💬

Rufinamide 💬

[1] 144 💬

5

Aldosterone synthesis and secretion 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
CACNA1F	calcium voltage-gated channel subunit alpha1 F
CACNA1S	calcium voltage-gated channel subunit alpha1 S

Topiramate 💬

[6] 6 , 97, 140, 144, 156, 193 💬

6

Alzheimer disease 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
CACNA1F	calcium voltage-gated channel subunit alpha1 F
CACNA1S	calcium voltage-gated channel subunit alpha1 S

Topiramate 💬

[6] 6 , 97, 140, 144, 156, 193 💬

7

Amphetamine addiction 💬

[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Topiramate 💬

[6] 6 , 97, 140, 144, 156, 193 💬

8

Amphetamine addiction 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Perampanel 💬

[3] 2 , 6 , 144 💬

9

Amyotrophic lateral sclerosis 💬

[2] GRIA1, GRIA2 💬

Perampanel 💬

[3] 2 , 6 , 144 💬

10

Amyotrophic lateral sclerosis 💬

[2] GRIA1, GRIA2 💬

Topiramate 💬

[6] 6 , 97, 140, 144, 156, 193 💬

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