Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adrenergic signaling in cardiomyocytes 💬	[5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S SCN5A sodium channel protein type 5 subunit alpha isoform a	Topiramate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 1. Adrenergic signaling in cardiomyocytes × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
2	Adrenergic signaling in cardiomyocytes 💬	[1] KCNQ1 💬 Adrenergic signaling in cardiomyocytes × Name Full Name KCNQ1 potassium voltage-gated channel subfamily KQT member 1 isoform 1	Ezogabine 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Ezogabine Retigabine Potiga	Ezogabine	[2]  2 , 144 💬 2. Adrenergic signaling in cardiomyocytes × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
3	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name SCN5A sodium channel protein type 5 subunit alpha isoform a	Lamotrigine 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Lamotrigine Lamictal SUBVENITE LAMOTRIGINE ER LAMOTRIGINE EXTENDED RELEASE	Lamotrigine	[7] 13, 34, 38, 113, 114, 115, 144 💬 3. Adrenergic signaling in cardiomyocytes × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 114 Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Thomsen syndrome;Autosomal-dominant myotonia congenita;Becker disease;Becker syndrome;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia; 115 Hereditary periodic paralysis;Periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 144 Lennox-Gastaut syndrome;
4	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name SCN5A sodium channel protein type 5 subunit alpha isoform a	Rufinamide 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Rufinamide Banzel	Rufinamide	[1] 144 💬 4. Adrenergic signaling in cardiomyocytes × Disease ID Name 144 Lennox-Gastaut syndrome;
5	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Aldosterone synthesis and secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 5. Aldosterone synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
6	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Alzheimer disease × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Alzheimer disease × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 6. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
7	Amphetamine addiction 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Amphetamine addiction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 7. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
8	Amphetamine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Amphetamine addiction × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 8. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
9	Amphetamine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Amphetamine addiction × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 8. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
10	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor	Perampanel 💬 Amyotrophic lateral sclerosis × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 10. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
11	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor	Perampanel hydrate 💬 Amyotrophic lateral sclerosis × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 10. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
12	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor	Topiramate 💬 Amyotrophic lateral sclerosis × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 12. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
13	Amyotrophic lateral sclerosis 💬	[1] SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1 isoform 1	Fenfluramine hydrochloride 💬 Amyotrophic lateral sclerosis × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 13. Amyotrophic lateral sclerosis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
14	Amyotrophic lateral sclerosis 💬	[1] SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1 isoform 1	Fenfluramine 💬 Amyotrophic lateral sclerosis × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 13. Amyotrophic lateral sclerosis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
15	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 15. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
16	Axon guidance 💬	[1] TRPC5 💬 Axon guidance × Name Full Name TRPC5 short transient receptor potential channel 5	Clemizole hydrochloride 💬 Axon guidance × Name Other Names Clemizole hydrochloride Allercur Reactrol	Clemizole	[2] 140, 144 💬 16. Axon guidance × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
17	Axon guidance 💬	[1] TRPC5 💬 Axon guidance × Name Full Name TRPC5 short transient receptor potential channel 5	Clemizole 💬 Axon guidance × Name Other Names Clemizole Clemizole	Clemizole	[2] 140, 144 💬 16. Axon guidance × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
18	Bile secretion 💬	[1] CA2 💬 Bile secretion × Name Full Name CA2 carbonic anhydrase 2 isoform 1	Topiramate 💬 Bile secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 18. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
19	Cadherin signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Cadherin signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Clobazam 💬 Cadherin signaling × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 19. Cadherin signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
20	Cadherin signaling 💬	[17] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, SCN5A 💬 Cadherin signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor SCN5A sodium channel protein type 5 subunit alpha isoform a	Topiramate 💬 Cadherin signaling × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 20. Cadherin signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
21	Cadherin signaling 💬	[1] SCN5A 💬 Cadherin signaling × Name Full Name SCN5A sodium channel protein type 5 subunit alpha isoform a	Lamotrigine 💬 Cadherin signaling × Name Other Names Lamotrigine Lamictal SUBVENITE LAMOTRIGINE ER LAMOTRIGINE EXTENDED RELEASE	Lamotrigine	[7] 13, 34, 38, 113, 114, 115, 144 💬 21. Cadherin signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 114 Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Thomsen syndrome;Autosomal-dominant myotonia congenita;Becker disease;Becker syndrome;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia; 115 Hereditary periodic paralysis;Periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 144 Lennox-Gastaut syndrome;
22	Cadherin signaling 💬	[1] SCN5A 💬 Cadherin signaling × Name Full Name SCN5A sodium channel protein type 5 subunit alpha isoform a	Rufinamide 💬 Cadherin signaling × Name Other Names Rufinamide Banzel	Rufinamide	[1] 144 💬 22. Cadherin signaling × Disease ID Name 144 Lennox-Gastaut syndrome;
23	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Calcium signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Calcium signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 23. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
24	Calcium signaling pathway 💬	[2] HTR2A, HTR2C 💬 Calcium signaling pathway × Name Full Name HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Fenfluramine hydrochloride 💬 Calcium signaling pathway × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 24. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
25	Calcium signaling pathway 💬	[2] HTR2A, HTR2C 💬 Calcium signaling pathway × Name Full Name HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Fenfluramine 💬 Calcium signaling pathway × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 24. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
26	Calcium signaling pathway 💬	[1] HTR2C 💬 Calcium signaling pathway × Name Full Name HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Bexicaserin 💬 Calcium signaling pathway × Name Other Names Bexicaserin Bexicaserin	Bexicaserin	[2] 140, 144 💬 26. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
27	cAMP signaling pathway 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 cAMP signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 27. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
28	cAMP signaling pathway 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 cAMP signaling pathway × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 28. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
29	cAMP signaling pathway 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 cAMP signaling pathway × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 28. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
30	cAMP signaling pathway 💬	[1] HTR1D 💬 cAMP signaling pathway × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D	Fenfluramine hydrochloride 💬 cAMP signaling pathway × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 30. cAMP signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
31	cAMP signaling pathway 💬	[1] HTR1D 💬 cAMP signaling pathway × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D	Fenfluramine 💬 cAMP signaling pathway × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 30. cAMP signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
32	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬 Carbohydrate digestion and absorption × Name Full Name CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b	Topiramate 💬 Carbohydrate digestion and absorption × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 32. Carbohydrate digestion and absorption × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
33	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cardiac muscle contraction × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Cardiac muscle contraction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 33. Cardiac muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
34	Cellular senescence 💬	[1] CACNA1D 💬 Cellular senescence × Name Full Name CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b	Topiramate 💬 Cellular senescence × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 34. Cellular senescence × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
35	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cGMP-PKG signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 cGMP-PKG signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 35. cGMP-PKG signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
36	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Chemical carcinogenesis - receptor activation × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 36. Chemical carcinogenesis - receptor activation × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
37	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cholinergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Cholinergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 37. Cholinergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
38	Cholinergic synapse 💬	[5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 Cholinergic synapse × Name Full Name KCNQ1 potassium voltage-gated channel subfamily KQT member 1 isoform 1 KCNQ2 potassium voltage-gated channel subfamily KQT member 2 isoform a KCNQ3 potassium voltage-gated channel subfamily KQT member 3 isoform 1 KCNQ4 potassium voltage-gated channel subfamily KQT member 4 isoform a KCNQ5 potassium voltage-gated channel subfamily KQT member 5 isoform 1	Ezogabine 💬 Cholinergic synapse × Name Other Names Ezogabine Retigabine Potiga	Ezogabine	[2]  2 , 144 💬 38. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
39	Circadian entrainment 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Circadian entrainment × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 39. Circadian entrainment × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
40	Circadian entrainment 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Circadian entrainment × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 40. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
41	Circadian entrainment 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Circadian entrainment × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 40. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
42	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate receptor 2 isoform 1 precursor	Perampanel 💬 Cocaine addiction × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 42. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
43	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate receptor 2 isoform 1 precursor	Perampanel hydrate 💬 Cocaine addiction × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 42. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
44	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate receptor 2 isoform 1 precursor	Topiramate 💬 Cocaine addiction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 44. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
45	Collecting duct acid secretion 💬	[1] CA2 💬 Collecting duct acid secretion × Name Full Name CA2 carbonic anhydrase 2 isoform 1	Topiramate 💬 Collecting duct acid secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 45. Collecting duct acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
46	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cortisol synthesis and secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Cortisol synthesis and secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 46. Cortisol synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
47	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cushing syndrome × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Cushing syndrome × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 47. Cushing syndrome × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
48	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Dilated cardiomyopathy × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Dilated cardiomyopathy × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 48. Dilated cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
49	Dopaminergic synapse 💬	[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Dopaminergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor SCN1A sodium channel protein type 1 subunit alpha isoform 1	Topiramate 💬 Dopaminergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 49. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
50	Dopaminergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Dopaminergic synapse × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Dopaminergic synapse × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 50. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
51	Dopaminergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Dopaminergic synapse × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Dopaminergic synapse × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 50. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
52	Dopaminergic synapse 💬	[1] SCN1A 💬 Dopaminergic synapse × Name Full Name SCN1A sodium channel protein type 1 subunit alpha isoform 1	Lamotrigine 💬 Dopaminergic synapse × Name Other Names Lamotrigine Lamictal SUBVENITE LAMOTRIGINE ER LAMOTRIGINE EXTENDED RELEASE	Lamotrigine	[7] 13, 34, 38, 113, 114, 115, 144 💬 52. Dopaminergic synapse × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 114 Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Thomsen syndrome;Autosomal-dominant myotonia congenita;Becker disease;Becker syndrome;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia; 115 Hereditary periodic paralysis;Periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 144 Lennox-Gastaut syndrome;
53	Dopaminergic synapse 💬	[1] SCN1A 💬 Dopaminergic synapse × Name Full Name SCN1A sodium channel protein type 1 subunit alpha isoform 1	Rufinamide 💬 Dopaminergic synapse × Name Other Names Rufinamide Banzel	Rufinamide	[1] 144 💬 53. Dopaminergic synapse × Disease ID Name 144 Lennox-Gastaut syndrome;
54	GABAergic synapse 💬	[20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Topiramate 💬 GABAergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 54. GABAergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
55	GABAergic synapse 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Clobazam 💬 GABAergic synapse × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 55. GABAergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
56	Gap junction 💬	[2] HTR2A, HTR2C 💬 Gap junction × Name Full Name HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Fenfluramine hydrochloride 💬 Gap junction × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 56. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
57	Gap junction 💬	[2] HTR2A, HTR2C 💬 Gap junction × Name Full Name HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Fenfluramine 💬 Gap junction × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 56. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
58	Gap junction 💬	[1] HTR2C 💬 Gap junction × Name Full Name HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Bexicaserin 💬 Gap junction × Name Other Names Bexicaserin Bexicaserin	Bexicaserin	[2] 140, 144 💬 58. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
59	Gastric acid secretion 💬	[1] CA2 💬 Gastric acid secretion × Name Full Name CA2 carbonic anhydrase 2 isoform 1	Topiramate 💬 Gastric acid secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 59. Gastric acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
60	Gastric acid secretion 💬	[1] KCNQ1 💬 Gastric acid secretion × Name Full Name KCNQ1 potassium voltage-gated channel subfamily KQT member 1 isoform 1	Ezogabine 💬 Gastric acid secretion × Name Other Names Ezogabine Retigabine Potiga	Ezogabine	[2]  2 , 144 💬 60. Gastric acid secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
61	Glutamatergic synapse 💬	[11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Glutamatergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor	Topiramate 💬 Glutamatergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 61. Glutamatergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
62	Glutamatergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Glutamatergic synapse × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Glutamatergic synapse × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 62. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
63	Glutamatergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Glutamatergic synapse × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Glutamatergic synapse × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 62. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
64	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 GnRH secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 64. GnRH secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
65	GnRH secretion 💬	[1] TRPC5 💬 GnRH secretion × Name Full Name TRPC5 short transient receptor potential channel 5	Clemizole hydrochloride 💬 GnRH secretion × Name Other Names Clemizole hydrochloride Allercur Reactrol	Clemizole	[2] 140, 144 💬 65. GnRH secretion × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
66	GnRH secretion 💬	[1] TRPC5 💬 GnRH secretion × Name Full Name TRPC5 short transient receptor potential channel 5	Clemizole 💬 GnRH secretion × Name Other Names Clemizole Clemizole	Clemizole	[2] 140, 144 💬 65. GnRH secretion × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
67	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 GnRH signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 67. GnRH signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
68	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Growth hormone synthesis, secretion and action × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Growth hormone synthesis, secretion and action × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 68. Growth hormone synthesis, secretion and action × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
69	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Huntington disease × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 69. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
70	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Huntington disease × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 69. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
71	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Huntington disease × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 71. Huntington disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
72	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Hypertrophic cardiomyopathy × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Hypertrophic cardiomyopathy × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 72. Hypertrophic cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
73	IgSF CAM signaling 💬	[2] KCNQ2, KCNQ3 💬 IgSF CAM signaling × Name Full Name KCNQ2 potassium voltage-gated channel subfamily KQT member 2 isoform a KCNQ3 potassium voltage-gated channel subfamily KQT member 3 isoform 1	Ezogabine 💬 IgSF CAM signaling × Name Other Names Ezogabine Retigabine Potiga	Ezogabine	[2]  2 , 144 💬 73. IgSF CAM signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
74	IgSF CAM signaling 💬	[1] SCN8A 💬 IgSF CAM signaling × Name Full Name SCN8A sodium channel protein type 8 subunit alpha isoform 3	Lamotrigine 💬 IgSF CAM signaling × Name Other Names Lamotrigine Lamictal SUBVENITE LAMOTRIGINE ER LAMOTRIGINE EXTENDED RELEASE	Lamotrigine	[7] 13, 34, 38, 113, 114, 115, 144 💬 74. IgSF CAM signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 114 Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Thomsen syndrome;Autosomal-dominant myotonia congenita;Becker disease;Becker syndrome;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia; 115 Hereditary periodic paralysis;Periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 144 Lennox-Gastaut syndrome;
75	IgSF CAM signaling 💬	[1] SCN8A 💬 IgSF CAM signaling × Name Full Name SCN8A sodium channel protein type 8 subunit alpha isoform 3	Rufinamide 💬 IgSF CAM signaling × Name Other Names Rufinamide Banzel	Rufinamide	[1] 144 💬 75. IgSF CAM signaling × Disease ID Name 144 Lennox-Gastaut syndrome;
76	IgSF CAM signaling 💬	[1] SCN8A 💬 IgSF CAM signaling × Name Full Name SCN8A sodium channel protein type 8 subunit alpha isoform 3	Topiramate 💬 IgSF CAM signaling × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 76. IgSF CAM signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
77	Inflammatory mediator regulation of TRP channels 💬	[2] HTR2A, HTR2C 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Fenfluramine hydrochloride 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 77. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
78	Inflammatory mediator regulation of TRP channels 💬	[2] HTR2A, HTR2C 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Fenfluramine 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 77. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
79	Inflammatory mediator regulation of TRP channels 💬	[1] HTR2C 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Bexicaserin 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Bexicaserin Bexicaserin	Bexicaserin	[2] 140, 144 💬 79. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
80	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Insulin secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Insulin secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 80. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
81	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Perampanel 💬 Long-term depression × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 81. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
82	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Perampanel hydrate 💬 Long-term depression × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 81. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
83	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Topiramate 💬 Long-term depression × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 83. Long-term depression × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
84	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor	Topiramate 💬 Long-term potentiation × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 84. Long-term potentiation × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
85	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor	Perampanel 💬 Long-term potentiation × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 85. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
86	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor	Perampanel hydrate 💬 Long-term potentiation × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 85. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
87	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 MAPK signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 MAPK signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 87. MAPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
88	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Clobazam 💬 Morphine addiction × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 88. Morphine addiction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
89	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Topiramate 💬 Morphine addiction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 89. Morphine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
90	Neuroactive ligand signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Neuroactive ligand signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Clobazam 💬 Neuroactive ligand signaling × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 90. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
91	Neuroactive ligand signaling 💬	[25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor	Topiramate 💬 Neuroactive ligand signaling × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 91. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
92	Neuroactive ligand signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Neuroactive ligand signaling × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Neuroactive ligand signaling × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 92. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
93	Neuroactive ligand signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Neuroactive ligand signaling × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Neuroactive ligand signaling × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 92. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
94	Neuroactive ligand signaling 💬	[4] HTR1D, HTR2A, HTR2C, SLC6A4 💬 Neuroactive ligand signaling × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor SLC6A4 sodium-dependent serotonin transporter	Fenfluramine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 94. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
95	Neuroactive ligand signaling 💬	[4] HTR1D, HTR2A, HTR2C, SLC6A4 💬 Neuroactive ligand signaling × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor SLC6A4 sodium-dependent serotonin transporter	Fenfluramine 💬 Neuroactive ligand signaling × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 94. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
96	Neuroactive ligand signaling 💬	[1] HTR2C 💬 Neuroactive ligand signaling × Name Full Name HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Bexicaserin 💬 Neuroactive ligand signaling × Name Other Names Bexicaserin Bexicaserin	Bexicaserin	[2] 140, 144 💬 96. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
97	Neuroactive ligand-receptor interaction 💬	[2] CNR1, CNR2 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1 isoform a CNR2 cannabinoid receptor 2	Cannabidiol 💬 Neuroactive ligand-receptor interaction × Name Other Names Cannabidiol CBD Epidiolex	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 97. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
98	Neuroactive ligand-receptor interaction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Clobazam 💬 Neuroactive ligand-receptor interaction × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 98. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
99	Neuroactive ligand-receptor interaction 💬	[25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor	Topiramate 💬 Neuroactive ligand-receptor interaction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 99. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
100	Neuroactive ligand-receptor interaction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Neuroactive ligand-receptor interaction × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 100. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
101	Neuroactive ligand-receptor interaction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Neuroactive ligand-receptor interaction × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 100. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
102	Neuroactive ligand-receptor interaction 💬	[3] HTR1D, HTR2A, HTR2C 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Fenfluramine hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 102. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
103	Neuroactive ligand-receptor interaction 💬	[3] HTR1D, HTR2A, HTR2C 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Fenfluramine 💬 Neuroactive ligand-receptor interaction × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 102. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
104	Neuroactive ligand-receptor interaction 💬	[1] HTR2C 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Bexicaserin 💬 Neuroactive ligand-receptor interaction × Name Other Names Bexicaserin Bexicaserin	Bexicaserin	[2] 140, 144 💬 104. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
105	Nicotine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Nicotine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Clobazam 💬 Nicotine addiction × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 105. Nicotine addiction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
106	Nicotine addiction 💬	[20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Nicotine addiction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 106. Nicotine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
107	Nicotine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Nicotine addiction × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 107. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
108	Nicotine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Nicotine addiction × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 107. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
109	Nitrogen metabolism 💬	[2] CA2, CA4 💬 Nitrogen metabolism × Name Full Name CA2 carbonic anhydrase 2 isoform 1 CA4 carbonic anhydrase 4 preproprotein	Topiramate 💬 Nitrogen metabolism × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 109. Nitrogen metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
110	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Oxytocin signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Oxytocin signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 110. Oxytocin signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
111	Pancreatic secretion 💬	[1] CA2 💬 Pancreatic secretion × Name Full Name CA2 carbonic anhydrase 2 isoform 1	Topiramate 💬 Pancreatic secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 111. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
112	Pancreatic secretion 💬	[1] KCNQ1 💬 Pancreatic secretion × Name Full Name KCNQ1 potassium voltage-gated channel subfamily KQT member 1 isoform 1	Ezogabine 💬 Pancreatic secretion × Name Other Names Ezogabine Retigabine Potiga	Ezogabine	[2]  2 , 144 💬 112. Pancreatic secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
113	Pathways of neurodegeneration - multiple diseases 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 113. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
114	Pathways of neurodegeneration - multiple diseases 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 114. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
115	Pathways of neurodegeneration - multiple diseases 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 114. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
116	Pathways of neurodegeneration - multiple diseases 💬	[1] SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1 isoform 1	Fenfluramine hydrochloride 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 116. Pathways of neurodegeneration - multiple diseases × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
117	Pathways of neurodegeneration - multiple diseases 💬	[1] SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1 isoform 1	Fenfluramine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 116. Pathways of neurodegeneration - multiple diseases × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
118	Primary bile acid biosynthesis 💬	[1] CYP46A1 💬 Primary bile acid biosynthesis × Name Full Name CYP46A1 cholesterol 24-hydroxylase	Soticlestat 💬 Primary bile acid biosynthesis × Name Other Names Soticlestat Soticlestat	Soticlestat	[2] 140, 144 💬 118. Primary bile acid biosynthesis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
119	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Prion disease × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Prion disease × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 119. Prion disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
120	Protein digestion and absorption 💬	[1] KCNQ1 💬 Protein digestion and absorption × Name Full Name KCNQ1 potassium voltage-gated channel subfamily KQT member 1 isoform 1	Ezogabine 💬 Protein digestion and absorption × Name Other Names Ezogabine Retigabine Potiga	Ezogabine	[2]  2 , 144 💬 120. Protein digestion and absorption × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
121	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬 Proximal tubule bicarbonate reclamation × Name Full Name CA2 carbonic anhydrase 2 isoform 1 CA4 carbonic anhydrase 4 preproprotein	Topiramate 💬 Proximal tubule bicarbonate reclamation × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 121. Proximal tubule bicarbonate reclamation × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
122	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Cannabidiol 💬 Rap1 signaling pathway × Name Other Names Cannabidiol CBD Epidiolex	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 122. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
123	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Renin secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Renin secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 123. Renin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
124	Retrograde endocannabinoid signaling 💬	[24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Retrograde endocannabinoid signaling × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 124. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
125	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Cannabidiol 💬 Retrograde endocannabinoid signaling × Name Other Names Cannabidiol CBD Epidiolex	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 125. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
126	Retrograde endocannabinoid signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Retrograde endocannabinoid signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Clobazam 💬 Retrograde endocannabinoid signaling × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 126. Retrograde endocannabinoid signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
127	Retrograde endocannabinoid signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel 💬 Retrograde endocannabinoid signaling × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 127. Retrograde endocannabinoid signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
128	Retrograde endocannabinoid signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Perampanel hydrate 💬 Retrograde endocannabinoid signaling × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 127. Retrograde endocannabinoid signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
129	Serotonergic synapse 💬	[7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬 Serotonergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor	Topiramate 💬 Serotonergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 129. Serotonergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
130	Serotonergic synapse 💬	[3] GABRB1, GABRB2, GABRB3 💬 Serotonergic synapse × Name Full Name GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor	Clobazam 💬 Serotonergic synapse × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 130. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
131	Serotonergic synapse 💬	[4] HTR1D, HTR2A, HTR2C, SLC6A4 💬 Serotonergic synapse × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor SLC6A4 sodium-dependent serotonin transporter	Fenfluramine hydrochloride 💬 Serotonergic synapse × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 131. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
132	Serotonergic synapse 💬	[4] HTR1D, HTR2A, HTR2C, SLC6A4 💬 Serotonergic synapse × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D HTR2A 5-hydroxytryptamine receptor 2A isoform 1 HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor SLC6A4 sodium-dependent serotonin transporter	Fenfluramine 💬 Serotonergic synapse × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 131. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
133	Serotonergic synapse 💬	[1] HTR2C 💬 Serotonergic synapse × Name Full Name HTR2C 5-hydroxytryptamine receptor 2C isoform a precursor	Bexicaserin 💬 Serotonergic synapse × Name Other Names Bexicaserin Bexicaserin	Bexicaserin	[2] 140, 144 💬 133. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
134	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Perampanel 💬 Spinocerebellar ataxia × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 134. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
135	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Perampanel hydrate 💬 Spinocerebellar ataxia × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 134. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
136	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Topiramate 💬 Spinocerebellar ataxia × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 136. Spinocerebellar ataxia × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
137	Synaptic vesicle cycle 💬	[1] SLC6A4 💬 Synaptic vesicle cycle × Name Full Name SLC6A4 sodium-dependent serotonin transporter	Fenfluramine hydrochloride 💬 Synaptic vesicle cycle × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 137. Synaptic vesicle cycle × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
138	Synaptic vesicle cycle 💬	[1] SLC6A4 💬 Synaptic vesicle cycle × Name Full Name SLC6A4 sodium-dependent serotonin transporter	Fenfluramine 💬 Synaptic vesicle cycle × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 137. Synaptic vesicle cycle × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
139	Taste transduction 💬	[10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor SCN2A sodium channel protein type 2 subunit alpha isoform 1 SCN3A sodium channel protein type 3 subunit alpha isoform 2 SCN9A sodium channel protein type 9 subunit alpha isoform 2	Topiramate 💬 Taste transduction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 139. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
140	Taste transduction 💬	[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 Taste transduction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor	Clobazam 💬 Taste transduction × Name Other Names Clobazam Mystan Onfi SYMPAZAN	Clobazam	[2] 140, 144 💬 140. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
141	Taste transduction 💬	[1] HTR1D 💬 Taste transduction × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D	Fenfluramine hydrochloride 💬 Taste transduction × Name Other Names Fenfluramine hydrochloride Fintepla Pondimin	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 141. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
142	Taste transduction 💬	[1] HTR1D 💬 Taste transduction × Name Full Name HTR1D 5-hydroxytryptamine receptor 1D	Fenfluramine 💬 Taste transduction × Name Other Names Fenfluramine Ponderax	Fenfluramine	[6] 140, 143, 144, 145, 149, 156 💬 141. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 143 Epilepsy with myoclonic-atonic seizures;Epilepsy with myoclonic cataplexy;Myoclonic-astatic epilepsy;Doose syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 156 Rett syndrome;
143	Taste transduction 💬	[3] SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name SCN2A sodium channel protein type 2 subunit alpha isoform 1 SCN3A sodium channel protein type 3 subunit alpha isoform 2 SCN9A sodium channel protein type 9 subunit alpha isoform 2	Lamotrigine 💬 Taste transduction × Name Other Names Lamotrigine Lamictal SUBVENITE LAMOTRIGINE ER LAMOTRIGINE EXTENDED RELEASE	Lamotrigine	[7] 13, 34, 38, 113, 114, 115, 144 💬 143. Taste transduction × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 114 Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Thomsen syndrome;Autosomal-dominant myotonia congenita;Becker disease;Becker syndrome;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia; 115 Hereditary periodic paralysis;Periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 144 Lennox-Gastaut syndrome;
144	Taste transduction 💬	[3] SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name SCN2A sodium channel protein type 2 subunit alpha isoform 1 SCN3A sodium channel protein type 3 subunit alpha isoform 2 SCN9A sodium channel protein type 9 subunit alpha isoform 2	Rufinamide 💬 Taste transduction × Name Other Names Rufinamide Banzel	Rufinamide	[1] 144 💬 144. Taste transduction × Disease ID Name 144 Lennox-Gastaut syndrome;
145	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Cannabidiol 💬 Thermogenesis × Name Other Names Cannabidiol CBD Epidiolex	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 145. Thermogenesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
146	Tight junction 💬	[1] CACNA1D 💬 Tight junction × Name Full Name CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b	Topiramate 💬 Tight junction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 146. Tight junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
147	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate receptor 3 isoform 2 precursor	Perampanel 💬 Transcriptional misregulation in cancer × Name Other Names Perampanel Fycompa	Perampanel	[3]  2 ,  6 , 144 💬 147. Transcriptional misregulation in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
148	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate receptor 3 isoform 2 precursor	Perampanel hydrate 💬 Transcriptional misregulation in cancer × Name Other Names Perampanel hydrate Fycompa PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 147. Transcriptional misregulation in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 144 Lennox-Gastaut syndrome;
149	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate receptor 3 isoform 2 precursor	Topiramate 💬 Transcriptional misregulation in cancer × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 149. Transcriptional misregulation in cancer × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
150	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬 Type II diabetes mellitus × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b	Topiramate 💬 Type II diabetes mellitus × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 150. Type II diabetes mellitus × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
151	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Vascular smooth muscle contraction × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Vascular smooth muscle contraction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 151. Vascular smooth muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
152	Vibrio cholerae infection 💬	[1] KCNQ1 💬 Vibrio cholerae infection × Name Full Name KCNQ1 potassium voltage-gated channel subfamily KQT member 1 isoform 1	Ezogabine 💬 Vibrio cholerae infection × Name Other Names Ezogabine Retigabine Potiga	Ezogabine	[2]  2 , 144 💬 152. Vibrio cholerae infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;

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