Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adrenergic signaling in cardiomyocytes 💬	[5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S SCN5A sodium voltage-gated channel alpha subunit 5	Topiramate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 1. Adrenergic signaling in cardiomyocytes × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
2	Adrenergic signaling in cardiomyocytes 💬	[1] KCNQ1 💬 Adrenergic signaling in cardiomyocytes × Name Full Name KCNQ1 potassium voltage-gated channel subfamily Q member 1	Ezogabine 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Ezogabine Ezogabine (USAN) Retigabine (INN) Potiga (TN)	Ezogabine	[2]  2 , 144 💬 2. Adrenergic signaling in cardiomyocytes × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
3	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name SCN5A sodium voltage-gated channel alpha subunit 5	Lamotrigine 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Lamotrigine Lamotrigine (JAN/USP/INN) Lamictal (TN) LAMICTAL LAMOTRIGINE LAMOTRIGINE ER LAMOTRIGINE EXTENDED RELEASE SUBVENITE	Lamotrigine	[6] 13, 34, 38, 113, 114, 144 💬 3. Adrenergic signaling in cardiomyocytes × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 114 Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Autosomal-dominant myotonia congenita;Becker disease;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia; 144 Lennox-Gastaut syndrome;
4	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name SCN5A sodium voltage-gated channel alpha subunit 5	Rufinamide 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Rufinamide Rufinamide (JAN/USP/INN) Banzel (TN) BANZEL RUFINAMIDE	Rufinamide	[1] 144 💬 4. Adrenergic signaling in cardiomyocytes × Disease ID Name 144 Lennox-Gastaut syndrome;
5	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Aldosterone synthesis and secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 5. Aldosterone synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
6	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Alzheimer disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Alzheimer disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 6. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
7	Amphetamine addiction 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Amphetamine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 7. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
8	Amphetamine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Amphetamine addiction × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 8. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
9	Amphetamine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Amphetamine addiction × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 8. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
10	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Perampanel 💬 Amyotrophic lateral sclerosis × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 10. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
11	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Perampanel hydrate 💬 Amyotrophic lateral sclerosis × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 10. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
12	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Amyotrophic lateral sclerosis × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 12. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
13	Amyotrophic lateral sclerosis 💬	[1] SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Fenfluramine hydrochloride 💬 Amyotrophic lateral sclerosis × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 13. Amyotrophic lateral sclerosis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
14	Amyotrophic lateral sclerosis 💬	[1] SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Fenfluramine 💬 Amyotrophic lateral sclerosis × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 13. Amyotrophic lateral sclerosis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
15	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 15. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
16	Axon guidance 💬	[1] TRPC5 💬 Axon guidance × Name Full Name TRPC5 transient receptor potential cation channel subfamily C member 5	Clemizole hydrochloride 💬 Axon guidance × Name Other Names Clemizole hydrochloride Clemizole hydrochloride (JAN/USAN) Allercur (TN) Reactrol (TN)	Clemizole	[2] 140, 144 💬 16. Axon guidance × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
17	Axon guidance 💬	[1] TRPC5 💬 Axon guidance × Name Full Name TRPC5 transient receptor potential cation channel subfamily C member 5	Clemizole 💬 Axon guidance × Name Other Names Clemizole Clemizole (USAN/INN)	Clemizole	[2] 140, 144 💬 16. Axon guidance × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
18	Bile secretion 💬	[1] CA2 💬 Bile secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Bile secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 18. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
19	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Calcium signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Calcium signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 19. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
20	Calcium signaling pathway 💬	[2] HTR2, HTR2 💬 Calcium signaling pathway × Name Full Name HTR2 HTR2	Fenfluramine hydrochloride 💬 Calcium signaling pathway × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 20. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
21	Calcium signaling pathway 💬	[2] HTR2, HTR2 💬 Calcium signaling pathway × Name Full Name HTR2 HTR2	Fenfluramine 💬 Calcium signaling pathway × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 20. Calcium signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
22	cAMP signaling pathway 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 cAMP signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 22. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
23	cAMP signaling pathway 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 cAMP signaling pathway × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 23. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
24	cAMP signaling pathway 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 cAMP signaling pathway × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 23. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
25	cAMP signaling pathway 💬	[1] HTR1 💬 cAMP signaling pathway × Name Full Name HTR1	Fenfluramine hydrochloride 💬 cAMP signaling pathway × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 25. cAMP signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
26	cAMP signaling pathway 💬	[1] HTR1 💬 cAMP signaling pathway × Name Full Name HTR1	Fenfluramine 💬 cAMP signaling pathway × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 25. cAMP signaling pathway × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
27	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬 Carbohydrate digestion and absorption × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Carbohydrate digestion and absorption × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 27. Carbohydrate digestion and absorption × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
28	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cardiac muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cardiac muscle contraction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 28. Cardiac muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
29	Cellular senescence 💬	[1] CACNA1D 💬 Cellular senescence × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Cellular senescence × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 29. Cellular senescence × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
30	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cGMP-PKG signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 cGMP-PKG signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 30. cGMP-PKG signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
31	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Chemical carcinogenesis - receptor activation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 31. Chemical carcinogenesis - receptor activation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
32	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cholinergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cholinergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 32. Cholinergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
33	Cholinergic synapse 💬	[5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 Cholinergic synapse × Name Full Name KCNQ1 potassium voltage-gated channel subfamily Q member 1 KCNQ2 potassium voltage-gated channel subfamily Q member 2 KCNQ3 potassium voltage-gated channel subfamily Q member 3 KCNQ4 potassium voltage-gated channel subfamily Q member 4 KCNQ5 potassium voltage-gated channel subfamily Q member 5	Ezogabine 💬 Cholinergic synapse × Name Other Names Ezogabine Ezogabine (USAN) Retigabine (INN) Potiga (TN)	Ezogabine	[2]  2 , 144 💬 33. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
34	Circadian entrainment 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Circadian entrainment × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 34. Circadian entrainment × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
35	Circadian entrainment 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Circadian entrainment × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 35. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
36	Circadian entrainment 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Circadian entrainment × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 35. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
37	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Perampanel 💬 Cocaine addiction × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 37. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
38	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Perampanel hydrate 💬 Cocaine addiction × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 37. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
39	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Cocaine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 39. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
40	Collecting duct acid secretion 💬	[1] CA2 💬 Collecting duct acid secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Collecting duct acid secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 40. Collecting duct acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
41	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cortisol synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cortisol synthesis and secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 41. Cortisol synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
42	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cushing syndrome × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cushing syndrome × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 42. Cushing syndrome × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
43	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Dilated cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Dilated cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 43. Dilated cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
44	Dopaminergic synapse 💬	[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Dopaminergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 SCN1A sodium voltage-gated channel alpha subunit 1	Topiramate 💬 Dopaminergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 44. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
45	Dopaminergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Dopaminergic synapse × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Dopaminergic synapse × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 45. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
46	Dopaminergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Dopaminergic synapse × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Dopaminergic synapse × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 45. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
47	Dopaminergic synapse 💬	[1] SCN1A 💬 Dopaminergic synapse × Name Full Name SCN1A sodium voltage-gated channel alpha subunit 1	Lamotrigine 💬 Dopaminergic synapse × Name Other Names Lamotrigine Lamotrigine (JAN/USP/INN) Lamictal (TN) LAMICTAL LAMOTRIGINE LAMOTRIGINE ER LAMOTRIGINE EXTENDED RELEASE SUBVENITE	Lamotrigine	[6] 13, 34, 38, 113, 114, 144 💬 47. Dopaminergic synapse × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 114 Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Autosomal-dominant myotonia congenita;Becker disease;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia; 144 Lennox-Gastaut syndrome;
48	Dopaminergic synapse 💬	[1] SCN1A 💬 Dopaminergic synapse × Name Full Name SCN1A sodium voltage-gated channel alpha subunit 1	Rufinamide 💬 Dopaminergic synapse × Name Other Names Rufinamide Rufinamide (JAN/USP/INN) Banzel (TN) BANZEL RUFINAMIDE	Rufinamide	[1] 144 💬 48. Dopaminergic synapse × Disease ID Name 144 Lennox-Gastaut syndrome;
49	GABAergic synapse 💬	[20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Topiramate 💬 GABAergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 49. GABAergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
50	GABAergic synapse 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 GABAergic synapse × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 50. GABAergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
51	Gap junction 💬	[2] HTR2, HTR2 💬 Gap junction × Name Full Name HTR2 HTR2	Fenfluramine 💬 Gap junction × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 51. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
52	Gap junction 💬	[2] HTR2, HTR2 💬 Gap junction × Name Full Name HTR2 HTR2	Fenfluramine hydrochloride 💬 Gap junction × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 52. Gap junction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
53	Gastric acid secretion 💬	[1] CA2 💬 Gastric acid secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Gastric acid secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 53. Gastric acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
54	Gastric acid secretion 💬	[1] KCNQ1 💬 Gastric acid secretion × Name Full Name KCNQ1 potassium voltage-gated channel subfamily Q member 1	Ezogabine 💬 Gastric acid secretion × Name Other Names Ezogabine Ezogabine (USAN) Retigabine (INN) Potiga (TN)	Ezogabine	[2]  2 , 144 💬 54. Gastric acid secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
55	Glutamatergic synapse 💬	[11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Glutamatergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Glutamatergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 55. Glutamatergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
56	Glutamatergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Glutamatergic synapse × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Glutamatergic synapse × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 56. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
57	Glutamatergic synapse 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Glutamatergic synapse × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Glutamatergic synapse × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 56. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
58	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 GnRH secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 58. GnRH secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
59	GnRH secretion 💬	[1] TRPC5 💬 GnRH secretion × Name Full Name TRPC5 transient receptor potential cation channel subfamily C member 5	Clemizole hydrochloride 💬 GnRH secretion × Name Other Names Clemizole hydrochloride Clemizole hydrochloride (JAN/USAN) Allercur (TN) Reactrol (TN)	Clemizole	[2] 140, 144 💬 59. GnRH secretion × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
60	GnRH secretion 💬	[1] TRPC5 💬 GnRH secretion × Name Full Name TRPC5 transient receptor potential cation channel subfamily C member 5	Clemizole 💬 GnRH secretion × Name Other Names Clemizole Clemizole (USAN/INN)	Clemizole	[2] 140, 144 💬 59. GnRH secretion × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
61	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 GnRH signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 61. GnRH signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
62	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Growth hormone synthesis, secretion and action × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Growth hormone synthesis, secretion and action × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 62. Growth hormone synthesis, secretion and action × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
63	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Huntington disease × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 63. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
64	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Huntington disease × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 63. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
65	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Huntington disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 65. Huntington disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
66	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Hypertrophic cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Hypertrophic cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 66. Hypertrophic cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
67	Inflammatory mediator regulation of TRP channels 💬	[2] HTR2, HTR2 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2 HTR2	Fenfluramine 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 67. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
68	Inflammatory mediator regulation of TRP channels 💬	[2] HTR2, HTR2 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2 HTR2	Fenfluramine hydrochloride 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 68. Inflammatory mediator regulation of TRP channels × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
69	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Insulin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Insulin secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 69. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
70	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Perampanel 💬 Long-term depression × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 70. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
71	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Perampanel hydrate 💬 Long-term depression × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 70. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
72	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Long-term depression × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 72. Long-term depression × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
73	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Long-term potentiation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 73. Long-term potentiation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
74	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Perampanel 💬 Long-term potentiation × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 74. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
75	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Perampanel hydrate 💬 Long-term potentiation × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 74. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
76	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 MAPK signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 MAPK signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 76. MAPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
77	Morphine addiction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Morphine addiction × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 77. Morphine addiction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
78	Morphine addiction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Topiramate 💬 Morphine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 78. Morphine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
79	Neuroactive ligand signaling 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Neuroactive ligand signaling × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Neuroactive ligand signaling × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 79. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
80	Neuroactive ligand signaling 💬	[25] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand signaling × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Neuroactive ligand signaling × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 80. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
81	Neuroactive ligand signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Neuroactive ligand signaling × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Neuroactive ligand signaling × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 81. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
82	Neuroactive ligand signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Neuroactive ligand signaling × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Neuroactive ligand signaling × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 81. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
83	Neuroactive ligand signaling 💬	[4] HTR1, HTR2, HTR2, SLC6A4 💬 Neuroactive ligand signaling × Name Full Name HTR1 HTR2 HTR2 SLC6A4 solute carrier family 6 member 4	Fenfluramine 💬 Neuroactive ligand signaling × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 83. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
84	Neuroactive ligand signaling 💬	[4] HTR1, HTR2, HTR2, SLC6A4 💬 Neuroactive ligand signaling × Name Full Name HTR1 HTR2 HTR2 SLC6A4 solute carrier family 6 member 4	Fenfluramine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 83. Neuroactive ligand signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
85	Neuroactive ligand-receptor interaction 💬	[2] CNR1, CNR2 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1 CNR2 cannabinoid receptor 2	Cannabidiol 💬 Neuroactive ligand-receptor interaction × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 85. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
86	Neuroactive ligand-receptor interaction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Neuroactive ligand-receptor interaction × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 86. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
87	Neuroactive ligand-receptor interaction 💬	[25] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Neuroactive ligand-receptor interaction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 87. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
88	Neuroactive ligand-receptor interaction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Neuroactive ligand-receptor interaction × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 88. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
89	Neuroactive ligand-receptor interaction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Neuroactive ligand-receptor interaction × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 88. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
90	Neuroactive ligand-receptor interaction 💬	[3] HTR1, HTR2, HTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR1 HTR2 HTR2	Fenfluramine hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 90. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
91	Neuroactive ligand-receptor interaction 💬	[3] HTR1, HTR2, HTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name HTR1 HTR2 HTR2	Fenfluramine 💬 Neuroactive ligand-receptor interaction × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 90. Neuroactive ligand-receptor interaction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
92	Nicotine addiction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Nicotine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Nicotine addiction × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 92. Nicotine addiction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
93	Nicotine addiction 💬	[20] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Nicotine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 93. Nicotine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
94	Nicotine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Nicotine addiction × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 94. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
95	Nicotine addiction 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Nicotine addiction × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 94. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
96	Nitrogen metabolism 💬	[2] CA2, CA4 💬 Nitrogen metabolism × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Nitrogen metabolism × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 96. Nitrogen metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
97	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Oxytocin signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Oxytocin signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 97. Oxytocin signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
98	Pancreatic secretion 💬	[1] CA2 💬 Pancreatic secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Pancreatic secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 98. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
99	Pancreatic secretion 💬	[1] KCNQ1 💬 Pancreatic secretion × Name Full Name KCNQ1 potassium voltage-gated channel subfamily Q member 1	Ezogabine 💬 Pancreatic secretion × Name Other Names Ezogabine Ezogabine (USAN) Retigabine (INN) Potiga (TN)	Ezogabine	[2]  2 , 144 💬 99. Pancreatic secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
100	Pathways of neurodegeneration - multiple diseases 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 100. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
101	Pathways of neurodegeneration - multiple diseases 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 101. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
102	Pathways of neurodegeneration - multiple diseases 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 101. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
103	Pathways of neurodegeneration - multiple diseases 💬	[1] SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Fenfluramine hydrochloride 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 103. Pathways of neurodegeneration - multiple diseases × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
104	Pathways of neurodegeneration - multiple diseases 💬	[1] SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Fenfluramine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 103. Pathways of neurodegeneration - multiple diseases × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
105	Primary bile acid biosynthesis 💬	[1] CYP46A1 💬 Primary bile acid biosynthesis × Name Full Name CYP46A1 cytochrome P450 family 46 subfamily A member 1	Soticlestat 💬 Primary bile acid biosynthesis × Name Other Names Soticlestat Soticlestat (JAN/USAN/INN)	Soticlestat	[2] 140, 144 💬 105. Primary bile acid biosynthesis × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
106	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Prion disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Prion disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 106. Prion disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
107	Protein digestion and absorption 💬	[1] KCNQ1 💬 Protein digestion and absorption × Name Full Name KCNQ1 potassium voltage-gated channel subfamily Q member 1	Ezogabine 💬 Protein digestion and absorption × Name Other Names Ezogabine Ezogabine (USAN) Retigabine (INN) Potiga (TN)	Ezogabine	[2]  2 , 144 💬 107. Protein digestion and absorption × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;
108	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬 Proximal tubule bicarbonate reclamation × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Proximal tubule bicarbonate reclamation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 108. Proximal tubule bicarbonate reclamation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
109	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Rap1 signaling pathway × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 109. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
110	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Renin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Renin secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 110. Renin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
111	Retrograde endocannabinoid signaling 💬	[24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Retrograde endocannabinoid signaling × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 111. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
112	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Retrograde endocannabinoid signaling × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 112. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
113	Retrograde endocannabinoid signaling 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Retrograde endocannabinoid signaling × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Clobazam 💬 Retrograde endocannabinoid signaling × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 113. Retrograde endocannabinoid signaling × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
114	Retrograde endocannabinoid signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel 💬 Retrograde endocannabinoid signaling × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 114. Retrograde endocannabinoid signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
115	Retrograde endocannabinoid signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Perampanel hydrate 💬 Retrograde endocannabinoid signaling × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 114. Retrograde endocannabinoid signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
116	Serotonergic synapse 💬	[7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB, GABRB, GABRB 💬 Serotonergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRB GABRB GABRB	Topiramate 💬 Serotonergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 116. Serotonergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
117	Serotonergic synapse 💬	[3] GABRB, GABRB, GABRB 💬 Serotonergic synapse × Name Full Name GABRB GABRB GABRB	Clobazam 💬 Serotonergic synapse × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 117. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
118	Serotonergic synapse 💬	[4] HTR1, HTR2, HTR2, SLC6A4 💬 Serotonergic synapse × Name Full Name HTR1 HTR2 HTR2 SLC6A4 solute carrier family 6 member 4	Fenfluramine 💬 Serotonergic synapse × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 118. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
119	Serotonergic synapse 💬	[4] HTR1, HTR2, HTR2, SLC6A4 💬 Serotonergic synapse × Name Full Name HTR1 HTR2 HTR2 SLC6A4 solute carrier family 6 member 4	Fenfluramine hydrochloride 💬 Serotonergic synapse × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 118. Serotonergic synapse × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
120	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Perampanel 💬 Spinocerebellar ataxia × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 120. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
121	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Perampanel hydrate 💬 Spinocerebellar ataxia × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 120. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
122	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Spinocerebellar ataxia × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 122. Spinocerebellar ataxia × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
123	Synaptic vesicle cycle 💬	[1] SLC6A4 💬 Synaptic vesicle cycle × Name Full Name SLC6A4 solute carrier family 6 member 4	Fenfluramine hydrochloride 💬 Synaptic vesicle cycle × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 123. Synaptic vesicle cycle × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
124	Synaptic vesicle cycle 💬	[1] SLC6A4 💬 Synaptic vesicle cycle × Name Full Name SLC6A4 solute carrier family 6 member 4	Fenfluramine 💬 Synaptic vesicle cycle × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 123. Synaptic vesicle cycle × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
125	Taste transduction 💬	[10] CACNA1C, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C GABRA GABRA GABRA GABRA GABRA GABRA SCN2A sodium voltage-gated channel alpha subunit 2 SCN3A sodium voltage-gated channel alpha subunit 3 SCN9A sodium voltage-gated channel alpha subunit 9	Topiramate 💬 Taste transduction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 125. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
126	Taste transduction 💬	[6] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA 💬 Taste transduction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA	Clobazam 💬 Taste transduction × Name Other Names Clobazam Clobazam (JAN/USAN/INN) Mystan (TN) Onfi (TN) ONFI SYMPAZAN CLOBAZAM	Clobazam	[2] 140, 144 💬 126. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome;
127	Taste transduction 💬	[1] HTR1 💬 Taste transduction × Name Full Name HTR1	Fenfluramine hydrochloride 💬 Taste transduction × Name Other Names Fenfluramine hydrochloride Fenfluramine hydrochloride (JAN/USAN) Fintepla (TN) Pondimin (TN) FINTEPLA	Fenfluramine	[4] 140, 144, 145, 149 💬 127. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
128	Taste transduction 💬	[1] HTR1 💬 Taste transduction × Name Full Name HTR1	Fenfluramine 💬 Taste transduction × Name Other Names Fenfluramine Fenfluramine (INN) Ponderax (TN)	Fenfluramine	[4] 140, 144, 145, 149 💬 127. Taste transduction × Disease ID Name 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
129	Taste transduction 💬	[3] SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name SCN2A sodium voltage-gated channel alpha subunit 2 SCN3A sodium voltage-gated channel alpha subunit 3 SCN9A sodium voltage-gated channel alpha subunit 9	Lamotrigine 💬 Taste transduction × Name Other Names Lamotrigine Lamotrigine (JAN/USP/INN) Lamictal (TN) LAMICTAL LAMOTRIGINE LAMOTRIGINE ER LAMOTRIGINE EXTENDED RELEASE SUBVENITE	Lamotrigine	[6] 13, 34, 38, 113, 114, 144 💬 129. Taste transduction × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 114 Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Autosomal-dominant myotonia congenita;Becker disease;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia; 144 Lennox-Gastaut syndrome;
130	Taste transduction 💬	[3] SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name SCN2A sodium voltage-gated channel alpha subunit 2 SCN3A sodium voltage-gated channel alpha subunit 3 SCN9A sodium voltage-gated channel alpha subunit 9	Rufinamide 💬 Taste transduction × Name Other Names Rufinamide Rufinamide (JAN/USP/INN) Banzel (TN) BANZEL RUFINAMIDE	Rufinamide	[1] 144 💬 130. Taste transduction × Disease ID Name 144 Lennox-Gastaut syndrome;
131	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Thermogenesis × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 131. Thermogenesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
132	Tight junction 💬	[1] CACNA1D 💬 Tight junction × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Tight junction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 132. Tight junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
133	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Perampanel 💬 Transcriptional misregulation in cancer × Name Other Names Perampanel Perampanel (USAN) Fycompa (TN)	Perampanel	[3]  2 ,  6 , 144 💬 133. Transcriptional misregulation in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
134	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Perampanel hydrate 💬 Transcriptional misregulation in cancer × Name Other Names Perampanel hydrate Perampanel hydrate (JAN) Fycompa (TN) FYCOMPA PERAMPANEL	Perampanel	[3]  2 ,  6 , 144 💬 133. Transcriptional misregulation in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 144 Lennox-Gastaut syndrome;
135	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Transcriptional misregulation in cancer × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 135. Transcriptional misregulation in cancer × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
136	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬 Type II diabetes mellitus × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Type II diabetes mellitus × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 136. Type II diabetes mellitus × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
137	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Vascular smooth muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Vascular smooth muscle contraction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 137. Vascular smooth muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
138	Vibrio cholerae infection 💬	[1] KCNQ1 💬 Vibrio cholerae infection × Name Full Name KCNQ1 potassium voltage-gated channel subfamily Q member 1	Ezogabine 💬 Vibrio cholerae infection × Name Other Names Ezogabine Ezogabine (USAN) Retigabine (INN) Potiga (TN)	Ezogabine	[2]  2 , 144 💬 138. Vibrio cholerae infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 144 Lennox-Gastaut syndrome;

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