Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MTOR 💬 Acute myeloid leukemia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Acute myeloid leukemia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 1. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
2	Adipocytokine signaling pathway 💬	[1] MTOR 💬 Adipocytokine signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Adipocytokine signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 2. Adipocytokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
3	Adipocytokine signaling pathway 💬	[1] TNF 💬 Adipocytokine signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Adipocytokine signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 3. Adipocytokine signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
4	African trypanosomiasis 💬	[1] TNF 💬 African trypanosomiasis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 African trypanosomiasis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 4. African trypanosomiasis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
5	AGE-RAGE signaling pathway in diabetic complications 💬	[1] TNF 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TNF tumor necrosis factor	Etanercept 💬 AGE-RAGE signaling pathway in diabetic complications × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 5. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
6	Alcoholic liver disease 💬	[1] TNF 💬 Alcoholic liver disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Alcoholic liver disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 6. Alcoholic liver disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
7	Allograft rejection 💬	[1] TNF 💬 Allograft rejection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Allograft rejection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 7. Allograft rejection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
8	Alzheimer disease 💬	[1] MTOR 💬 Alzheimer disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Alzheimer disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 8. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
9	Alzheimer disease 💬	[1] TNF 💬 Alzheimer disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Alzheimer disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 9. Alzheimer disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
10	Amoebiasis 💬	[2] IL1R1, IL1R2 💬 Amoebiasis × Name Full Name IL1R1 interleukin 1 receptor type 1 IL1R2 interleukin 1 receptor type 2	Anakinra 💬 Amoebiasis × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 10. Amoebiasis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
11	Amoebiasis 💬	[1] TNF 💬 Amoebiasis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Amoebiasis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 11. Amoebiasis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
12	AMPK signaling pathway 💬	[1] HMGCR 💬 AMPK signaling pathway × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 AMPK signaling pathway × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 12. AMPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 34 Neurofibromatosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex; 160 Congenital ichthyosis; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis; 310 Congenital anomalies syndrome;
13	AMPK signaling pathway 💬	[1] MTOR 💬 AMPK signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 AMPK signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 13. AMPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
14	AMPK signaling pathway 💬	[1] PPARG 💬 AMPK signaling pathway × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 AMPK signaling pathway × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 14. AMPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
15	Amyotrophic lateral sclerosis 💬	[1] MTOR 💬 Amyotrophic lateral sclerosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 15. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
16	Amyotrophic lateral sclerosis 💬	[1] TNF 💬 Amyotrophic lateral sclerosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Amyotrophic lateral sclerosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 16. Amyotrophic lateral sclerosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
17	Antifolate resistance 💬	[1] TNF 💬 Antifolate resistance × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Antifolate resistance × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 17. Antifolate resistance × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
18	Antigen processing and presentation 💬	[1] TNF 💬 Antigen processing and presentation × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Antigen processing and presentation × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 18. Antigen processing and presentation × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
19	Apelin signaling pathway 💬	[1] MTOR 💬 Apelin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Apelin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 19. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
20	Apoptosis 💬	[1] TNF 💬 Apoptosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Apoptosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 20. Apoptosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
21	Arrhythmogenic right ventricular cardiomyopathy 💬	[1] ITGA4 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 21. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
22	Asthma 💬	[1] TNF 💬 Asthma × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Asthma × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 22. Asthma × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
23	Autophagy - animal 💬	[1] MTOR 💬 Autophagy - animal × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - animal × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 23. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
24	Autophagy - other 💬	[1] MTOR 💬 Autophagy - other × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - other × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 24. Autophagy - other × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
25	Bile secretion 💬	[1] HMGCR 💬 Bile secretion × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 Bile secretion × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 25. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 34 Neurofibromatosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex; 160 Congenital ichthyosis; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis; 310 Congenital anomalies syndrome;
26	Breast cancer 💬	[1] MTOR 💬 Breast cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Breast cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 26. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
27	C-type lectin receptor signaling pathway 💬	[1] TNF 💬 C-type lectin receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 C-type lectin receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 27. C-type lectin receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
28	Cell adhesion molecules 💬	[1] ITGA4 💬 Cell adhesion molecules × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Cell adhesion molecules × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 28. Cell adhesion molecules × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
29	Cellular senescence 💬	[1] MTOR 💬 Cellular senescence × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Cellular senescence × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 29. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
30	Central carbon metabolism in cancer 💬	[1] MTOR 💬 Central carbon metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Central carbon metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 30. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
31	Chagas disease 💬	[1] TNF 💬 Chagas disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Chagas disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 31. Chagas disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
32	Chemical carcinogenesis - receptor activation 💬	[1] MTOR 💬 Chemical carcinogenesis - receptor activation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Chemical carcinogenesis - receptor activation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 32. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
33	Choline metabolism in cancer 💬	[1] MTOR 💬 Choline metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Choline metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 33. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
34	Colorectal cancer 💬	[1] MTOR 💬 Colorectal cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Colorectal cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 34. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
35	Coronavirus disease - COVID-19 💬	[1] TNF 💬 Coronavirus disease - COVID-19 × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Coronavirus disease - COVID-19 × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 35. Coronavirus disease - COVID-19 × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
36	Cytokine-cytokine receptor interaction 💬	[2] ACVR2A, ACVR2B 💬 Cytokine-cytokine receptor interaction × Name Full Name ACVR2A activin A receptor type 2A ACVR2B activin A receptor type 2B	Bimagrumab 💬 Cytokine-cytokine receptor interaction × Name Other Names Bimagrumab Bimagrumab (JAN/USAN/INN)	Bimagrumab	[1] 15 💬 36. Cytokine-cytokine receptor interaction × Disease ID Name 15 Inclusion body myositis;
37	Cytokine-cytokine receptor interaction 💬	[2] IL1R1, IL1R2 💬 Cytokine-cytokine receptor interaction × Name Full Name IL1R1 interleukin 1 receptor type 1 IL1R2 interleukin 1 receptor type 2	Anakinra 💬 Cytokine-cytokine receptor interaction × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 37. Cytokine-cytokine receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
38	Cytokine-cytokine receptor interaction 💬	[2] LTA, TNF 💬 Cytokine-cytokine receptor interaction × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Cytokine-cytokine receptor interaction × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 38. Cytokine-cytokine receptor interaction × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
39	Diabetic cardiomyopathy 💬	[1] MTOR 💬 Diabetic cardiomyopathy × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Diabetic cardiomyopathy × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 39. Diabetic cardiomyopathy × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
40	Dilated cardiomyopathy 💬	[1] ITGA4 💬 Dilated cardiomyopathy × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Dilated cardiomyopathy × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 40. Dilated cardiomyopathy × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
41	Dilated cardiomyopathy 💬	[1] TNF 💬 Dilated cardiomyopathy × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Dilated cardiomyopathy × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 41. Dilated cardiomyopathy × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
42	ECM-receptor interaction 💬	[1] ITGA4 💬 ECM-receptor interaction × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 ECM-receptor interaction × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 42. ECM-receptor interaction × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
43	EGFR tyrosine kinase inhibitor resistance 💬	[1] MTOR 💬 EGFR tyrosine kinase inhibitor resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 43. EGFR tyrosine kinase inhibitor resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
44	Endocrine resistance 💬	[1] MTOR 💬 Endocrine resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Endocrine resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 44. Endocrine resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
45	Epstein-Barr virus infection 💬	[1] TNF 💬 Epstein-Barr virus infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Epstein-Barr virus infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 45. Epstein-Barr virus infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
46	ErbB signaling pathway 💬	[1] MTOR 💬 ErbB signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 ErbB signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 46. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
47	Fc epsilon RI signaling pathway 💬	[1] TNF 💬 Fc epsilon RI signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Fc epsilon RI signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 47. Fc epsilon RI signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
48	Fluid shear stress and atherosclerosis 💬	[2] ACVR2A, ACVR2B 💬 Fluid shear stress and atherosclerosis × Name Full Name ACVR2A activin A receptor type 2A ACVR2B activin A receptor type 2B	Bimagrumab 💬 Fluid shear stress and atherosclerosis × Name Other Names Bimagrumab Bimagrumab (JAN/USAN/INN)	Bimagrumab	[1] 15 💬 48. Fluid shear stress and atherosclerosis × Disease ID Name 15 Inclusion body myositis;
49	Fluid shear stress and atherosclerosis 💬	[2] IL1R1, IL1R2 💬 Fluid shear stress and atherosclerosis × Name Full Name IL1R1 interleukin 1 receptor type 1 IL1R2 interleukin 1 receptor type 2	Anakinra 💬 Fluid shear stress and atherosclerosis × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 49. Fluid shear stress and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
50	Fluid shear stress and atherosclerosis 💬	[1] TNF 💬 Fluid shear stress and atherosclerosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Fluid shear stress and atherosclerosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 50. Fluid shear stress and atherosclerosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
51	Focal adhesion 💬	[1] ITGA4 💬 Focal adhesion × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Focal adhesion × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 51. Focal adhesion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
52	Gastric cancer 💬	[1] MTOR 💬 Gastric cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Gastric cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 52. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
53	Glioma 💬	[1] MTOR 💬 Glioma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Glioma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 53. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
54	Graft-versus-host disease 💬	[1] TNF 💬 Graft-versus-host disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Graft-versus-host disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 54. Graft-versus-host disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
55	Growth hormone synthesis, secretion and action 💬	[1] MTOR 💬 Growth hormone synthesis, secretion and action × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Growth hormone synthesis, secretion and action × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 55. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
56	Hematopoietic cell lineage 💬	[2] IL1R1, IL1R2 💬 Hematopoietic cell lineage × Name Full Name IL1R1 interleukin 1 receptor type 1 IL1R2 interleukin 1 receptor type 2	Anakinra 💬 Hematopoietic cell lineage × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 56. Hematopoietic cell lineage × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
57	Hematopoietic cell lineage 💬	[1] ITGA4 💬 Hematopoietic cell lineage × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Hematopoietic cell lineage × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 57. Hematopoietic cell lineage × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
58	Hematopoietic cell lineage 💬	[1] TNF 💬 Hematopoietic cell lineage × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Hematopoietic cell lineage × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 58. Hematopoietic cell lineage × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
59	Hepatitis B 💬	[1] TNF 💬 Hepatitis B × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Hepatitis B × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 59. Hepatitis B × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
60	Hepatitis C 💬	[1] TNF 💬 Hepatitis C × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Hepatitis C × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 60. Hepatitis C × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
61	Hepatocellular carcinoma 💬	[1] MTOR 💬 Hepatocellular carcinoma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Hepatocellular carcinoma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 61. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
62	Herpes simplex virus 1 infection 💬	[2] LTA, TNF 💬 Herpes simplex virus 1 infection × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Herpes simplex virus 1 infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 62. Herpes simplex virus 1 infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
63	Herpes simplex virus 1 infection 💬	[1] MTOR 💬 Herpes simplex virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Herpes simplex virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 63. Herpes simplex virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
64	HIF-1 signaling pathway 💬	[1] MTOR 💬 HIF-1 signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 HIF-1 signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 64. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
65	Human cytomegalovirus infection 💬	[1] IL1R1 💬 Human cytomegalovirus infection × Name Full Name IL1R1 interleukin 1 receptor type 1	Anakinra 💬 Human cytomegalovirus infection × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 65. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
66	Human cytomegalovirus infection 💬	[1] MTOR 💬 Human cytomegalovirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human cytomegalovirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 66. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
67	Human cytomegalovirus infection 💬	[1] TNF 💬 Human cytomegalovirus infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Human cytomegalovirus infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 67. Human cytomegalovirus infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
68	Human immunodeficiency virus 1 infection 💬	[1] MTOR 💬 Human immunodeficiency virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 68. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
69	Human immunodeficiency virus 1 infection 💬	[1] TNF 💬 Human immunodeficiency virus 1 infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Human immunodeficiency virus 1 infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 69. Human immunodeficiency virus 1 infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
70	Human papillomavirus infection 💬	[1] ITGA4 💬 Human papillomavirus infection × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Human papillomavirus infection × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 70. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
71	Human papillomavirus infection 💬	[1] MTOR 💬 Human papillomavirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human papillomavirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 71. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
72	Human papillomavirus infection 💬	[1] TNF 💬 Human papillomavirus infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Human papillomavirus infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 72. Human papillomavirus infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
73	Human T-cell leukemia virus 1 infection 💬	[2] IL1R1, IL1R2 💬 Human T-cell leukemia virus 1 infection × Name Full Name IL1R1 interleukin 1 receptor type 1 IL1R2 interleukin 1 receptor type 2	Anakinra 💬 Human T-cell leukemia virus 1 infection × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 73. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
74	Human T-cell leukemia virus 1 infection 💬	[2] LTA, TNF 💬 Human T-cell leukemia virus 1 infection × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Human T-cell leukemia virus 1 infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 74. Human T-cell leukemia virus 1 infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
75	Huntington disease 💬	[1] MTOR 💬 Huntington disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Huntington disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 75. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
76	Huntington disease 💬	[1] PPARG 💬 Huntington disease × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Huntington disease × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 76. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
77	Hypertrophic cardiomyopathy 💬	[1] ITGA4 💬 Hypertrophic cardiomyopathy × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Hypertrophic cardiomyopathy × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 77. Hypertrophic cardiomyopathy × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
78	Hypertrophic cardiomyopathy 💬	[1] TNF 💬 Hypertrophic cardiomyopathy × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Hypertrophic cardiomyopathy × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 78. Hypertrophic cardiomyopathy × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
79	IL-17 signaling pathway 💬	[1] TNF 💬 IL-17 signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 IL-17 signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 79. IL-17 signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
80	Inflammatory bowel disease 💬	[1] TNF 💬 Inflammatory bowel disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Inflammatory bowel disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 80. Inflammatory bowel disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
81	Inflammatory mediator regulation of TRP channels 💬	[1] IL1R1 💬 Inflammatory mediator regulation of TRP channels × Name Full Name IL1R1 interleukin 1 receptor type 1	Anakinra 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 81. Inflammatory mediator regulation of TRP channels × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
82	Influenza A 💬	[1] TNF 💬 Influenza A × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Influenza A × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 82. Influenza A × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
83	Insulin resistance 💬	[1] MTOR 💬 Insulin resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 83. Insulin resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
84	Insulin resistance 💬	[1] TNF 💬 Insulin resistance × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Insulin resistance × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 84. Insulin resistance × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
85	Insulin secretion 💬	[1] SNAP25 💬 Insulin secretion × Name Full Name SNAP25 synaptosome associated protein 25	Botulinum toxin type A 💬 Insulin secretion × Name Other Names Botulinum toxin type A Botulinum toxin type A (JAN) Botox (TN) Dysport (TN) DAXXIFY	Botulinum toxin type A	[14]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬 85. Insulin secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 36 Epidermolysis bullosa; 47 Buerger disease;Thromboangiitis obliterans; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
86	Insulin signaling pathway 💬	[1] MTOR 💬 Insulin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 86. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
87	Intestinal immune network for IgA production 💬	[1] ITGA4 💬 Intestinal immune network for IgA production × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Intestinal immune network for IgA production × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 87. Intestinal immune network for IgA production × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
88	JAK-STAT signaling pathway 💬	[1] MTOR 💬 JAK-STAT signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 JAK-STAT signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 88. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
89	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MTOR 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 89. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
90	Legionellosis 💬	[1] TNF 💬 Legionellosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Legionellosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 90. Legionellosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
91	Leishmaniasis 💬	[1] ITGA4 💬 Leishmaniasis × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Leishmaniasis × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 91. Leishmaniasis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
92	Leishmaniasis 💬	[1] TNF 💬 Leishmaniasis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Leishmaniasis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 92. Leishmaniasis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
93	Leukocyte transendothelial migration 💬	[1] ITGA4 💬 Leukocyte transendothelial migration × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Leukocyte transendothelial migration × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 93. Leukocyte transendothelial migration × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
94	Lipid and atherosclerosis 💬	[1] PPARG 💬 Lipid and atherosclerosis × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Lipid and atherosclerosis × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 94. Lipid and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
95	Lipid and atherosclerosis 💬	[1] TNF 💬 Lipid and atherosclerosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Lipid and atherosclerosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 95. Lipid and atherosclerosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
96	Longevity regulating pathway 💬	[1] MTOR 💬 Longevity regulating pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 96. Longevity regulating pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
97	Longevity regulating pathway 💬	[1] PPARG 💬 Longevity regulating pathway × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Longevity regulating pathway × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 97. Longevity regulating pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
98	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬 Longevity regulating pathway - multiple species × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway - multiple species × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 98. Longevity regulating pathway - multiple species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
99	Malaria 💬	[1] TNF 💬 Malaria × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Malaria × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 99. Malaria × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
100	MAPK signaling pathway 💬	[1] IL1R1 💬 MAPK signaling pathway × Name Full Name IL1R1 interleukin 1 receptor type 1	Anakinra 💬 MAPK signaling pathway × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 100. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
101	MAPK signaling pathway 💬	[1] TNF 💬 MAPK signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 MAPK signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 101. MAPK signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
102	Metabolic pathways 💬	[1] HMGCR 💬 Metabolic pathways × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 Metabolic pathways × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 102. Metabolic pathways × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 34 Neurofibromatosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex; 160 Congenital ichthyosis; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis; 310 Congenital anomalies syndrome;
103	MicroRNAs in cancer 💬	[1] MTOR 💬 MicroRNAs in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 MicroRNAs in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 103. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
104	mTOR signaling pathway 💬	[1] MTOR 💬 mTOR signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 mTOR signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 104. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
105	mTOR signaling pathway 💬	[1] TNF 💬 mTOR signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 mTOR signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 105. mTOR signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
106	Natural killer cell mediated cytotoxicity 💬	[1] TNF 💬 Natural killer cell mediated cytotoxicity × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Natural killer cell mediated cytotoxicity × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 106. Natural killer cell mediated cytotoxicity × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
107	Necroptosis 💬	[1] TNF 💬 Necroptosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Necroptosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 107. Necroptosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
108	Neutrophil extracellular trap formation 💬	[1] MTOR 💬 Neutrophil extracellular trap formation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Neutrophil extracellular trap formation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 108. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
109	NF-kappa B signaling pathway 💬	[1] IL1R1 💬 NF-kappa B signaling pathway × Name Full Name IL1R1 interleukin 1 receptor type 1	Anakinra 💬 NF-kappa B signaling pathway × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 109. NF-kappa B signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
110	NF-kappa B signaling pathway 💬	[2] LTA, TNF 💬 NF-kappa B signaling pathway × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 NF-kappa B signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 110. NF-kappa B signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
111	NOD-like receptor signaling pathway 💬	[1] TNF 💬 NOD-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 NOD-like receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 111. NOD-like receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
112	Non-alcoholic fatty liver disease 💬	[1] PPARG 💬 Non-alcoholic fatty liver disease × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Non-alcoholic fatty liver disease × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 112. Non-alcoholic fatty liver disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
113	Non-alcoholic fatty liver disease 💬	[1] TNF 💬 Non-alcoholic fatty liver disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Non-alcoholic fatty liver disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 113. Non-alcoholic fatty liver disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
114	Osteoclast differentiation 💬	[1] IL1R1 💬 Osteoclast differentiation × Name Full Name IL1R1 interleukin 1 receptor type 1	Anakinra 💬 Osteoclast differentiation × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 114. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
115	Osteoclast differentiation 💬	[1] PPARG 💬 Osteoclast differentiation × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Osteoclast differentiation × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 115. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
116	Osteoclast differentiation 💬	[1] TNF 💬 Osteoclast differentiation × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Osteoclast differentiation × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 116. Osteoclast differentiation × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
117	Pancreatic cancer 💬	[1] MTOR 💬 Pancreatic cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pancreatic cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 117. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
118	Pathogenic Escherichia coli infection 💬	[1] IL1R1 💬 Pathogenic Escherichia coli infection × Name Full Name IL1R1 interleukin 1 receptor type 1	Anakinra 💬 Pathogenic Escherichia coli infection × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 118. Pathogenic Escherichia coli infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
119	Pathogenic Escherichia coli infection 💬	[1] TNF 💬 Pathogenic Escherichia coli infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Pathogenic Escherichia coli infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 119. Pathogenic Escherichia coli infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
120	Pathways in cancer 💬	[1] MTOR 💬 Pathways in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 120. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
121	Pathways in cancer 💬	[1] PPARG 💬 Pathways in cancer × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Pathways in cancer × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 121. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
122	Pathways of neurodegeneration - multiple diseases 💬	[1] MTOR 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 122. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
123	Pathways of neurodegeneration - multiple diseases 💬	[1] TNF 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 123. Pathways of neurodegeneration - multiple diseases × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
124	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MTOR 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 124. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
125	Pertussis 💬	[1] TNF 💬 Pertussis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Pertussis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 125. Pertussis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
126	Phospholipase D signaling pathway 💬	[1] MTOR 💬 Phospholipase D signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Phospholipase D signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 126. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
127	PI3K-Akt signaling pathway 💬	[1] ITGA4 💬 PI3K-Akt signaling pathway × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 PI3K-Akt signaling pathway × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 127. PI3K-Akt signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
128	PI3K-Akt signaling pathway 💬	[1] MTOR 💬 PI3K-Akt signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PI3K-Akt signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 128. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
129	PPAR signaling pathway 💬	[1] PPARG 💬 PPAR signaling pathway × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 PPAR signaling pathway × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 129. PPAR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
130	Prion disease 💬	[1] TNF 💬 Prion disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Prion disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 130. Prion disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
131	Prostate cancer 💬	[1] IL1R2 💬 Prostate cancer × Name Full Name IL1R2 interleukin 1 receptor type 2	Anakinra 💬 Prostate cancer × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 131. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
132	Prostate cancer 💬	[1] MTOR 💬 Prostate cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Prostate cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 132. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
133	Proteoglycans in cancer 💬	[1] MTOR 💬 Proteoglycans in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Proteoglycans in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 133. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
134	Proteoglycans in cancer 💬	[1] TNF 💬 Proteoglycans in cancer × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Proteoglycans in cancer × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 134. Proteoglycans in cancer × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
135	Regulation of actin cytoskeleton 💬	[1] ITGA4 💬 Regulation of actin cytoskeleton × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Regulation of actin cytoskeleton × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 135. Regulation of actin cytoskeleton × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
136	Rheumatoid arthritis 💬	[1] TNF 💬 Rheumatoid arthritis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Rheumatoid arthritis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 136. Rheumatoid arthritis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
137	RIG-I-like receptor signaling pathway 💬	[1] TNF 💬 RIG-I-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 RIG-I-like receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 137. RIG-I-like receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
138	Salmonella infection 💬	[1] TNF 💬 Salmonella infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Salmonella infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 138. Salmonella infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
139	Shigellosis 💬	[1] IL1R1 💬 Shigellosis × Name Full Name IL1R1 interleukin 1 receptor type 1	Anakinra 💬 Shigellosis × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 139. Shigellosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
140	Shigellosis 💬	[1] MTOR 💬 Shigellosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Shigellosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 140. Shigellosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
141	Shigellosis 💬	[1] TNF 💬 Shigellosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Shigellosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 141. Shigellosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
142	Signaling pathways regulating pluripotency of stem cells 💬	[2] ACVR2A, ACVR2B 💬 Signaling pathways regulating pluripotency of stem cells × Name Full Name ACVR2A activin A receptor type 2A ACVR2B activin A receptor type 2B	Bimagrumab 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Bimagrumab Bimagrumab (JAN/USAN/INN)	Bimagrumab	[1] 15 💬 142. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 15 Inclusion body myositis;
143	Sphingolipid signaling pathway 💬	[1] TNF 💬 Sphingolipid signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Sphingolipid signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 143. Sphingolipid signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
144	Spinocerebellar ataxia 💬	[1] MTOR 💬 Spinocerebellar ataxia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Spinocerebellar ataxia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 144. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
145	Synaptic vesicle cycle 💬	[1] SNAP25 💬 Synaptic vesicle cycle × Name Full Name SNAP25 synaptosome associated protein 25	Botulinum toxin type A 💬 Synaptic vesicle cycle × Name Other Names Botulinum toxin type A Botulinum toxin type A (JAN) Botox (TN) Dysport (TN) DAXXIFY	Botulinum toxin type A	[14]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬 145. Synaptic vesicle cycle × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 36 Epidermolysis bullosa; 47 Buerger disease;Thromboangiitis obliterans; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
146	Systemic lupus erythematosus 💬	[1] TNF 💬 Systemic lupus erythematosus × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Systemic lupus erythematosus × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 146. Systemic lupus erythematosus × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
147	T cell receptor signaling pathway 💬	[1] TNF 💬 T cell receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 T cell receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 147. T cell receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
148	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬 Terpenoid backbone biosynthesis × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 Terpenoid backbone biosynthesis × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 148. Terpenoid backbone biosynthesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 34 Neurofibromatosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex; 160 Congenital ichthyosis; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis; 310 Congenital anomalies syndrome;
149	TGF-beta signaling pathway 💬	[2] ACVR2A, ACVR2B 💬 TGF-beta signaling pathway × Name Full Name ACVR2A activin A receptor type 2A ACVR2B activin A receptor type 2B	Bimagrumab 💬 TGF-beta signaling pathway × Name Other Names Bimagrumab Bimagrumab (JAN/USAN/INN)	Bimagrumab	[1] 15 💬 149. TGF-beta signaling pathway × Disease ID Name 15 Inclusion body myositis;
150	TGF-beta signaling pathway 💬	[1] TNF 💬 TGF-beta signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 TGF-beta signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 150. TGF-beta signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
151	Th17 cell differentiation 💬	[1] IL1R1 💬 Th17 cell differentiation × Name Full Name IL1R1 interleukin 1 receptor type 1	Anakinra 💬 Th17 cell differentiation × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 151. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
152	Th17 cell differentiation 💬	[1] MTOR 💬 Th17 cell differentiation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Th17 cell differentiation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 152. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
153	Thermogenesis 💬	[1] MTOR 💬 Thermogenesis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thermogenesis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 153. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
154	Thermogenesis 💬	[1] PPARG 💬 Thermogenesis × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Thermogenesis × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 154. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
155	Thyroid cancer 💬	[1] PPARG 💬 Thyroid cancer × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Thyroid cancer × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 155. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
156	Thyroid hormone signaling pathway 💬	[1] MTOR 💬 Thyroid hormone signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thyroid hormone signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 156. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
157	TNF signaling pathway 💬	[2] LTA, TNF 💬 TNF signaling pathway × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 TNF signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 157. TNF signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
158	Toll-like receptor signaling pathway 💬	[1] TNF 💬 Toll-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Toll-like receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 158. Toll-like receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
159	Toxoplasmosis 💬	[1] TNF 💬 Toxoplasmosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Toxoplasmosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 159. Toxoplasmosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
160	Transcriptional misregulation in cancer 💬	[1] IL1R2 💬 Transcriptional misregulation in cancer × Name Full Name IL1R2 interleukin 1 receptor type 2	Anakinra 💬 Transcriptional misregulation in cancer × Name Other Names Anakinra Anakinra (USAN/INN) Kineret (TN)	Anakinra	[18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 160. Transcriptional misregulation in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 37 Generalised pustular psoriasis;Pustular psoriasis; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 106 Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome; 107 Juvenile idiopathic arthritis;JIA; 266 Familial mediterranean fever; 299 Cystic fibrosis;
161	Transcriptional misregulation in cancer 💬	[1] PPARG 💬 Transcriptional misregulation in cancer × Name Full Name PPARG peroxisome proliferator activated receptor gamma	Pioglitazone 💬 Transcriptional misregulation in cancer × Name Other Names Pioglitazone Pioglitazone (INN) Actos (TN)	Pioglitazone	[17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 161. Transcriptional misregulation in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 20 Adrenoleukodystrophy;ALD; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 96 Crohn disease;Terminal ileitis; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;
162	Tuberculosis 💬	[1] TNF 💬 Tuberculosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Tuberculosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 162. Tuberculosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
163	Type I diabetes mellitus 💬	[2] LTA, TNF 💬 Type I diabetes mellitus × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Type I diabetes mellitus × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 163. Type I diabetes mellitus × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
164	Type II diabetes mellitus 💬	[1] MTOR 💬 Type II diabetes mellitus × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Type II diabetes mellitus × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 164. Type II diabetes mellitus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
165	Type II diabetes mellitus 💬	[1] TNF 💬 Type II diabetes mellitus × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Type II diabetes mellitus × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 165. Type II diabetes mellitus × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
166	Viral protein interaction with cytokine and cytokine receptor 💬	[2] LTA, TNF 💬 Viral protein interaction with cytokine and cytokine receptor × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Viral protein interaction with cytokine and cytokine receptor × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 166. Viral protein interaction with cytokine and cytokine receptor × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
167	Yersinia infection 💬	[1] ITGA4 💬 Yersinia infection × Name Full Name ITGA4 integrin subunit alpha 4	Natalizumab 💬 Yersinia infection × Name Other Names Natalizumab Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 167. Yersinia infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 96 Crohn disease;Terminal ileitis;
168	Yersinia infection 💬	[1] TNF 💬 Yersinia infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Yersinia infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 168. Yersinia infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;

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