Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MTOR 💬 Acute myeloid leukemia × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Acute myeloid leukemia × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 1. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
2	Acute myeloid leukemia 💬	[1] MTOR 💬 Acute myeloid leukemia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Acute myeloid leukemia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 2. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
3	Adipocytokine signaling pathway 💬	[1] MTOR 💬 Adipocytokine signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Adipocytokine signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 3. Adipocytokine signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
4	Adipocytokine signaling pathway 💬	[1] MTOR 💬 Adipocytokine signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Adipocytokine signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 4. Adipocytokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
5	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 Adipocytokine signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Adipocytokine signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 5. Adipocytokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
6	Adrenergic signaling in cardiomyocytes 💬	[2] ADRB1, ADRB2 💬 Adrenergic signaling in cardiomyocytes × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2	Propranolol 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 6. Adrenergic signaling in cardiomyocytes × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
7	Alanine, aspartate and glutamate metabolism 💬	[1] ABAT 💬 Alanine, aspartate and glutamate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase	Vigabatrin 💬 Alanine, aspartate and glutamate metabolism × Name Other Names Vigabatrin Vigabatrin (JAN/USP/INN) Sabril (TN) VIGABATRIN FOR ORAL SOLUTION VIGABATRIN FOR ORAL SOLUTION USP, 500 MG VIGADRONE	Vigabatrin	[2] 145, 158 💬 7. Alanine, aspartate and glutamate metabolism × Disease ID Name 145 West syndrome;Infantile spasm; 158 Tuberous sclerosis;Tuberous sclerosis complex;
8	Alcoholic liver disease 💬	[2] PRKAA1, PRKAA2 💬 Alcoholic liver disease × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Alcoholic liver disease × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 8. Alcoholic liver disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
9	Alzheimer disease 💬	[1] MTOR 💬 Alzheimer disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Alzheimer disease × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 9. Alzheimer disease × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
10	Alzheimer disease 💬	[1] MTOR 💬 Alzheimer disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Alzheimer disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 10. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
11	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Alzheimer disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Alzheimer disease × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 11. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
12	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Alzheimer disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Alzheimer disease × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 11. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
13	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Alzheimer disease × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 13. Alzheimer disease × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
14	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amphetamine addiction × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Amphetamine addiction × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 14. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
15	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amphetamine addiction × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Amphetamine addiction × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 14. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
16	AMPK signaling pathway 💬	[1] HMGCR 💬 AMPK signaling pathway × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 AMPK signaling pathway × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 16. AMPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 34 Neurofibromatosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex; 160 Congenital ichthyosis; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis; 310 Congenital anomalies syndrome;
17	AMPK signaling pathway 💬	[1] MTOR 💬 AMPK signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 AMPK signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 17. AMPK signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
18	AMPK signaling pathway 💬	[1] MTOR 💬 AMPK signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 AMPK signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 18. AMPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
19	AMPK signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 AMPK signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 AMPK signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 19. AMPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
20	Amyotrophic lateral sclerosis 💬	[1] MTOR 💬 Amyotrophic lateral sclerosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 20. Amyotrophic lateral sclerosis × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
21	Amyotrophic lateral sclerosis 💬	[1] MTOR 💬 Amyotrophic lateral sclerosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 21. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
22	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amyotrophic lateral sclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 22. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
23	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amyotrophic lateral sclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 22. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
24	Apelin signaling pathway 💬	[1] MTOR 💬 Apelin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Apelin signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 24. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
25	Apelin signaling pathway 💬	[1] MTOR 💬 Apelin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Apelin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 25. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
26	Apelin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 Apelin signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Apelin signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 26. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
27	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Arachidonic acid metabolism × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 27. Arachidonic acid metabolism × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
28	Autophagy - animal 💬	[1] MTOR 💬 Autophagy - animal × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Autophagy - animal × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 28. Autophagy - animal × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
29	Autophagy - animal 💬	[1] MTOR 💬 Autophagy - animal × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - animal × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 29. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
30	Autophagy - animal 💬	[2] PRKAA1, PRKAA2 💬 Autophagy - animal × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Autophagy - animal × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 30. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
31	Autophagy - other 💬	[1] MTOR 💬 Autophagy - other × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Autophagy - other × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 31. Autophagy - other × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
32	Autophagy - other 💬	[1] MTOR 💬 Autophagy - other × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - other × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 32. Autophagy - other × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
33	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Axon guidance × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Axon guidance × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 33. Axon guidance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
34	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Axon guidance × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Axon guidance × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 33. Axon guidance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
35	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 B cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 B cell receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 35. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
36	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 B cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 B cell receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 35. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
37	beta-Alanine metabolism 💬	[1] ABAT 💬 beta-Alanine metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase	Vigabatrin 💬 beta-Alanine metabolism × Name Other Names Vigabatrin Vigabatrin (JAN/USP/INN) Sabril (TN) VIGABATRIN FOR ORAL SOLUTION VIGABATRIN FOR ORAL SOLUTION USP, 500 MG VIGADRONE	Vigabatrin	[2] 145, 158 💬 37. beta-Alanine metabolism × Disease ID Name 145 West syndrome;Infantile spasm; 158 Tuberous sclerosis;Tuberous sclerosis complex;
38	Bile secretion 💬	[1] HMGCR 💬 Bile secretion × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 Bile secretion × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 38. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 34 Neurofibromatosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex; 160 Congenital ichthyosis; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis; 310 Congenital anomalies syndrome;
39	Breast cancer 💬	[1] MTOR 💬 Breast cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Breast cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 39. Breast cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
40	Breast cancer 💬	[1] MTOR 💬 Breast cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Breast cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 40. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
41	Butanoate metabolism 💬	[1] ABAT 💬 Butanoate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase	Vigabatrin 💬 Butanoate metabolism × Name Other Names Vigabatrin Vigabatrin (JAN/USP/INN) Sabril (TN) VIGABATRIN FOR ORAL SOLUTION VIGABATRIN FOR ORAL SOLUTION USP, 500 MG VIGADRONE	Vigabatrin	[2] 145, 158 💬 41. Butanoate metabolism × Disease ID Name 145 West syndrome;Infantile spasm; 158 Tuberous sclerosis;Tuberous sclerosis complex;
42	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 C-type lectin receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 C-type lectin receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 42. C-type lectin receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
43	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 C-type lectin receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 C-type lectin receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 42. C-type lectin receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
44	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 C-type lectin receptor signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 44. C-type lectin receptor signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
45	Calcium signaling pathway 💬	[3] ADRB1, ADRB2, ADRB3 💬 Calcium signaling pathway × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2 ADRB3 adrenoceptor beta 3	Propranolol 💬 Calcium signaling pathway × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 45. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
46	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Calcium signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Calcium signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 46. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
47	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Calcium signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Calcium signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 46. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
48	cAMP signaling pathway 💬	[2] ADRB1, ADRB2 💬 cAMP signaling pathway × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2	Propranolol 💬 cAMP signaling pathway × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 48. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
49	Cellular senescence 💬	[1] MTOR 💬 Cellular senescence × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Cellular senescence × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 49. Cellular senescence × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
50	Cellular senescence 💬	[1] MTOR 💬 Cellular senescence × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Cellular senescence × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 50. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
51	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cellular senescence × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Cellular senescence × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 51. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
52	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cellular senescence × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Cellular senescence × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 51. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
53	Central carbon metabolism in cancer 💬	[1] MTOR 💬 Central carbon metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Central carbon metabolism in cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 53. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
54	Central carbon metabolism in cancer 💬	[1] MTOR 💬 Central carbon metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Central carbon metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 54. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
55	cGMP-PKG signaling pathway 💬	[3] ADRB1, ADRB2, ADRB3 💬 cGMP-PKG signaling pathway × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2 ADRB3 adrenoceptor beta 3	Propranolol 💬 cGMP-PKG signaling pathway × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 55. cGMP-PKG signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
56	cGMP-PKG signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 cGMP-PKG signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 cGMP-PKG signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 56. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
57	cGMP-PKG signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 cGMP-PKG signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 cGMP-PKG signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 56. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
58	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 58. Chemical carcinogenesis - DNA adducts × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
59	Chemical carcinogenesis - receptor activation 💬	[3] ADRB1, ADRB2, ADRB3 💬 Chemical carcinogenesis - receptor activation × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2 ADRB3 adrenoceptor beta 3	Propranolol 💬 Chemical carcinogenesis - receptor activation × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 59. Chemical carcinogenesis - receptor activation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
60	Chemical carcinogenesis - receptor activation 💬	[1] MTOR 💬 Chemical carcinogenesis - receptor activation × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Chemical carcinogenesis - receptor activation × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 60. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
61	Chemical carcinogenesis - receptor activation 💬	[1] MTOR 💬 Chemical carcinogenesis - receptor activation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Chemical carcinogenesis - receptor activation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 61. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
62	Chemical carcinogenesis - receptor activation 💬	[1] VDR 💬 Chemical carcinogenesis - receptor activation × Name Full Name VDR vitamin D receptor	Calcitriol 💬 Chemical carcinogenesis - receptor activation × Name Other Names Calcitriol Calcitriol (JAN/USP/INN) Rocaltrol (TN) VECTICAL	Calcitriol	[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 62. Chemical carcinogenesis - receptor activation × Disease ID Name 18 Spinocerebellar degeneration;SCD; 37 Generalised pustular psoriasis;Pustular psoriasis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 96 Crohn disease;Terminal ileitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 235 Hypoparathyroidism;Accessory thyroid hypergasia disease; 326 Osteopetrosis;
63	Choline metabolism in cancer 💬	[1] MTOR 💬 Choline metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Choline metabolism in cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 63. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
64	Choline metabolism in cancer 💬	[1] MTOR 💬 Choline metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Choline metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 64. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
65	Circadian rhythm 💬	[2] PRKAA1, PRKAA2 💬 Circadian rhythm × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Circadian rhythm × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 65. Circadian rhythm × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
66	Colorectal cancer 💬	[1] MTOR 💬 Colorectal cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Colorectal cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 66. Colorectal cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
67	Colorectal cancer 💬	[1] MTOR 💬 Colorectal cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Colorectal cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 67. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
68	Diabetic cardiomyopathy 💬	[1] MTOR 💬 Diabetic cardiomyopathy × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Diabetic cardiomyopathy × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 68. Diabetic cardiomyopathy × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
69	Diabetic cardiomyopathy 💬	[1] MTOR 💬 Diabetic cardiomyopathy × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Diabetic cardiomyopathy × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 69. Diabetic cardiomyopathy × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
70	Dilated cardiomyopathy 💬	[1] ADRB1 💬 Dilated cardiomyopathy × Name Full Name ADRB1 adrenoceptor beta 1	Propranolol 💬 Dilated cardiomyopathy × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 70. Dilated cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
71	Dopaminergic synapse 💬	[3] PPP3CA, PPP3CB, PPP3CC 💬 Dopaminergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma	Tacrolimus 💬 Dopaminergic synapse × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 71. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
72	Dopaminergic synapse 💬	[3] PPP3CA, PPP3CB, PPP3CC 💬 Dopaminergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma	Tacrolimus 💬 Dopaminergic synapse × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 71. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
73	EGFR tyrosine kinase inhibitor resistance 💬	[1] MTOR 💬 EGFR tyrosine kinase inhibitor resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 73. EGFR tyrosine kinase inhibitor resistance × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
74	EGFR tyrosine kinase inhibitor resistance 💬	[1] MTOR 💬 EGFR tyrosine kinase inhibitor resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 74. EGFR tyrosine kinase inhibitor resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
75	Endocrine and other factor-regulated calcium reabsorption 💬	[1] VDR 💬 Endocrine and other factor-regulated calcium reabsorption × Name Full Name VDR vitamin D receptor	Calcitriol 💬 Endocrine and other factor-regulated calcium reabsorption × Name Other Names Calcitriol Calcitriol (JAN/USP/INN) Rocaltrol (TN) VECTICAL	Calcitriol	[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 75. Endocrine and other factor-regulated calcium reabsorption × Disease ID Name 18 Spinocerebellar degeneration;SCD; 37 Generalised pustular psoriasis;Pustular psoriasis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 96 Crohn disease;Terminal ileitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 235 Hypoparathyroidism;Accessory thyroid hypergasia disease; 326 Osteopetrosis;
76	Endocrine resistance 💬	[1] MTOR 💬 Endocrine resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Endocrine resistance × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 76. Endocrine resistance × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
77	Endocrine resistance 💬	[1] MTOR 💬 Endocrine resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Endocrine resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 77. Endocrine resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
78	ErbB signaling pathway 💬	[1] MTOR 💬 ErbB signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 ErbB signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 78. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
79	ErbB signaling pathway 💬	[1] MTOR 💬 ErbB signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 ErbB signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 79. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
80	Fluid shear stress and atherosclerosis 💬	[2] PRKAA1, PRKAA2 💬 Fluid shear stress and atherosclerosis × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Fluid shear stress and atherosclerosis × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 80. Fluid shear stress and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
81	FoxO signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 FoxO signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 FoxO signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 81. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
82	GABAergic synapse 💬	[1] ABAT 💬 GABAergic synapse × Name Full Name ABAT 4-aminobutyrate aminotransferase	Vigabatrin 💬 GABAergic synapse × Name Other Names Vigabatrin Vigabatrin (JAN/USP/INN) Sabril (TN) VIGABATRIN FOR ORAL SOLUTION VIGABATRIN FOR ORAL SOLUTION USP, 500 MG VIGADRONE	Vigabatrin	[2] 145, 158 💬 82. GABAergic synapse × Disease ID Name 145 West syndrome;Infantile spasm; 158 Tuberous sclerosis;Tuberous sclerosis complex;
83	GABAergic synapse 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Ganaxolone 💬 GABAergic synapse × Name Other Names Ganaxolone Ganaxolone (USAN/INN) Ztalmy (TN)	Ganaxolone	[4] 145, 152, 158, 206 💬 83. GABAergic synapse × Disease ID Name 145 West syndrome;Infantile spasm; 152 PCDH19 related syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19-related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome;
84	Gap junction 💬	[1] ADRB1 💬 Gap junction × Name Full Name ADRB1 adrenoceptor beta 1	Propranolol 💬 Gap junction × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 84. Gap junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
85	Gastric cancer 💬	[1] MTOR 💬 Gastric cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Gastric cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 85. Gastric cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
86	Gastric cancer 💬	[1] MTOR 💬 Gastric cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Gastric cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 86. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
87	Glioma 💬	[1] MTOR 💬 Glioma × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Glioma × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 87. Glioma × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
88	Glioma 💬	[1] MTOR 💬 Glioma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Glioma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 88. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
89	Glucagon signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glucagon signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Glucagon signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 89. Glucagon signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
90	Glucagon signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glucagon signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Glucagon signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 89. Glucagon signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
91	Glucagon signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 Glucagon signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Glucagon signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 91. Glucagon signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
92	Glutamatergic synapse 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glutamatergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Glutamatergic synapse × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 92. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
93	Glutamatergic synapse 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glutamatergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Glutamatergic synapse × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 92. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
94	Growth hormone synthesis, secretion and action 💬	[1] MTOR 💬 Growth hormone synthesis, secretion and action × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Growth hormone synthesis, secretion and action × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 94. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
95	Growth hormone synthesis, secretion and action 💬	[1] MTOR 💬 Growth hormone synthesis, secretion and action × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Growth hormone synthesis, secretion and action × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 95. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
96	Hepatocellular carcinoma 💬	[1] MTOR 💬 Hepatocellular carcinoma × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Hepatocellular carcinoma × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 96. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
97	Hepatocellular carcinoma 💬	[1] MTOR 💬 Hepatocellular carcinoma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Hepatocellular carcinoma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 97. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
98	Herpes simplex virus 1 infection 💬	[1] MTOR 💬 Herpes simplex virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Herpes simplex virus 1 infection × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 98. Herpes simplex virus 1 infection × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
99	Herpes simplex virus 1 infection 💬	[1] MTOR 💬 Herpes simplex virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Herpes simplex virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 99. Herpes simplex virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
100	HIF-1 signaling pathway 💬	[1] MTOR 💬 HIF-1 signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 HIF-1 signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 100. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
101	HIF-1 signaling pathway 💬	[1] MTOR 💬 HIF-1 signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 HIF-1 signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 101. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
102	Human cytomegalovirus infection 💬	[1] MTOR 💬 Human cytomegalovirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Human cytomegalovirus infection × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 102. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
103	Human cytomegalovirus infection 💬	[1] MTOR 💬 Human cytomegalovirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human cytomegalovirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 103. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
104	Human cytomegalovirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human cytomegalovirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human cytomegalovirus infection × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 104. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
105	Human cytomegalovirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human cytomegalovirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human cytomegalovirus infection × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 104. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
106	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Human cytomegalovirus infection × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 106. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
107	Human immunodeficiency virus 1 infection 💬	[1] MTOR 💬 Human immunodeficiency virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 107. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
108	Human immunodeficiency virus 1 infection 💬	[1] MTOR 💬 Human immunodeficiency virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 108. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
109	Human immunodeficiency virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human immunodeficiency virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 109. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
110	Human immunodeficiency virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human immunodeficiency virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 109. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
111	Human papillomavirus infection 💬	[1] MTOR 💬 Human papillomavirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Human papillomavirus infection × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 111. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
112	Human papillomavirus infection 💬	[1] MTOR 💬 Human papillomavirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human papillomavirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 112. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
113	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Human papillomavirus infection × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 113. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
114	Human T-cell leukemia virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human T-cell leukemia virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human T-cell leukemia virus 1 infection × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 114. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
115	Human T-cell leukemia virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human T-cell leukemia virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human T-cell leukemia virus 1 infection × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 114. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
116	Huntington disease 💬	[1] MTOR 💬 Huntington disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Huntington disease × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 116. Huntington disease × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
117	Huntington disease 💬	[1] MTOR 💬 Huntington disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Huntington disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 117. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
118	Hypertrophic cardiomyopathy 💬	[2] PRKAA1, PRKAA2 💬 Hypertrophic cardiomyopathy × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Hypertrophic cardiomyopathy × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 118. Hypertrophic cardiomyopathy × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
119	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 IL-17 signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 119. IL-17 signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
120	Insulin resistance 💬	[1] MTOR 💬 Insulin resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Insulin resistance × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 120. Insulin resistance × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
121	Insulin resistance 💬	[1] MTOR 💬 Insulin resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 121. Insulin resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
122	Insulin resistance 💬	[2] PRKAA1, PRKAA2 💬 Insulin resistance × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Insulin resistance × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 122. Insulin resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
123	Insulin signaling pathway 💬	[1] MTOR 💬 Insulin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Insulin signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 123. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
124	Insulin signaling pathway 💬	[1] MTOR 💬 Insulin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 124. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
125	Insulin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 Insulin signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Insulin signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 125. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
126	JAK-STAT signaling pathway 💬	[1] MTOR 💬 JAK-STAT signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 JAK-STAT signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 126. JAK-STAT signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
127	JAK-STAT signaling pathway 💬	[1] MTOR 💬 JAK-STAT signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 JAK-STAT signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 127. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
128	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MTOR 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 128. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
129	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MTOR 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 129. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
130	Kaposi sarcoma-associated herpesvirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 130. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
131	Kaposi sarcoma-associated herpesvirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 130. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
132	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 132. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
133	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Leishmaniasis × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 133. Leishmaniasis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
134	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Lipid and atherosclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Lipid and atherosclerosis × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 134. Lipid and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
135	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Lipid and atherosclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Lipid and atherosclerosis × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 134. Lipid and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
136	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Long-term potentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Long-term potentiation × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 136. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
137	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Long-term potentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Long-term potentiation × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 136. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
138	Longevity regulating pathway 💬	[1] MTOR 💬 Longevity regulating pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Longevity regulating pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 138. Longevity regulating pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
139	Longevity regulating pathway 💬	[1] MTOR 💬 Longevity regulating pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 139. Longevity regulating pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
140	Longevity regulating pathway 💬	[2] PRKAA1, PRKAA2 💬 Longevity regulating pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Longevity regulating pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 140. Longevity regulating pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
141	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬 Longevity regulating pathway - multiple species × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Longevity regulating pathway - multiple species × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 141. Longevity regulating pathway - multiple species × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
142	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬 Longevity regulating pathway - multiple species × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway - multiple species × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 142. Longevity regulating pathway - multiple species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
143	Longevity regulating pathway - multiple species 💬	[2] PRKAA1, PRKAA2 💬 Longevity regulating pathway - multiple species × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Longevity regulating pathway - multiple species × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 143. Longevity regulating pathway - multiple species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
144	MAPK signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 MAPK signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 MAPK signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 144. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
145	MAPK signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 MAPK signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 MAPK signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 144. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
146	Metabolic pathways 💬	[1] ABAT 💬 Metabolic pathways × Name Full Name ABAT 4-aminobutyrate aminotransferase	Vigabatrin 💬 Metabolic pathways × Name Other Names Vigabatrin Vigabatrin (JAN/USP/INN) Sabril (TN) VIGABATRIN FOR ORAL SOLUTION VIGABATRIN FOR ORAL SOLUTION USP, 500 MG VIGADRONE	Vigabatrin	[2] 145, 158 💬 146. Metabolic pathways × Disease ID Name 145 West syndrome;Infantile spasm; 158 Tuberous sclerosis;Tuberous sclerosis complex;
147	Metabolic pathways 💬	[1] HMGCR 💬 Metabolic pathways × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 Metabolic pathways × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 147. Metabolic pathways × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 34 Neurofibromatosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex; 160 Congenital ichthyosis; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis; 310 Congenital anomalies syndrome;
148	Metabolic pathways 💬	[2] PTGS1, PTGS2 💬 Metabolic pathways × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Metabolic pathways × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 148. Metabolic pathways × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
149	MicroRNAs in cancer 💬	[1] MTOR 💬 MicroRNAs in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 MicroRNAs in cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 149. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
150	MicroRNAs in cancer 💬	[1] MTOR 💬 MicroRNAs in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 MicroRNAs in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 150. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
151	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 MicroRNAs in cancer × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 151. MicroRNAs in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
152	Mineral absorption 💬	[1] VDR 💬 Mineral absorption × Name Full Name VDR vitamin D receptor	Calcitriol 💬 Mineral absorption × Name Other Names Calcitriol Calcitriol (JAN/USP/INN) Rocaltrol (TN) VECTICAL	Calcitriol	[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 152. Mineral absorption × Disease ID Name 18 Spinocerebellar degeneration;SCD; 37 Generalised pustular psoriasis;Pustular psoriasis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 96 Crohn disease;Terminal ileitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 235 Hypoparathyroidism;Accessory thyroid hypergasia disease; 326 Osteopetrosis;
153	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Ganaxolone 💬 Morphine addiction × Name Other Names Ganaxolone Ganaxolone (USAN/INN) Ztalmy (TN)	Ganaxolone	[4] 145, 152, 158, 206 💬 153. Morphine addiction × Disease ID Name 145 West syndrome;Infantile spasm; 152 PCDH19 related syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19-related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome;
154	mTOR signaling pathway 💬	[1] MTOR 💬 mTOR signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 mTOR signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 154. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
155	mTOR signaling pathway 💬	[1] MTOR 💬 mTOR signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 mTOR signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 155. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
156	mTOR signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 mTOR signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 mTOR signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 156. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
157	Natural killer cell mediated cytotoxicity 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Natural killer cell mediated cytotoxicity × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Natural killer cell mediated cytotoxicity × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 157. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
158	Natural killer cell mediated cytotoxicity 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Natural killer cell mediated cytotoxicity × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Natural killer cell mediated cytotoxicity × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 157. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
159	Neuroactive ligand-receptor interaction 💬	[3] ADRB1, ADRB2, ADRB3 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2 ADRB3 adrenoceptor beta 3	Propranolol 💬 Neuroactive ligand-receptor interaction × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 159. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
160	Neuroactive ligand-receptor interaction 💬	[2] CNR1, CNR2 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1 CNR2 cannabinoid receptor 2	Cannabidiol 💬 Neuroactive ligand-receptor interaction × Name Other Names Cannabidiol Cannabidiol (USAN/INN) Epidiolex (TN)	Cannabidiol	[20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 160. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
161	Neuroactive ligand-receptor interaction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Ganaxolone 💬 Neuroactive ligand-receptor interaction × Name Other Names Ganaxolone Ganaxolone (USAN/INN) Ztalmy (TN)	Ganaxolone	[4] 145, 152, 158, 206 💬 161. Neuroactive ligand-receptor interaction × Disease ID Name 145 West syndrome;Infantile spasm; 152 PCDH19 related syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19-related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome;
162	Neutrophil extracellular trap formation 💬	[1] MTOR 💬 Neutrophil extracellular trap formation × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Neutrophil extracellular trap formation × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 162. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
163	Neutrophil extracellular trap formation 💬	[1] MTOR 💬 Neutrophil extracellular trap formation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Neutrophil extracellular trap formation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 163. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
164	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 NF-kappa B signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 164. NF-kappa B signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
165	Nicotine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Nicotine addiction × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Ganaxolone 💬 Nicotine addiction × Name Other Names Ganaxolone Ganaxolone (USAN/INN) Ztalmy (TN)	Ganaxolone	[4] 145, 152, 158, 206 💬 165. Nicotine addiction × Disease ID Name 145 West syndrome;Infantile spasm; 152 PCDH19 related syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19-related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome;
166	Non-alcoholic fatty liver disease 💬	[2] PRKAA1, PRKAA2 💬 Non-alcoholic fatty liver disease × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Non-alcoholic fatty liver disease × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 166. Non-alcoholic fatty liver disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
167	Oocyte meiosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oocyte meiosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Oocyte meiosis × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 167. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
168	Oocyte meiosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oocyte meiosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Oocyte meiosis × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 167. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
169	Osteoclast differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Osteoclast differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Osteoclast differentiation × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 169. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
170	Osteoclast differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Osteoclast differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Osteoclast differentiation × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 169. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
171	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Ovarian steroidogenesis × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 171. Ovarian steroidogenesis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
172	Oxytocin signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oxytocin signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Oxytocin signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 172. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
173	Oxytocin signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oxytocin signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Oxytocin signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 172. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
174	Oxytocin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 Oxytocin signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Oxytocin signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 174. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
175	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Oxytocin signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 175. Oxytocin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
176	Pancreatic cancer 💬	[1] MTOR 💬 Pancreatic cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Pancreatic cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 176. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
177	Pancreatic cancer 💬	[1] MTOR 💬 Pancreatic cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pancreatic cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 177. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
178	Pancreatic secretion 💬	[1] SLC12A2 💬 Pancreatic secretion × Name Full Name SLC12A2 solute carrier family 12 member 2	Bumetanide 💬 Pancreatic secretion × Name Other Names Bumetanide Bumetanide (JP18/USP/INN) Bumex (TN)	Bumetanide	[2]  6 , 158 💬 178. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex;
179	Parathyroid hormone synthesis, secretion and action 💬	[1] VDR 💬 Parathyroid hormone synthesis, secretion and action × Name Full Name VDR vitamin D receptor	Calcitriol 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Calcitriol Calcitriol (JAN/USP/INN) Rocaltrol (TN) VECTICAL	Calcitriol	[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 179. Parathyroid hormone synthesis, secretion and action × Disease ID Name 18 Spinocerebellar degeneration;SCD; 37 Generalised pustular psoriasis;Pustular psoriasis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 96 Crohn disease;Terminal ileitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 235 Hypoparathyroidism;Accessory thyroid hypergasia disease; 326 Osteopetrosis;
180	Pathways in cancer 💬	[1] MTOR 💬 Pathways in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Pathways in cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 180. Pathways in cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
181	Pathways in cancer 💬	[1] MTOR 💬 Pathways in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 181. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
182	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Pathways in cancer × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 182. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
183	Pathways of neurodegeneration - multiple diseases 💬	[1] MTOR 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 183. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
184	Pathways of neurodegeneration - multiple diseases 💬	[1] MTOR 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 184. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
185	Pathways of neurodegeneration - multiple diseases 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 185. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
186	Pathways of neurodegeneration - multiple diseases 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 185. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
187	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 187. Pathways of neurodegeneration - multiple diseases × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
188	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MTOR 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 188. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
189	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MTOR 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 189. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
190	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 190. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
191	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 190. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
192	Phospholipase D signaling pathway 💬	[1] MTOR 💬 Phospholipase D signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Phospholipase D signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 192. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
193	Phospholipase D signaling pathway 💬	[1] MTOR 💬 Phospholipase D signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Phospholipase D signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 193. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
194	PI3K-Akt signaling pathway 💬	[1] MTOR 💬 PI3K-Akt signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 PI3K-Akt signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 194. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
195	PI3K-Akt signaling pathway 💬	[1] MTOR 💬 PI3K-Akt signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PI3K-Akt signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 195. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
196	PI3K-Akt signaling pathway 💬	[2] PRKAA1, PRKAA2 💬 PI3K-Akt signaling pathway × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 PI3K-Akt signaling pathway × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 196. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
197	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1	Aspirin 💬 Platelet activation × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 197. Platelet activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
198	Prion disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Prion disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Prion disease × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 198. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
199	Prion disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Prion disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Prion disease × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 198. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
200	Propanoate metabolism 💬	[1] ABAT 💬 Propanoate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase	Vigabatrin 💬 Propanoate metabolism × Name Other Names Vigabatrin Vigabatrin (JAN/USP/INN) Sabril (TN) VIGABATRIN FOR ORAL SOLUTION VIGABATRIN FOR ORAL SOLUTION USP, 500 MG VIGADRONE	Vigabatrin	[2] 145, 158 💬 200. Propanoate metabolism × Disease ID Name 145 West syndrome;Infantile spasm; 158 Tuberous sclerosis;Tuberous sclerosis complex;
201	Prostate cancer 💬	[1] MTOR 💬 Prostate cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Prostate cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 201. Prostate cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
202	Prostate cancer 💬	[1] MTOR 💬 Prostate cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Prostate cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 202. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
203	Proteoglycans in cancer 💬	[1] MTOR 💬 Proteoglycans in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Proteoglycans in cancer × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 203. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
204	Proteoglycans in cancer 💬	[1] MTOR 💬 Proteoglycans in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Proteoglycans in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 204. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
205	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Rap1 signaling pathway × Name Other Names Cannabidiol Cannabidiol (USAN/INN) Epidiolex (TN)	Cannabidiol	[20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 205. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
206	Regulation of lipolysis in adipocytes 💬	[3] ADRB1, ADRB2, ADRB3 💬 Regulation of lipolysis in adipocytes × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2 ADRB3 adrenoceptor beta 3	Propranolol 💬 Regulation of lipolysis in adipocytes × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 206. Regulation of lipolysis in adipocytes × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
207	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Regulation of lipolysis in adipocytes × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 207. Regulation of lipolysis in adipocytes × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
208	Renin secretion 💬	[3] ADRB1, ADRB2, ADRB3 💬 Renin secretion × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2 ADRB3 adrenoceptor beta 3	Propranolol 💬 Renin secretion × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 208. Renin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
209	Renin secretion 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Renin secretion × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Renin secretion × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 209. Renin secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
210	Renin secretion 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Renin secretion × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Renin secretion × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 209. Renin secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
211	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Retrograde endocannabinoid signaling × Name Other Names Cannabidiol Cannabidiol (USAN/INN) Epidiolex (TN)	Cannabidiol	[20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 211. Retrograde endocannabinoid signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
212	Retrograde endocannabinoid signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Retrograde endocannabinoid signaling × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Ganaxolone 💬 Retrograde endocannabinoid signaling × Name Other Names Ganaxolone Ganaxolone (USAN/INN) Ztalmy (TN)	Ganaxolone	[4] 145, 152, 158, 206 💬 212. Retrograde endocannabinoid signaling × Disease ID Name 145 West syndrome;Infantile spasm; 152 PCDH19 related syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19-related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome;
213	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Retrograde endocannabinoid signaling × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 213. Retrograde endocannabinoid signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
214	Salivary secretion 💬	[3] ADRB1, ADRB2, ADRB3 💬 Salivary secretion × Name Full Name ADRB1 adrenoceptor beta 1 ADRB2 adrenoceptor beta 2 ADRB3 adrenoceptor beta 3	Propranolol 💬 Salivary secretion × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 214. Salivary secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
215	Salivary secretion 💬	[1] SLC12A2 💬 Salivary secretion × Name Full Name SLC12A2 solute carrier family 12 member 2	Bumetanide 💬 Salivary secretion × Name Other Names Bumetanide Bumetanide (JP18/USP/INN) Bumex (TN)	Bumetanide	[2]  6 , 158 💬 215. Salivary secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex;
216	Serotonergic synapse 💬	[3] GABRB1, GABRB2, GABRB3 💬 Serotonergic synapse × Name Full Name GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3	Ganaxolone 💬 Serotonergic synapse × Name Other Names Ganaxolone Ganaxolone (USAN/INN) Ztalmy (TN)	Ganaxolone	[4] 145, 152, 158, 206 💬 216. Serotonergic synapse × Disease ID Name 145 West syndrome;Infantile spasm; 152 PCDH19 related syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19-related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome;
217	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Serotonergic synapse × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 217. Serotonergic synapse × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
218	Shigellosis 💬	[1] MTOR 💬 Shigellosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Shigellosis × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 218. Shigellosis × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
219	Shigellosis 💬	[1] MTOR 💬 Shigellosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Shigellosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 219. Shigellosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
220	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Small cell lung cancer × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 220. Small cell lung cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
221	Spinocerebellar ataxia 💬	[1] MTOR 💬 Spinocerebellar ataxia × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Spinocerebellar ataxia × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 221. Spinocerebellar ataxia × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
222	Spinocerebellar ataxia 💬	[1] MTOR 💬 Spinocerebellar ataxia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Spinocerebellar ataxia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 222. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
223	T cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 T cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 T cell receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 223. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
224	T cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 T cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 T cell receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 223. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
225	Taste transduction 💬	[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 Taste transduction × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6	Ganaxolone 💬 Taste transduction × Name Other Names Ganaxolone Ganaxolone (USAN/INN) Ztalmy (TN)	Ganaxolone	[4] 145, 152, 158, 206 💬 225. Taste transduction × Disease ID Name 145 West syndrome;Infantile spasm; 152 PCDH19 related syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19-related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome;
226	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬 Terpenoid backbone biosynthesis × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 Terpenoid backbone biosynthesis × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 226. Terpenoid backbone biosynthesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 34 Neurofibromatosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex; 160 Congenital ichthyosis; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis; 310 Congenital anomalies syndrome;
227	Th1 and Th2 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th1 and Th2 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Th1 and Th2 cell differentiation × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 227. Th1 and Th2 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
228	Th1 and Th2 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th1 and Th2 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Th1 and Th2 cell differentiation × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 227. Th1 and Th2 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
229	Th17 cell differentiation 💬	[1] MTOR 💬 Th17 cell differentiation × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Th17 cell differentiation × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 229. Th17 cell differentiation × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
230	Th17 cell differentiation 💬	[1] MTOR 💬 Th17 cell differentiation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Th17 cell differentiation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 230. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
231	Th17 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th17 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Th17 cell differentiation × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 231. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
232	Th17 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th17 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Th17 cell differentiation × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 231. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
233	Thermogenesis 💬	[1] ADRB3 💬 Thermogenesis × Name Full Name ADRB3 adrenoceptor beta 3	Propranolol 💬 Thermogenesis × Name Other Names Propranolol Propranolol (INN) Propranolol (TN)	Propranolol	[6]  6 , 158, 167, 227, 278, 296 💬 233. Thermogenesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex; 167 Marfan syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 296 Biliary atresia;
234	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Thermogenesis × Name Other Names Cannabidiol Cannabidiol (USAN/INN) Epidiolex (TN)	Cannabidiol	[20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 234. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
235	Thermogenesis 💬	[1] MTOR 💬 Thermogenesis × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Thermogenesis × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 235. Thermogenesis × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
236	Thermogenesis 💬	[1] MTOR 💬 Thermogenesis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thermogenesis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 236. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
237	Thermogenesis 💬	[2] PRKAA1, PRKAA2 💬 Thermogenesis × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Thermogenesis × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 237. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
238	Thyroid hormone signaling pathway 💬	[1] MTOR 💬 Thyroid hormone signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Thyroid hormone signaling pathway × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 238. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
239	Thyroid hormone signaling pathway 💬	[1] MTOR 💬 Thyroid hormone signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thyroid hormone signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 239. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
240	Tight junction 💬	[2] PRKAA1, PRKAA2 💬 Tight junction × Name Full Name PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2	Metformin 💬 Tight junction × Name Other Names Metformin Metformin (USAN/INN)	Metformin	[25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 240. Tight junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 60 Aplastic anemia; 65 Primary immunodeficiency; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 127 Frontotemporal lobar degeneration; 158 Tuberous sclerosis;Tuberous sclerosis complex; 206 Fragile X syndrome; 218 Alport syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy; 285 Fanconi anemia; 299 Cystic fibrosis; 301 Macular dystrophy;
241	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 TNF signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 241. TNF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
242	Tuberculosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tuberculosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Tuberculosis × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 242. Tuberculosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
243	Tuberculosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tuberculosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Tuberculosis × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 242. Tuberculosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
244	Tuberculosis 💬	[1] VDR 💬 Tuberculosis × Name Full Name VDR vitamin D receptor	Calcitriol 💬 Tuberculosis × Name Other Names Calcitriol Calcitriol (JAN/USP/INN) Rocaltrol (TN) VECTICAL	Calcitriol	[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 244. Tuberculosis × Disease ID Name 18 Spinocerebellar degeneration;SCD; 37 Generalised pustular psoriasis;Pustular psoriasis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 96 Crohn disease;Terminal ileitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 235 Hypoparathyroidism;Accessory thyroid hypergasia disease; 326 Osteopetrosis;
245	Type II diabetes mellitus 💬	[1] MTOR 💬 Type II diabetes mellitus × Name Full Name MTOR mechanistic target of rapamycin kinase	Everolimus 💬 Type II diabetes mellitus × Name Other Names Everolimus Everolimus (JAN/USAN/INN) Afinitor (TN) Votubia (TN) Zortress (TN)	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 245. Type II diabetes mellitus × Disease ID Name 34 Neurofibromatosis; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
246	Type II diabetes mellitus 💬	[1] MTOR 💬 Type II diabetes mellitus × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Type II diabetes mellitus × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 246. Type II diabetes mellitus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
247	Valine, leucine and isoleucine degradation 💬	[1] ABAT 💬 Valine, leucine and isoleucine degradation × Name Full Name ABAT 4-aminobutyrate aminotransferase	Vigabatrin 💬 Valine, leucine and isoleucine degradation × Name Other Names Vigabatrin Vigabatrin (JAN/USP/INN) Sabril (TN) VIGABATRIN FOR ORAL SOLUTION VIGABATRIN FOR ORAL SOLUTION USP, 500 MG VIGADRONE	Vigabatrin	[2] 145, 158 💬 247. Valine, leucine and isoleucine degradation × Disease ID Name 145 West syndrome;Infantile spasm; 158 Tuberous sclerosis;Tuberous sclerosis complex;
248	VEGF signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 VEGF signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 VEGF signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 248. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
249	VEGF signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 VEGF signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 VEGF signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 248. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
250	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 VEGF signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 250. VEGF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
251	Vibrio cholerae infection 💬	[1] SLC12A2 💬 Vibrio cholerae infection × Name Full Name SLC12A2 solute carrier family 12 member 2	Bumetanide 💬 Vibrio cholerae infection × Name Other Names Bumetanide Bumetanide (JP18/USP/INN) Bumex (TN)	Bumetanide	[2]  6 , 158 💬 251. Vibrio cholerae infection × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 158 Tuberous sclerosis;Tuberous sclerosis complex;
252	Wnt signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Wnt signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Wnt signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 252. Wnt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
253	Wnt signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Wnt signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Wnt signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 252. Wnt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;

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