Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	ABC transporters 💬	[1] ABCC8 💬 ABC transporters × Name Full Name ABCC8 ATP-binding cassette sub-family C member 8 isoform 2	Diazoxide 💬 ABC transporters × Name Other Names Diazoxide Hyperstat Proglycem	Diazoxide	[2] 13, 193 💬 1. ABC transporters × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 193 Prader-Willi syndrome;
2	ABC transporters 💬	[1] ABCC8 💬 ABC transporters × Name Full Name ABCC8 ATP-binding cassette sub-family C member 8 isoform 2	Diazoxide choline 💬 ABC transporters × Name Other Names Diazoxide choline Vykat xr	Diazoxide	[2] 13, 193 💬 1. ABC transporters × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 193 Prader-Willi syndrome;
3	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB1 💬 Adrenergic signaling in cardiomyocytes × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 3. Adrenergic signaling in cardiomyocytes × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
4	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB1 💬 Adrenergic signaling in cardiomyocytes × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 3. Adrenergic signaling in cardiomyocytes × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
5	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB1 💬 Adrenergic signaling in cardiomyocytes × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 3. Adrenergic signaling in cardiomyocytes × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
6	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB1 💬 Adrenergic signaling in cardiomyocytes × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 3. Adrenergic signaling in cardiomyocytes × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
7	Adrenergic signaling in cardiomyocytes 💬	[5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S SCN5A sodium channel protein type 5 subunit alpha isoform a	Topiramate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 7. Adrenergic signaling in cardiomyocytes × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
8	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Aldosterone synthesis and secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 8. Aldosterone synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
9	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Alzheimer disease × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Alzheimer disease × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 9. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
10	Amphetamine addiction 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Amphetamine addiction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 10. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
11	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor	Topiramate 💬 Amyotrophic lateral sclerosis × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 11. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
12	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 12. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
13	Bile secretion 💬	[1] CA2 💬 Bile secretion × Name Full Name CA2 carbonic anhydrase 2 isoform 1	Topiramate 💬 Bile secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 13. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
14	Cadherin signaling 💬	[17] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, SCN5A 💬 Cadherin signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor SCN5A sodium channel protein type 5 subunit alpha isoform a	Topiramate 💬 Cadherin signaling × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 14. Cadherin signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
15	Calcium signaling pathway 💬	[1] ADRB1 💬 Calcium signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Calcium signaling pathway × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 15. Calcium signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
16	Calcium signaling pathway 💬	[1] ADRB1 💬 Calcium signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Calcium signaling pathway × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 15. Calcium signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
17	Calcium signaling pathway 💬	[1] ADRB1 💬 Calcium signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Calcium signaling pathway × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 15. Calcium signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
18	Calcium signaling pathway 💬	[1] ADRB1 💬 Calcium signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Calcium signaling pathway × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 15. Calcium signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
19	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Calcium signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Calcium signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 19. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
20	Calcium signaling pathway 💬	[1] OXTR 💬 Calcium signaling pathway × Name Full Name OXTR oxytocin receptor	Carbetocin 💬 Calcium signaling pathway × Name Other Names Carbetocin Duratocin	Carbetocin	[1] 193 💬 20. Calcium signaling pathway × Disease ID Name 193 Prader-Willi syndrome;
21	Calcium signaling pathway 💬	[1] OXTR 💬 Calcium signaling pathway × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 Calcium signaling pathway × Name Other Names Oxytocin Pitocin Syntocinon	Oxytocin	[8]  6 , 70, 72, 127, 168, 193, 206, 226 💬 21. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 70 Spinal stenosis;Extensive spinal canal stenosis; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 168 Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
22	cAMP signaling pathway 💬	[1] ADRB1 💬 cAMP signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 cAMP signaling pathway × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 22. cAMP signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
23	cAMP signaling pathway 💬	[1] ADRB1 💬 cAMP signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 cAMP signaling pathway × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 22. cAMP signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
24	cAMP signaling pathway 💬	[1] ADRB1 💬 cAMP signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 cAMP signaling pathway × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 22. cAMP signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
25	cAMP signaling pathway 💬	[1] ADRB1 💬 cAMP signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 cAMP signaling pathway × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 22. cAMP signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
26	cAMP signaling pathway 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 cAMP signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 26. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
27	cAMP signaling pathway 💬	[2] GIPR, GLP1R 💬 cAMP signaling pathway × Name Full Name GIPR gastric inhibitory polypeptide receptor isoform 1 precursor GLP1R glucagon-like peptide 1 receptor precursor	Tirzepatide 💬 cAMP signaling pathway × Name Other Names Tirzepatide Mounjaro Zepbound	Tirzepatide	[6] 67, 96, 97, 193, 233, 265 💬 27. cAMP signaling pathway × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy;
28	cAMP signaling pathway 💬	[1] GLP1R 💬 cAMP signaling pathway × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Exenatide 💬 cAMP signaling pathway × Name Other Names Exenatide Byetta	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 28. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
29	cAMP signaling pathway 💬	[1] GLP1R 💬 cAMP signaling pathway × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Liraglutide 💬 cAMP signaling pathway × Name Other Names Liraglutide Victoza SAXENDA	Liraglutide	[5]  6 , 13, 75, 77, 193 💬 29. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 193 Prader-Willi syndrome;
30	cAMP signaling pathway 💬	[1] OXTR 💬 cAMP signaling pathway × Name Full Name OXTR oxytocin receptor	Carbetocin 💬 cAMP signaling pathway × Name Other Names Carbetocin Duratocin	Carbetocin	[1] 193 💬 30. cAMP signaling pathway × Disease ID Name 193 Prader-Willi syndrome;
31	cAMP signaling pathway 💬	[1] OXTR 💬 cAMP signaling pathway × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 cAMP signaling pathway × Name Other Names Oxytocin Pitocin Syntocinon	Oxytocin	[8]  6 , 70, 72, 127, 168, 193, 206, 226 💬 31. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 70 Spinal stenosis;Extensive spinal canal stenosis; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 168 Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
32	cAMP signaling pathway 💬	[1] SSTR2 💬 cAMP signaling pathway × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide 💬 cAMP signaling pathway × Name Other Names Octreotide Octreotide	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 32. cAMP signaling pathway × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
33	cAMP signaling pathway 💬	[1] SSTR2 💬 cAMP signaling pathway × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 cAMP signaling pathway × Name Other Names Octreotide acetate Octreotide diacetate Sandostatin	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 32. cAMP signaling pathway × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
34	cAMP signaling pathway 💬	[1] SSTR2 💬 cAMP signaling pathway × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide pamoate 💬 cAMP signaling pathway × Name Other Names Octreotide pamoate Octreotide pamoate	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 32. cAMP signaling pathway × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
35	cAMP signaling pathway 💬	[1] SSTR2 💬 cAMP signaling pathway × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 cAMP signaling pathway × Name Other Names Octreotide acetate Sandostatin BYNFEZIA PEN MYCAPSSA SANDOSTATIN LAR DEPOT OCTREOTIDE	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 32. cAMP signaling pathway × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
36	cAMP signaling pathway 💬	[1] SSTR2 💬 cAMP signaling pathway × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide hydrochloride 💬 cAMP signaling pathway × Name Other Names Octreotide hydrochloride Oczyesa	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 32. cAMP signaling pathway × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
37	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬 Carbohydrate digestion and absorption × Name Full Name CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b	Topiramate 💬 Carbohydrate digestion and absorption × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 37. Carbohydrate digestion and absorption × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
38	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cardiac muscle contraction × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Cardiac muscle contraction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 38. Cardiac muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
39	Cellular senescence 💬	[1] CACNA1D 💬 Cellular senescence × Name Full Name CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b	Topiramate 💬 Cellular senescence × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 39. Cellular senescence × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
40	cGMP-PKG signaling pathway 💬	[1] ADRA2A 💬 cGMP-PKG signaling pathway × Name Full Name ADRA2A alpha-2A adrenergic receptor	Guanfacine hydrochloride 💬 cGMP-PKG signaling pathway × Name Other Names Guanfacine hydrochloride Intuniv Tenex GUANFACINE GUANFACINE ER GUANFACINE EXTENDED-RELEASE	Guanfacine	[1] 193 💬 40. cGMP-PKG signaling pathway × Disease ID Name 193 Prader-Willi syndrome;
41	cGMP-PKG signaling pathway 💬	[1] ADRA2A 💬 cGMP-PKG signaling pathway × Name Full Name ADRA2A alpha-2A adrenergic receptor	Guanfacine 💬 cGMP-PKG signaling pathway × Name Other Names Guanfacine Estulic	Guanfacine	[1] 193 💬 40. cGMP-PKG signaling pathway × Disease ID Name 193 Prader-Willi syndrome;
42	cGMP-PKG signaling pathway 💬	[1] ADRB1 💬 cGMP-PKG signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 cGMP-PKG signaling pathway × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 42. cGMP-PKG signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
43	cGMP-PKG signaling pathway 💬	[1] ADRB1 💬 cGMP-PKG signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 cGMP-PKG signaling pathway × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 42. cGMP-PKG signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
44	cGMP-PKG signaling pathway 💬	[1] ADRB1 💬 cGMP-PKG signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 cGMP-PKG signaling pathway × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 42. cGMP-PKG signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
45	cGMP-PKG signaling pathway 💬	[1] ADRB1 💬 cGMP-PKG signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 cGMP-PKG signaling pathway × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 42. cGMP-PKG signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
46	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cGMP-PKG signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 cGMP-PKG signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 46. cGMP-PKG signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
47	Chemical carcinogenesis - receptor activation 💬	[1] ADRB1 💬 Chemical carcinogenesis - receptor activation × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 47. Chemical carcinogenesis - receptor activation × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
48	Chemical carcinogenesis - receptor activation 💬	[1] ADRB1 💬 Chemical carcinogenesis - receptor activation × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 47. Chemical carcinogenesis - receptor activation × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
49	Chemical carcinogenesis - receptor activation 💬	[1] ADRB1 💬 Chemical carcinogenesis - receptor activation × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Chemical carcinogenesis - receptor activation × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 47. Chemical carcinogenesis - receptor activation × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
50	Chemical carcinogenesis - receptor activation 💬	[1] ADRB1 💬 Chemical carcinogenesis - receptor activation × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 47. Chemical carcinogenesis - receptor activation × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
51	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Chemical carcinogenesis - receptor activation × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 51. Chemical carcinogenesis - receptor activation × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
52	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cholinergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Cholinergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 52. Cholinergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
53	Circadian entrainment 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Circadian entrainment × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 53. Circadian entrainment × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
54	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate receptor 2 isoform 1 precursor	Topiramate 💬 Cocaine addiction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 54. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
55	Collecting duct acid secretion 💬	[1] CA2 💬 Collecting duct acid secretion × Name Full Name CA2 carbonic anhydrase 2 isoform 1	Topiramate 💬 Collecting duct acid secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 55. Collecting duct acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
56	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cortisol synthesis and secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Cortisol synthesis and secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 56. Cortisol synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
57	Cortisol synthesis and secretion 💬	[1] CYP11B1 💬 Cortisol synthesis and secretion × Name Full Name CYP11B1 cytochrome P450 11B1, mitochondrial isoform 1 precursor	Metyrapone 💬 Cortisol synthesis and secretion × Name Other Names Metyrapone Metopirone	Metyrapone	[2] 75, 193 💬 57. Cortisol synthesis and secretion × Disease ID Name 75 Cushing disease;Cushing syndrome; 193 Prader-Willi syndrome;
58	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cushing syndrome × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Cushing syndrome × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 58. Cushing syndrome × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
59	Cushing syndrome 💬	[1] CYP11B1 💬 Cushing syndrome × Name Full Name CYP11B1 cytochrome P450 11B1, mitochondrial isoform 1 precursor	Metyrapone 💬 Cushing syndrome × Name Other Names Metyrapone Metopirone	Metyrapone	[2] 75, 193 💬 59. Cushing syndrome × Disease ID Name 75 Cushing disease;Cushing syndrome; 193 Prader-Willi syndrome;
60	Dilated cardiomyopathy 💬	[1] ADRB1 💬 Dilated cardiomyopathy × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Dilated cardiomyopathy × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 60. Dilated cardiomyopathy × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
61	Dilated cardiomyopathy 💬	[1] ADRB1 💬 Dilated cardiomyopathy × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Dilated cardiomyopathy × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 60. Dilated cardiomyopathy × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
62	Dilated cardiomyopathy 💬	[1] ADRB1 💬 Dilated cardiomyopathy × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Dilated cardiomyopathy × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 60. Dilated cardiomyopathy × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
63	Dilated cardiomyopathy 💬	[1] ADRB1 💬 Dilated cardiomyopathy × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Dilated cardiomyopathy × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 60. Dilated cardiomyopathy × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
64	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Dilated cardiomyopathy × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Dilated cardiomyopathy × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 64. Dilated cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
65	Dopaminergic synapse 💬	[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Dopaminergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor SCN1A sodium channel protein type 1 subunit alpha isoform 1	Topiramate 💬 Dopaminergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 65. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
66	GABAergic synapse 💬	[20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Topiramate 💬 GABAergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 66. GABAergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
67	Gap junction 💬	[1] ADRB1 💬 Gap junction × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Gap junction × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 67. Gap junction × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
68	Gap junction 💬	[1] ADRB1 💬 Gap junction × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Gap junction × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 67. Gap junction × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
69	Gap junction 💬	[1] ADRB1 💬 Gap junction × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Gap junction × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 67. Gap junction × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
70	Gap junction 💬	[1] ADRB1 💬 Gap junction × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Gap junction × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 67. Gap junction × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
71	Gastric acid secretion 💬	[1] CA2 💬 Gastric acid secretion × Name Full Name CA2 carbonic anhydrase 2 isoform 1	Topiramate 💬 Gastric acid secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 71. Gastric acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
72	Gastric acid secretion 💬	[1] SSTR2 💬 Gastric acid secretion × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide 💬 Gastric acid secretion × Name Other Names Octreotide Octreotide	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 72. Gastric acid secretion × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
73	Gastric acid secretion 💬	[1] SSTR2 💬 Gastric acid secretion × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 Gastric acid secretion × Name Other Names Octreotide acetate Octreotide diacetate Sandostatin	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 72. Gastric acid secretion × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
74	Gastric acid secretion 💬	[1] SSTR2 💬 Gastric acid secretion × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide pamoate 💬 Gastric acid secretion × Name Other Names Octreotide pamoate Octreotide pamoate	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 72. Gastric acid secretion × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
75	Gastric acid secretion 💬	[1] SSTR2 💬 Gastric acid secretion × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 Gastric acid secretion × Name Other Names Octreotide acetate Sandostatin BYNFEZIA PEN MYCAPSSA SANDOSTATIN LAR DEPOT OCTREOTIDE	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 72. Gastric acid secretion × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
76	Gastric acid secretion 💬	[1] SSTR2 💬 Gastric acid secretion × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide hydrochloride 💬 Gastric acid secretion × Name Other Names Octreotide hydrochloride Oczyesa	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 72. Gastric acid secretion × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
77	Glutamatergic synapse 💬	[11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Glutamatergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor	Topiramate 💬 Glutamatergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 77. Glutamatergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
78	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 GnRH secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 78. GnRH secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
79	GnRH secretion 💬	[1] KCNJ11 💬 GnRH secretion × Name Full Name KCNJ11 ATP-sensitive inward rectifier potassium channel 11 isoform 1	Diazoxide 💬 GnRH secretion × Name Other Names Diazoxide Hyperstat Proglycem	Diazoxide	[2] 13, 193 💬 79. GnRH secretion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 193 Prader-Willi syndrome;
80	GnRH secretion 💬	[1] KCNJ11 💬 GnRH secretion × Name Full Name KCNJ11 ATP-sensitive inward rectifier potassium channel 11 isoform 1	Diazoxide choline 💬 GnRH secretion × Name Other Names Diazoxide choline Vykat xr	Diazoxide	[2] 13, 193 💬 79. GnRH secretion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 193 Prader-Willi syndrome;
81	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 GnRH signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 81. GnRH signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
82	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Growth hormone synthesis, secretion and action × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Growth hormone synthesis, secretion and action × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 82. Growth hormone synthesis, secretion and action × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
83	Growth hormone synthesis, secretion and action 💬	[1] SSTR2 💬 Growth hormone synthesis, secretion and action × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide 💬 Growth hormone synthesis, secretion and action × Name Other Names Octreotide Octreotide	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 83. Growth hormone synthesis, secretion and action × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
84	Growth hormone synthesis, secretion and action 💬	[1] SSTR2 💬 Growth hormone synthesis, secretion and action × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 Growth hormone synthesis, secretion and action × Name Other Names Octreotide acetate Octreotide diacetate Sandostatin	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 83. Growth hormone synthesis, secretion and action × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
85	Growth hormone synthesis, secretion and action 💬	[1] SSTR2 💬 Growth hormone synthesis, secretion and action × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide pamoate 💬 Growth hormone synthesis, secretion and action × Name Other Names Octreotide pamoate Octreotide pamoate	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 83. Growth hormone synthesis, secretion and action × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
86	Growth hormone synthesis, secretion and action 💬	[1] SSTR2 💬 Growth hormone synthesis, secretion and action × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 Growth hormone synthesis, secretion and action × Name Other Names Octreotide acetate Sandostatin BYNFEZIA PEN MYCAPSSA SANDOSTATIN LAR DEPOT OCTREOTIDE	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 83. Growth hormone synthesis, secretion and action × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
87	Growth hormone synthesis, secretion and action 💬	[1] SSTR2 💬 Growth hormone synthesis, secretion and action × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide hydrochloride 💬 Growth hormone synthesis, secretion and action × Name Other Names Octreotide hydrochloride Oczyesa	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 83. Growth hormone synthesis, secretion and action × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
88	Hormone signaling 💬	[1] ADRA2A 💬 Hormone signaling × Name Full Name ADRA2A alpha-2A adrenergic receptor	Guanfacine hydrochloride 💬 Hormone signaling × Name Other Names Guanfacine hydrochloride Intuniv Tenex GUANFACINE GUANFACINE ER GUANFACINE EXTENDED-RELEASE	Guanfacine	[1] 193 💬 88. Hormone signaling × Disease ID Name 193 Prader-Willi syndrome;
89	Hormone signaling 💬	[1] ADRA2A 💬 Hormone signaling × Name Full Name ADRA2A alpha-2A adrenergic receptor	Guanfacine 💬 Hormone signaling × Name Other Names Guanfacine Estulic	Guanfacine	[1] 193 💬 88. Hormone signaling × Disease ID Name 193 Prader-Willi syndrome;
90	Hormone signaling 💬	[1] ADRB1 💬 Hormone signaling × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Hormone signaling × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 90. Hormone signaling × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
91	Hormone signaling 💬	[1] ADRB1 💬 Hormone signaling × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Hormone signaling × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 90. Hormone signaling × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
92	Hormone signaling 💬	[1] ADRB1 💬 Hormone signaling × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Hormone signaling × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 90. Hormone signaling × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
93	Hormone signaling 💬	[1] ADRB1 💬 Hormone signaling × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Hormone signaling × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 90. Hormone signaling × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
94	Hormone signaling 💬	[2] GIPR, GLP1R 💬 Hormone signaling × Name Full Name GIPR gastric inhibitory polypeptide receptor isoform 1 precursor GLP1R glucagon-like peptide 1 receptor precursor	Tirzepatide 💬 Hormone signaling × Name Other Names Tirzepatide Mounjaro Zepbound	Tirzepatide	[6] 67, 96, 97, 193, 233, 265 💬 94. Hormone signaling × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy;
95	Hormone signaling 💬	[1] GLP1R 💬 Hormone signaling × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Exenatide 💬 Hormone signaling × Name Other Names Exenatide Byetta	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 95. Hormone signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
96	Hormone signaling 💬	[1] GLP1R 💬 Hormone signaling × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Liraglutide 💬 Hormone signaling × Name Other Names Liraglutide Victoza SAXENDA	Liraglutide	[5]  6 , 13, 75, 77, 193 💬 96. Hormone signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 193 Prader-Willi syndrome;
97	Hormone signaling 💬	[1] MC4R 💬 Hormone signaling × Name Full Name MC4R melanocortin receptor 4	Setmelanotide 💬 Hormone signaling × Name Other Names Setmelanotide Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 97. Hormone signaling × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
98	Hormone signaling 💬	[1] MC4R 💬 Hormone signaling × Name Full Name MC4R melanocortin receptor 4	Setmelanotide acetate 💬 Hormone signaling × Name Other Names Setmelanotide acetate Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 97. Hormone signaling × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
99	Hormone signaling 💬	[1] OXTR 💬 Hormone signaling × Name Full Name OXTR oxytocin receptor	Carbetocin 💬 Hormone signaling × Name Other Names Carbetocin Duratocin	Carbetocin	[1] 193 💬 99. Hormone signaling × Disease ID Name 193 Prader-Willi syndrome;
100	Hormone signaling 💬	[1] OXTR 💬 Hormone signaling × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 Hormone signaling × Name Other Names Oxytocin Pitocin Syntocinon	Oxytocin	[8]  6 , 70, 72, 127, 168, 193, 206, 226 💬 100. Hormone signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 70 Spinal stenosis;Extensive spinal canal stenosis; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 168 Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
101	Hormone signaling 💬	[1] SSTR2 💬 Hormone signaling × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide 💬 Hormone signaling × Name Other Names Octreotide Octreotide	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 101. Hormone signaling × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
102	Hormone signaling 💬	[1] SSTR2 💬 Hormone signaling × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 Hormone signaling × Name Other Names Octreotide acetate Octreotide diacetate Sandostatin	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 101. Hormone signaling × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
103	Hormone signaling 💬	[1] SSTR2 💬 Hormone signaling × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide pamoate 💬 Hormone signaling × Name Other Names Octreotide pamoate Octreotide pamoate	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 101. Hormone signaling × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
104	Hormone signaling 💬	[1] SSTR2 💬 Hormone signaling × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 Hormone signaling × Name Other Names Octreotide acetate Sandostatin BYNFEZIA PEN MYCAPSSA SANDOSTATIN LAR DEPOT OCTREOTIDE	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 101. Hormone signaling × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
105	Hormone signaling 💬	[1] SSTR2 💬 Hormone signaling × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide hydrochloride 💬 Hormone signaling × Name Other Names Octreotide hydrochloride Oczyesa	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 101. Hormone signaling × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
106	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Huntington disease × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 106. Huntington disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
107	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Hypertrophic cardiomyopathy × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Hypertrophic cardiomyopathy × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 107. Hypertrophic cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
108	IgSF CAM signaling 💬	[1] SCN8A 💬 IgSF CAM signaling × Name Full Name SCN8A sodium channel protein type 8 subunit alpha isoform 3	Topiramate 💬 IgSF CAM signaling × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 108. IgSF CAM signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
109	Insulin secretion 💬	[2] ABCC8, KCNJ11 💬 Insulin secretion × Name Full Name ABCC8 ATP-binding cassette sub-family C member 8 isoform 2 KCNJ11 ATP-sensitive inward rectifier potassium channel 11 isoform 1	Diazoxide 💬 Insulin secretion × Name Other Names Diazoxide Hyperstat Proglycem	Diazoxide	[2] 13, 193 💬 109. Insulin secretion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 193 Prader-Willi syndrome;
110	Insulin secretion 💬	[2] ABCC8, KCNJ11 💬 Insulin secretion × Name Full Name ABCC8 ATP-binding cassette sub-family C member 8 isoform 2 KCNJ11 ATP-sensitive inward rectifier potassium channel 11 isoform 1	Diazoxide choline 💬 Insulin secretion × Name Other Names Diazoxide choline Vykat xr	Diazoxide	[2] 13, 193 💬 109. Insulin secretion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 193 Prader-Willi syndrome;
111	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Insulin secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Insulin secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 111. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
112	Insulin secretion 💬	[1] GLP1R 💬 Insulin secretion × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Exenatide 💬 Insulin secretion × Name Other Names Exenatide Byetta	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 112. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
113	Insulin secretion 💬	[1] GLP1R 💬 Insulin secretion × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Liraglutide 💬 Insulin secretion × Name Other Names Liraglutide Victoza SAXENDA	Liraglutide	[5]  6 , 13, 75, 77, 193 💬 113. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 193 Prader-Willi syndrome;
114	Insulin secretion 💬	[1] GLP1R 💬 Insulin secretion × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Tirzepatide 💬 Insulin secretion × Name Other Names Tirzepatide Mounjaro Zepbound	Tirzepatide	[6] 67, 96, 97, 193, 233, 265 💬 114. Insulin secretion × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy;
115	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Topiramate 💬 Long-term depression × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 115. Long-term depression × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
116	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor	Topiramate 💬 Long-term potentiation × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 116. Long-term potentiation × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
117	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 MAPK signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 MAPK signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 117. MAPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
118	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Topiramate 💬 Morphine addiction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 118. Morphine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
119	Neuroactive ligand signaling 💬	[1] ADRA2A 💬 Neuroactive ligand signaling × Name Full Name ADRA2A alpha-2A adrenergic receptor	Guanfacine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Guanfacine hydrochloride Intuniv Tenex GUANFACINE GUANFACINE ER GUANFACINE EXTENDED-RELEASE	Guanfacine	[1] 193 💬 119. Neuroactive ligand signaling × Disease ID Name 193 Prader-Willi syndrome;
120	Neuroactive ligand signaling 💬	[1] ADRA2A 💬 Neuroactive ligand signaling × Name Full Name ADRA2A alpha-2A adrenergic receptor	Guanfacine 💬 Neuroactive ligand signaling × Name Other Names Guanfacine Estulic	Guanfacine	[1] 193 💬 119. Neuroactive ligand signaling × Disease ID Name 193 Prader-Willi syndrome;
121	Neuroactive ligand signaling 💬	[1] ADRB1 💬 Neuroactive ligand signaling × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Neuroactive ligand signaling × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 121. Neuroactive ligand signaling × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
122	Neuroactive ligand signaling 💬	[1] ADRB1 💬 Neuroactive ligand signaling × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Neuroactive ligand signaling × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 121. Neuroactive ligand signaling × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
123	Neuroactive ligand signaling 💬	[1] ADRB1 💬 Neuroactive ligand signaling × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Neuroactive ligand signaling × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 121. Neuroactive ligand signaling × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
124	Neuroactive ligand signaling 💬	[1] ADRB1 💬 Neuroactive ligand signaling × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Neuroactive ligand signaling × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 121. Neuroactive ligand signaling × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
125	Neuroactive ligand signaling 💬	[25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor	Topiramate 💬 Neuroactive ligand signaling × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 125. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
126	Neuroactive ligand signaling 💬	[1] HRH3 💬 Neuroactive ligand signaling × Name Full Name HRH3 histamine H3 receptor	Pitolisant 💬 Neuroactive ligand signaling × Name Other Names Pitolisant Wakix Ozawade	Pitolisant	[3]  6 , 113, 193 💬 126. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome;
127	Neuroactive ligand signaling 💬	[1] HRH3 💬 Neuroactive ligand signaling × Name Full Name HRH3 histamine H3 receptor	Pitolisant hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Pitolisant hydrochloride Wakix	Pitolisant	[3]  6 , 113, 193 💬 126. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome;
128	Neuroactive ligand signaling 💬	[1] MC4R 💬 Neuroactive ligand signaling × Name Full Name MC4R melanocortin receptor 4	Setmelanotide 💬 Neuroactive ligand signaling × Name Other Names Setmelanotide Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 128. Neuroactive ligand signaling × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
129	Neuroactive ligand signaling 💬	[1] MC4R 💬 Neuroactive ligand signaling × Name Full Name MC4R melanocortin receptor 4	Setmelanotide acetate 💬 Neuroactive ligand signaling × Name Other Names Setmelanotide acetate Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 128. Neuroactive ligand signaling × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
130	Neuroactive ligand-receptor interaction 💬	[1] ADRA2A 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRA2A alpha-2A adrenergic receptor	Guanfacine hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Guanfacine hydrochloride Intuniv Tenex GUANFACINE GUANFACINE ER GUANFACINE EXTENDED-RELEASE	Guanfacine	[1] 193 💬 130. Neuroactive ligand-receptor interaction × Disease ID Name 193 Prader-Willi syndrome;
131	Neuroactive ligand-receptor interaction 💬	[1] ADRA2A 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRA2A alpha-2A adrenergic receptor	Guanfacine 💬 Neuroactive ligand-receptor interaction × Name Other Names Guanfacine Estulic	Guanfacine	[1] 193 💬 130. Neuroactive ligand-receptor interaction × Disease ID Name 193 Prader-Willi syndrome;
132	Neuroactive ligand-receptor interaction 💬	[1] ADRB1 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Neuroactive ligand-receptor interaction × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 132. Neuroactive ligand-receptor interaction × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
133	Neuroactive ligand-receptor interaction 💬	[1] ADRB1 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Neuroactive ligand-receptor interaction × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 132. Neuroactive ligand-receptor interaction × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
134	Neuroactive ligand-receptor interaction 💬	[1] ADRB1 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Neuroactive ligand-receptor interaction × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 132. Neuroactive ligand-receptor interaction × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
135	Neuroactive ligand-receptor interaction 💬	[1] ADRB1 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Neuroactive ligand-receptor interaction × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 132. Neuroactive ligand-receptor interaction × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
136	Neuroactive ligand-receptor interaction 💬	[1] CNR1 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Rimonabant 💬 Neuroactive ligand-receptor interaction × Name Other Names Rimonabant Acomplia	Rimonabant	[1] 193 💬 136. Neuroactive ligand-receptor interaction × Disease ID Name 193 Prader-Willi syndrome;
137	Neuroactive ligand-receptor interaction 💬	[2] CNR1, CNR2 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1 isoform a CNR2 cannabinoid receptor 2	Cannabidiol 💬 Neuroactive ligand-receptor interaction × Name Other Names Cannabidiol CBD Epidiolex	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 137. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
138	Neuroactive ligand-receptor interaction 💬	[25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor	Topiramate 💬 Neuroactive ligand-receptor interaction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 138. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
139	Neuroactive ligand-receptor interaction 💬	[2] GIPR, GLP1R 💬 Neuroactive ligand-receptor interaction × Name Full Name GIPR gastric inhibitory polypeptide receptor isoform 1 precursor GLP1R glucagon-like peptide 1 receptor precursor	Tirzepatide 💬 Neuroactive ligand-receptor interaction × Name Other Names Tirzepatide Mounjaro Zepbound	Tirzepatide	[6] 67, 96, 97, 193, 233, 265 💬 139. Neuroactive ligand-receptor interaction × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome; 265 Lipodystrophy;
140	Neuroactive ligand-receptor interaction 💬	[1] GLP1R 💬 Neuroactive ligand-receptor interaction × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Exenatide 💬 Neuroactive ligand-receptor interaction × Name Other Names Exenatide Byetta	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 140. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
141	Neuroactive ligand-receptor interaction 💬	[1] GLP1R 💬 Neuroactive ligand-receptor interaction × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Liraglutide 💬 Neuroactive ligand-receptor interaction × Name Other Names Liraglutide Victoza SAXENDA	Liraglutide	[5]  6 , 13, 75, 77, 193 💬 141. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 193 Prader-Willi syndrome;
142	Neuroactive ligand-receptor interaction 💬	[1] HRH3 💬 Neuroactive ligand-receptor interaction × Name Full Name HRH3 histamine H3 receptor	Pitolisant 💬 Neuroactive ligand-receptor interaction × Name Other Names Pitolisant Wakix Ozawade	Pitolisant	[3]  6 , 113, 193 💬 142. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome;
143	Neuroactive ligand-receptor interaction 💬	[1] HRH3 💬 Neuroactive ligand-receptor interaction × Name Full Name HRH3 histamine H3 receptor	Pitolisant hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Pitolisant hydrochloride Wakix	Pitolisant	[3]  6 , 113, 193 💬 142. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome;
144	Neuroactive ligand-receptor interaction 💬	[1] MC4R 💬 Neuroactive ligand-receptor interaction × Name Full Name MC4R melanocortin receptor 4	Setmelanotide 💬 Neuroactive ligand-receptor interaction × Name Other Names Setmelanotide Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 144. Neuroactive ligand-receptor interaction × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
145	Neuroactive ligand-receptor interaction 💬	[1] MC4R 💬 Neuroactive ligand-receptor interaction × Name Full Name MC4R melanocortin receptor 4	Setmelanotide acetate 💬 Neuroactive ligand-receptor interaction × Name Other Names Setmelanotide acetate Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 144. Neuroactive ligand-receptor interaction × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
146	Neuroactive ligand-receptor interaction 💬	[1] OXTR 💬 Neuroactive ligand-receptor interaction × Name Full Name OXTR oxytocin receptor	Carbetocin 💬 Neuroactive ligand-receptor interaction × Name Other Names Carbetocin Duratocin	Carbetocin	[1] 193 💬 146. Neuroactive ligand-receptor interaction × Disease ID Name 193 Prader-Willi syndrome;
147	Neuroactive ligand-receptor interaction 💬	[1] OXTR 💬 Neuroactive ligand-receptor interaction × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 Neuroactive ligand-receptor interaction × Name Other Names Oxytocin Pitocin Syntocinon	Oxytocin	[8]  6 , 70, 72, 127, 168, 193, 206, 226 💬 147. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 70 Spinal stenosis;Extensive spinal canal stenosis; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 168 Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
148	Neuroactive ligand-receptor interaction 💬	[1] SSTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide 💬 Neuroactive ligand-receptor interaction × Name Other Names Octreotide Octreotide	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 148. Neuroactive ligand-receptor interaction × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
149	Neuroactive ligand-receptor interaction 💬	[1] SSTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 Neuroactive ligand-receptor interaction × Name Other Names Octreotide acetate Octreotide diacetate Sandostatin	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 148. Neuroactive ligand-receptor interaction × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
150	Neuroactive ligand-receptor interaction 💬	[1] SSTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide pamoate 💬 Neuroactive ligand-receptor interaction × Name Other Names Octreotide pamoate Octreotide pamoate	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 148. Neuroactive ligand-receptor interaction × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
151	Neuroactive ligand-receptor interaction 💬	[1] SSTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide acetate 💬 Neuroactive ligand-receptor interaction × Name Other Names Octreotide acetate Sandostatin BYNFEZIA PEN MYCAPSSA SANDOSTATIN LAR DEPOT OCTREOTIDE	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 148. Neuroactive ligand-receptor interaction × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
152	Neuroactive ligand-receptor interaction 💬	[1] SSTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name SSTR2 somatostatin receptor type 2	Octreotide hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Octreotide hydrochloride Oczyesa	Octreotide	[8] 67, 75, 77, 84, 85, 89, 193, 227 💬 148. Neuroactive ligand-receptor interaction × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
153	Nicotine addiction 💬	[20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Nicotine addiction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 153. Nicotine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
154	Nitrogen metabolism 💬	[2] CA2, CA4 💬 Nitrogen metabolism × Name Full Name CA2 carbonic anhydrase 2 isoform 1 CA4 carbonic anhydrase 4 preproprotein	Topiramate 💬 Nitrogen metabolism × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 154. Nitrogen metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
155	Ovarian steroidogenesis 💬	[1] CYP19A1 💬 Ovarian steroidogenesis × Name Full Name CYP19A1 aromatase	Anastrozole 💬 Ovarian steroidogenesis × Name Other Names Anastrozole Arimidex	Anastrozole	[3] 78, 86, 193 💬 155. Ovarian steroidogenesis × Disease ID Name 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 86 Pulmonary arterial hypertension;PAH; 193 Prader-Willi syndrome;
156	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Oxytocin signaling pathway × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Oxytocin signaling pathway × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 156. Oxytocin signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
157	Oxytocin signaling pathway 💬	[1] OXTR 💬 Oxytocin signaling pathway × Name Full Name OXTR oxytocin receptor	Carbetocin 💬 Oxytocin signaling pathway × Name Other Names Carbetocin Duratocin	Carbetocin	[1] 193 💬 157. Oxytocin signaling pathway × Disease ID Name 193 Prader-Willi syndrome;
158	Oxytocin signaling pathway 💬	[1] OXTR 💬 Oxytocin signaling pathway × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 Oxytocin signaling pathway × Name Other Names Oxytocin Pitocin Syntocinon	Oxytocin	[8]  6 , 70, 72, 127, 168, 193, 206, 226 💬 158. Oxytocin signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 70 Spinal stenosis;Extensive spinal canal stenosis; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 168 Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
159	Pancreatic secretion 💬	[1] CA2 💬 Pancreatic secretion × Name Full Name CA2 carbonic anhydrase 2 isoform 1	Topiramate 💬 Pancreatic secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 159. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
160	Pathways of neurodegeneration - multiple diseases 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 160. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
161	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Prion disease × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Prion disease × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 161. Prion disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
162	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬 Proximal tubule bicarbonate reclamation × Name Full Name CA2 carbonic anhydrase 2 isoform 1 CA4 carbonic anhydrase 4 preproprotein	Topiramate 💬 Proximal tubule bicarbonate reclamation × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 162. Proximal tubule bicarbonate reclamation × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
163	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Cannabidiol 💬 Rap1 signaling pathway × Name Other Names Cannabidiol CBD Epidiolex	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 163. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
164	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Rimonabant 💬 Rap1 signaling pathway × Name Other Names Rimonabant Acomplia	Rimonabant	[1] 193 💬 164. Rap1 signaling pathway × Disease ID Name 193 Prader-Willi syndrome;
165	Regulation of lipolysis in adipocytes 💬	[1] ADRB1 💬 Regulation of lipolysis in adipocytes × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Regulation of lipolysis in adipocytes × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 165. Regulation of lipolysis in adipocytes × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
166	Regulation of lipolysis in adipocytes 💬	[1] ADRB1 💬 Regulation of lipolysis in adipocytes × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Regulation of lipolysis in adipocytes × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 165. Regulation of lipolysis in adipocytes × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
167	Regulation of lipolysis in adipocytes 💬	[1] ADRB1 💬 Regulation of lipolysis in adipocytes × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Regulation of lipolysis in adipocytes × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 165. Regulation of lipolysis in adipocytes × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
168	Regulation of lipolysis in adipocytes 💬	[1] ADRB1 💬 Regulation of lipolysis in adipocytes × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Regulation of lipolysis in adipocytes × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 165. Regulation of lipolysis in adipocytes × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
169	Renin secretion 💬	[1] ADRB1 💬 Renin secretion × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Renin secretion × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 169. Renin secretion × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
170	Renin secretion 💬	[1] ADRB1 💬 Renin secretion × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Renin secretion × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 169. Renin secretion × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
171	Renin secretion 💬	[1] ADRB1 💬 Renin secretion × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Renin secretion × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 169. Renin secretion × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
172	Renin secretion 💬	[1] ADRB1 💬 Renin secretion × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Renin secretion × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 169. Renin secretion × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
173	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Renin secretion × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Renin secretion × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 173. Renin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
174	Retrograde endocannabinoid signaling 💬	[24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Topiramate 💬 Retrograde endocannabinoid signaling × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 174. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
175	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Cannabidiol 💬 Retrograde endocannabinoid signaling × Name Other Names Cannabidiol CBD Epidiolex	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 175. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
176	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Rimonabant 💬 Retrograde endocannabinoid signaling × Name Other Names Rimonabant Acomplia	Rimonabant	[1] 193 💬 176. Retrograde endocannabinoid signaling × Disease ID Name 193 Prader-Willi syndrome;
177	Salivary secretion 💬	[1] ADRB1 💬 Salivary secretion × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol tartrate 💬 Salivary secretion × Name Other Names Metoprolol tartrate Lopressor METOPROLOL	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 177. Salivary secretion × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
178	Salivary secretion 💬	[1] ADRB1 💬 Salivary secretion × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol succinate 💬 Salivary secretion × Name Other Names Metoprolol succinate Toprol XL KAPSPARGO TOPROL METOPROLOL SUCCINATE ER	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 177. Salivary secretion × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
179	Salivary secretion 💬	[1] ADRB1 💬 Salivary secretion × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol 💬 Salivary secretion × Name Other Names Metoprolol Metoprolol	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 177. Salivary secretion × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
180	Salivary secretion 💬	[1] ADRB1 💬 Salivary secretion × Name Full Name ADRB1 beta-1 adrenergic receptor	Metoprolol fumarate 💬 Salivary secretion × Name Other Names Metoprolol fumarate Lopressor	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 177. Salivary secretion × Disease ID Name 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
181	Serotonergic synapse 💬	[7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬 Serotonergic synapse × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor	Topiramate 💬 Serotonergic synapse × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 181. Serotonergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
182	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Topiramate 💬 Spinocerebellar ataxia × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 182. Spinocerebellar ataxia × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
183	Steroid hormone biosynthesis 💬	[1] CYP11B1 💬 Steroid hormone biosynthesis × Name Full Name CYP11B1 cytochrome P450 11B1, mitochondrial isoform 1 precursor	Metyrapone 💬 Steroid hormone biosynthesis × Name Other Names Metyrapone Metopirone	Metyrapone	[2] 75, 193 💬 183. Steroid hormone biosynthesis × Disease ID Name 75 Cushing disease;Cushing syndrome; 193 Prader-Willi syndrome;
184	Steroid hormone biosynthesis 💬	[1] CYP19A1 💬 Steroid hormone biosynthesis × Name Full Name CYP19A1 aromatase	Anastrozole 💬 Steroid hormone biosynthesis × Name Other Names Anastrozole Arimidex	Anastrozole	[3] 78, 86, 193 💬 184. Steroid hormone biosynthesis × Disease ID Name 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 86 Pulmonary arterial hypertension;PAH; 193 Prader-Willi syndrome;
185	Taste transduction 💬	[10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor SCN2A sodium channel protein type 2 subunit alpha isoform 1 SCN3A sodium channel protein type 3 subunit alpha isoform 2 SCN9A sodium channel protein type 9 subunit alpha isoform 2	Topiramate 💬 Taste transduction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 185. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
186	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Cannabidiol 💬 Thermogenesis × Name Other Names Cannabidiol CBD Epidiolex	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 186. Thermogenesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
187	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1 isoform a	Rimonabant 💬 Thermogenesis × Name Other Names Rimonabant Acomplia	Rimonabant	[1] 193 💬 187. Thermogenesis × Disease ID Name 193 Prader-Willi syndrome;
188	Tight junction 💬	[1] CACNA1D 💬 Tight junction × Name Full Name CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b	Topiramate 💬 Tight junction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 188. Tight junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
189	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate receptor 3 isoform 2 precursor	Topiramate 💬 Transcriptional misregulation in cancer × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 189. Transcriptional misregulation in cancer × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
190	Type II diabetes mellitus 💬	[2] ABCC8, KCNJ11 💬 Type II diabetes mellitus × Name Full Name ABCC8 ATP-binding cassette sub-family C member 8 isoform 2 KCNJ11 ATP-sensitive inward rectifier potassium channel 11 isoform 1	Diazoxide 💬 Type II diabetes mellitus × Name Other Names Diazoxide Hyperstat Proglycem	Diazoxide	[2] 13, 193 💬 190. Type II diabetes mellitus × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 193 Prader-Willi syndrome;
191	Type II diabetes mellitus 💬	[2] ABCC8, KCNJ11 💬 Type II diabetes mellitus × Name Full Name ABCC8 ATP-binding cassette sub-family C member 8 isoform 2 KCNJ11 ATP-sensitive inward rectifier potassium channel 11 isoform 1	Diazoxide choline 💬 Type II diabetes mellitus × Name Other Names Diazoxide choline Vykat xr	Diazoxide	[2] 13, 193 💬 190. Type II diabetes mellitus × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 193 Prader-Willi syndrome;
192	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬 Type II diabetes mellitus × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b	Topiramate 💬 Type II diabetes mellitus × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 192. Type II diabetes mellitus × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
193	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Vascular smooth muscle contraction × Name Full Name CACNA1C voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 CACNA1D voltage-dependent L-type calcium channel subunit alpha-1D isoform b CACNA1F voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 CACNA1S voltage-dependent L-type calcium channel subunit alpha-1S	Topiramate 💬 Vascular smooth muscle contraction × Name Other Names Topiramate Topamax Trokendi xr EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 193. Vascular smooth muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;

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