Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	ABC transporters 💬	[1] ABCC8 💬 ABC transporters × Name Full Name ABCC8 ATP binding cassette subfamily C member 8	Diazoxide 💬 ABC transporters × Name Other Names Diazoxide Diazoxide (JAN/USP/INN) Hyperstat (TN) Proglycem (TN)	Diazoxide	[2] 13, 193 💬 1. ABC transporters × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 193 Prader-Willi syndrome;
2	Acute myeloid leukemia 💬	[1] MTOR 💬 Acute myeloid leukemia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Acute myeloid leukemia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 2. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
3	Adipocytokine signaling pathway 💬	[1] MTOR 💬 Adipocytokine signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Adipocytokine signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 3. Adipocytokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
4	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB1 💬 Adrenergic signaling in cardiomyocytes × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 4. Adrenergic signaling in cardiomyocytes × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
5	Adrenergic signaling in cardiomyocytes 💬	[5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S SCN5A sodium voltage-gated channel alpha subunit 5	Topiramate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 5. Adrenergic signaling in cardiomyocytes × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
6	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Aldosterone synthesis and secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 6. Aldosterone synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
7	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Alzheimer disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Alzheimer disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 7. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
8	Alzheimer disease 💬	[1] MTOR 💬 Alzheimer disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Alzheimer disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 8. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
9	Amphetamine addiction 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Amphetamine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 9. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
10	AMPK signaling pathway 💬	[1] MTOR 💬 AMPK signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 AMPK signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 10. AMPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
11	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Amyotrophic lateral sclerosis × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 11. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
12	Amyotrophic lateral sclerosis 💬	[1] MTOR 💬 Amyotrophic lateral sclerosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 12. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
13	Apelin signaling pathway 💬	[1] MTOR 💬 Apelin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Apelin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 13. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
14	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 14. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
15	Autophagy - animal 💬	[1] MTOR 💬 Autophagy - animal × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - animal × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 15. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
16	Autophagy - other 💬	[1] MTOR 💬 Autophagy - other × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - other × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 16. Autophagy - other × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
17	Bile secretion 💬	[1] CA2 💬 Bile secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Bile secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 17. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
18	Breast cancer 💬	[1] MTOR 💬 Breast cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Breast cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 18. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
19	Calcium signaling pathway 💬	[1] ADRB1 💬 Calcium signaling pathway × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Calcium signaling pathway × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 19. Calcium signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
20	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Calcium signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Calcium signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 20. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
21	Calcium signaling pathway 💬	[1] OXTR 💬 Calcium signaling pathway × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 Calcium signaling pathway × Name Other Names Oxytocin Oxytocin (JP18/USP/INN) Oxytocin (TN) Pitocin (TN) Syntocinon (TN)	Oxytocin	[7]  6 , 72, 127, 168, 193, 206, 226 💬 21. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 127 Frontotemporal lobar degeneration; 168 Ehlers-Danlos syndrome;EDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
22	cAMP signaling pathway 💬	[1] ADRB1 💬 cAMP signaling pathway × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 cAMP signaling pathway × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 22. cAMP signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
23	cAMP signaling pathway 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 cAMP signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 23. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
24	cAMP signaling pathway 💬	[1] GLP1R 💬 cAMP signaling pathway × Name Full Name GLP1R glucagon like peptide 1 receptor	Exenatide 💬 cAMP signaling pathway × Name Other Names Exenatide Exenatide (JAN/USAN/INN) Byetta (TN) BYDUREON BYDUREON BCISE	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 24. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA-C;MSA-P; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
25	cAMP signaling pathway 💬	[1] GLP1R 💬 cAMP signaling pathway × Name Full Name GLP1R glucagon like peptide 1 receptor	Liraglutide 💬 cAMP signaling pathway × Name Other Names Liraglutide Liraglutide (USAN/INN) Liraglutide (genetical recombination) (JAN) Victoza (TN) SAXENDA	Liraglutide	[3]  6 , 75, 193 💬 25. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 75 Cushing disease;Cushing; 193 Prader-Willi syndrome;
26	cAMP signaling pathway 💬	[1] OXTR 💬 cAMP signaling pathway × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 cAMP signaling pathway × Name Other Names Oxytocin Oxytocin (JP18/USP/INN) Oxytocin (TN) Pitocin (TN) Syntocinon (TN)	Oxytocin	[7]  6 , 72, 127, 168, 193, 206, 226 💬 26. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 127 Frontotemporal lobar degeneration; 168 Ehlers-Danlos syndrome;EDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
27	cAMP signaling pathway 💬	[1] SSTR2 💬 cAMP signaling pathway × Name Full Name SSTR2 somatostatin receptor 2	Octreotide 💬 cAMP signaling pathway × Name Other Names Octreotide Octreotide (USAN/INN)	Octreotide	[7] 67, 75, 84, 85, 89, 193, 227 💬 27. cAMP signaling pathway × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
28	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬 Carbohydrate digestion and absorption × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Carbohydrate digestion and absorption × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 28. Carbohydrate digestion and absorption × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
29	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cardiac muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cardiac muscle contraction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 29. Cardiac muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
30	Cellular senescence 💬	[1] CACNA1D 💬 Cellular senescence × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Cellular senescence × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 30. Cellular senescence × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
31	Cellular senescence 💬	[1] MTOR 💬 Cellular senescence × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Cellular senescence × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 31. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
32	Central carbon metabolism in cancer 💬	[1] MTOR 💬 Central carbon metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Central carbon metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 32. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
33	cGMP-PKG signaling pathway 💬	[1] ADRA2A 💬 cGMP-PKG signaling pathway × Name Full Name ADRA2A adrenoceptor alpha 2A	Guanfacine 💬 cGMP-PKG signaling pathway × Name Other Names Guanfacine Guanfacine (INN) Estulic (TN)	Guanfacine	[1] 193 💬 33. cGMP-PKG signaling pathway × Disease ID Name 193 Prader-Willi syndrome;
34	cGMP-PKG signaling pathway 💬	[1] ADRB1 💬 cGMP-PKG signaling pathway × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 cGMP-PKG signaling pathway × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 34. cGMP-PKG signaling pathway × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
35	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cGMP-PKG signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 cGMP-PKG signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 35. cGMP-PKG signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
36	Chemical carcinogenesis - receptor activation 💬	[1] ADRB1 💬 Chemical carcinogenesis - receptor activation × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Chemical carcinogenesis - receptor activation × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 36. Chemical carcinogenesis - receptor activation × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
37	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Chemical carcinogenesis - receptor activation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 37. Chemical carcinogenesis - receptor activation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
38	Chemical carcinogenesis - receptor activation 💬	[1] MTOR 💬 Chemical carcinogenesis - receptor activation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Chemical carcinogenesis - receptor activation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 38. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
39	Choline metabolism in cancer 💬	[1] MTOR 💬 Choline metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Choline metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 39. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
40	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cholinergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cholinergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 40. Cholinergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
41	Circadian entrainment 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Circadian entrainment × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 41. Circadian entrainment × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
42	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Cocaine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 42. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
43	Collecting duct acid secretion 💬	[1] CA2 💬 Collecting duct acid secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Collecting duct acid secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 43. Collecting duct acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
44	Colorectal cancer 💬	[1] MTOR 💬 Colorectal cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Colorectal cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 44. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
45	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cortisol synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cortisol synthesis and secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 45. Cortisol synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
46	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cushing syndrome × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cushing syndrome × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 46. Cushing syndrome × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
47	Diabetic cardiomyopathy 💬	[1] MTOR 💬 Diabetic cardiomyopathy × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Diabetic cardiomyopathy × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 47. Diabetic cardiomyopathy × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
48	Dilated cardiomyopathy 💬	[1] ADRB1 💬 Dilated cardiomyopathy × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Dilated cardiomyopathy × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 48. Dilated cardiomyopathy × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
49	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Dilated cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Dilated cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 49. Dilated cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
50	Dopaminergic synapse 💬	[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Dopaminergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 SCN1A sodium voltage-gated channel alpha subunit 1	Topiramate 💬 Dopaminergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 50. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
51	EGFR tyrosine kinase inhibitor resistance 💬	[1] MTOR 💬 EGFR tyrosine kinase inhibitor resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 51. EGFR tyrosine kinase inhibitor resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
52	Endocrine resistance 💬	[1] MTOR 💬 Endocrine resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Endocrine resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 52. Endocrine resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
53	ErbB signaling pathway 💬	[1] MTOR 💬 ErbB signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 ErbB signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 53. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
54	GABAergic synapse 💬	[20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Topiramate 💬 GABAergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 54. GABAergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
55	Gap junction 💬	[1] ADRB1 💬 Gap junction × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Gap junction × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 55. Gap junction × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
56	Gastric acid secretion 💬	[1] CA2 💬 Gastric acid secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Gastric acid secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 56. Gastric acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
57	Gastric acid secretion 💬	[1] SSTR2 💬 Gastric acid secretion × Name Full Name SSTR2 somatostatin receptor 2	Octreotide 💬 Gastric acid secretion × Name Other Names Octreotide Octreotide (USAN/INN)	Octreotide	[7] 67, 75, 84, 85, 89, 193, 227 💬 57. Gastric acid secretion × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
58	Gastric cancer 💬	[1] MTOR 💬 Gastric cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Gastric cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 58. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
59	Glioma 💬	[1] MTOR 💬 Glioma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Glioma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 59. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
60	Glutamatergic synapse 💬	[11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Glutamatergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Glutamatergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 60. Glutamatergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
61	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 GnRH secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 61. GnRH secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
62	GnRH secretion 💬	[1] KCNJ11 💬 GnRH secretion × Name Full Name KCNJ11 potassium inwardly rectifying channel subfamily J member 11	Diazoxide 💬 GnRH secretion × Name Other Names Diazoxide Diazoxide (JAN/USP/INN) Hyperstat (TN) Proglycem (TN)	Diazoxide	[2] 13, 193 💬 62. GnRH secretion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 193 Prader-Willi syndrome;
63	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 GnRH signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 63. GnRH signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
64	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Growth hormone synthesis, secretion and action × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Growth hormone synthesis, secretion and action × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 64. Growth hormone synthesis, secretion and action × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
65	Growth hormone synthesis, secretion and action 💬	[1] MTOR 💬 Growth hormone synthesis, secretion and action × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Growth hormone synthesis, secretion and action × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 65. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
66	Growth hormone synthesis, secretion and action 💬	[1] SSTR2 💬 Growth hormone synthesis, secretion and action × Name Full Name SSTR2 somatostatin receptor 2	Octreotide 💬 Growth hormone synthesis, secretion and action × Name Other Names Octreotide Octreotide (USAN/INN)	Octreotide	[7] 67, 75, 84, 85, 89, 193, 227 💬 66. Growth hormone synthesis, secretion and action × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
67	Hepatocellular carcinoma 💬	[1] MTOR 💬 Hepatocellular carcinoma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Hepatocellular carcinoma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 67. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
68	Herpes simplex virus 1 infection 💬	[1] MTOR 💬 Herpes simplex virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Herpes simplex virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 68. Herpes simplex virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
69	HIF-1 signaling pathway 💬	[1] MTOR 💬 HIF-1 signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 HIF-1 signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 69. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
70	Human cytomegalovirus infection 💬	[1] MTOR 💬 Human cytomegalovirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human cytomegalovirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 70. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
71	Human immunodeficiency virus 1 infection 💬	[1] MTOR 💬 Human immunodeficiency virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 71. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
72	Human papillomavirus infection 💬	[1] MTOR 💬 Human papillomavirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human papillomavirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 72. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
73	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Huntington disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 73. Huntington disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
74	Huntington disease 💬	[1] MTOR 💬 Huntington disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Huntington disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 74. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
75	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Hypertrophic cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Hypertrophic cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 75. Hypertrophic cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
76	Insulin resistance 💬	[1] MTOR 💬 Insulin resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 76. Insulin resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
77	Insulin secretion 💬	[2] ABCC8, KCNJ11 💬 Insulin secretion × Name Full Name ABCC8 ATP binding cassette subfamily C member 8 KCNJ11 potassium inwardly rectifying channel subfamily J member 11	Diazoxide 💬 Insulin secretion × Name Other Names Diazoxide Diazoxide (JAN/USP/INN) Hyperstat (TN) Proglycem (TN)	Diazoxide	[2] 13, 193 💬 77. Insulin secretion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 193 Prader-Willi syndrome;
78	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Insulin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Insulin secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 78. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
79	Insulin secretion 💬	[1] GLP1R 💬 Insulin secretion × Name Full Name GLP1R glucagon like peptide 1 receptor	Exenatide 💬 Insulin secretion × Name Other Names Exenatide Exenatide (JAN/USAN/INN) Byetta (TN) BYDUREON BYDUREON BCISE	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 79. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA-C;MSA-P; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
80	Insulin secretion 💬	[1] GLP1R 💬 Insulin secretion × Name Full Name GLP1R glucagon like peptide 1 receptor	Liraglutide 💬 Insulin secretion × Name Other Names Liraglutide Liraglutide (USAN/INN) Liraglutide (genetical recombination) (JAN) Victoza (TN) SAXENDA	Liraglutide	[3]  6 , 75, 193 💬 80. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 75 Cushing disease;Cushing; 193 Prader-Willi syndrome;
81	Insulin signaling pathway 💬	[1] MTOR 💬 Insulin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 81. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
82	JAK-STAT signaling pathway 💬	[1] MTOR 💬 JAK-STAT signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 JAK-STAT signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 82. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
83	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MTOR 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 83. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
84	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Long-term depression × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 84. Long-term depression × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
85	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Long-term potentiation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 85. Long-term potentiation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
86	Longevity regulating pathway 💬	[1] MTOR 💬 Longevity regulating pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 86. Longevity regulating pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
87	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬 Longevity regulating pathway - multiple species × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway - multiple species × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 87. Longevity regulating pathway - multiple species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
88	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 MAPK signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 MAPK signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 88. MAPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
89	Metabolic pathways 💬	[2] CA2, CA4 💬 Metabolic pathways × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Metabolic pathways × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 89. Metabolic pathways × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
90	Metabolic pathways 💬	[1] CYP19A1 💬 Metabolic pathways × Name Full Name CYP19A1 cytochrome P450 family 19 subfamily A member 1	Anastrozole 💬 Metabolic pathways × Name Other Names Anastrozole Anastrozole (JP18/USP/INN) Arimidex (TN)	Anastrozole	[3] 78, 86, 193 💬 90. Metabolic pathways × Disease ID Name 78 Hypopituitarism;Anterior pituitary hypothyroidism; 86 Pulmonary arterial hypertension;PAH; 193 Prader-Willi syndrome;
91	MicroRNAs in cancer 💬	[1] MTOR 💬 MicroRNAs in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 MicroRNAs in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 91. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
92	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Topiramate 💬 Morphine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 92. Morphine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
93	mTOR signaling pathway 💬	[1] MTOR 💬 mTOR signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 mTOR signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 93. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
94	Neuroactive ligand-receptor interaction 💬	[1] ADRA2A 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRA2A adrenoceptor alpha 2A	Guanfacine 💬 Neuroactive ligand-receptor interaction × Name Other Names Guanfacine Guanfacine (INN) Estulic (TN)	Guanfacine	[1] 193 💬 94. Neuroactive ligand-receptor interaction × Disease ID Name 193 Prader-Willi syndrome;
95	Neuroactive ligand-receptor interaction 💬	[1] ADRB1 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Neuroactive ligand-receptor interaction × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 95. Neuroactive ligand-receptor interaction × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
96	Neuroactive ligand-receptor interaction 💬	[1] CNR1 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1	Rimonabant 💬 Neuroactive ligand-receptor interaction × Name Other Names Rimonabant Rimonabant (JAN/USAN/INN) Acomplia (TN)	Rimonabant	[1] 193 💬 96. Neuroactive ligand-receptor interaction × Disease ID Name 193 Prader-Willi syndrome;
97	Neuroactive ligand-receptor interaction 💬	[2] CNR1, CNR2 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1 CNR2 cannabinoid receptor 2	Cannabidiol 💬 Neuroactive ligand-receptor interaction × Name Other Names Cannabidiol Cannabidiol (USAN/INN) Epidiolex (TN)	Cannabidiol	[20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 97. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
98	Neuroactive ligand-receptor interaction 💬	[25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Neuroactive ligand-receptor interaction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 98. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
99	Neuroactive ligand-receptor interaction 💬	[1] GLP1R 💬 Neuroactive ligand-receptor interaction × Name Full Name GLP1R glucagon like peptide 1 receptor	Exenatide 💬 Neuroactive ligand-receptor interaction × Name Other Names Exenatide Exenatide (JAN/USAN/INN) Byetta (TN) BYDUREON BYDUREON BCISE	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 99. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 17 Multiple system atrophy;MSA-C;MSA-P; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
100	Neuroactive ligand-receptor interaction 💬	[1] GLP1R 💬 Neuroactive ligand-receptor interaction × Name Full Name GLP1R glucagon like peptide 1 receptor	Liraglutide 💬 Neuroactive ligand-receptor interaction × Name Other Names Liraglutide Liraglutide (USAN/INN) Liraglutide (genetical recombination) (JAN) Victoza (TN) SAXENDA	Liraglutide	[3]  6 , 75, 193 💬 100. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 75 Cushing disease;Cushing; 193 Prader-Willi syndrome;
101	Neuroactive ligand-receptor interaction 💬	[1] HRH3 💬 Neuroactive ligand-receptor interaction × Name Full Name HRH3 histamine receptor H3	Pitolisant 💬 Neuroactive ligand-receptor interaction × Name Other Names Pitolisant Pitolisant (USAN/INN) Wakix (TN) Ozawade (TN)	Pitolisant	[3]  6 , 113, 193 💬 101. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 113 Muscular dystrophy; 193 Prader-Willi syndrome;
102	Neuroactive ligand-receptor interaction 💬	[1] OXTR 💬 Neuroactive ligand-receptor interaction × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 Neuroactive ligand-receptor interaction × Name Other Names Oxytocin Oxytocin (JP18/USP/INN) Oxytocin (TN) Pitocin (TN) Syntocinon (TN)	Oxytocin	[7]  6 , 72, 127, 168, 193, 206, 226 💬 102. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 127 Frontotemporal lobar degeneration; 168 Ehlers-Danlos syndrome;EDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
103	Neuroactive ligand-receptor interaction 💬	[1] SSTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name SSTR2 somatostatin receptor 2	Octreotide 💬 Neuroactive ligand-receptor interaction × Name Other Names Octreotide Octreotide (USAN/INN)	Octreotide	[7] 67, 75, 84, 85, 89, 193, 227 💬 103. Neuroactive ligand-receptor interaction × Disease ID Name 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 75 Cushing disease;Cushing; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 89 Lymphangioleiomyomatosis;LAM; 193 Prader-Willi syndrome; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
104	Neutrophil extracellular trap formation 💬	[1] MTOR 💬 Neutrophil extracellular trap formation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Neutrophil extracellular trap formation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 104. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
105	Nicotine addiction 💬	[20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Nicotine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 105. Nicotine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
106	Nitrogen metabolism 💬	[2] CA2, CA4 💬 Nitrogen metabolism × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Nitrogen metabolism × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 106. Nitrogen metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
107	Ovarian steroidogenesis 💬	[1] CYP19A1 💬 Ovarian steroidogenesis × Name Full Name CYP19A1 cytochrome P450 family 19 subfamily A member 1	Anastrozole 💬 Ovarian steroidogenesis × Name Other Names Anastrozole Anastrozole (JP18/USP/INN) Arimidex (TN)	Anastrozole	[3] 78, 86, 193 💬 107. Ovarian steroidogenesis × Disease ID Name 78 Hypopituitarism;Anterior pituitary hypothyroidism; 86 Pulmonary arterial hypertension;PAH; 193 Prader-Willi syndrome;
108	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Oxytocin signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Oxytocin signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 108. Oxytocin signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
109	Oxytocin signaling pathway 💬	[1] OXTR 💬 Oxytocin signaling pathway × Name Full Name OXTR oxytocin receptor	Oxytocin 💬 Oxytocin signaling pathway × Name Other Names Oxytocin Oxytocin (JP18/USP/INN) Oxytocin (TN) Pitocin (TN) Syntocinon (TN)	Oxytocin	[7]  6 , 72, 127, 168, 193, 206, 226 💬 109. Oxytocin signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 127 Frontotemporal lobar degeneration; 168 Ehlers-Danlos syndrome;EDS; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
110	Pancreatic cancer 💬	[1] MTOR 💬 Pancreatic cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pancreatic cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 110. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
111	Pancreatic secretion 💬	[1] CA2 💬 Pancreatic secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Pancreatic secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 111. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
112	Pathways in cancer 💬	[1] MTOR 💬 Pathways in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 112. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
113	Pathways of neurodegeneration - multiple diseases 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 113. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
114	Pathways of neurodegeneration - multiple diseases 💬	[1] MTOR 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 114. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
115	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MTOR 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 115. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
116	Phospholipase D signaling pathway 💬	[1] MTOR 💬 Phospholipase D signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Phospholipase D signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 116. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
117	PI3K-Akt signaling pathway 💬	[1] MTOR 💬 PI3K-Akt signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PI3K-Akt signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 117. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
118	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Prion disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Prion disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 118. Prion disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
119	Prostate cancer 💬	[1] MTOR 💬 Prostate cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Prostate cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 119. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
120	Proteoglycans in cancer 💬	[1] MTOR 💬 Proteoglycans in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Proteoglycans in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 120. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
121	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬 Proximal tubule bicarbonate reclamation × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Proximal tubule bicarbonate reclamation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 121. Proximal tubule bicarbonate reclamation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
122	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Rap1 signaling pathway × Name Other Names Cannabidiol Cannabidiol (USAN/INN) Epidiolex (TN)	Cannabidiol	[20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 122. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
123	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1	Rimonabant 💬 Rap1 signaling pathway × Name Other Names Rimonabant Rimonabant (JAN/USAN/INN) Acomplia (TN)	Rimonabant	[1] 193 💬 123. Rap1 signaling pathway × Disease ID Name 193 Prader-Willi syndrome;
124	Regulation of lipolysis in adipocytes 💬	[1] ADRB1 💬 Regulation of lipolysis in adipocytes × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Regulation of lipolysis in adipocytes × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 124. Regulation of lipolysis in adipocytes × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
125	Renin secretion 💬	[1] ADRB1 💬 Renin secretion × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Renin secretion × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 125. Renin secretion × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
126	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Renin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Renin secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 126. Renin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
127	Retrograde endocannabinoid signaling 💬	[24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Retrograde endocannabinoid signaling × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 127. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
128	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Retrograde endocannabinoid signaling × Name Other Names Cannabidiol Cannabidiol (USAN/INN) Epidiolex (TN)	Cannabidiol	[20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 128. Retrograde endocannabinoid signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
129	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1	Rimonabant 💬 Retrograde endocannabinoid signaling × Name Other Names Rimonabant Rimonabant (JAN/USAN/INN) Acomplia (TN)	Rimonabant	[1] 193 💬 129. Retrograde endocannabinoid signaling × Disease ID Name 193 Prader-Willi syndrome;
130	Salivary secretion 💬	[1] ADRB1 💬 Salivary secretion × Name Full Name ADRB1 adrenoceptor beta 1	Metoprolol 💬 Salivary secretion × Name Other Names Metoprolol Metoprolol (USAN/INN)	Metoprolol	[6] 17, 57, 58, 113, 193, 226 💬 130. Salivary secretion × Disease ID Name 17 Multiple system atrophy;MSA-C;MSA-P; 57 Idiopathic dilated cardiomyopathy; 58 Hypertrophic cardiomyopathy;HCM; 113 Muscular dystrophy; 193 Prader-Willi syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
131	Serotonergic synapse 💬	[7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬 Serotonergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3	Topiramate 💬 Serotonergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 131. Serotonergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
132	Shigellosis 💬	[1] MTOR 💬 Shigellosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Shigellosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 132. Shigellosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
133	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Spinocerebellar ataxia × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 133. Spinocerebellar ataxia × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
134	Spinocerebellar ataxia 💬	[1] MTOR 💬 Spinocerebellar ataxia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Spinocerebellar ataxia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 134. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
135	Steroid hormone biosynthesis 💬	[1] CYP19A1 💬 Steroid hormone biosynthesis × Name Full Name CYP19A1 cytochrome P450 family 19 subfamily A member 1	Anastrozole 💬 Steroid hormone biosynthesis × Name Other Names Anastrozole Anastrozole (JP18/USP/INN) Arimidex (TN)	Anastrozole	[3] 78, 86, 193 💬 135. Steroid hormone biosynthesis × Disease ID Name 78 Hypopituitarism;Anterior pituitary hypothyroidism; 86 Pulmonary arterial hypertension;PAH; 193 Prader-Willi syndrome;
136	Taste transduction 💬	[10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 SCN2A sodium voltage-gated channel alpha subunit 2 SCN3A sodium voltage-gated channel alpha subunit 3 SCN9A sodium voltage-gated channel alpha subunit 9	Topiramate 💬 Taste transduction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 136. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
137	Th17 cell differentiation 💬	[1] MTOR 💬 Th17 cell differentiation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Th17 cell differentiation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 137. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
138	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Thermogenesis × Name Other Names Cannabidiol Cannabidiol (USAN/INN) Epidiolex (TN)	Cannabidiol	[20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 138. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
139	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1	Rimonabant 💬 Thermogenesis × Name Other Names Rimonabant Rimonabant (JAN/USAN/INN) Acomplia (TN)	Rimonabant	[1] 193 💬 139. Thermogenesis × Disease ID Name 193 Prader-Willi syndrome;
140	Thermogenesis 💬	[1] MTOR 💬 Thermogenesis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thermogenesis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 140. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
141	Thyroid hormone signaling pathway 💬	[1] MTOR 💬 Thyroid hormone signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thyroid hormone signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 141. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
142	Tight junction 💬	[1] CACNA1D 💬 Tight junction × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Tight junction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 142. Tight junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
143	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Transcriptional misregulation in cancer × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 143. Transcriptional misregulation in cancer × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
144	Type II diabetes mellitus 💬	[2] ABCC8, KCNJ11 💬 Type II diabetes mellitus × Name Full Name ABCC8 ATP binding cassette subfamily C member 8 KCNJ11 potassium inwardly rectifying channel subfamily J member 11	Diazoxide 💬 Type II diabetes mellitus × Name Other Names Diazoxide Diazoxide (JAN/USP/INN) Hyperstat (TN) Proglycem (TN)	Diazoxide	[2] 13, 193 💬 144. Type II diabetes mellitus × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 193 Prader-Willi syndrome;
145	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬 Type II diabetes mellitus × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Type II diabetes mellitus × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 145. Type II diabetes mellitus × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
146	Type II diabetes mellitus 💬	[1] MTOR 💬 Type II diabetes mellitus × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Type II diabetes mellitus × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 146. Type II diabetes mellitus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
147	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Vascular smooth muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Vascular smooth muscle contraction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY	Topiramate	[6]  6 , 97, 140, 144, 156, 193 💬 147. Vascular smooth muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 97 Ulcerative colitis; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;

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