Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
3 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
4 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
5 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine [15]  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
6 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine hydrochloride 💬 Dexmedetomidine [15]  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
7 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
8 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
9 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 Sildenafil citrate 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
10 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 Sildenafil 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
11 Hormone signaling 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine [15]  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
12 Hormone signaling 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine hydrochloride 💬 Dexmedetomidine [15]  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
13 Hormone signaling 💬
 [2] THRA, THRB 💬 Liothyronine sodium 💬 Liothyronine [3] 13, 210, 212 💬
14 Hormone signaling 💬
 [2] THRA, THRB 💬 Liothyronine 💬 Liothyronine [3] 13, 210, 212 💬
15 Melanogenesis 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
16 Melanogenesis 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
17 Neuroactive ligand signaling 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine [15]  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
18 Neuroactive ligand signaling 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine hydrochloride 💬 Dexmedetomidine [15]  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
19 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine [15]  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
20 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine hydrochloride 💬 Dexmedetomidine [15]  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
21 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
22 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
23 Neuroactive ligand-receptor interaction 💬
 [2] THRA, THRB 💬 Liothyronine sodium 💬 Liothyronine [3] 13, 210, 212 💬
24 Neuroactive ligand-receptor interaction 💬
 [2] THRA, THRB 💬 Liothyronine 💬 Liothyronine [3] 13, 210, 212 💬
25 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
26 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
27 Purine metabolism 💬
 [1] PDE5A 💬 Sildenafil citrate 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
28 Purine metabolism 💬
 [1] PDE5A 💬 Sildenafil 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
29 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
30 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
31 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
32 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
33 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 Liothyronine sodium 💬 Liothyronine [3] 13, 210, 212 💬
34 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 Liothyronine 💬 Liothyronine [3] 13, 210, 212 💬
35 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
36 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

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