Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Alcoholism 💬	[1] DRD2 💬 Alcoholism × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Alcoholism × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 1. Alcoholism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
2	Alcoholism 💬	[1] DRD2 💬 Alcoholism × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Alcoholism × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 1. Alcoholism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
3	Bile secretion 💬	[1] CA2 💬 Bile secretion × Name Full Name CA2 carbonic anhydrase 2	Acetazolamide 💬 Bile secretion × Name Other Names Acetazolamide Acetazolamide (JP18/USP/INN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 3. Bile secretion × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
4	Bile secretion 💬	[1] CA2 💬 Bile secretion × Name Full Name CA2 carbonic anhydrase 2	Acetazolamide sodium 💬 Bile secretion × Name Other Names Acetazolamide sodium Acetazolamide sodium (JAN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 3. Bile secretion × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
5	Breast cancer 💬	[2] ESR1, PGR 💬 Breast cancer × Name Full Name ESR1 estrogen receptor 1 PGR progesterone receptor	Desogestrel 💬 Breast cancer × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 5. Breast cancer × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
6	cAMP signaling pathway 💬	[1] DRD2 💬 cAMP signaling pathway × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 cAMP signaling pathway × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 6. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
7	cAMP signaling pathway 💬	[1] DRD2 💬 cAMP signaling pathway × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 cAMP signaling pathway × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 6. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
8	Chemical carcinogenesis - receptor activation 💬	[2] ESR1, PGR 💬 Chemical carcinogenesis - receptor activation × Name Full Name ESR1 estrogen receptor 1 PGR progesterone receptor	Desogestrel 💬 Chemical carcinogenesis - receptor activation × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 8. Chemical carcinogenesis - receptor activation × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
9	Cocaine addiction 💬	[1] DRD2 💬 Cocaine addiction × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Cocaine addiction × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 9. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
10	Cocaine addiction 💬	[1] DRD2 💬 Cocaine addiction × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Cocaine addiction × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 9. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
11	Collecting duct acid secretion 💬	[1] CA2 💬 Collecting duct acid secretion × Name Full Name CA2 carbonic anhydrase 2	Acetazolamide 💬 Collecting duct acid secretion × Name Other Names Acetazolamide Acetazolamide (JP18/USP/INN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 11. Collecting duct acid secretion × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
12	Collecting duct acid secretion 💬	[1] CA2 💬 Collecting duct acid secretion × Name Full Name CA2 carbonic anhydrase 2	Acetazolamide sodium 💬 Collecting duct acid secretion × Name Other Names Acetazolamide sodium Acetazolamide sodium (JAN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 11. Collecting duct acid secretion × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
13	Dopaminergic synapse 💬	[1] DRD2 💬 Dopaminergic synapse × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Dopaminergic synapse × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 13. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
14	Dopaminergic synapse 💬	[1] DRD2 💬 Dopaminergic synapse × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Dopaminergic synapse × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 13. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
15	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬 Endocrine and other factor-regulated calcium reabsorption × Name Full Name ESR1 estrogen receptor 1	Desogestrel 💬 Endocrine and other factor-regulated calcium reabsorption × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 15. Endocrine and other factor-regulated calcium reabsorption × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
16	Estrogen signaling pathway 💬	[2] ESR1, PGR 💬 Estrogen signaling pathway × Name Full Name ESR1 estrogen receptor 1 PGR progesterone receptor	Desogestrel 💬 Estrogen signaling pathway × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 16. Estrogen signaling pathway × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
17	Gap junction 💬	[1] DRD2 💬 Gap junction × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Gap junction × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 17. Gap junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
18	Gap junction 💬	[1] DRD2 💬 Gap junction × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Gap junction × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 17. Gap junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
19	Gastric acid secretion 💬	[1] CA2 💬 Gastric acid secretion × Name Full Name CA2 carbonic anhydrase 2	Acetazolamide 💬 Gastric acid secretion × Name Other Names Acetazolamide Acetazolamide (JP18/USP/INN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 19. Gastric acid secretion × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
20	Gastric acid secretion 💬	[1] CA2 💬 Gastric acid secretion × Name Full Name CA2 carbonic anhydrase 2	Acetazolamide sodium 💬 Gastric acid secretion × Name Other Names Acetazolamide sodium Acetazolamide sodium (JAN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 19. Gastric acid secretion × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
21	Hormone signaling 💬	[1] DRD2 💬 Hormone signaling × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Hormone signaling × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 21. Hormone signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
22	Hormone signaling 💬	[1] DRD2 💬 Hormone signaling × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Hormone signaling × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 21. Hormone signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
23	Hormone signaling 💬	[1] ESR1 💬 Hormone signaling × Name Full Name ESR1 estrogen receptor 1	Desogestrel 💬 Hormone signaling × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 23. Hormone signaling × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
24	Neuroactive ligand signaling 💬	[1] DRD2 💬 Neuroactive ligand signaling × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Neuroactive ligand signaling × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 24. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
25	Neuroactive ligand signaling 💬	[1] DRD2 💬 Neuroactive ligand signaling × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Neuroactive ligand signaling × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 24. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
26	Neuroactive ligand signaling 💬	[1] SLC6A2 💬 Neuroactive ligand signaling × Name Full Name SLC6A2 solute carrier family 6 member 2	Atomoxetine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Atomoxetine hydrochloride Atomoxetine hydrochloride (JAN/USP) Tomoxetine hydrochloride Strattera (TN) STRATTERA ATOMOXETINE ATOMOXETINE HYDROCHLORIDE	Atomoxetine	[4]  6 ,  8 , 13, 230 💬 26. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
27	Neuroactive ligand signaling 💬	[1] SLC6A2 💬 Neuroactive ligand signaling × Name Full Name SLC6A2 solute carrier family 6 member 2	Atomoxetine 💬 Neuroactive ligand signaling × Name Other Names Atomoxetine Atomoxetine (USP/INN) Tomoxetine	Atomoxetine	[4]  6 ,  8 , 13, 230 💬 26. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
28	Neuroactive ligand-receptor interaction 💬	[1] DRD2 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Neuroactive ligand-receptor interaction × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 28. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
29	Neuroactive ligand-receptor interaction 💬	[1] DRD2 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Neuroactive ligand-receptor interaction × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 28. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
30	Nitrogen metabolism 💬	[13] CA, CA, CA, CA, CA, CA, CA, CA, CA, CA, CA, CA2, CA4 💬 Nitrogen metabolism × Name Full Name CA CA CA CA CA CA CA CA CA CA CA CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Acetazolamide sodium 💬 Nitrogen metabolism × Name Other Names Acetazolamide sodium Acetazolamide sodium (JAN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 30. Nitrogen metabolism × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
31	Nitrogen metabolism 💬	[13] CA, CA, CA, CA, CA, CA, CA, CA, CA, CA, CA, CA2, CA4 💬 Nitrogen metabolism × Name Full Name CA CA CA CA CA CA CA CA CA CA CA CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Acetazolamide 💬 Nitrogen metabolism × Name Other Names Acetazolamide Acetazolamide (JP18/USP/INN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 31. Nitrogen metabolism × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
32	Oocyte meiosis 💬	[1] PGR 💬 Oocyte meiosis × Name Full Name PGR progesterone receptor	Desogestrel 💬 Oocyte meiosis × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 32. Oocyte meiosis × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
33	Pancreatic secretion 💬	[1] CA2 💬 Pancreatic secretion × Name Full Name CA2 carbonic anhydrase 2	Acetazolamide 💬 Pancreatic secretion × Name Other Names Acetazolamide Acetazolamide (JP18/USP/INN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 33. Pancreatic secretion × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
34	Pancreatic secretion 💬	[1] CA2 💬 Pancreatic secretion × Name Full Name CA2 carbonic anhydrase 2	Acetazolamide sodium 💬 Pancreatic secretion × Name Other Names Acetazolamide sodium Acetazolamide sodium (JAN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 33. Pancreatic secretion × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
35	Parkinson disease 💬	[1] DRD2 💬 Parkinson disease × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Parkinson disease × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 35. Parkinson disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
36	Parkinson disease 💬	[1] DRD2 💬 Parkinson disease × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Parkinson disease × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 35. Parkinson disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
37	Pathways in cancer 💬	[1] ESR1 💬 Pathways in cancer × Name Full Name ESR1 estrogen receptor 1	Desogestrel 💬 Pathways in cancer × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 37. Pathways in cancer × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
38	Progesterone-mediated oocyte maturation 💬	[1] PGR 💬 Progesterone-mediated oocyte maturation × Name Full Name PGR progesterone receptor	Desogestrel 💬 Progesterone-mediated oocyte maturation × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 38. Progesterone-mediated oocyte maturation × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
39	Prolactin signaling pathway 💬	[1] ESR1 💬 Prolactin signaling pathway × Name Full Name ESR1 estrogen receptor 1	Desogestrel 💬 Prolactin signaling pathway × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 39. Prolactin signaling pathway × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
40	Proteoglycans in cancer 💬	[1] ESR1 💬 Proteoglycans in cancer × Name Full Name ESR1 estrogen receptor 1	Desogestrel 💬 Proteoglycans in cancer × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 40. Proteoglycans in cancer × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
41	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬 Proximal tubule bicarbonate reclamation × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Acetazolamide 💬 Proximal tubule bicarbonate reclamation × Name Other Names Acetazolamide Acetazolamide (JP18/USP/INN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 41. Proximal tubule bicarbonate reclamation × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
42	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬 Proximal tubule bicarbonate reclamation × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Acetazolamide sodium 💬 Proximal tubule bicarbonate reclamation × Name Other Names Acetazolamide sodium Acetazolamide sodium (JAN) Diamox (TN)	Acetazolamide	[6] 13, 90, 115, 155, 225, 230 💬 41. Proximal tubule bicarbonate reclamation × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 115 Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis; 155 Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
43	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 dopamine receptor D2	Domperidone 💬 Rap1 signaling pathway × Name Other Names Domperidone Domperidone (JP18/USAN/INN) Motilium (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 43. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
44	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 dopamine receptor D2	Domperidone maleate 💬 Rap1 signaling pathway × Name Other Names Domperidone maleate Domperidone maleate Domperidone (TN)	Domperidone	[5]  6 , 13, 17, 51, 230 💬 43. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
45	Synaptic vesicle cycle 💬	[1] SLC6A2 💬 Synaptic vesicle cycle × Name Full Name SLC6A2 solute carrier family 6 member 2	Atomoxetine hydrochloride 💬 Synaptic vesicle cycle × Name Other Names Atomoxetine hydrochloride Atomoxetine hydrochloride (JAN/USP) Tomoxetine hydrochloride Strattera (TN) STRATTERA ATOMOXETINE ATOMOXETINE HYDROCHLORIDE	Atomoxetine	[4]  6 ,  8 , 13, 230 💬 45. Synaptic vesicle cycle × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
46	Synaptic vesicle cycle 💬	[1] SLC6A2 💬 Synaptic vesicle cycle × Name Full Name SLC6A2 solute carrier family 6 member 2	Atomoxetine 💬 Synaptic vesicle cycle × Name Other Names Atomoxetine Atomoxetine (USP/INN) Tomoxetine	Atomoxetine	[4]  6 ,  8 , 13, 230 💬 45. Synaptic vesicle cycle × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;
47	Thyroid hormone signaling pathway 💬	[1] ESR1 💬 Thyroid hormone signaling pathway × Name Full Name ESR1 estrogen receptor 1	Desogestrel 💬 Thyroid hormone signaling pathway × Name Other Names Desogestrel Desogestrel (USAN/INN)	Desogestrel	[1] 230 💬 47. Thyroid hormone signaling pathway × Disease ID Name 230 Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

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