Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adherens junction 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Adherens junction × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 1. Adherens junction × Disease ID Name 232 Carney complex;CNC;
2	AMPK signaling pathway 💬	[1] IGF1R 💬 AMPK signaling pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 AMPK signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 2. AMPK signaling pathway × Disease ID Name 232 Carney complex;CNC;
3	Autophagy - animal 💬	[1] IGF1R 💬 Autophagy - animal × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Autophagy - animal × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 3. Autophagy - animal × Disease ID Name 232 Carney complex;CNC;
4	Breast cancer 💬	[1] IGF1R 💬 Breast cancer × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Breast cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 4. Breast cancer × Disease ID Name 232 Carney complex;CNC;
5	Endocytosis 💬	[1] IGF1R 💬 Endocytosis × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Endocytosis × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 5. Endocytosis × Disease ID Name 232 Carney complex;CNC;
6	Focal adhesion 💬	[1] IGF1R 💬 Focal adhesion × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Focal adhesion × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 6. Focal adhesion × Disease ID Name 232 Carney complex;CNC;
7	FoxO signaling pathway 💬	[1] IGF1R 💬 FoxO signaling pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 FoxO signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 7. FoxO signaling pathway × Disease ID Name 232 Carney complex;CNC;
8	Glioma 💬	[1] IGF1R 💬 Glioma × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Glioma × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 8. Glioma × Disease ID Name 232 Carney complex;CNC;
9	Hepatocellular carcinoma 💬	[1] IGF1R 💬 Hepatocellular carcinoma × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Hepatocellular carcinoma × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 9. Hepatocellular carcinoma × Disease ID Name 232 Carney complex;CNC;
10	HIF-1 signaling pathway 💬	[1] IGF1R 💬 HIF-1 signaling pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 HIF-1 signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 10. HIF-1 signaling pathway × Disease ID Name 232 Carney complex;CNC;
11	Hormone signaling 💬	[1] IGF1R 💬 Hormone signaling × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Hormone signaling × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 11. Hormone signaling × Disease ID Name 232 Carney complex;CNC;
12	Long-term depression 💬	[1] IGF1R 💬 Long-term depression × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Long-term depression × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 12. Long-term depression × Disease ID Name 232 Carney complex;CNC;
13	Longevity regulating pathway 💬	[1] IGF1R 💬 Longevity regulating pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Longevity regulating pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 13. Longevity regulating pathway × Disease ID Name 232 Carney complex;CNC;
14	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬 Longevity regulating pathway - multiple species × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Longevity regulating pathway - multiple species × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 14. Longevity regulating pathway - multiple species × Disease ID Name 232 Carney complex;CNC;
15	MAPK signaling pathway 💬	[1] IGF1R 💬 MAPK signaling pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 MAPK signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 15. MAPK signaling pathway × Disease ID Name 232 Carney complex;CNC;
16	Melanoma 💬	[1] IGF1R 💬 Melanoma × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Melanoma × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 16. Melanoma × Disease ID Name 232 Carney complex;CNC;
17	mTOR signaling pathway 💬	[1] IGF1R 💬 mTOR signaling pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 mTOR signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 17. mTOR signaling pathway × Disease ID Name 232 Carney complex;CNC;
18	Oocyte meiosis 💬	[1] IGF1R 💬 Oocyte meiosis × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Oocyte meiosis × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 18. Oocyte meiosis × Disease ID Name 232 Carney complex;CNC;
19	Ovarian steroidogenesis 💬	[1] IGF1R 💬 Ovarian steroidogenesis × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Ovarian steroidogenesis × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 19. Ovarian steroidogenesis × Disease ID Name 232 Carney complex;CNC;
20	Pathways in cancer 💬	[1] IGF1R 💬 Pathways in cancer × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Pathways in cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 20. Pathways in cancer × Disease ID Name 232 Carney complex;CNC;
21	PI3K-Akt signaling pathway 💬	[1] IGF1R 💬 PI3K-Akt signaling pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 PI3K-Akt signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 21. PI3K-Akt signaling pathway × Disease ID Name 232 Carney complex;CNC;
22	Progesterone-mediated oocyte maturation 💬	[1] IGF1R 💬 Progesterone-mediated oocyte maturation × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 22. Progesterone-mediated oocyte maturation × Disease ID Name 232 Carney complex;CNC;
23	Prostate cancer 💬	[1] IGF1R 💬 Prostate cancer × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Prostate cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 23. Prostate cancer × Disease ID Name 232 Carney complex;CNC;
24	Proteoglycans in cancer 💬	[1] IGF1R 💬 Proteoglycans in cancer × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Proteoglycans in cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 24. Proteoglycans in cancer × Disease ID Name 232 Carney complex;CNC;
25	Rap1 signaling pathway 💬	[1] IGF1R 💬 Rap1 signaling pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Rap1 signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 25. Rap1 signaling pathway × Disease ID Name 232 Carney complex;CNC;
26	Ras signaling pathway 💬	[1] IGF1R 💬 Ras signaling pathway × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Ras signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 26. Ras signaling pathway × Disease ID Name 232 Carney complex;CNC;
27	Signaling pathways regulating pluripotency of stem cells 💬	[1] IGF1R 💬 Signaling pathways regulating pluripotency of stem cells × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 27. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 232 Carney complex;CNC;
28	Transcriptional misregulation in cancer 💬	[1] IGF1R 💬 Transcriptional misregulation in cancer × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Transcriptional misregulation in cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 28. Transcriptional misregulation in cancer × Disease ID Name 232 Carney complex;CNC;

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