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Target Gene/Pathway Pathway / Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

cAMP signaling pathway 💬

[2] GIPR, GLP1R 💬

Tirzepatide 💬

[5] 67, 96, 97, 193, 233 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
193	Prader-Willi syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;

2

cAMP signaling pathway 💬

[1] GLP1R 💬

[5] 6 , 17, 78, 193, 233 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
193	Prader-Willi syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;

3

Hormone signaling 💬

[2] GIPR, GLP1R 💬

Tirzepatide 💬

[5] 67, 96, 97, 193, 233 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
193	Prader-Willi syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;

4

Hormone signaling 💬

[1] GLP1R 💬

[5] 6 , 17, 78, 193, 233 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
193	Prader-Willi syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;

5

Insulin secretion 💬

[1] GLP1R 💬

[5] 6 , 17, 78, 193, 233 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
193	Prader-Willi syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;

6

Insulin secretion 💬

[1] GLP1R 💬

Tirzepatide 💬

[5] 67, 96, 97, 193, 233 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
193	Prader-Willi syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;

7

Neuroactive ligand-receptor interaction 💬

[2] GIPR, GLP1R 💬

Tirzepatide 💬

[5] 67, 96, 97, 193, 233 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
193	Prader-Willi syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;

8

Neuroactive ligand-receptor interaction 💬

[1] GLP1R 💬

[5] 6 , 17, 78, 193, 233 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
193	Prader-Willi syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;

9

Protein digestion and absorption 💬

[1] DPP4 💬

Sitagliptin phosphate 💬

[5] 6 , 75, 77, 233, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
75	Cushing disease;Cushing syndrome;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
299	Cystic fibrosis;CF;

10

Protein digestion and absorption 💬

[1] DPP4 💬

Sitagliptin 💬

[5] 6 , 75, 77, 233, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
75	Cushing disease;Cushing syndrome;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
299	Cystic fibrosis;CF;

11

Protein digestion and absorption 💬

[1] DPP4 💬

Sitagliptin phosphate 💬

[5] 6 , 75, 77, 233, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
75	Cushing disease;Cushing syndrome;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
299	Cystic fibrosis;CF;

12

Virion - Hepatitis viruses 💬

[1] DPP4 💬

Sitagliptin phosphate 💬

[5] 6 , 75, 77, 233, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
75	Cushing disease;Cushing syndrome;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
299	Cystic fibrosis;CF;

13

Virion - Hepatitis viruses 💬

[1] DPP4 💬

Sitagliptin 💬

[5] 6 , 75, 77, 233, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
75	Cushing disease;Cushing syndrome;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
299	Cystic fibrosis;CF;

14

Virion - Hepatitis viruses 💬

[1] DPP4 💬

Sitagliptin phosphate 💬

[5] 6 , 75, 77, 233, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
75	Cushing disease;Cushing syndrome;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
299	Cystic fibrosis;CF;