Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholism 💬
 [1] ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
2 Alcoholism 💬
 [1] ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
3 Alcoholism 💬
 [1] ADORA2B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
4 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
5 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
6 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
7 Apelin signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
8 Apelin signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
9 Apelin signaling pathway 💬
 [1] PDE3B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
10 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1, PDE1, PDE1 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
11 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1, PDE1, PDE1 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
12 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1, PDE1, PDE1 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
13 cAMP signaling pathway 💬
 [8] ADORA1, PDE10, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
14 cAMP signaling pathway 💬
 [8] ADORA1, PDE10, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
15 cAMP signaling pathway 💬
 [8] ADORA1, PDE10, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
16 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
17 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
18 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
19 Cortisol synthesis and secretion 💬
 [2] PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
20 Cortisol synthesis and secretion 💬
 [2] PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
21 Cortisol synthesis and secretion 💬
 [2] PDE8, PDE8 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
22 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
23 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
24 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
25 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
26 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
27 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
28 Insulin signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
29 Insulin signaling pathway 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
30 Insulin signaling pathway 💬
 [1] PDE3B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
31 Morphine addiction 💬
 [17] ADORA1, PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
32 Morphine addiction 💬
 [17] ADORA1, PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
33 Morphine addiction 💬
 [17] ADORA1, PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
34 Neuroactive ligand signaling 💬
 [2] ADORA1, ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
35 Neuroactive ligand signaling 💬
 [2] ADORA1, ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
36 Neuroactive ligand signaling 💬
 [2] ADORA1, ADORA2B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
37 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
38 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
39 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
40 Olfactory transduction 💬
 [4] PDE1, PDE1, PDE1, PDE2A 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
41 Olfactory transduction 💬
 [4] PDE1, PDE1, PDE1, PDE2A 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
42 Olfactory transduction 💬
 [4] PDE1, PDE1, PDE1, PDE2A 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
43 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
44 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
45 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
46 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
47 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
48 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
49 Purine metabolism 💬
 [16] PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
50 Purine metabolism 💬
 [16] PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
51 Purine metabolism 💬
 [16] PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
52 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
53 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
54 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
55 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
56 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
57 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
58 Renin secretion 💬
 [6] ADORA1, PDE1, PDE1, PDE1, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
59 Renin secretion 💬
 [6] ADORA1, PDE1, PDE1, PDE1, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
60 Renin secretion 💬
 [6] ADORA1, PDE1, PDE1, PDE1, PDE3A, PDE3B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
61 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
62 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
63 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
64 Taste transduction 💬
 [3] PDE1, PDE1, PDE1 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
65 Taste transduction 💬
 [3] PDE1, PDE1, PDE1 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
66 Taste transduction 💬
 [3] PDE1, PDE1, PDE1 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
67 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
68 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
69 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬

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