Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Alcoholism 💬	[1] ADORA2B 💬 Alcoholism × Name Full Name ADORA2B adenosine receptor A2b	Theophylline 💬 Alcoholism × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 1. Alcoholism × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
2	Alcoholism 💬	[1] ADORA2B 💬 Alcoholism × Name Full Name ADORA2B adenosine receptor A2b	Theophylline 💬 Alcoholism × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 1. Alcoholism × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
3	Alcoholism 💬	[1] ADORA2B 💬 Alcoholism × Name Full Name ADORA2B adenosine receptor A2b	Theophylline sodium glycinate 💬 Alcoholism × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 1. Alcoholism × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
4	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬 Aldosterone synthesis and secretion × Name Full Name PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3	Theophylline 💬 Aldosterone synthesis and secretion × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 4. Aldosterone synthesis and secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
5	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬 Aldosterone synthesis and secretion × Name Full Name PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3	Theophylline 💬 Aldosterone synthesis and secretion × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 4. Aldosterone synthesis and secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
6	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬 Aldosterone synthesis and secretion × Name Full Name PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3	Theophylline sodium glycinate 💬 Aldosterone synthesis and secretion × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 4. Aldosterone synthesis and secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
7	Apelin signaling pathway 💬	[1] PDE3B 💬 Apelin signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Apelin signaling pathway × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 7. Apelin signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
8	Apelin signaling pathway 💬	[1] PDE3B 💬 Apelin signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Apelin signaling pathway × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 7. Apelin signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
9	Apelin signaling pathway 💬	[1] PDE3B 💬 Apelin signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline sodium glycinate 💬 Apelin signaling pathway × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 7. Apelin signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
10	Calcium signaling pathway 💬	[4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 Calcium signaling pathway × Name Full Name ADORA2B adenosine receptor A2b PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2	Theophylline 💬 Calcium signaling pathway × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 10. Calcium signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
11	Calcium signaling pathway 💬	[4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 Calcium signaling pathway × Name Full Name ADORA2B adenosine receptor A2b PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2	Theophylline 💬 Calcium signaling pathway × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 10. Calcium signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
12	Calcium signaling pathway 💬	[4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 Calcium signaling pathway × Name Full Name ADORA2B adenosine receptor A2b PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2	Theophylline sodium glycinate 💬 Calcium signaling pathway × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 10. Calcium signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
13	cAMP signaling pathway 💬	[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 cAMP signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4	Theophylline 💬 cAMP signaling pathway × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 13. cAMP signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
14	cAMP signaling pathway 💬	[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 cAMP signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4	Theophylline 💬 cAMP signaling pathway × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 13. cAMP signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
15	cAMP signaling pathway 💬	[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 cAMP signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4	Theophylline sodium glycinate 💬 cAMP signaling pathway × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 13. cAMP signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
16	cGMP-PKG signaling pathway 💬	[4] ADORA1, PDE2A, PDE3A, PDE3B 💬 cGMP-PKG signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 cGMP-PKG signaling pathway × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 16. cGMP-PKG signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
17	cGMP-PKG signaling pathway 💬	[4] ADORA1, PDE2A, PDE3A, PDE3B 💬 cGMP-PKG signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 cGMP-PKG signaling pathway × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 16. cGMP-PKG signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
18	cGMP-PKG signaling pathway 💬	[4] ADORA1, PDE2A, PDE3A, PDE3B 💬 cGMP-PKG signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline sodium glycinate 💬 cGMP-PKG signaling pathway × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 16. cGMP-PKG signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
19	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬 Cortisol synthesis and secretion × Name Full Name PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline 💬 Cortisol synthesis and secretion × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 19. Cortisol synthesis and secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
20	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬 Cortisol synthesis and secretion × Name Full Name PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline 💬 Cortisol synthesis and secretion × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 19. Cortisol synthesis and secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
21	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬 Cortisol synthesis and secretion × Name Full Name PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline sodium glycinate 💬 Cortisol synthesis and secretion × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 19. Cortisol synthesis and secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
22	Cushing syndrome 💬	[3] PDE11A, PDE8A, PDE8B 💬 Cushing syndrome × Name Full Name PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline 💬 Cushing syndrome × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 22. Cushing syndrome × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
23	Cushing syndrome 💬	[3] PDE11A, PDE8A, PDE8B 💬 Cushing syndrome × Name Full Name PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline 💬 Cushing syndrome × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 22. Cushing syndrome × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
24	Cushing syndrome 💬	[3] PDE11A, PDE8A, PDE8B 💬 Cushing syndrome × Name Full Name PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline sodium glycinate 💬 Cushing syndrome × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 22. Cushing syndrome × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
25	Cytokine-cytokine receptor interaction 💬	[1] GHR 💬 Cytokine-cytokine receptor interaction × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somatropin 💬 Cytokine-cytokine receptor interaction × Name Other Names Somatropin Human growth hormone Asellacrin Humatrope Nutropin Omnitrope GENOTROPIN NORDITROPIN SEROSTIM ZOMACTON	Somatotropin	[3]  3 , 65, 236 💬 25. Cytokine-cytokine receptor interaction × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 236 Pseudohypoparathyroidism;PHP;
26	Glucagon signaling pathway 💬	[1] PDE3B 💬 Glucagon signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Glucagon signaling pathway × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 26. Glucagon signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
27	Glucagon signaling pathway 💬	[1] PDE3B 💬 Glucagon signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Glucagon signaling pathway × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 26. Glucagon signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
28	Glucagon signaling pathway 💬	[1] PDE3B 💬 Glucagon signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline sodium glycinate 💬 Glucagon signaling pathway × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 26. Glucagon signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
29	Growth hormone synthesis, secretion and action 💬	[1] GHR 💬 Growth hormone synthesis, secretion and action × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somatropin 💬 Growth hormone synthesis, secretion and action × Name Other Names Somatropin Human growth hormone Asellacrin Humatrope Nutropin Omnitrope GENOTROPIN NORDITROPIN SEROSTIM ZOMACTON	Somatotropin	[3]  3 , 65, 236 💬 29. Growth hormone synthesis, secretion and action × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 236 Pseudohypoparathyroidism;PHP;
30	Hormone signaling 💬	[1] GHR 💬 Hormone signaling × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somatropin 💬 Hormone signaling × Name Other Names Somatropin Human growth hormone Asellacrin Humatrope Nutropin Omnitrope GENOTROPIN NORDITROPIN SEROSTIM ZOMACTON	Somatotropin	[3]  3 , 65, 236 💬 30. Hormone signaling × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 236 Pseudohypoparathyroidism;PHP;
31	Hormone signaling 💬	[1] MC4R 💬 Hormone signaling × Name Full Name MC4R melanocortin receptor 4	Setmelanotide 💬 Hormone signaling × Name Other Names Setmelanotide Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 31. Hormone signaling × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
32	Hormone signaling 💬	[1] MC4R 💬 Hormone signaling × Name Full Name MC4R melanocortin receptor 4	Setmelanotide acetate 💬 Hormone signaling × Name Other Names Setmelanotide acetate Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 31. Hormone signaling × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
33	Insulin signaling pathway 💬	[1] PDE3B 💬 Insulin signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Insulin signaling pathway × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 33. Insulin signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
34	Insulin signaling pathway 💬	[1] PDE3B 💬 Insulin signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Insulin signaling pathway × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 33. Insulin signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
35	Insulin signaling pathway 💬	[1] PDE3B 💬 Insulin signaling pathway × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline sodium glycinate 💬 Insulin signaling pathway × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 33. Insulin signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
36	JAK-STAT signaling pathway 💬	[1] GHR 💬 JAK-STAT signaling pathway × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somatropin 💬 JAK-STAT signaling pathway × Name Other Names Somatropin Human growth hormone Asellacrin Humatrope Nutropin Omnitrope GENOTROPIN NORDITROPIN SEROSTIM ZOMACTON	Somatotropin	[3]  3 , 65, 236 💬 36. JAK-STAT signaling pathway × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 236 Pseudohypoparathyroidism;PHP;
37	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Morphine addiction × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4 PDE7A high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform c PDE7B 3',5'-cyclic-AMP phosphodiesterase 7B PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline 💬 Morphine addiction × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 37. Morphine addiction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
38	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Morphine addiction × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4 PDE7A high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform c PDE7B 3',5'-cyclic-AMP phosphodiesterase 7B PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline 💬 Morphine addiction × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 37. Morphine addiction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
39	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Morphine addiction × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4 PDE7A high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform c PDE7B 3',5'-cyclic-AMP phosphodiesterase 7B PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline sodium glycinate 💬 Morphine addiction × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 37. Morphine addiction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
40	Neuroactive ligand signaling 💬	[2] ADORA1, ADORA2B 💬 Neuroactive ligand signaling × Name Full Name ADORA1 adenosine receptor A1 isoform 1 ADORA2B adenosine receptor A2b	Theophylline 💬 Neuroactive ligand signaling × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 40. Neuroactive ligand signaling × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
41	Neuroactive ligand signaling 💬	[2] ADORA1, ADORA2B 💬 Neuroactive ligand signaling × Name Full Name ADORA1 adenosine receptor A1 isoform 1 ADORA2B adenosine receptor A2b	Theophylline 💬 Neuroactive ligand signaling × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 40. Neuroactive ligand signaling × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
42	Neuroactive ligand signaling 💬	[2] ADORA1, ADORA2B 💬 Neuroactive ligand signaling × Name Full Name ADORA1 adenosine receptor A1 isoform 1 ADORA2B adenosine receptor A2b	Theophylline sodium glycinate 💬 Neuroactive ligand signaling × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 40. Neuroactive ligand signaling × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
43	Neuroactive ligand signaling 💬	[1] MC4R 💬 Neuroactive ligand signaling × Name Full Name MC4R melanocortin receptor 4	Setmelanotide 💬 Neuroactive ligand signaling × Name Other Names Setmelanotide Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 43. Neuroactive ligand signaling × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
44	Neuroactive ligand signaling 💬	[1] MC4R 💬 Neuroactive ligand signaling × Name Full Name MC4R melanocortin receptor 4	Setmelanotide acetate 💬 Neuroactive ligand signaling × Name Other Names Setmelanotide acetate Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 43. Neuroactive ligand signaling × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
45	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬 Neuroactive ligand-receptor interaction × Name Full Name ADORA1 adenosine receptor A1 isoform 1 ADORA2B adenosine receptor A2b	Theophylline 💬 Neuroactive ligand-receptor interaction × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 45. Neuroactive ligand-receptor interaction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
46	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬 Neuroactive ligand-receptor interaction × Name Full Name ADORA1 adenosine receptor A1 isoform 1 ADORA2B adenosine receptor A2b	Theophylline 💬 Neuroactive ligand-receptor interaction × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 45. Neuroactive ligand-receptor interaction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
47	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬 Neuroactive ligand-receptor interaction × Name Full Name ADORA1 adenosine receptor A1 isoform 1 ADORA2B adenosine receptor A2b	Theophylline sodium glycinate 💬 Neuroactive ligand-receptor interaction × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 45. Neuroactive ligand-receptor interaction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
48	Neuroactive ligand-receptor interaction 💬	[1] GHR 💬 Neuroactive ligand-receptor interaction × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somatropin 💬 Neuroactive ligand-receptor interaction × Name Other Names Somatropin Human growth hormone Asellacrin Humatrope Nutropin Omnitrope GENOTROPIN NORDITROPIN SEROSTIM ZOMACTON	Somatotropin	[3]  3 , 65, 236 💬 48. Neuroactive ligand-receptor interaction × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 236 Pseudohypoparathyroidism;PHP;
49	Neuroactive ligand-receptor interaction 💬	[1] MC4R 💬 Neuroactive ligand-receptor interaction × Name Full Name MC4R melanocortin receptor 4	Setmelanotide 💬 Neuroactive ligand-receptor interaction × Name Other Names Setmelanotide Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 49. Neuroactive ligand-receptor interaction × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
50	Neuroactive ligand-receptor interaction 💬	[1] MC4R 💬 Neuroactive ligand-receptor interaction × Name Full Name MC4R melanocortin receptor 4	Setmelanotide acetate 💬 Neuroactive ligand-receptor interaction × Name Other Names Setmelanotide acetate Imcivree	Setmelanotide	[5] 134, 193, 202, 236, 265 💬 49. Neuroactive ligand-receptor interaction × Disease ID Name 134 Septo-optic dysplasia;De Morsier syndrome; 193 Prader-Willi syndrome; 202 Smith-Magenis syndrome; 236 Pseudohypoparathyroidism;PHP; 265 Lipodystrophy;
51	Olfactory transduction 💬	[4] PDE1A, PDE1B, PDE1C, PDE2A 💬 Olfactory transduction × Name Full Name PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3	Theophylline 💬 Olfactory transduction × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 51. Olfactory transduction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
52	Olfactory transduction 💬	[4] PDE1A, PDE1B, PDE1C, PDE2A 💬 Olfactory transduction × Name Full Name PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3	Theophylline 💬 Olfactory transduction × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 51. Olfactory transduction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
53	Olfactory transduction 💬	[4] PDE1A, PDE1B, PDE1C, PDE2A 💬 Olfactory transduction × Name Full Name PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3	Theophylline sodium glycinate 💬 Olfactory transduction × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 51. Olfactory transduction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
54	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬 Parathyroid hormone synthesis, secretion and action × Name Full Name PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4	Theophylline 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 54. Parathyroid hormone synthesis, secretion and action × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
55	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬 Parathyroid hormone synthesis, secretion and action × Name Full Name PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4	Theophylline 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 54. Parathyroid hormone synthesis, secretion and action × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
56	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬 Parathyroid hormone synthesis, secretion and action × Name Full Name PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4	Theophylline sodium glycinate 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 54. Parathyroid hormone synthesis, secretion and action × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
57	PI3K-Akt signaling pathway 💬	[1] GHR 💬 PI3K-Akt signaling pathway × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somatropin 💬 PI3K-Akt signaling pathway × Name Other Names Somatropin Human growth hormone Asellacrin Humatrope Nutropin Omnitrope GENOTROPIN NORDITROPIN SEROSTIM ZOMACTON	Somatotropin	[3]  3 , 65, 236 💬 57. PI3K-Akt signaling pathway × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 236 Pseudohypoparathyroidism;PHP;
58	Progesterone-mediated oocyte maturation 💬	[1] PDE3B 💬 Progesterone-mediated oocyte maturation × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Progesterone-mediated oocyte maturation × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 58. Progesterone-mediated oocyte maturation × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
59	Progesterone-mediated oocyte maturation 💬	[1] PDE3B 💬 Progesterone-mediated oocyte maturation × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Progesterone-mediated oocyte maturation × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 58. Progesterone-mediated oocyte maturation × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
60	Progesterone-mediated oocyte maturation 💬	[1] PDE3B 💬 Progesterone-mediated oocyte maturation × Name Full Name PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline sodium glycinate 💬 Progesterone-mediated oocyte maturation × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 58. Progesterone-mediated oocyte maturation × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
61	Purine metabolism 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Purine metabolism × Name Full Name PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4 PDE7A high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform c PDE7B 3',5'-cyclic-AMP phosphodiesterase 7B PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline 💬 Purine metabolism × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 61. Purine metabolism × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
62	Purine metabolism 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Purine metabolism × Name Full Name PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4 PDE7A high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform c PDE7B 3',5'-cyclic-AMP phosphodiesterase 7B PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline 💬 Purine metabolism × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 61. Purine metabolism × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
63	Purine metabolism 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Purine metabolism × Name Full Name PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3 PDE11A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 PDE4A 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 PDE4B 3',5'-cyclic-AMP phosphodiesterase 4B isoform 1 PDE4C 3',5'-cyclic-AMP phosphodiesterase 4C isoform 1 PDE4D 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4 PDE7A high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform c PDE7B 3',5'-cyclic-AMP phosphodiesterase 7B PDE8A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1 PDE8B high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1	Theophylline sodium glycinate 💬 Purine metabolism × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 61. Purine metabolism × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
64	Rap1 signaling pathway 💬	[1] ADORA2B 💬 Rap1 signaling pathway × Name Full Name ADORA2B adenosine receptor A2b	Theophylline 💬 Rap1 signaling pathway × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 64. Rap1 signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
65	Rap1 signaling pathway 💬	[1] ADORA2B 💬 Rap1 signaling pathway × Name Full Name ADORA2B adenosine receptor A2b	Theophylline 💬 Rap1 signaling pathway × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 64. Rap1 signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
66	Rap1 signaling pathway 💬	[1] ADORA2B 💬 Rap1 signaling pathway × Name Full Name ADORA2B adenosine receptor A2b	Theophylline sodium glycinate 💬 Rap1 signaling pathway × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 64. Rap1 signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
67	Regulation of lipolysis in adipocytes 💬	[2] ADORA1, PDE3B 💬 Regulation of lipolysis in adipocytes × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Regulation of lipolysis in adipocytes × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 67. Regulation of lipolysis in adipocytes × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
68	Regulation of lipolysis in adipocytes 💬	[2] ADORA1, PDE3B 💬 Regulation of lipolysis in adipocytes × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Regulation of lipolysis in adipocytes × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 67. Regulation of lipolysis in adipocytes × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
69	Regulation of lipolysis in adipocytes 💬	[2] ADORA1, PDE3B 💬 Regulation of lipolysis in adipocytes × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline sodium glycinate 💬 Regulation of lipolysis in adipocytes × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 67. Regulation of lipolysis in adipocytes × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
70	Renin secretion 💬	[6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Renin secretion × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Renin secretion × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 70. Renin secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
71	Renin secretion 💬	[6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Renin secretion × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline 💬 Renin secretion × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 70. Renin secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
72	Renin secretion 💬	[6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Renin secretion × Name Full Name ADORA1 adenosine receptor A1 isoform 1 PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2	Theophylline sodium glycinate 💬 Renin secretion × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 70. Renin secretion × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
73	Sphingolipid signaling pathway 💬	[1] ADORA1 💬 Sphingolipid signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1	Theophylline 💬 Sphingolipid signaling pathway × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 73. Sphingolipid signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
74	Sphingolipid signaling pathway 💬	[1] ADORA1 💬 Sphingolipid signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1	Theophylline 💬 Sphingolipid signaling pathway × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 73. Sphingolipid signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
75	Sphingolipid signaling pathway 💬	[1] ADORA1 💬 Sphingolipid signaling pathway × Name Full Name ADORA1 adenosine receptor A1 isoform 1	Theophylline sodium glycinate 💬 Sphingolipid signaling pathway × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 73. Sphingolipid signaling pathway × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
76	Taste transduction 💬	[3] PDE1A, PDE1B, PDE1C 💬 Taste transduction × Name Full Name PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2	Theophylline 💬 Taste transduction × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 76. Taste transduction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
77	Taste transduction 💬	[3] PDE1A, PDE1B, PDE1C 💬 Taste transduction × Name Full Name PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2	Theophylline 💬 Taste transduction × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 76. Taste transduction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
78	Taste transduction 💬	[3] PDE1A, PDE1B, PDE1C 💬 Taste transduction × Name Full Name PDE1A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 PDE1B dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 PDE1C dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2	Theophylline sodium glycinate 💬 Taste transduction × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 76. Taste transduction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
79	Vascular smooth muscle contraction 💬	[1] ADORA2B 💬 Vascular smooth muscle contraction × Name Full Name ADORA2B adenosine receptor A2b	Theophylline 💬 Vascular smooth muscle contraction × Name Other Names Theophylline Elixophyllin Quibron-t Theo-24 Theodur G Theolair Uniphyl	Theophylline	[2] 236, 299 💬 79. Vascular smooth muscle contraction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
80	Vascular smooth muscle contraction 💬	[1] ADORA2B 💬 Vascular smooth muscle contraction × Name Full Name ADORA2B adenosine receptor A2b	Theophylline 💬 Vascular smooth muscle contraction × Name Other Names Theophylline Theophylline monohydrate Accurbron	Theophylline	[2] 236, 299 💬 79. Vascular smooth muscle contraction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;
81	Vascular smooth muscle contraction 💬	[1] ADORA2B 💬 Vascular smooth muscle contraction × Name Full Name ADORA2B adenosine receptor A2b	Theophylline sodium glycinate 💬 Vascular smooth muscle contraction × Name Other Names Theophylline sodium glycinate Asbron	Theophylline	[2] 236, 299 💬 79. Vascular smooth muscle contraction × Disease ID Name 236 Pseudohypoparathyroidism;PHP; 299 Cystic fibrosis;CF;

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