Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MTOR 💬 Acute myeloid leukemia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Acute myeloid leukemia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 1. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
2	Adipocytokine signaling pathway 💬	[1] MTOR 💬 Adipocytokine signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Adipocytokine signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 2. Adipocytokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
3	Alcoholism 💬	[1] DRD2 💬 Alcoholism × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine maleate 💬 Alcoholism × Name Other Names Trifluoperazine maleate Trifluoperazine maleate (JAN) Trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 3. Alcoholism × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
4	Alcoholism 💬	[1] DRD2 💬 Alcoholism × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine 💬 Alcoholism × Name Other Names Trifluoperazine Trifluoperazine (INN) Apo-trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 3. Alcoholism × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
5	Alzheimer disease 💬	[1] MTOR 💬 Alzheimer disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Alzheimer disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 5. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
6	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Alzheimer disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Alzheimer disease × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 6. Alzheimer disease × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
7	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Alzheimer disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Alzheimer disease × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 7. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
8	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Alzheimer disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Alzheimer disease × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 7. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
9	Alzheimer disease 💬	[1] PSMB5 💬 Alzheimer disease × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Alzheimer disease × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 9. Alzheimer disease × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
10	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amphetamine addiction × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Amphetamine addiction × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 10. Amphetamine addiction × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
11	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amphetamine addiction × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Amphetamine addiction × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 11. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
12	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amphetamine addiction × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Amphetamine addiction × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 11. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
13	AMPK signaling pathway 💬	[1] MTOR 💬 AMPK signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 AMPK signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 13. AMPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
14	Amyotrophic lateral sclerosis 💬	[1] MTOR 💬 Amyotrophic lateral sclerosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 14. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
15	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amyotrophic lateral sclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Amyotrophic lateral sclerosis × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 15. Amyotrophic lateral sclerosis × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
16	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amyotrophic lateral sclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 16. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
17	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amyotrophic lateral sclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 16. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
18	Amyotrophic lateral sclerosis 💬	[1] PSMB5 💬 Amyotrophic lateral sclerosis × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Amyotrophic lateral sclerosis × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 18. Amyotrophic lateral sclerosis × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
19	Antifolate resistance 💬	[2] DHFR, DHFR2 💬 Antifolate resistance × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 Antifolate resistance × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 19. Antifolate resistance × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
20	Apelin signaling pathway 💬	[1] MTOR 💬 Apelin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Apelin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 20. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
21	Autophagy - animal 💬	[1] MTOR 💬 Autophagy - animal × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - animal × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 21. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
22	Autophagy - other 💬	[1] MTOR 💬 Autophagy - other × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - other × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 22. Autophagy - other × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
23	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Axon guidance × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Axon guidance × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 23. Axon guidance × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
24	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Axon guidance × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Axon guidance × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 24. Axon guidance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
25	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Axon guidance × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Axon guidance × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 24. Axon guidance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
26	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 B cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 B cell receptor signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 26. B cell receptor signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
27	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 B cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 B cell receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 27. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
28	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 B cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 B cell receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 27. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
29	Biosynthesis of cofactors 💬	[2] DHFR, DHFR2 💬 Biosynthesis of cofactors × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 Biosynthesis of cofactors × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 29. Biosynthesis of cofactors × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
30	Breast cancer 💬	[1] MTOR 💬 Breast cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Breast cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 30. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
31	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 C-type lectin receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 C-type lectin receptor signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 31. C-type lectin receptor signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
32	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 C-type lectin receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 C-type lectin receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 32. C-type lectin receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
33	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 C-type lectin receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 C-type lectin receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 32. C-type lectin receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
34	Calcium signaling pathway 💬	[1] CD38 💬 Calcium signaling pathway × Name Full Name CD38 CD38 molecule	Isatuximab 💬 Calcium signaling pathway × Name Other Names Isatuximab Isatuximab (USAN/INN) Isatuximab (genetical recombination) (JAN) Isatuximab-irfc Sarclisa (TN)	Isatuximab	[3] 28, 61, 283 💬 34. Calcium signaling pathway × Disease ID Name 28 Systemic amyloidosis;AL amyloidosis; 61 Autoimmune hemolytic anemia;AIHA; 283 Acquired pure red cell aplasia;Pure red cell aplasia;
35	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Calcium signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Calcium signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 35. Calcium signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
36	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Calcium signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Calcium signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 36. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
37	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Calcium signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Calcium signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 36. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
38	cAMP signaling pathway 💬	[1] DRD2 💬 cAMP signaling pathway × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine maleate 💬 cAMP signaling pathway × Name Other Names Trifluoperazine maleate Trifluoperazine maleate (JAN) Trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 38. cAMP signaling pathway × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
39	cAMP signaling pathway 💬	[1] DRD2 💬 cAMP signaling pathway × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine 💬 cAMP signaling pathway × Name Other Names Trifluoperazine Trifluoperazine (INN) Apo-trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 38. cAMP signaling pathway × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
40	Cellular senescence 💬	[1] MTOR 💬 Cellular senescence × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Cellular senescence × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 40. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
41	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cellular senescence × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Cellular senescence × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 41. Cellular senescence × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
42	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cellular senescence × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Cellular senescence × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 42. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
43	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cellular senescence × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Cellular senescence × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 42. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
44	Central carbon metabolism in cancer 💬	[1] MTOR 💬 Central carbon metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Central carbon metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 44. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
45	cGMP-PKG signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 cGMP-PKG signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 cGMP-PKG signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 45. cGMP-PKG signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
46	cGMP-PKG signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 cGMP-PKG signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 cGMP-PKG signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 46. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
47	cGMP-PKG signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 cGMP-PKG signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 cGMP-PKG signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 46. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
48	Chemical carcinogenesis - receptor activation 💬	[1] MTOR 💬 Chemical carcinogenesis - receptor activation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Chemical carcinogenesis - receptor activation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 48. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
49	Choline metabolism in cancer 💬	[1] MTOR 💬 Choline metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Choline metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 49. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
50	Cocaine addiction 💬	[1] DRD2 💬 Cocaine addiction × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine maleate 💬 Cocaine addiction × Name Other Names Trifluoperazine maleate Trifluoperazine maleate (JAN) Trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 50. Cocaine addiction × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
51	Cocaine addiction 💬	[1] DRD2 💬 Cocaine addiction × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine 💬 Cocaine addiction × Name Other Names Trifluoperazine Trifluoperazine (INN) Apo-trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 50. Cocaine addiction × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
52	Colorectal cancer 💬	[1] MTOR 💬 Colorectal cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Colorectal cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 52. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
53	Cytokine-cytokine receptor interaction 💬	[1] CSF3R 💬 Cytokine-cytokine receptor interaction × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 Cytokine-cytokine receptor interaction × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 53. Cytokine-cytokine receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
54	Cytokine-cytokine receptor interaction 💬	[1] EPOR 💬 Cytokine-cytokine receptor interaction × Name Full Name EPOR erythropoietin receptor	Peginesatide 💬 Cytokine-cytokine receptor interaction × Name Other Names Peginesatide Peginesatide (USAN/INN)	Peginesatide	[1] 283 💬 54. Cytokine-cytokine receptor interaction × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia;
55	Cytokine-cytokine receptor interaction 💬	[1] IL2RA 💬 Cytokine-cytokine receptor interaction × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Cytokine-cytokine receptor interaction × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 55. Cytokine-cytokine receptor interaction × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
56	Diabetic cardiomyopathy 💬	[1] MTOR 💬 Diabetic cardiomyopathy × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Diabetic cardiomyopathy × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 56. Diabetic cardiomyopathy × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
57	Dopaminergic synapse 💬	[1] DRD2 💬 Dopaminergic synapse × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine maleate 💬 Dopaminergic synapse × Name Other Names Trifluoperazine maleate Trifluoperazine maleate (JAN) Trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 57. Dopaminergic synapse × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
58	Dopaminergic synapse 💬	[1] DRD2 💬 Dopaminergic synapse × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine 💬 Dopaminergic synapse × Name Other Names Trifluoperazine Trifluoperazine (INN) Apo-trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 57. Dopaminergic synapse × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
59	Dopaminergic synapse 💬	[3] PPP3CA, PPP3CB, PPP3CC 💬 Dopaminergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma	Cyclosporine 💬 Dopaminergic synapse × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 59. Dopaminergic synapse × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
60	Dopaminergic synapse 💬	[3] PPP3CA, PPP3CB, PPP3CC 💬 Dopaminergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma	Tacrolimus 💬 Dopaminergic synapse × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 60. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
61	Dopaminergic synapse 💬	[3] PPP3CA, PPP3CB, PPP3CC 💬 Dopaminergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma	Tacrolimus 💬 Dopaminergic synapse × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 60. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
62	Drug metabolism - other enzymes 💬	[2] IMPDH1, IMPDH2 💬 Drug metabolism - other enzymes × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolate mofetil 💬 Drug metabolism - other enzymes × Name Other Names Mycophenolate mofetil Mycophenolate mofetil (JAN/USP) Cellcept (TN)	Mycophenolate mofetil	[34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 62. Drug metabolism - other enzymes × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
63	Drug metabolism - other enzymes 💬	[2] IMPDH1, IMPDH2 💬 Drug metabolism - other enzymes × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolic acid 💬 Drug metabolism - other enzymes × Name Other Names Mycophenolic acid Mycophenolic acid (USAN/INN) Mycophenolic acid (TN)	Mycophenolic acid	[36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 63. Drug metabolism - other enzymes × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
64	Drug metabolism - other enzymes 💬	[1] RRM1 💬 Drug metabolism - other enzymes × Name Full Name RRM1 ribonucleotide reductase catalytic subunit M1	Fludarabine 💬 Drug metabolism - other enzymes × Name Other Names Fludarabine Fludarabine (INN) Fluradosa (TN)	Fludarabine	[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬 64. Drug metabolism - other enzymes × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 164 Oculocutaneous albinism; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis;
65	EGFR tyrosine kinase inhibitor resistance 💬	[1] MTOR 💬 EGFR tyrosine kinase inhibitor resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 65. EGFR tyrosine kinase inhibitor resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
66	Endocrine resistance 💬	[1] MTOR 💬 Endocrine resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Endocrine resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 66. Endocrine resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
67	Endocytosis 💬	[1] IL2RA 💬 Endocytosis × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Endocytosis × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 67. Endocytosis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
68	ErbB signaling pathway 💬	[1] MTOR 💬 ErbB signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 ErbB signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 68. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
69	Folate biosynthesis 💬	[2] DHFR, DHFR2 💬 Folate biosynthesis × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 Folate biosynthesis × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 69. Folate biosynthesis × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
70	Gap junction 💬	[1] DRD2 💬 Gap junction × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine maleate 💬 Gap junction × Name Other Names Trifluoperazine maleate Trifluoperazine maleate (JAN) Trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 70. Gap junction × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
71	Gap junction 💬	[1] DRD2 💬 Gap junction × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine 💬 Gap junction × Name Other Names Trifluoperazine Trifluoperazine (INN) Apo-trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 70. Gap junction × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
72	Gastric cancer 💬	[1] MTOR 💬 Gastric cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Gastric cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 72. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
73	Glioma 💬	[1] MTOR 💬 Glioma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Glioma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 73. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
74	Glucagon signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glucagon signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Glucagon signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 74. Glucagon signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
75	Glucagon signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glucagon signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Glucagon signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 75. Glucagon signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
76	Glucagon signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glucagon signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Glucagon signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 75. Glucagon signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
77	Glutamatergic synapse 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glutamatergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Glutamatergic synapse × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 77. Glutamatergic synapse × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
78	Glutamatergic synapse 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glutamatergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Glutamatergic synapse × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 78. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
79	Glutamatergic synapse 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glutamatergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Glutamatergic synapse × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 78. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
80	Glutathione metabolism 💬	[1] RRM1 💬 Glutathione metabolism × Name Full Name RRM1 ribonucleotide reductase catalytic subunit M1	Fludarabine 💬 Glutathione metabolism × Name Other Names Fludarabine Fludarabine (INN) Fluradosa (TN)	Fludarabine	[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬 80. Glutathione metabolism × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 164 Oculocutaneous albinism; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis;
81	Growth hormone synthesis, secretion and action 💬	[1] MTOR 💬 Growth hormone synthesis, secretion and action × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Growth hormone synthesis, secretion and action × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 81. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
82	Hematopoietic cell lineage 💬	[1] CD38 💬 Hematopoietic cell lineage × Name Full Name CD38 CD38 molecule	Isatuximab 💬 Hematopoietic cell lineage × Name Other Names Isatuximab Isatuximab (USAN/INN) Isatuximab (genetical recombination) (JAN) Isatuximab-irfc Sarclisa (TN)	Isatuximab	[3] 28, 61, 283 💬 82. Hematopoietic cell lineage × Disease ID Name 28 Systemic amyloidosis;AL amyloidosis; 61 Autoimmune hemolytic anemia;AIHA; 283 Acquired pure red cell aplasia;Pure red cell aplasia;
83	Hematopoietic cell lineage 💬	[1] CSF3R 💬 Hematopoietic cell lineage × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 Hematopoietic cell lineage × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 83. Hematopoietic cell lineage × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
84	Hematopoietic cell lineage 💬	[1] EPOR 💬 Hematopoietic cell lineage × Name Full Name EPOR erythropoietin receptor	Peginesatide 💬 Hematopoietic cell lineage × Name Other Names Peginesatide Peginesatide (USAN/INN)	Peginesatide	[1] 283 💬 84. Hematopoietic cell lineage × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia;
85	Hematopoietic cell lineage 💬	[1] IL2RA 💬 Hematopoietic cell lineage × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Hematopoietic cell lineage × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 85. Hematopoietic cell lineage × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
86	Hematopoietic cell lineage 💬	[1] MS4A1 💬 Hematopoietic cell lineage × Name Full Name MS4A1 membrane spanning 4-domains A1	Rituximab 💬 Hematopoietic cell lineage × Name Other Names Rituximab Rituximab (USAN/INN) Rituximab (genetical recombination) (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 1] (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 2] (JAN) Rituximab-abbs Rituximab-pvvr Rituximab-arrx Rituxan (TN) Riabni (TN) Truximab (TN) RUXIENCE TRUXIMA	Rituximab	[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬 86. Hematopoietic cell lineage × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 19 Lysosomal storage disease;Lysosomal disease; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 36 Epidermolysis bullosa; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 52 Mixed connective tissue disease; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 83 Addison disease;Primary chronic adrenocortical insufficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 94 Primary sclerosing cholangitis;PSC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 162 Pemphigoid; 222 Primary nephrotic syndrome; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 296 Biliary atresia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
87	Hepatocellular carcinoma 💬	[1] MTOR 💬 Hepatocellular carcinoma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Hepatocellular carcinoma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 87. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
88	Herpes simplex virus 1 infection 💬	[1] MTOR 💬 Herpes simplex virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Herpes simplex virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 88. Herpes simplex virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
89	HIF-1 signaling pathway 💬	[1] MTOR 💬 HIF-1 signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 HIF-1 signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 89. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
90	Human cytomegalovirus infection 💬	[1] MTOR 💬 Human cytomegalovirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human cytomegalovirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 90. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
91	Human cytomegalovirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human cytomegalovirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Human cytomegalovirus infection × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 91. Human cytomegalovirus infection × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
92	Human cytomegalovirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human cytomegalovirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human cytomegalovirus infection × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 92. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
93	Human cytomegalovirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human cytomegalovirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human cytomegalovirus infection × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 92. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
94	Human immunodeficiency virus 1 infection 💬	[1] MTOR 💬 Human immunodeficiency virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 94. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
95	Human immunodeficiency virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human immunodeficiency virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Human immunodeficiency virus 1 infection × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 95. Human immunodeficiency virus 1 infection × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
96	Human immunodeficiency virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human immunodeficiency virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 96. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
97	Human immunodeficiency virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human immunodeficiency virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 96. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
98	Human papillomavirus infection 💬	[1] MTOR 💬 Human papillomavirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human papillomavirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 98. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
99	Human T-cell leukemia virus 1 infection 💬	[1] IL2RA 💬 Human T-cell leukemia virus 1 infection × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Human T-cell leukemia virus 1 infection × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 99. Human T-cell leukemia virus 1 infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
100	Human T-cell leukemia virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human T-cell leukemia virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Human T-cell leukemia virus 1 infection × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 100. Human T-cell leukemia virus 1 infection × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
101	Human T-cell leukemia virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human T-cell leukemia virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human T-cell leukemia virus 1 infection × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 101. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
102	Human T-cell leukemia virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human T-cell leukemia virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Human T-cell leukemia virus 1 infection × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 101. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
103	Huntington disease 💬	[1] MTOR 💬 Huntington disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Huntington disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 103. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
104	Huntington disease 💬	[1] PSMB5 💬 Huntington disease × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Huntington disease × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 104. Huntington disease × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
105	Insulin resistance 💬	[1] MTOR 💬 Insulin resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 105. Insulin resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
106	Insulin signaling pathway 💬	[1] MTOR 💬 Insulin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 106. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
107	JAK-STAT signaling pathway 💬	[1] CSF3R 💬 JAK-STAT signaling pathway × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 JAK-STAT signaling pathway × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 107. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
108	JAK-STAT signaling pathway 💬	[1] EPOR 💬 JAK-STAT signaling pathway × Name Full Name EPOR erythropoietin receptor	Peginesatide 💬 JAK-STAT signaling pathway × Name Other Names Peginesatide Peginesatide (USAN/INN)	Peginesatide	[1] 283 💬 108. JAK-STAT signaling pathway × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia;
109	JAK-STAT signaling pathway 💬	[1] IL2RA 💬 JAK-STAT signaling pathway × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 JAK-STAT signaling pathway × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 109. JAK-STAT signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
110	JAK-STAT signaling pathway 💬	[1] MTOR 💬 JAK-STAT signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 JAK-STAT signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 110. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
111	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MTOR 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 111. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
112	Kaposi sarcoma-associated herpesvirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 112. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
113	Kaposi sarcoma-associated herpesvirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 113. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
114	Kaposi sarcoma-associated herpesvirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 113. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
115	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Lipid and atherosclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Lipid and atherosclerosis × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 115. Lipid and atherosclerosis × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
116	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Lipid and atherosclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Lipid and atherosclerosis × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 116. Lipid and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
117	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Lipid and atherosclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Lipid and atherosclerosis × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 116. Lipid and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
118	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Long-term potentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Long-term potentiation × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 118. Long-term potentiation × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
119	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Long-term potentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Long-term potentiation × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 119. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
120	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Long-term potentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Long-term potentiation × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 119. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
121	Longevity regulating pathway 💬	[1] MTOR 💬 Longevity regulating pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 121. Longevity regulating pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
122	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬 Longevity regulating pathway - multiple species × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway - multiple species × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 122. Longevity regulating pathway - multiple species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
123	MAPK signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 MAPK signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 MAPK signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 123. MAPK signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
124	MAPK signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 MAPK signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 MAPK signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 124. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
125	MAPK signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 MAPK signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 MAPK signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 124. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
126	Measles 💬	[1] IL2RA 💬 Measles × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Measles × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 126. Measles × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
127	Metabolic pathways 💬	[1] CD38 💬 Metabolic pathways × Name Full Name CD38 CD38 molecule	Isatuximab 💬 Metabolic pathways × Name Other Names Isatuximab Isatuximab (USAN/INN) Isatuximab (genetical recombination) (JAN) Isatuximab-irfc Sarclisa (TN)	Isatuximab	[3] 28, 61, 283 💬 127. Metabolic pathways × Disease ID Name 28 Systemic amyloidosis;AL amyloidosis; 61 Autoimmune hemolytic anemia;AIHA; 283 Acquired pure red cell aplasia;Pure red cell aplasia;
128	Metabolic pathways 💬	[2] DHFR, DHFR2 💬 Metabolic pathways × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 Metabolic pathways × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 128. Metabolic pathways × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
129	Metabolic pathways 💬	[2] IMPDH1, IMPDH2 💬 Metabolic pathways × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolate mofetil 💬 Metabolic pathways × Name Other Names Mycophenolate mofetil Mycophenolate mofetil (JAN/USP) Cellcept (TN)	Mycophenolate mofetil	[34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 129. Metabolic pathways × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
130	Metabolic pathways 💬	[2] IMPDH1, IMPDH2 💬 Metabolic pathways × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolic acid 💬 Metabolic pathways × Name Other Names Mycophenolic acid Mycophenolic acid (USAN/INN) Mycophenolic acid (TN)	Mycophenolic acid	[36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 130. Metabolic pathways × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
131	Metabolic pathways 💬	[1] RRM1 💬 Metabolic pathways × Name Full Name RRM1 ribonucleotide reductase catalytic subunit M1	Fludarabine 💬 Metabolic pathways × Name Other Names Fludarabine Fludarabine (INN) Fluradosa (TN)	Fludarabine	[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬 131. Metabolic pathways × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 164 Oculocutaneous albinism; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis;
132	MicroRNAs in cancer 💬	[1] MTOR 💬 MicroRNAs in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 MicroRNAs in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 132. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
133	mTOR signaling pathway 💬	[1] MTOR 💬 mTOR signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 mTOR signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 133. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
134	Natural killer cell mediated cytotoxicity 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Natural killer cell mediated cytotoxicity × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Natural killer cell mediated cytotoxicity × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 134. Natural killer cell mediated cytotoxicity × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
135	Natural killer cell mediated cytotoxicity 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Natural killer cell mediated cytotoxicity × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Natural killer cell mediated cytotoxicity × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 135. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
136	Natural killer cell mediated cytotoxicity 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Natural killer cell mediated cytotoxicity × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Natural killer cell mediated cytotoxicity × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 135. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
137	Neuroactive ligand-receptor interaction 💬	[1] DRD2 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine maleate 💬 Neuroactive ligand-receptor interaction × Name Other Names Trifluoperazine maleate Trifluoperazine maleate (JAN) Trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 137. Neuroactive ligand-receptor interaction × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
138	Neuroactive ligand-receptor interaction 💬	[1] DRD2 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine 💬 Neuroactive ligand-receptor interaction × Name Other Names Trifluoperazine Trifluoperazine (INN) Apo-trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 137. Neuroactive ligand-receptor interaction × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
139	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Dexamethasone 💬 Neuroactive ligand-receptor interaction × Name Other Names Dexamethasone Dexamethasone (JP18/USP/INN) Decadron (TN) Maxidex (TN) DEXTENZA DEXYCU HEMADY OZURDEX DEXAMETHASONE 6-DAY DEXAMETHASONE INTENSOL TAPERDEX 12-DAY TAPERDEX 6-DAY TAPERDEX 7-DAY	Dexamethasone	[22] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299 💬 139. Neuroactive ligand-receptor interaction × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 16 Crow-Fukase syndrome;POEMS syndrome; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 70 Spinal stenosis;Extensive spinal canal stenosis; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 84 Sarcoidosis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 162 Pemphigoid; 222 Primary nephrotic syndrome; 235 Hypoparathyroidism;Accessory thyroid hypergasia disease; 257 Hepatic glycogenosis;Liver glycogenosis;Hepatic glycogen storage disease;Liver glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 296 Biliary atresia; 299 Cystic fibrosis;
140	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Methylprednisolone 💬 Neuroactive ligand-receptor interaction × Name Other Names Methylprednisolone Methylprednisolone (JP18/USP/INN) Medrol (TN) METHYLPRED DP	Methylprednisolone	[46]  2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 140. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 18 Spinocerebellar degeneration;SCD; 19 Lysosomal storage disease;Lysosomal disease; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 83 Addison disease;Primary chronic adrenocortical insufficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 145 West syndrome;Infantile spasm; 162 Pemphigoid; 164 Oculocutaneous albinism; 211 Hypoplastic left heart syndrome;HLHS; 220 Rapidly progressive glomerulonephritis; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia;
141	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Prednisone 💬 Neuroactive ligand-receptor interaction × Name Other Names Prednisone Prednisone (USP) Prednisone monohydrate Deltasone (TN) Meticorten (TN) Rayos (TN)	Prednisone	[45]  2 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬 141. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 19 Lysosomal storage disease;Lysosomal disease; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 299 Cystic fibrosis; 300 IgG4-related disease; 307 Canavan disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
142	Neutrophil extracellular trap formation 💬	[1] MTOR 💬 Neutrophil extracellular trap formation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Neutrophil extracellular trap formation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 142. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
143	Nicotinate and nicotinamide metabolism 💬	[1] CD38 💬 Nicotinate and nicotinamide metabolism × Name Full Name CD38 CD38 molecule	Isatuximab 💬 Nicotinate and nicotinamide metabolism × Name Other Names Isatuximab Isatuximab (USAN/INN) Isatuximab (genetical recombination) (JAN) Isatuximab-irfc Sarclisa (TN)	Isatuximab	[3] 28, 61, 283 💬 143. Nicotinate and nicotinamide metabolism × Disease ID Name 28 Systemic amyloidosis;AL amyloidosis; 61 Autoimmune hemolytic anemia;AIHA; 283 Acquired pure red cell aplasia;Pure red cell aplasia;
144	Nucleotide metabolism 💬	[2] IMPDH1, IMPDH2 💬 Nucleotide metabolism × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolate mofetil 💬 Nucleotide metabolism × Name Other Names Mycophenolate mofetil Mycophenolate mofetil (JAN/USP) Cellcept (TN)	Mycophenolate mofetil	[34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 144. Nucleotide metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
145	Nucleotide metabolism 💬	[2] IMPDH1, IMPDH2 💬 Nucleotide metabolism × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolic acid 💬 Nucleotide metabolism × Name Other Names Mycophenolic acid Mycophenolic acid (USAN/INN) Mycophenolic acid (TN)	Mycophenolic acid	[36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 145. Nucleotide metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
146	Nucleotide metabolism 💬	[1] RRM1 💬 Nucleotide metabolism × Name Full Name RRM1 ribonucleotide reductase catalytic subunit M1	Fludarabine 💬 Nucleotide metabolism × Name Other Names Fludarabine Fludarabine (INN) Fluradosa (TN)	Fludarabine	[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬 146. Nucleotide metabolism × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 164 Oculocutaneous albinism; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis;
147	One carbon pool by folate 💬	[2] DHFR, DHFR2 💬 One carbon pool by folate × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 One carbon pool by folate × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 147. One carbon pool by folate × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
148	Oocyte meiosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oocyte meiosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Oocyte meiosis × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 148. Oocyte meiosis × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
149	Oocyte meiosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oocyte meiosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Oocyte meiosis × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 149. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
150	Oocyte meiosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oocyte meiosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Oocyte meiosis × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 149. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
151	Osteoclast differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Osteoclast differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Osteoclast differentiation × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 151. Osteoclast differentiation × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
152	Osteoclast differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Osteoclast differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Osteoclast differentiation × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 152. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
153	Osteoclast differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Osteoclast differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Osteoclast differentiation × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 152. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
154	Oxytocin signaling pathway 💬	[1] CD38 💬 Oxytocin signaling pathway × Name Full Name CD38 CD38 molecule	Isatuximab 💬 Oxytocin signaling pathway × Name Other Names Isatuximab Isatuximab (USAN/INN) Isatuximab (genetical recombination) (JAN) Isatuximab-irfc Sarclisa (TN)	Isatuximab	[3] 28, 61, 283 💬 154. Oxytocin signaling pathway × Disease ID Name 28 Systemic amyloidosis;AL amyloidosis; 61 Autoimmune hemolytic anemia;AIHA; 283 Acquired pure red cell aplasia;Pure red cell aplasia;
155	Oxytocin signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oxytocin signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Oxytocin signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 155. Oxytocin signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
156	Oxytocin signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oxytocin signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Oxytocin signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 156. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
157	Oxytocin signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oxytocin signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Oxytocin signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 156. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
158	Pancreatic cancer 💬	[1] MTOR 💬 Pancreatic cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pancreatic cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 158. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
159	Pancreatic secretion 💬	[1] CD38 💬 Pancreatic secretion × Name Full Name CD38 CD38 molecule	Isatuximab 💬 Pancreatic secretion × Name Other Names Isatuximab Isatuximab (USAN/INN) Isatuximab (genetical recombination) (JAN) Isatuximab-irfc Sarclisa (TN)	Isatuximab	[3] 28, 61, 283 💬 159. Pancreatic secretion × Disease ID Name 28 Systemic amyloidosis;AL amyloidosis; 61 Autoimmune hemolytic anemia;AIHA; 283 Acquired pure red cell aplasia;Pure red cell aplasia;
160	Parkinson disease 💬	[1] DRD2 💬 Parkinson disease × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine maleate 💬 Parkinson disease × Name Other Names Trifluoperazine maleate Trifluoperazine maleate (JAN) Trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 160. Parkinson disease × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
161	Parkinson disease 💬	[1] DRD2 💬 Parkinson disease × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine 💬 Parkinson disease × Name Other Names Trifluoperazine Trifluoperazine (INN) Apo-trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 160. Parkinson disease × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
162	Parkinson disease 💬	[1] PSMB5 💬 Parkinson disease × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Parkinson disease × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 162. Parkinson disease × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
163	Pathways in cancer 💬	[1] CSF3R 💬 Pathways in cancer × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 Pathways in cancer × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 163. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
164	Pathways in cancer 💬	[1] EPOR 💬 Pathways in cancer × Name Full Name EPOR erythropoietin receptor	Peginesatide 💬 Pathways in cancer × Name Other Names Peginesatide Peginesatide (USAN/INN)	Peginesatide	[1] 283 💬 164. Pathways in cancer × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia;
165	Pathways in cancer 💬	[1] IL2RA 💬 Pathways in cancer × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Pathways in cancer × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 165. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
166	Pathways in cancer 💬	[1] MTOR 💬 Pathways in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 166. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
167	Pathways of neurodegeneration - multiple diseases 💬	[1] MTOR 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 167. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
168	Pathways of neurodegeneration - multiple diseases 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 168. Pathways of neurodegeneration - multiple diseases × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
169	Pathways of neurodegeneration - multiple diseases 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 169. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
170	Pathways of neurodegeneration - multiple diseases 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 169. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
171	Pathways of neurodegeneration - multiple diseases 💬	[1] PSMB5 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 171. Pathways of neurodegeneration - multiple diseases × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
172	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MTOR 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 172. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
173	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 173. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
174	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 174. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
175	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 174. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
176	Phospholipase D signaling pathway 💬	[1] MTOR 💬 Phospholipase D signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Phospholipase D signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 176. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
177	PI3K-Akt signaling pathway 💬	[1] CSF3R 💬 PI3K-Akt signaling pathway × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 PI3K-Akt signaling pathway × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 177. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
178	PI3K-Akt signaling pathway 💬	[1] EPOR 💬 PI3K-Akt signaling pathway × Name Full Name EPOR erythropoietin receptor	Peginesatide 💬 PI3K-Akt signaling pathway × Name Other Names Peginesatide Peginesatide (USAN/INN)	Peginesatide	[1] 283 💬 178. PI3K-Akt signaling pathway × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia;
179	PI3K-Akt signaling pathway 💬	[1] IL2RA 💬 PI3K-Akt signaling pathway × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 PI3K-Akt signaling pathway × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 179. PI3K-Akt signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
180	PI3K-Akt signaling pathway 💬	[1] MTOR 💬 PI3K-Akt signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PI3K-Akt signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 180. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
181	Prion disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Prion disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Prion disease × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 181. Prion disease × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
182	Prion disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Prion disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Prion disease × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 182. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
183	Prion disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Prion disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Prion disease × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 182. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
184	Prion disease 💬	[1] PSMB5 💬 Prion disease × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Prion disease × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 184. Prion disease × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
185	Prostate cancer 💬	[1] MTOR 💬 Prostate cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Prostate cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 185. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
186	Proteasome 💬	[1] PSMB5 💬 Proteasome × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Proteasome × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 186. Proteasome × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
187	Proteoglycans in cancer 💬	[1] MTOR 💬 Proteoglycans in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Proteoglycans in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 187. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
188	Purine metabolism 💬	[2] IMPDH1, IMPDH2 💬 Purine metabolism × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolate mofetil 💬 Purine metabolism × Name Other Names Mycophenolate mofetil Mycophenolate mofetil (JAN/USP) Cellcept (TN)	Mycophenolate mofetil	[34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 188. Purine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
189	Purine metabolism 💬	[2] IMPDH1, IMPDH2 💬 Purine metabolism × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolic acid 💬 Purine metabolism × Name Other Names Mycophenolic acid Mycophenolic acid (USAN/INN) Mycophenolic acid (TN)	Mycophenolic acid	[36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 189. Purine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
190	Purine metabolism 💬	[1] RRM1 💬 Purine metabolism × Name Full Name RRM1 ribonucleotide reductase catalytic subunit M1	Fludarabine 💬 Purine metabolism × Name Other Names Fludarabine Fludarabine (INN) Fluradosa (TN)	Fludarabine	[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬 190. Purine metabolism × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 164 Oculocutaneous albinism; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis;
191	Pyrimidine metabolism 💬	[1] RRM1 💬 Pyrimidine metabolism × Name Full Name RRM1 ribonucleotide reductase catalytic subunit M1	Fludarabine 💬 Pyrimidine metabolism × Name Other Names Fludarabine Fludarabine (INN) Fluradosa (TN)	Fludarabine	[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬 191. Pyrimidine metabolism × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 164 Oculocutaneous albinism; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis;
192	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine maleate 💬 Rap1 signaling pathway × Name Other Names Trifluoperazine maleate Trifluoperazine maleate (JAN) Trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 192. Rap1 signaling pathway × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
193	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 dopamine receptor D2	Trifluoperazine 💬 Rap1 signaling pathway × Name Other Names Trifluoperazine Trifluoperazine (INN) Apo-trifluoperazine (TN)	Trifluoperazine	[2] 283, 284 💬 192. Rap1 signaling pathway × Disease ID Name 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
194	Renin secretion 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Renin secretion × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Renin secretion × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 194. Renin secretion × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
195	Renin secretion 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Renin secretion × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Renin secretion × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 195. Renin secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
196	Renin secretion 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Renin secretion × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Renin secretion × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 195. Renin secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
197	Salivary secretion 💬	[1] CD38 💬 Salivary secretion × Name Full Name CD38 CD38 molecule	Isatuximab 💬 Salivary secretion × Name Other Names Isatuximab Isatuximab (USAN/INN) Isatuximab (genetical recombination) (JAN) Isatuximab-irfc Sarclisa (TN)	Isatuximab	[3] 28, 61, 283 💬 197. Salivary secretion × Disease ID Name 28 Systemic amyloidosis;AL amyloidosis; 61 Autoimmune hemolytic anemia;AIHA; 283 Acquired pure red cell aplasia;Pure red cell aplasia;
198	Shigellosis 💬	[1] MTOR 💬 Shigellosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Shigellosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 198. Shigellosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
199	Spinocerebellar ataxia 💬	[1] MTOR 💬 Spinocerebellar ataxia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Spinocerebellar ataxia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 199. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
200	Spinocerebellar ataxia 💬	[1] PSMB5 💬 Spinocerebellar ataxia × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Spinocerebellar ataxia × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 200. Spinocerebellar ataxia × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
201	T cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 T cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 T cell receptor signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 201. T cell receptor signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
202	T cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 T cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 T cell receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 202. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
203	T cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 T cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 T cell receptor signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 202. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
204	Th1 and Th2 cell differentiation 💬	[1] IL2RA 💬 Th1 and Th2 cell differentiation × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Th1 and Th2 cell differentiation × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 204. Th1 and Th2 cell differentiation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
205	Th1 and Th2 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th1 and Th2 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Th1 and Th2 cell differentiation × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 205. Th1 and Th2 cell differentiation × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
206	Th1 and Th2 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th1 and Th2 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Th1 and Th2 cell differentiation × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 206. Th1 and Th2 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
207	Th1 and Th2 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th1 and Th2 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Th1 and Th2 cell differentiation × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 206. Th1 and Th2 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
208	Th17 cell differentiation 💬	[1] IL2RA 💬 Th17 cell differentiation × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Th17 cell differentiation × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 208. Th17 cell differentiation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
209	Th17 cell differentiation 💬	[1] MTOR 💬 Th17 cell differentiation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Th17 cell differentiation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 209. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
210	Th17 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th17 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Th17 cell differentiation × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 210. Th17 cell differentiation × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
211	Th17 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th17 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Th17 cell differentiation × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 211. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
212	Th17 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th17 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Th17 cell differentiation × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 211. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
213	Thermogenesis 💬	[1] MTOR 💬 Thermogenesis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thermogenesis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 213. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
214	Thyroid hormone signaling pathway 💬	[1] MTOR 💬 Thyroid hormone signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thyroid hormone signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 214. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
215	Tuberculosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tuberculosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Tuberculosis × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 215. Tuberculosis × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
216	Tuberculosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tuberculosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Tuberculosis × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 216. Tuberculosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
217	Tuberculosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tuberculosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Tuberculosis × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 216. Tuberculosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
218	Type II diabetes mellitus 💬	[1] MTOR 💬 Type II diabetes mellitus × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Type II diabetes mellitus × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 218. Type II diabetes mellitus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
219	VEGF signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 VEGF signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 VEGF signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 219. VEGF signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
220	VEGF signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 VEGF signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 VEGF signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 220. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
221	VEGF signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 VEGF signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 VEGF signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 220. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
222	Viral protein interaction with cytokine and cytokine receptor 💬	[1] IL2RA 💬 Viral protein interaction with cytokine and cytokine receptor × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Daclizumab 💬 Viral protein interaction with cytokine and cytokine receptor × Name Other Names Daclizumab Daclizumab (USAN/INN) Zenapax (TN) Zinbryta (TN)	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬 222. Viral protein interaction with cytokine and cytokine receptor × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 65 Primary immunodeficiency; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia;
223	Wnt signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Wnt signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Wnt signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 223. Wnt signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
224	Wnt signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Wnt signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Wnt signaling pathway × Name Other Names Tacrolimus Tacrolimus (USP/INN) Tacrolimus hydrate (JP18) Prograf (TN) Protopic (TN) ASTAGRAF XL ENVARSUS	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 224. Wnt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;
225	Wnt signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Wnt signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Tacrolimus 💬 Wnt signaling pathway × Name Other Names Tacrolimus Tacrolimus (INN) Prograf (TN)	Tacrolimus	[34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 224. Wnt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 151 Rasmussen encephalitis; 158 Tuberous sclerosis;Tuberous sclerosis complex; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 227 Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 299 Cystic fibrosis;

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