Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
3 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
4 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
5 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
6 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
7 Complement and coagulation cascades 💬
 [1] SERPINC1 💬 Heparin sodium 💬 Heparin [15] 47, 48, 60, 65, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317, 344 💬
8 Complement and coagulation cascades 💬
 [1] SERPINC1 💬 Heparin calcium 💬 Heparin [15] 47, 48, 60, 65, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317, 344 💬
9 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [30]  2 ,  6 , 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 47, 49, 51, 60, 62, 63, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
10 Cytokine-cytokine receptor interaction 💬
 [1] EPOR 💬 Epoetin alfa 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
11 Cytokine-cytokine receptor interaction 💬
 [1] EPOR 💬 Epoetin epsilon 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
12 Cytokine-cytokine receptor interaction 💬
 [1] EPOR 💬 Epoetin theta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
13 Cytokine-cytokine receptor interaction 💬
 [1] EPOR 💬 Epoetin zeta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
14 Efferocytosis 💬
 [1] EPOR 💬 Epoetin alfa 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
15 Efferocytosis 💬
 [1] EPOR 💬 Epoetin epsilon 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
16 Efferocytosis 💬
 [1] EPOR 💬 Epoetin theta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
17 Efferocytosis 💬
 [1] EPOR 💬 Epoetin zeta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
18 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [30]  2 ,  6 , 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 47, 49, 51, 60, 62, 63, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
19 Hematopoietic cell lineage 💬
 [1] EPOR 💬 Epoetin alfa 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
20 Hematopoietic cell lineage 💬
 [1] EPOR 💬 Epoetin epsilon 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
21 Hematopoietic cell lineage 💬
 [1] EPOR 💬 Epoetin theta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
22 Hematopoietic cell lineage 💬
 [1] EPOR 💬 Epoetin zeta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
23 Hormone signaling 💬
 [1] EPOR 💬 Epoetin alfa 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
24 Hormone signaling 💬
 [1] EPOR 💬 Epoetin epsilon 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
25 Hormone signaling 💬
 [1] EPOR 💬 Epoetin theta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
26 Hormone signaling 💬
 [1] EPOR 💬 Epoetin zeta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
27 Insulin secretion 💬
 [1] SNAP25 💬 Botulinum toxin type A 💬 Botulinum toxin type A [13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬
28 Insulin secretion 💬
 [1] SNAP25 💬 Incobotulinumtoxin A 💬 Botulinum toxin type A [13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬
29 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [30]  2 ,  6 , 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 47, 49, 51, 60, 62, 63, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
30 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 Epoetin alfa 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
31 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 Epoetin epsilon 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
32 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 Epoetin theta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
33 JAK-STAT signaling pathway 💬
 [1] EPOR 💬 Epoetin zeta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
34 Melanogenesis 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
35 Melanogenesis 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
36 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
37 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
38 Neuroactive ligand-receptor interaction 💬
 [1] PTGIR 💬 Selexipag 💬 Selexipag [6] 47, 51, 70, 84, 86, 88 💬
39 Pathways in cancer 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [30]  2 ,  6 , 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 47, 49, 51, 60, 62, 63, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
40 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
41 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
42 Pathways in cancer 💬
 [1] EPOR 💬 Epoetin alfa 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
43 Pathways in cancer 💬
 [1] EPOR 💬 Epoetin epsilon 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
44 Pathways in cancer 💬
 [1] EPOR 💬 Epoetin theta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
45 Pathways in cancer 💬
 [1] EPOR 💬 Epoetin zeta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
46 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [30]  2 ,  6 , 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 47, 49, 51, 60, 62, 63, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
47 PI3K-Akt signaling pathway 💬
 [1] EPOR 💬 Epoetin alfa 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
48 PI3K-Akt signaling pathway 💬
 [1] EPOR 💬 Epoetin epsilon 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
49 PI3K-Akt signaling pathway 💬
 [1] EPOR 💬 Epoetin theta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
50 PI3K-Akt signaling pathway 💬
 [1] EPOR 💬 Epoetin zeta 💬 Erythropoietin [11]  2 ,  6 , 13, 18, 22, 47, 61, 63, 70, 95, 96 💬
51 Platelet activation 💬
 [1] PTGIR 💬 Selexipag 💬 Selexipag [6] 47, 51, 70, 84, 86, 88 💬
52 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
53 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
54 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
55 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
56 Synaptic vesicle cycle 💬
 [1] SNAP25 💬 Botulinum toxin type A 💬 Botulinum toxin type A [13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬
57 Synaptic vesicle cycle 💬
 [1] SNAP25 💬 Incobotulinumtoxin A 💬 Botulinum toxin type A [13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬
58 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
59 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
60 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Selexipag 💬 Selexipag [6] 47, 51, 70, 84, 86, 88 💬

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