Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] KIT 💬 Acute myeloid leukemia × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Acute myeloid leukemia × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 1. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
2	Adherens junction 💬	[2] ROCK1, ROCK2 💬 Adherens junction × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Adherens junction × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 2. Adherens junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
3	Adherens junction 💬	[2] ROCK1, ROCK2 💬 Adherens junction × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Adherens junction × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 2. Adherens junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
4	Adrenergic signaling in cardiomyocytes 💬	[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 Adrenergic signaling in cardiomyocytes × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1 ADRA1B alpha-1B adrenergic receptor ADRA1D alpha-1D adrenergic receptor ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor	Droxidopa 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 4. Adrenergic signaling in cardiomyocytes × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
5	Alanine, aspartate and glutamate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬 Alanine, aspartate and glutamate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor ALDH5A1 succinate-semialdehyde dehydrogenase, mitochondrial isoform 2 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Divalproex sodium 💬 Alanine, aspartate and glutamate metabolism × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 5. Alanine, aspartate and glutamate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
6	Alanine, aspartate and glutamate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬 Alanine, aspartate and glutamate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor ALDH5A1 succinate-semialdehyde dehydrogenase, mitochondrial isoform 2 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproic acid 💬 Alanine, aspartate and glutamate metabolism × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 5. Alanine, aspartate and glutamate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
7	Alanine, aspartate and glutamate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬 Alanine, aspartate and glutamate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor ALDH5A1 succinate-semialdehyde dehydrogenase, mitochondrial isoform 2 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproate sodium 💬 Alanine, aspartate and glutamate metabolism × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 5. Alanine, aspartate and glutamate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
8	Alcoholism 💬	[2] DRD1, DRD2 💬 Alcoholism × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Alcoholism × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 8. Alcoholism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
9	Alcoholism 💬	[2] DRD1, DRD2 💬 Alcoholism × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Alcoholism × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 8. Alcoholism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
10	Alcoholism 💬	[2] DRD1, DRD2 💬 Alcoholism × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Levodopa 💬 Alcoholism × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 10. Alcoholism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
11	Alcoholism 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alcoholism × Name Full Name GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Alcoholism × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 11. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
12	Alcoholism 💬	[1] MAOB 💬 Alcoholism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Alcoholism × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 12. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
13	Alcoholism 💬	[1] MAOB 💬 Alcoholism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Alcoholism × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 12. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
14	Alcoholism 💬	[1] MAOB 💬 Alcoholism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Alcoholism × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 12. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
15	Aldosterone synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Divalproex sodium 💬 Aldosterone synthesis and secretion × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 15. Aldosterone synthesis and secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
16	Aldosterone synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproic acid 💬 Aldosterone synthesis and secretion × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 15. Aldosterone synthesis and secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
17	Aldosterone synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproate sodium 💬 Aldosterone synthesis and secretion × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 15. Aldosterone synthesis and secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
18	Alzheimer disease 💬	[3] CHRM1, CHRM3, CHRM5 💬 Alzheimer disease × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM3 muscarinic acetylcholine receptor M3 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl hydrochloride 💬 Alzheimer disease × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 18. Alzheimer disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
19	Alzheimer disease 💬	[3] CHRM1, CHRM3, CHRM5 💬 Alzheimer disease × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM3 muscarinic acetylcholine receptor M3 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl 💬 Alzheimer disease × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 18. Alzheimer disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
20	Alzheimer disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alzheimer disease × Name Full Name GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Alzheimer disease × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 20. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
21	Alzheimer disease 💬	[1] MAPT 💬 Alzheimer disease × Name Full Name MAPT microtubule-associated protein tau isoform 1	Bepranemab 💬 Alzheimer disease × Name Other Names Bepranemab Bepranemab	Bepranemab	[1]  5  💬 21. Alzheimer disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;
22	Alzheimer disease 💬	[1] MAPT 💬 Alzheimer disease × Name Full Name MAPT microtubule-associated protein tau isoform 1	Flortaucipir F 18 💬 Alzheimer disease × Name Other Names Flortaucipir F 18 Flortaucipir Tauvid	Flortaucipir	[3]  5 ,  7 , 127 💬 22. Alzheimer disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;
23	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Alzheimer disease × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 23. Alzheimer disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;
24	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Alzheimer disease × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 24. Alzheimer disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;
25	Amphetamine addiction 💬	[1] DRD1 💬 Amphetamine addiction × Name Full Name DRD1 D(1A) dopamine receptor	Apomorphine hydrochloride 💬 Amphetamine addiction × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 25. Amphetamine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
26	Amphetamine addiction 💬	[1] DRD1 💬 Amphetamine addiction × Name Full Name DRD1 D(1A) dopamine receptor	Apomorphine 💬 Amphetamine addiction × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 25. Amphetamine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
27	Amphetamine addiction 💬	[1] DRD1 💬 Amphetamine addiction × Name Full Name DRD1 D(1A) dopamine receptor	Levodopa 💬 Amphetamine addiction × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 27. Amphetamine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
28	Amphetamine addiction 💬	[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amphetamine addiction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Amphetamine addiction × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 28. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
29	Amphetamine addiction 💬	[1] MAOB 💬 Amphetamine addiction × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Amphetamine addiction × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 29. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
30	Amphetamine addiction 💬	[1] MAOB 💬 Amphetamine addiction × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Amphetamine addiction × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 29. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
31	Amphetamine addiction 💬	[1] MAOB 💬 Amphetamine addiction × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Amphetamine addiction × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 29. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
32	AMPK signaling pathway 💬	[1] ADRA1A 💬 AMPK signaling pathway × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1	Droxidopa 💬 AMPK signaling pathway × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 32. AMPK signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
33	Amyotrophic lateral sclerosis 💬	[7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Amyotrophic lateral sclerosis × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 33. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
34	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Arachidonic acid metabolism × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 34. Arachidonic acid metabolism × Disease ID Name  5  Progressive supranuclear palsy;PSP;
35	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Arachidonic acid metabolism × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 35. Arachidonic acid metabolism × Disease ID Name  5  Progressive supranuclear palsy;PSP;
36	Arginine and proline metabolism 💬	[1] MAOB 💬 Arginine and proline metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Arginine and proline metabolism × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 36. Arginine and proline metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
37	Arginine and proline metabolism 💬	[1] MAOB 💬 Arginine and proline metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Arginine and proline metabolism × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 36. Arginine and proline metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
38	Arginine and proline metabolism 💬	[1] MAOB 💬 Arginine and proline metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Arginine and proline metabolism × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 36. Arginine and proline metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
39	Axon guidance 💬	[2] ROCK1, ROCK2 💬 Axon guidance × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Axon guidance × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 39. Axon guidance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
40	Axon guidance 💬	[2] ROCK1, ROCK2 💬 Axon guidance × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Axon guidance × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 39. Axon guidance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
41	beta-Alanine metabolism 💬	[3] ABAT, GAD1, GAD2 💬 beta-Alanine metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Divalproex sodium 💬 beta-Alanine metabolism × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 41. beta-Alanine metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
42	beta-Alanine metabolism 💬	[3] ABAT, GAD1, GAD2 💬 beta-Alanine metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproic acid 💬 beta-Alanine metabolism × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 41. beta-Alanine metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
43	beta-Alanine metabolism 💬	[3] ABAT, GAD1, GAD2 💬 beta-Alanine metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproate sodium 💬 beta-Alanine metabolism × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 41. beta-Alanine metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
44	Breast cancer 💬	[1] KIT 💬 Breast cancer × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Breast cancer × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 44. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
45	Butanoate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬 Butanoate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor ALDH5A1 succinate-semialdehyde dehydrogenase, mitochondrial isoform 2 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Divalproex sodium 💬 Butanoate metabolism × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 45. Butanoate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
46	Butanoate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬 Butanoate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor ALDH5A1 succinate-semialdehyde dehydrogenase, mitochondrial isoform 2 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproic acid 💬 Butanoate metabolism × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 45. Butanoate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
47	Butanoate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬 Butanoate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor ALDH5A1 succinate-semialdehyde dehydrogenase, mitochondrial isoform 2 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproate sodium 💬 Butanoate metabolism × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 45. Butanoate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
48	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 C-type lectin receptor signaling pathway × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 48. C-type lectin receptor signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
49	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 C-type lectin receptor signaling pathway × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 49. C-type lectin receptor signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
50	Cadherin signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Cadherin signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem tartrate 💬 Cadherin signaling × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 50. Cadherin signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Cadherin signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Cadherin signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem 💬 Cadherin signaling × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 50. Cadherin signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
52	Cadherin signaling 💬	[2] ROCK1, ROCK2 💬 Cadherin signaling × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Cadherin signaling × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 52. Cadherin signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
53	Cadherin signaling 💬	[2] ROCK1, ROCK2 💬 Cadherin signaling × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Cadherin signaling × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 52. Cadherin signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
54	Calcium signaling pathway 💬	[6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬 Calcium signaling pathway × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1 ADRA1B alpha-1B adrenergic receptor ADRA1D alpha-1D adrenergic receptor ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 Calcium signaling pathway × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 54. Calcium signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
55	Calcium signaling pathway 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Calcium signaling pathway × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Divalproex sodium 💬 Calcium signaling pathway × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 55. Calcium signaling pathway × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
56	Calcium signaling pathway 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Calcium signaling pathway × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproic acid 💬 Calcium signaling pathway × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 55. Calcium signaling pathway × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
57	Calcium signaling pathway 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Calcium signaling pathway × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproate sodium 💬 Calcium signaling pathway × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 55. Calcium signaling pathway × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
58	Calcium signaling pathway 💬	[4] CHRM1, CHRM2, CHRM3, CHRM5 💬 Calcium signaling pathway × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl hydrochloride 💬 Calcium signaling pathway × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 58. Calcium signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
59	Calcium signaling pathway 💬	[4] CHRM1, CHRM2, CHRM3, CHRM5 💬 Calcium signaling pathway × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl 💬 Calcium signaling pathway × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 58. Calcium signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
60	Calcium signaling pathway 💬	[1] DRD1 💬 Calcium signaling pathway × Name Full Name DRD1 D(1A) dopamine receptor	Apomorphine hydrochloride 💬 Calcium signaling pathway × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 60. Calcium signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
61	Calcium signaling pathway 💬	[1] DRD1 💬 Calcium signaling pathway × Name Full Name DRD1 D(1A) dopamine receptor	Apomorphine 💬 Calcium signaling pathway × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 60. Calcium signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
62	Calcium signaling pathway 💬	[2] DRD1, DRD5 💬 Calcium signaling pathway × Name Full Name DRD1 D(1A) dopamine receptor DRD5 D(1B) dopamine receptor	Levodopa 💬 Calcium signaling pathway × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 62. Calcium signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
63	Calcium signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Calcium signaling pathway × Name Full Name GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Calcium signaling pathway × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 63. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
64	cAMP signaling pathway 💬	[2] ADRB1, ADRB2 💬 cAMP signaling pathway × Name Full Name ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor	Droxidopa 💬 cAMP signaling pathway × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 64. cAMP signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
65	cAMP signaling pathway 💬	[2] CHRM1, CHRM2 💬 cAMP signaling pathway × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2	Trihexyphenidyl hydrochloride 💬 cAMP signaling pathway × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 65. cAMP signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
66	cAMP signaling pathway 💬	[2] CHRM1, CHRM2 💬 cAMP signaling pathway × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2	Trihexyphenidyl 💬 cAMP signaling pathway × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 65. cAMP signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
67	cAMP signaling pathway 💬	[2] DRD1, DRD2 💬 cAMP signaling pathway × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 cAMP signaling pathway × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 67. cAMP signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
68	cAMP signaling pathway 💬	[2] DRD1, DRD2 💬 cAMP signaling pathway × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 cAMP signaling pathway × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 67. cAMP signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
69	cAMP signaling pathway 💬	[3] DRD1, DRD2, DRD5 💬 cAMP signaling pathway × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long DRD5 D(1B) dopamine receptor	Levodopa 💬 cAMP signaling pathway × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 69. cAMP signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
70	cAMP signaling pathway 💬	[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 cAMP signaling pathway × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 cAMP signaling pathway × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 70. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
71	cAMP signaling pathway 💬	[2] ROCK1, ROCK2 💬 cAMP signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 cAMP signaling pathway × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 71. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
72	cAMP signaling pathway 💬	[2] ROCK1, ROCK2 💬 cAMP signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 cAMP signaling pathway × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 71. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
73	Central carbon metabolism in cancer 💬	[1] KIT 💬 Central carbon metabolism in cancer × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Central carbon metabolism in cancer × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 73. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
74	cGMP-PKG signaling pathway 💬	[9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 cGMP-PKG signaling pathway × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1 ADRA1B alpha-1B adrenergic receptor ADRA1D alpha-1D adrenergic receptor ADRA2A alpha-2A adrenergic receptor ADRA2B alpha-2B adrenergic receptor ADRA2C alpha-2C adrenergic receptor ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 cGMP-PKG signaling pathway × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 74. cGMP-PKG signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
75	cGMP-PKG signaling pathway 💬	[2] ROCK1, ROCK2 💬 cGMP-PKG signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 cGMP-PKG signaling pathway × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 75. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
76	cGMP-PKG signaling pathway 💬	[2] ROCK1, ROCK2 💬 cGMP-PKG signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 cGMP-PKG signaling pathway × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 75. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
77	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 77. Chemical carcinogenesis - DNA adducts × Disease ID Name  5  Progressive supranuclear palsy;PSP;
78	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 78. Chemical carcinogenesis - DNA adducts × Disease ID Name  5  Progressive supranuclear palsy;PSP;
79	Chemical carcinogenesis - receptor activation 💬	[3] ADRB1, ADRB2, ADRB3 💬 Chemical carcinogenesis - receptor activation × Name Full Name ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 Chemical carcinogenesis - receptor activation × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 79. Chemical carcinogenesis - receptor activation × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
80	Chemokine signaling pathway 💬	[2] ROCK1, ROCK2 💬 Chemokine signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Chemokine signaling pathway × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 80. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
81	Chemokine signaling pathway 💬	[2] ROCK1, ROCK2 💬 Chemokine signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Chemokine signaling pathway × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 80. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
82	Cholinergic synapse 💬	[1] ACHE 💬 Cholinergic synapse × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Donepezil hydrochloride 💬 Cholinergic synapse × Name Other Names Donepezil hydrochloride Aricept DONEPEZIL	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 82. Cholinergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
83	Cholinergic synapse 💬	[1] ACHE 💬 Cholinergic synapse × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Donepezil 💬 Cholinergic synapse × Name Other Names Donepezil Donaz Allydone	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 82. Cholinergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
84	Cholinergic synapse 💬	[1] ACHE 💬 Cholinergic synapse × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Rivastigmine tartrate 💬 Cholinergic synapse × Name Other Names Rivastigmine tartrate Rivastigmine hydrogen tartrate Exelon Nimvastid	Rivastigmine	[3]  5 ,  6 , 13 💬 84. Cholinergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
85	Cholinergic synapse 💬	[1] ACHE 💬 Cholinergic synapse × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Rivastigmine 💬 Cholinergic synapse × Name Other Names Rivastigmine Exelon Prometax RIVASTIGMINE TRANSDERMAL SYSTEM	Rivastigmine	[3]  5 ,  6 , 13 💬 84. Cholinergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
86	Cholinergic synapse 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Cholinergic synapse × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM4 muscarinic acetylcholine receptor M4 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl hydrochloride 💬 Cholinergic synapse × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 86. Cholinergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
87	Cholinergic synapse 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Cholinergic synapse × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM4 muscarinic acetylcholine receptor M4 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl 💬 Cholinergic synapse × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 86. Cholinergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
88	Circadian entrainment 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Circadian entrainment × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Divalproex sodium 💬 Circadian entrainment × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 88. Circadian entrainment × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
89	Circadian entrainment 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Circadian entrainment × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproic acid 💬 Circadian entrainment × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 88. Circadian entrainment × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
90	Circadian entrainment 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Circadian entrainment × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproate sodium 💬 Circadian entrainment × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 88. Circadian entrainment × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
91	Circadian entrainment 💬	[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Circadian entrainment × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Circadian entrainment × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 91. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
92	Cocaine addiction 💬	[2] DRD1, DRD2 💬 Cocaine addiction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Cocaine addiction × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 92. Cocaine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
93	Cocaine addiction 💬	[2] DRD1, DRD2 💬 Cocaine addiction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Cocaine addiction × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 92. Cocaine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
94	Cocaine addiction 💬	[2] DRD1, DRD2 💬 Cocaine addiction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Levodopa 💬 Cocaine addiction × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 94. Cocaine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
95	Cocaine addiction 💬	[6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Cocaine addiction × Name Full Name GRIA2 glutamate receptor 2 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Cocaine addiction × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 95. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
96	Cocaine addiction 💬	[1] MAOB 💬 Cocaine addiction × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Cocaine addiction × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 96. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
97	Cocaine addiction 💬	[1] MAOB 💬 Cocaine addiction × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Cocaine addiction × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 96. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
98	Cocaine addiction 💬	[1] MAOB 💬 Cocaine addiction × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Cocaine addiction × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 96. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
99	Cortisol synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Cortisol synthesis and secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Divalproex sodium 💬 Cortisol synthesis and secretion × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 99. Cortisol synthesis and secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
100	Cortisol synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Cortisol synthesis and secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproic acid 💬 Cortisol synthesis and secretion × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 99. Cortisol synthesis and secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
101	Cortisol synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Cortisol synthesis and secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproate sodium 💬 Cortisol synthesis and secretion × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 99. Cortisol synthesis and secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
102	Cushing syndrome 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Cushing syndrome × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Divalproex sodium 💬 Cushing syndrome × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 102. Cushing syndrome × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
103	Cushing syndrome 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Cushing syndrome × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproic acid 💬 Cushing syndrome × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 102. Cushing syndrome × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
104	Cushing syndrome 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 Cushing syndrome × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproate sodium 💬 Cushing syndrome × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 102. Cushing syndrome × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
105	Dilated cardiomyopathy 💬	[1] ADRB1 💬 Dilated cardiomyopathy × Name Full Name ADRB1 beta-1 adrenergic receptor	Droxidopa 💬 Dilated cardiomyopathy × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 105. Dilated cardiomyopathy × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
106	Dopaminergic synapse 💬	[2] DRD1, DRD2 💬 Dopaminergic synapse × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Dopaminergic synapse × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 106. Dopaminergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
107	Dopaminergic synapse 💬	[2] DRD1, DRD2 💬 Dopaminergic synapse × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Dopaminergic synapse × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 106. Dopaminergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
108	Dopaminergic synapse 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopaminergic synapse × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long DRD3 D(3) dopamine receptor isoform a DRD4 D(4) dopamine receptor DRD5 D(1B) dopamine receptor	Levodopa 💬 Dopaminergic synapse × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 108. Dopaminergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
109	Dopaminergic synapse 💬	[6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 Dopaminergic synapse × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor	Riluzole 💬 Dopaminergic synapse × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 109. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
110	Dopaminergic synapse 💬	[1] MAOB 💬 Dopaminergic synapse × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Dopaminergic synapse × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 110. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
111	Dopaminergic synapse 💬	[1] MAOB 💬 Dopaminergic synapse × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Dopaminergic synapse × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 110. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
112	Dopaminergic synapse 💬	[1] MAOB 💬 Dopaminergic synapse × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Dopaminergic synapse × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 110. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
113	Drug metabolism - cytochrome P450 💬	[1] MAOB 💬 Drug metabolism - cytochrome P450 × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Drug metabolism - cytochrome P450 × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 113. Drug metabolism - cytochrome P450 × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
114	Drug metabolism - cytochrome P450 💬	[1] MAOB 💬 Drug metabolism - cytochrome P450 × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Drug metabolism - cytochrome P450 × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 113. Drug metabolism - cytochrome P450 × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
115	Drug metabolism - cytochrome P450 💬	[1] MAOB 💬 Drug metabolism - cytochrome P450 × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Drug metabolism - cytochrome P450 × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 113. Drug metabolism - cytochrome P450 × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
116	Efferocytosis 💬	[1] PTGS2 💬 Efferocytosis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Efferocytosis × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 116. Efferocytosis × Disease ID Name  5  Progressive supranuclear palsy;PSP;
117	Efferocytosis 💬	[1] PTGS2 💬 Efferocytosis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Efferocytosis × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 117. Efferocytosis × Disease ID Name  5  Progressive supranuclear palsy;PSP;
118	Focal adhesion 💬	[2] ROCK1, ROCK2 💬 Focal adhesion × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Focal adhesion × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 118. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
119	Focal adhesion 💬	[2] ROCK1, ROCK2 💬 Focal adhesion × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Focal adhesion × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 118. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
120	GABAergic synapse 💬	[3] ABAT, GAD1, GAD2 💬 GABAergic synapse × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Divalproex sodium 💬 GABAergic synapse × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 120. GABAergic synapse × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
121	GABAergic synapse 💬	[3] ABAT, GAD1, GAD2 💬 GABAergic synapse × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproic acid 💬 GABAergic synapse × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 120. GABAergic synapse × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
122	GABAergic synapse 💬	[3] ABAT, GAD1, GAD2 💬 GABAergic synapse × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproate sodium 💬 GABAergic synapse × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 120. GABAergic synapse × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
123	GABAergic synapse 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem tartrate 💬 GABAergic synapse × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 123. GABAergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
124	GABAergic synapse 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem 💬 GABAergic synapse × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 123. GABAergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
125	Gap junction 💬	[1] ADRB1 💬 Gap junction × Name Full Name ADRB1 beta-1 adrenergic receptor	Droxidopa 💬 Gap junction × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 125. Gap junction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
126	Gap junction 💬	[2] DRD1, DRD2 💬 Gap junction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Gap junction × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 126. Gap junction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
127	Gap junction 💬	[2] DRD1, DRD2 💬 Gap junction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Gap junction × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 126. Gap junction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
128	Gap junction 💬	[2] DRD1, DRD2 💬 Gap junction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Levodopa 💬 Gap junction × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 128. Gap junction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
129	Gastric acid secretion 💬	[1] CHRM3 💬 Gastric acid secretion × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl hydrochloride 💬 Gastric acid secretion × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 129. Gastric acid secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
130	Gastric acid secretion 💬	[1] CHRM3 💬 Gastric acid secretion × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl 💬 Gastric acid secretion × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 129. Gastric acid secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
131	Glutamatergic synapse 💬	[14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Glutamatergic synapse × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Glutamatergic synapse × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 131. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
132	Glycerophospholipid metabolism 💬	[1] ACHE 💬 Glycerophospholipid metabolism × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Donepezil hydrochloride 💬 Glycerophospholipid metabolism × Name Other Names Donepezil hydrochloride Aricept DONEPEZIL	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 132. Glycerophospholipid metabolism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
133	Glycerophospholipid metabolism 💬	[1] ACHE 💬 Glycerophospholipid metabolism × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Donepezil 💬 Glycerophospholipid metabolism × Name Other Names Donepezil Donaz Allydone	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 132. Glycerophospholipid metabolism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
134	Glycerophospholipid metabolism 💬	[1] ACHE 💬 Glycerophospholipid metabolism × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Rivastigmine tartrate 💬 Glycerophospholipid metabolism × Name Other Names Rivastigmine tartrate Rivastigmine hydrogen tartrate Exelon Nimvastid	Rivastigmine	[3]  5 ,  6 , 13 💬 134. Glycerophospholipid metabolism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
135	Glycerophospholipid metabolism 💬	[1] ACHE 💬 Glycerophospholipid metabolism × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Rivastigmine 💬 Glycerophospholipid metabolism × Name Other Names Rivastigmine Exelon Prometax RIVASTIGMINE TRANSDERMAL SYSTEM	Rivastigmine	[3]  5 ,  6 , 13 💬 134. Glycerophospholipid metabolism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
136	Glycine, serine and threonine metabolism 💬	[1] MAOB 💬 Glycine, serine and threonine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Glycine, serine and threonine metabolism × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 136. Glycine, serine and threonine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
137	Glycine, serine and threonine metabolism 💬	[1] MAOB 💬 Glycine, serine and threonine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Glycine, serine and threonine metabolism × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 136. Glycine, serine and threonine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
138	Glycine, serine and threonine metabolism 💬	[1] MAOB 💬 Glycine, serine and threonine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Glycine, serine and threonine metabolism × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 136. Glycine, serine and threonine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
139	GnRH secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 GnRH secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Divalproex sodium 💬 GnRH secretion × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 139. GnRH secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
140	GnRH secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 GnRH secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproic acid 💬 GnRH secretion × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 139. GnRH secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
141	GnRH secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 GnRH secretion × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproate sodium 💬 GnRH secretion × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 139. GnRH secretion × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
142	Hematopoietic cell lineage 💬	[1] KIT 💬 Hematopoietic cell lineage × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Hematopoietic cell lineage × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 142. Hematopoietic cell lineage × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
143	Histidine metabolism 💬	[1] MAOB 💬 Histidine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Histidine metabolism × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 143. Histidine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
144	Histidine metabolism 💬	[1] MAOB 💬 Histidine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Histidine metabolism × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 143. Histidine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
145	Histidine metabolism 💬	[1] MAOB 💬 Histidine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Histidine metabolism × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 143. Histidine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
146	Hormone signaling 💬	[9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Hormone signaling × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1 ADRA1B alpha-1B adrenergic receptor ADRA1D alpha-1D adrenergic receptor ADRA2A alpha-2A adrenergic receptor ADRA2B alpha-2B adrenergic receptor ADRA2C alpha-2C adrenergic receptor ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 Hormone signaling × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 146. Hormone signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
147	Hormone signaling 💬	[2] DRD1, DRD2 💬 Hormone signaling × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Hormone signaling × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 147. Hormone signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
148	Hormone signaling 💬	[2] DRD1, DRD2 💬 Hormone signaling × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Hormone signaling × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 147. Hormone signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
149	Hormone signaling 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Hormone signaling × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long DRD3 D(3) dopamine receptor isoform a DRD4 D(4) dopamine receptor DRD5 D(1B) dopamine receptor	Levodopa 💬 Hormone signaling × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 149. Hormone signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
150	Hormone signaling 💬	[2] HCRTR1, HCRTR2 💬 Hormone signaling × Name Full Name HCRTR1 orexin/Hypocretin receptor type 1 HCRTR2 orexin receptor type 2	Suvorexant 💬 Hormone signaling × Name Other Names Suvorexant MK-4305 Belsomra	Suvorexant	[3]  5 ,  6 , 13 💬 150. Hormone signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
151	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Human cytomegalovirus infection × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 151. Human cytomegalovirus infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;
152	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Human cytomegalovirus infection × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 152. Human cytomegalovirus infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;
153	Human cytomegalovirus infection 💬	[2] ROCK1, ROCK2 💬 Human cytomegalovirus infection × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Human cytomegalovirus infection × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 153. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
154	Human cytomegalovirus infection 💬	[2] ROCK1, ROCK2 💬 Human cytomegalovirus infection × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Human cytomegalovirus infection × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 153. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
155	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Human papillomavirus infection × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 155. Human papillomavirus infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;
156	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Human papillomavirus infection × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 156. Human papillomavirus infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;
157	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬 Human T-cell leukemia virus 1 infection × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid 💬 Human T-cell leukemia virus 1 infection × Name Other Names Zoledronic acid Zoledronic acid hydrate Zometa Reclast	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 157. Human T-cell leukemia virus 1 infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
158	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬 Human T-cell leukemia virus 1 infection × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronate disodium 💬 Human T-cell leukemia virus 1 infection × Name Other Names Zoledronate disodium Zoledronate disodium hydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 157. Human T-cell leukemia virus 1 infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
159	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬 Human T-cell leukemia virus 1 infection × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronate trisodium 💬 Human T-cell leukemia virus 1 infection × Name Other Names Zoledronate trisodium Zoledronate trisodium hydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 157. Human T-cell leukemia virus 1 infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
160	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬 Human T-cell leukemia virus 1 infection × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid 💬 Human T-cell leukemia virus 1 infection × Name Other Names Zoledronic acid Zometa Reclast	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 157. Human T-cell leukemia virus 1 infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
161	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬 Human T-cell leukemia virus 1 infection × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid hemipentahydrate 💬 Human T-cell leukemia virus 1 infection × Name Other Names Zoledronic acid hemipentahydrate Zoledronic acid hemipentahydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 157. Human T-cell leukemia virus 1 infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
162	Huntington disease 💬	[6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2B 💬 Huntington disease × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor	Riluzole 💬 Huntington disease × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 162. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
163	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 IL-17 signaling pathway × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 163. IL-17 signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
164	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 IL-17 signaling pathway × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 164. IL-17 signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
165	Influenza A 💬	[1] FDPS 💬 Influenza A × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid 💬 Influenza A × Name Other Names Zoledronic acid Zoledronic acid hydrate Zometa Reclast	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 165. Influenza A × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
166	Influenza A 💬	[1] FDPS 💬 Influenza A × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronate disodium 💬 Influenza A × Name Other Names Zoledronate disodium Zoledronate disodium hydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 165. Influenza A × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
167	Influenza A 💬	[1] FDPS 💬 Influenza A × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronate trisodium 💬 Influenza A × Name Other Names Zoledronate trisodium Zoledronate trisodium hydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 165. Influenza A × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
168	Influenza A 💬	[1] FDPS 💬 Influenza A × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid 💬 Influenza A × Name Other Names Zoledronic acid Zometa Reclast	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 165. Influenza A × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
169	Influenza A 💬	[1] FDPS 💬 Influenza A × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid hemipentahydrate 💬 Influenza A × Name Other Names Zoledronic acid hemipentahydrate Zoledronic acid hemipentahydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 165. Influenza A × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
170	Insulin secretion 💬	[1] CHRM3 💬 Insulin secretion × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl hydrochloride 💬 Insulin secretion × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 170. Insulin secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
171	Insulin secretion 💬	[1] CHRM3 💬 Insulin secretion × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl 💬 Insulin secretion × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 170. Insulin secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
172	Insulin secretion 💬	[1] SNAP25 💬 Insulin secretion × Name Full Name SNAP25 synaptosomal-associated protein 25 isoform SNAP25A	Botulinum toxin type A 💬 Insulin secretion × Name Other Names Botulinum toxin type A Botox Dysport DAXXIFY	Botulinum toxin type A	[13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬 172. Insulin secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 47 Buerger disease;Thromboangiitis obliterans; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 171 Wilson disease;WD; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
173	Insulin secretion 💬	[1] SNAP25 💬 Insulin secretion × Name Full Name SNAP25 synaptosomal-associated protein 25 isoform SNAP25A	Incobotulinumtoxin A 💬 Insulin secretion × Name Other Names Incobotulinumtoxin A Onaclostox Xeomin	Botulinum toxin type A	[13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬 172. Insulin secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 47 Buerger disease;Thromboangiitis obliterans; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 171 Wilson disease;WD; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
174	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 174. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;
175	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 175. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  5  Progressive supranuclear palsy;PSP;
176	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Leishmaniasis × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 176. Leishmaniasis × Disease ID Name  5  Progressive supranuclear palsy;PSP;
177	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Leishmaniasis × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 177. Leishmaniasis × Disease ID Name  5  Progressive supranuclear palsy;PSP;
178	Leukocyte transendothelial migration 💬	[2] ROCK1, ROCK2 💬 Leukocyte transendothelial migration × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Leukocyte transendothelial migration × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 178. Leukocyte transendothelial migration × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
179	Leukocyte transendothelial migration 💬	[2] ROCK1, ROCK2 💬 Leukocyte transendothelial migration × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Leukocyte transendothelial migration × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 178. Leukocyte transendothelial migration × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
180	Lipid and atherosclerosis 💬	[1] ROCK2 💬 Lipid and atherosclerosis × Name Full Name ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Lipid and atherosclerosis × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 180. Lipid and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
181	Lipid and atherosclerosis 💬	[1] ROCK2 💬 Lipid and atherosclerosis × Name Full Name ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Lipid and atherosclerosis × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 180. Lipid and atherosclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
182	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor	Riluzole 💬 Long-term depression × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 182. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
183	Long-term potentiation 💬	[7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Long-term potentiation × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Long-term potentiation × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 183. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
184	MAPK signaling pathway 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 MAPK signaling pathway × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Divalproex sodium 💬 MAPK signaling pathway × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 184. MAPK signaling pathway × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
185	MAPK signaling pathway 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 MAPK signaling pathway × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproic acid 💬 MAPK signaling pathway × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 184. MAPK signaling pathway × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
186	MAPK signaling pathway 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬 MAPK signaling pathway × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 CACNA1H voltage-dependent T-type calcium channel subunit alpha-1H isoform a CACNA1I voltage-dependent T-type calcium channel subunit alpha-1I isoform a	Valproate sodium 💬 MAPK signaling pathway × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 184. MAPK signaling pathway × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
187	MAPK signaling pathway 💬	[1] KIT 💬 MAPK signaling pathway × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 MAPK signaling pathway × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 187. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
188	MAPK signaling pathway 💬	[1] MAPT 💬 MAPK signaling pathway × Name Full Name MAPT microtubule-associated protein tau isoform 1	Bepranemab 💬 MAPK signaling pathway × Name Other Names Bepranemab Bepranemab	Bepranemab	[1]  5  💬 188. MAPK signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
189	MAPK signaling pathway 💬	[1] MAPT 💬 MAPK signaling pathway × Name Full Name MAPT microtubule-associated protein tau isoform 1	Flortaucipir F 18 💬 MAPK signaling pathway × Name Other Names Flortaucipir F 18 Flortaucipir Tauvid	Flortaucipir	[3]  5 ,  7 , 127 💬 189. MAPK signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;
190	Melanogenesis 💬	[1] KIT 💬 Melanogenesis × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Melanogenesis × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 190. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
191	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 MicroRNAs in cancer × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 191. MicroRNAs in cancer × Disease ID Name  5  Progressive supranuclear palsy;PSP;
192	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 MicroRNAs in cancer × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 192. MicroRNAs in cancer × Disease ID Name  5  Progressive supranuclear palsy;PSP;
193	MicroRNAs in cancer 💬	[1] ROCK1 💬 MicroRNAs in cancer × Name Full Name ROCK1 rho-associated protein kinase 1	Fasudil hydrochloride 💬 MicroRNAs in cancer × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 193. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
194	MicroRNAs in cancer 💬	[1] ROCK1 💬 MicroRNAs in cancer × Name Full Name ROCK1 rho-associated protein kinase 1	Fasudil 💬 MicroRNAs in cancer × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 193. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
195	Morphine addiction 💬	[1] DRD1 💬 Morphine addiction × Name Full Name DRD1 D(1A) dopamine receptor	Apomorphine hydrochloride 💬 Morphine addiction × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 195. Morphine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
196	Morphine addiction 💬	[1] DRD1 💬 Morphine addiction × Name Full Name DRD1 D(1A) dopamine receptor	Apomorphine 💬 Morphine addiction × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 195. Morphine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
197	Morphine addiction 💬	[1] DRD1 💬 Morphine addiction × Name Full Name DRD1 D(1A) dopamine receptor	Levodopa 💬 Morphine addiction × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 197. Morphine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
198	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem tartrate 💬 Morphine addiction × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 198. Morphine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
199	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem 💬 Morphine addiction × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 198. Morphine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
200	Neuroactive ligand signaling 💬	[1] ACHE 💬 Neuroactive ligand signaling × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Donepezil hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Donepezil hydrochloride Aricept DONEPEZIL	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 200. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
201	Neuroactive ligand signaling 💬	[1] ACHE 💬 Neuroactive ligand signaling × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Donepezil 💬 Neuroactive ligand signaling × Name Other Names Donepezil Donaz Allydone	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 200. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
202	Neuroactive ligand signaling 💬	[1] ACHE 💬 Neuroactive ligand signaling × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Rivastigmine tartrate 💬 Neuroactive ligand signaling × Name Other Names Rivastigmine tartrate Rivastigmine hydrogen tartrate Exelon Nimvastid	Rivastigmine	[3]  5 ,  6 , 13 💬 202. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
203	Neuroactive ligand signaling 💬	[1] ACHE 💬 Neuroactive ligand signaling × Name Full Name ACHE acetylcholinesterase isoform E4-E6 precursor	Rivastigmine 💬 Neuroactive ligand signaling × Name Other Names Rivastigmine Exelon Prometax RIVASTIGMINE TRANSDERMAL SYSTEM	Rivastigmine	[3]  5 ,  6 , 13 💬 202. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
204	Neuroactive ligand signaling 💬	[8] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2 💬 Neuroactive ligand signaling × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1 ADRA1B alpha-1B adrenergic receptor ADRA1D alpha-1D adrenergic receptor ADRA2A alpha-2A adrenergic receptor ADRA2B alpha-2B adrenergic receptor ADRA2C alpha-2C adrenergic receptor ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor	Droxidopa 💬 Neuroactive ligand signaling × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 204. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
205	Neuroactive ligand signaling 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Neuroactive ligand signaling × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM4 muscarinic acetylcholine receptor M4 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 205. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
206	Neuroactive ligand signaling 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Neuroactive ligand signaling × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM4 muscarinic acetylcholine receptor M4 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl 💬 Neuroactive ligand signaling × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 205. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
207	Neuroactive ligand signaling 💬	[2] DRD1, DRD2 💬 Neuroactive ligand signaling × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 207. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
208	Neuroactive ligand signaling 💬	[2] DRD1, DRD2 💬 Neuroactive ligand signaling × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Neuroactive ligand signaling × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 207. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
209	Neuroactive ligand signaling 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Neuroactive ligand signaling × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long DRD3 D(3) dopamine receptor isoform a DRD4 D(4) dopamine receptor DRD5 D(1B) dopamine receptor	Levodopa 💬 Neuroactive ligand signaling × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 209. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
210	Neuroactive ligand signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Neuroactive ligand signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem tartrate 💬 Neuroactive ligand signaling × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 210. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
211	Neuroactive ligand signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Neuroactive ligand signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem 💬 Neuroactive ligand signaling × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 210. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
212	Neuroactive ligand signaling 💬	[14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand signaling × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Neuroactive ligand signaling × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 212. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
213	Neuroactive ligand-receptor interaction 💬	[9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Neuroactive ligand-receptor interaction × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1 ADRA1B alpha-1B adrenergic receptor ADRA1D alpha-1D adrenergic receptor ADRA2A alpha-2A adrenergic receptor ADRA2B alpha-2B adrenergic receptor ADRA2C alpha-2C adrenergic receptor ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 Neuroactive ligand-receptor interaction × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 213. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
214	Neuroactive ligand-receptor interaction 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Neuroactive ligand-receptor interaction × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM4 muscarinic acetylcholine receptor M4 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 214. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
215	Neuroactive ligand-receptor interaction 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Neuroactive ligand-receptor interaction × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM4 muscarinic acetylcholine receptor M4 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl 💬 Neuroactive ligand-receptor interaction × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 214. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
216	Neuroactive ligand-receptor interaction 💬	[2] DRD1, DRD2 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 216. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
217	Neuroactive ligand-receptor interaction 💬	[2] DRD1, DRD2 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Neuroactive ligand-receptor interaction × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 216. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
218	Neuroactive ligand-receptor interaction 💬	[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long DRD3 D(3) dopamine receptor isoform a DRD4 D(4) dopamine receptor DRD5 D(1B) dopamine receptor	Levodopa 💬 Neuroactive ligand-receptor interaction × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 218. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
219	Neuroactive ligand-receptor interaction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem tartrate 💬 Neuroactive ligand-receptor interaction × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 219. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
220	Neuroactive ligand-receptor interaction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem 💬 Neuroactive ligand-receptor interaction × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 219. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
221	Neuroactive ligand-receptor interaction 💬	[14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIK1 glutamate receptor ionotropic, kainate 1 isoform 1 precursor GRIK2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor GRIK3 glutamate receptor ionotropic, kainate 3 precursor GRIK4 glutamate receptor ionotropic, kainate 4 isoform 1 precursor GRIK5 glutamate receptor ionotropic, kainate 5 isoform 2 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Neuroactive ligand-receptor interaction × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 221. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
222	Neuroactive ligand-receptor interaction 💬	[2] HCRTR1, HCRTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name HCRTR1 orexin/Hypocretin receptor type 1 HCRTR2 orexin receptor type 2	Suvorexant 💬 Neuroactive ligand-receptor interaction × Name Other Names Suvorexant MK-4305 Belsomra	Suvorexant	[3]  5 ,  6 , 13 💬 222. Neuroactive ligand-receptor interaction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
223	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 NF-kappa B signaling pathway × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 223. NF-kappa B signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
224	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 NF-kappa B signaling pathway × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 224. NF-kappa B signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
225	Nicotine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Nicotine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem tartrate 💬 Nicotine addiction × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 225. Nicotine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
226	Nicotine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Nicotine addiction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem 💬 Nicotine addiction × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 225. Nicotine addiction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
227	Nicotine addiction 💬	[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Nicotine addiction × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Nicotine addiction × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 227. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
228	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Ovarian steroidogenesis × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 228. Ovarian steroidogenesis × Disease ID Name  5  Progressive supranuclear palsy;PSP;
229	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Ovarian steroidogenesis × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 229. Ovarian steroidogenesis × Disease ID Name  5  Progressive supranuclear palsy;PSP;
230	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Oxytocin signaling pathway × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 230. Oxytocin signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
231	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Oxytocin signaling pathway × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 231. Oxytocin signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
232	Oxytocin signaling pathway 💬	[2] ROCK1, ROCK2 💬 Oxytocin signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Oxytocin signaling pathway × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 232. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
233	Oxytocin signaling pathway 💬	[2] ROCK1, ROCK2 💬 Oxytocin signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Oxytocin signaling pathway × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 232. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
234	Pancreatic secretion 💬	[1] CHRM3 💬 Pancreatic secretion × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl hydrochloride 💬 Pancreatic secretion × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 234. Pancreatic secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
235	Pancreatic secretion 💬	[1] CHRM3 💬 Pancreatic secretion × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl 💬 Pancreatic secretion × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 234. Pancreatic secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
236	Parkinson disease 💬	[2] DRD1, DRD2 💬 Parkinson disease × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Parkinson disease × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 236. Parkinson disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
237	Parkinson disease 💬	[2] DRD1, DRD2 💬 Parkinson disease × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Parkinson disease × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 236. Parkinson disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
238	Parkinson disease 💬	[2] DRD1, DRD2 💬 Parkinson disease × Name Full Name DRD1 D(1A) dopamine receptor DRD2 D(2) dopamine receptor isoform long	Levodopa 💬 Parkinson disease × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 238. Parkinson disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
239	Parkinson disease 💬	[1] MAOB 💬 Parkinson disease × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Parkinson disease × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 239. Parkinson disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
240	Parkinson disease 💬	[1] MAOB 💬 Parkinson disease × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Parkinson disease × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 239. Parkinson disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
241	Parkinson disease 💬	[1] MAOB 💬 Parkinson disease × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Parkinson disease × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 239. Parkinson disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
242	Parkinson disease 💬	[1] MAPT 💬 Parkinson disease × Name Full Name MAPT microtubule-associated protein tau isoform 1	Bepranemab 💬 Parkinson disease × Name Other Names Bepranemab Bepranemab	Bepranemab	[1]  5  💬 242. Parkinson disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;
243	Parkinson disease 💬	[1] MAPT 💬 Parkinson disease × Name Full Name MAPT microtubule-associated protein tau isoform 1	Flortaucipir F 18 💬 Parkinson disease × Name Other Names Flortaucipir F 18 Flortaucipir Tauvid	Flortaucipir	[3]  5 ,  7 , 127 💬 243. Parkinson disease × Disease ID Name  5  Progressive supranuclear palsy;PSP;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;
244	Pathogenic Escherichia coli infection 💬	[2] ROCK1, ROCK2 💬 Pathogenic Escherichia coli infection × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Pathogenic Escherichia coli infection × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 244. Pathogenic Escherichia coli infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
245	Pathogenic Escherichia coli infection 💬	[2] ROCK1, ROCK2 💬 Pathogenic Escherichia coli infection × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Pathogenic Escherichia coli infection × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 244. Pathogenic Escherichia coli infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
246	Pathways in cancer 💬	[1] KIT 💬 Pathways in cancer × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Pathways in cancer × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 246. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
247	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Pathways in cancer × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 247. Pathways in cancer × Disease ID Name  5  Progressive supranuclear palsy;PSP;
248	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Pathways in cancer × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 248. Pathways in cancer × Disease ID Name  5  Progressive supranuclear palsy;PSP;
249	Pathways in cancer 💬	[2] ROCK1, ROCK2 💬 Pathways in cancer × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Pathways in cancer × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 249. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
250	Pathways in cancer 💬	[2] ROCK1, ROCK2 💬 Pathways in cancer × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Pathways in cancer × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 249. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
251	Pathways of neurodegeneration - multiple diseases 💬	[3] CHRM1, CHRM3, CHRM5 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM3 muscarinic acetylcholine receptor M3 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl hydrochloride 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 251. Pathways of neurodegeneration - multiple diseases × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
252	Pathways of neurodegeneration - multiple diseases 💬	[3] CHRM1, CHRM3, CHRM5 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM3 muscarinic acetylcholine receptor M3 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 251. Pathways of neurodegeneration - multiple diseases × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
253	Pathways of neurodegeneration - multiple diseases 💬	[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 253. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
254	Pathways of neurodegeneration - multiple diseases 💬	[1] MAPT 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MAPT microtubule-associated protein tau isoform 1	Bepranemab 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Bepranemab Bepranemab	Bepranemab	[1]  5  💬 254. Pathways of neurodegeneration - multiple diseases × Disease ID Name  5  Progressive supranuclear palsy;PSP;
255	Pathways of neurodegeneration - multiple diseases 💬	[1] MAPT 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MAPT microtubule-associated protein tau isoform 1	Flortaucipir F 18 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Flortaucipir F 18 Flortaucipir Tauvid	Flortaucipir	[3]  5 ,  7 , 127 💬 255. Pathways of neurodegeneration - multiple diseases × Disease ID Name  5  Progressive supranuclear palsy;PSP;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;
256	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 256. Pathways of neurodegeneration - multiple diseases × Disease ID Name  5  Progressive supranuclear palsy;PSP;
257	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 257. Pathways of neurodegeneration - multiple diseases × Disease ID Name  5  Progressive supranuclear palsy;PSP;
258	Phenylalanine metabolism 💬	[1] MAOB 💬 Phenylalanine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Phenylalanine metabolism × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 258. Phenylalanine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
259	Phenylalanine metabolism 💬	[1] MAOB 💬 Phenylalanine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Phenylalanine metabolism × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 258. Phenylalanine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
260	Phenylalanine metabolism 💬	[1] MAOB 💬 Phenylalanine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Phenylalanine metabolism × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 258. Phenylalanine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
261	Phospholipase D signaling pathway 💬	[1] KIT 💬 Phospholipase D signaling pathway × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Phospholipase D signaling pathway × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 261. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
262	PI3K-Akt signaling pathway 💬	[2] CHRM1, CHRM2 💬 PI3K-Akt signaling pathway × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2	Trihexyphenidyl hydrochloride 💬 PI3K-Akt signaling pathway × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 262. PI3K-Akt signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
263	PI3K-Akt signaling pathway 💬	[2] CHRM1, CHRM2 💬 PI3K-Akt signaling pathway × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2	Trihexyphenidyl 💬 PI3K-Akt signaling pathway × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 262. PI3K-Akt signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
264	PI3K-Akt signaling pathway 💬	[1] KIT 💬 PI3K-Akt signaling pathway × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 PI3K-Akt signaling pathway × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 264. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
265	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor	Salsalate 💬 Platelet activation × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 265. Platelet activation × Disease ID Name  5  Progressive supranuclear palsy;PSP;
266	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor	Tolfenamic acid 💬 Platelet activation × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 266. Platelet activation × Disease ID Name  5  Progressive supranuclear palsy;PSP;
267	Platelet activation 💬	[2] ROCK1, ROCK2 💬 Platelet activation × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Platelet activation × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 267. Platelet activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
268	Platelet activation 💬	[2] ROCK1, ROCK2 💬 Platelet activation × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Platelet activation × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 267. Platelet activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
269	Prion disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Prion disease × Name Full Name GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Prion disease × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 269. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
270	Propanoate metabolism 💬	[1] ABAT 💬 Propanoate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor	Divalproex sodium 💬 Propanoate metabolism × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 270. Propanoate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
271	Propanoate metabolism 💬	[1] ABAT 💬 Propanoate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor	Valproic acid 💬 Propanoate metabolism × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 270. Propanoate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
272	Propanoate metabolism 💬	[1] ABAT 💬 Propanoate metabolism × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor	Valproate sodium 💬 Propanoate metabolism × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 270. Propanoate metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
273	Proteoglycans in cancer 💬	[2] ROCK1, ROCK2 💬 Proteoglycans in cancer × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Proteoglycans in cancer × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 273. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
274	Proteoglycans in cancer 💬	[2] ROCK1, ROCK2 💬 Proteoglycans in cancer × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Proteoglycans in cancer × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 273. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
275	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 D(2) dopamine receptor isoform long	Apomorphine hydrochloride 💬 Rap1 signaling pathway × Name Other Names Apomorphine hydrochloride Apomorphine hydrochloride hydrate Apokyn Ixense Uprima ONAPGO APOMORPHINE HYDROCLORIDE	Apomorphine	[3]  5 ,  6 ,  7  💬 275. Rap1 signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
276	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 D(2) dopamine receptor isoform long	Apomorphine 💬 Rap1 signaling pathway × Name Other Names Apomorphine Uprima	Apomorphine	[3]  5 ,  6 ,  7  💬 275. Rap1 signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD;
277	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 D(2) dopamine receptor isoform long	Levodopa 💬 Rap1 signaling pathway × Name Other Names Levodopa Dopar INBRIJA	Levodopa	[8]  5 ,  6 , 17, 90, 120, 140, 164, 201 💬 277. Rap1 signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 120 Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome; 140 Dorabe syndrome;Dravet syndrome; 164 Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome; 201 Angelman syndrome;
278	Rap1 signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Rap1 signaling pathway × Name Full Name GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor	Riluzole 💬 Rap1 signaling pathway × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 278. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
279	Rap1 signaling pathway 💬	[1] KIT 💬 Rap1 signaling pathway × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Rap1 signaling pathway × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 279. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
280	Ras signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Ras signaling pathway × Name Full Name GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor	Riluzole 💬 Ras signaling pathway × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 280. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
281	Ras signaling pathway 💬	[1] KIT 💬 Ras signaling pathway × Name Full Name KIT mast/stem cell growth factor receptor Kit isoform 1 precursor	Masitinib 💬 Ras signaling pathway × Name Other Names Masitinib Masitinib	Masitinib	[6]  2 ,  5 ,  6 , 13, 46, 96 💬 281. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
282	Regulation of actin cytoskeleton 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Regulation of actin cytoskeleton × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM4 muscarinic acetylcholine receptor M4 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl hydrochloride 💬 Regulation of actin cytoskeleton × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 282. Regulation of actin cytoskeleton × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
283	Regulation of actin cytoskeleton 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Regulation of actin cytoskeleton × Name Full Name CHRM1 muscarinic acetylcholine receptor M1 CHRM2 muscarinic acetylcholine receptor M2 CHRM3 muscarinic acetylcholine receptor M3 CHRM4 muscarinic acetylcholine receptor M4 CHRM5 muscarinic acetylcholine receptor M5	Trihexyphenidyl 💬 Regulation of actin cytoskeleton × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 282. Regulation of actin cytoskeleton × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
284	Regulation of actin cytoskeleton 💬	[2] ROCK1, ROCK2 💬 Regulation of actin cytoskeleton × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Regulation of actin cytoskeleton × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 284. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
285	Regulation of actin cytoskeleton 💬	[2] ROCK1, ROCK2 💬 Regulation of actin cytoskeleton × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Regulation of actin cytoskeleton × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 284. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
286	Regulation of lipolysis in adipocytes 💬	[3] ADRB1, ADRB2, ADRB3 💬 Regulation of lipolysis in adipocytes × Name Full Name ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 Regulation of lipolysis in adipocytes × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 286. Regulation of lipolysis in adipocytes × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
287	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Regulation of lipolysis in adipocytes × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 287. Regulation of lipolysis in adipocytes × Disease ID Name  5  Progressive supranuclear palsy;PSP;
288	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Regulation of lipolysis in adipocytes × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 288. Regulation of lipolysis in adipocytes × Disease ID Name  5  Progressive supranuclear palsy;PSP;
289	Renin secretion 💬	[3] ADRB1, ADRB2, ADRB3 💬 Renin secretion × Name Full Name ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 Renin secretion × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 289. Renin secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
290	Retrograde endocannabinoid signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Retrograde endocannabinoid signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem tartrate 💬 Retrograde endocannabinoid signaling × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 290. Retrograde endocannabinoid signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
291	Retrograde endocannabinoid signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Retrograde endocannabinoid signaling × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor GABRD gamma-aminobutyric acid receptor subunit delta precursor GABRE gamma-aminobutyric acid receptor subunit epsilon precursor GABRG1 gamma-aminobutyric acid receptor subunit gamma-1 precursor GABRG2 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor GABRG3 gamma-aminobutyric acid receptor subunit gamma-3 isoform 1 precursor GABRP gamma-aminobutyric acid receptor subunit pi isoform 1 precursor GABRQ gamma-aminobutyric acid receptor subunit theta precursor	Zolpidem 💬 Retrograde endocannabinoid signaling × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 290. Retrograde endocannabinoid signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
292	Retrograde endocannabinoid signaling 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIA4 glutamate receptor 4 isoform 1 precursor	Riluzole 💬 Retrograde endocannabinoid signaling × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 292. Retrograde endocannabinoid signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
293	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Retrograde endocannabinoid signaling × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 293. Retrograde endocannabinoid signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;
294	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Retrograde endocannabinoid signaling × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 294. Retrograde endocannabinoid signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;
295	Salivary secretion 💬	[6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬 Salivary secretion × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1 ADRA1B alpha-1B adrenergic receptor ADRA1D alpha-1D adrenergic receptor ADRB1 beta-1 adrenergic receptor ADRB2 beta-2 adrenergic receptor ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 Salivary secretion × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 295. Salivary secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
296	Salivary secretion 💬	[1] CHRM3 💬 Salivary secretion × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl hydrochloride 💬 Salivary secretion × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 296. Salivary secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
297	Salivary secretion 💬	[1] CHRM3 💬 Salivary secretion × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl 💬 Salivary secretion × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 296. Salivary secretion × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
298	Salmonella infection 💬	[1] ROCK2 💬 Salmonella infection × Name Full Name ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Salmonella infection × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 298. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
299	Salmonella infection 💬	[1] ROCK2 💬 Salmonella infection × Name Full Name ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Salmonella infection × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 298. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
300	Serotonergic synapse 💬	[3] GABRB1, GABRB2, GABRB3 💬 Serotonergic synapse × Name Full Name GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor	Zolpidem tartrate 💬 Serotonergic synapse × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 300. Serotonergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
301	Serotonergic synapse 💬	[3] GABRB1, GABRB2, GABRB3 💬 Serotonergic synapse × Name Full Name GABRB1 gamma-aminobutyric acid receptor subunit beta-1 precursor GABRB2 gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor GABRB3 gamma-aminobutyric acid receptor subunit beta-3 isoform 1 precursor	Zolpidem 💬 Serotonergic synapse × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 300. Serotonergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
302	Serotonergic synapse 💬	[1] MAOB 💬 Serotonergic synapse × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Serotonergic synapse × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 302. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
303	Serotonergic synapse 💬	[1] MAOB 💬 Serotonergic synapse × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Serotonergic synapse × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 302. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
304	Serotonergic synapse 💬	[1] MAOB 💬 Serotonergic synapse × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Serotonergic synapse × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 302. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
305	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Serotonergic synapse × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 305. Serotonergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;
306	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Serotonergic synapse × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 306. Serotonergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;
307	Shigellosis 💬	[2] ROCK1, ROCK2 💬 Shigellosis × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Shigellosis × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 307. Shigellosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
308	Shigellosis 💬	[2] ROCK1, ROCK2 💬 Shigellosis × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Shigellosis × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 307. Shigellosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
309	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 Small cell lung cancer × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 309. Small cell lung cancer × Disease ID Name  5  Progressive supranuclear palsy;PSP;
310	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 Small cell lung cancer × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 310. Small cell lung cancer × Disease ID Name  5  Progressive supranuclear palsy;PSP;
311	Sphingolipid signaling pathway 💬	[2] ROCK1, ROCK2 💬 Sphingolipid signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Sphingolipid signaling pathway × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 311. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
312	Sphingolipid signaling pathway 💬	[2] ROCK1, ROCK2 💬 Sphingolipid signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Sphingolipid signaling pathway × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 311. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
313	Spinocerebellar ataxia 💬	[8] GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate receptor 1 isoform 1 precursor GRIA2 glutamate receptor 2 isoform 1 precursor GRIA3 glutamate receptor 3 isoform 2 precursor GRIN1 glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor GRIN2C glutamate receptor ionotropic, NMDA 2C isoform 1 precursor GRIN2D glutamate receptor ionotropic, NMDA 2D precursor	Riluzole 💬 Spinocerebellar ataxia × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 313. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
314	Synaptic vesicle cycle 💬	[1] SNAP25 💬 Synaptic vesicle cycle × Name Full Name SNAP25 synaptosomal-associated protein 25 isoform SNAP25A	Botulinum toxin type A 💬 Synaptic vesicle cycle × Name Other Names Botulinum toxin type A Botox Dysport DAXXIFY	Botulinum toxin type A	[13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬 314. Synaptic vesicle cycle × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 47 Buerger disease;Thromboangiitis obliterans; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 171 Wilson disease;WD; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
315	Synaptic vesicle cycle 💬	[1] SNAP25 💬 Synaptic vesicle cycle × Name Full Name SNAP25 synaptosomal-associated protein 25 isoform SNAP25A	Incobotulinumtoxin A 💬 Synaptic vesicle cycle × Name Other Names Incobotulinumtoxin A Onaclostox Xeomin	Botulinum toxin type A	[13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬 314. Synaptic vesicle cycle × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 47 Buerger disease;Thromboangiitis obliterans; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 171 Wilson disease;WD; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
316	Systemic lupus erythematosus 💬	[2] GRIN2A, GRIN2B 💬 Systemic lupus erythematosus × Name Full Name GRIN2A glutamate receptor ionotropic, NMDA 2A isoform 1 precursor GRIN2B glutamate receptor ionotropic, NMDA 2B isoform a precursor	Riluzole 💬 Systemic lupus erythematosus × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 316. Systemic lupus erythematosus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
317	Taste transduction 💬	[1] CHRM3 💬 Taste transduction × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl hydrochloride 💬 Taste transduction × Name Other Names Trihexyphenidyl hydrochloride Artane	Trihexyphenidyl	[2]  5 ,  6  💬 317. Taste transduction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
318	Taste transduction 💬	[1] CHRM3 💬 Taste transduction × Name Full Name CHRM3 muscarinic acetylcholine receptor M3	Trihexyphenidyl 💬 Taste transduction × Name Other Names Trihexyphenidyl Apo-trihex	Trihexyphenidyl	[2]  5 ,  6  💬 317. Taste transduction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
319	Taste transduction 💬	[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 Taste transduction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor	Zolpidem tartrate 💬 Taste transduction × Name Other Names Zolpidem tartrate Ambien Intermezzo EDLUAR ZOLPIDEM ZOLPIDEM TARTRATE SUBLINGUAL	Zolpidem	[3]  5 ,  6 , 46 💬 319. Taste transduction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
320	Taste transduction 💬	[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 Taste transduction × Name Full Name GABRA1 gamma-aminobutyric acid receptor subunit alpha-1 precursor GABRA2 gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor GABRA3 gamma-aminobutyric acid receptor subunit alpha-3 precursor GABRA4 gamma-aminobutyric acid receptor subunit alpha-4 isoform 1 precursor GABRA5 gamma-aminobutyric acid receptor subunit alpha-5 precursor GABRA6 gamma-aminobutyric acid receptor subunit alpha-6 precursor	Zolpidem 💬 Taste transduction × Name Other Names Zolpidem Sanval	Zolpidem	[3]  5 ,  6 , 46 💬 319. Taste transduction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
321	Taurine and hypotaurine metabolism 💬	[2] GAD1, GAD2 💬 Taurine and hypotaurine metabolism × Name Full Name GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Divalproex sodium 💬 Taurine and hypotaurine metabolism × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 321. Taurine and hypotaurine metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
322	Taurine and hypotaurine metabolism 💬	[2] GAD1, GAD2 💬 Taurine and hypotaurine metabolism × Name Full Name GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproic acid 💬 Taurine and hypotaurine metabolism × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 321. Taurine and hypotaurine metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
323	Taurine and hypotaurine metabolism 💬	[2] GAD1, GAD2 💬 Taurine and hypotaurine metabolism × Name Full Name GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproate sodium 💬 Taurine and hypotaurine metabolism × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 321. Taurine and hypotaurine metabolism × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
324	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬 Terpenoid backbone biosynthesis × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid 💬 Terpenoid backbone biosynthesis × Name Other Names Zoledronic acid Zoledronic acid hydrate Zometa Reclast	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 324. Terpenoid backbone biosynthesis × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
325	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬 Terpenoid backbone biosynthesis × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronate disodium 💬 Terpenoid backbone biosynthesis × Name Other Names Zoledronate disodium Zoledronate disodium hydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 324. Terpenoid backbone biosynthesis × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
326	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬 Terpenoid backbone biosynthesis × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronate trisodium 💬 Terpenoid backbone biosynthesis × Name Other Names Zoledronate trisodium Zoledronate trisodium hydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 324. Terpenoid backbone biosynthesis × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
327	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬 Terpenoid backbone biosynthesis × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid 💬 Terpenoid backbone biosynthesis × Name Other Names Zoledronic acid Zometa Reclast	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 324. Terpenoid backbone biosynthesis × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
328	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬 Terpenoid backbone biosynthesis × Name Full Name FDPS farnesyl pyrophosphate synthase isoform a	Zoledronic acid hemipentahydrate 💬 Terpenoid backbone biosynthesis × Name Other Names Zoledronic acid hemipentahydrate Zoledronic acid hemipentahydrate	Zoledronic acid	[16]  5 ,  6 , 13, 17, 46, 75, 77, 93, 95, 96, 97, 270, 274, 282, 299, 333 💬 324. Terpenoid backbone biosynthesis × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 77 Growth hormone secreting pituitary adenoma;Excessive secretion of growth hormone;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 270 Chronic recurrent multifocal osteomyelitis; 274 Osteogenesis Imperfecta; 282 Congenital dyserythropoietic anemia;CDA; 299 Cystic fibrosis;CF; 333 Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;Progeria syndrome;
329	TGF-beta signaling pathway 💬	[1] ROCK1 💬 TGF-beta signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1	Fasudil hydrochloride 💬 TGF-beta signaling pathway × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 329. TGF-beta signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
330	TGF-beta signaling pathway 💬	[1] ROCK1 💬 TGF-beta signaling pathway × Name Full Name ROCK1 rho-associated protein kinase 1	Fasudil 💬 TGF-beta signaling pathway × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 329. TGF-beta signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
331	Thermogenesis 💬	[1] ADRB3 💬 Thermogenesis × Name Full Name ADRB3 beta-3 adrenergic receptor	Droxidopa 💬 Thermogenesis × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 331. Thermogenesis × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
332	Tight junction 💬	[2] ROCK1, ROCK2 💬 Tight junction × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Tight junction × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 332. Tight junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
333	Tight junction 💬	[2] ROCK1, ROCK2 💬 Tight junction × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Tight junction × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 332. Tight junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
334	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 TNF signaling pathway × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 334. TNF signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
335	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 TNF signaling pathway × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 335. TNF signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
336	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate receptor 3 isoform 2 precursor	Riluzole 💬 Transcriptional misregulation in cancer × Name Other Names Riluzole Rilutek TIGLUTIK	Riluzole	[9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 336. Transcriptional misregulation in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 18 Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia; 203 22q11.2 deletion syndrome; 206 Fragile X syndrome;
337	Tryptophan metabolism 💬	[1] MAOB 💬 Tryptophan metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Tryptophan metabolism × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 337. Tryptophan metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
338	Tryptophan metabolism 💬	[1] MAOB 💬 Tryptophan metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Tryptophan metabolism × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 337. Tryptophan metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
339	Tryptophan metabolism 💬	[1] MAOB 💬 Tryptophan metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Tryptophan metabolism × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 337. Tryptophan metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
340	Type I diabetes mellitus 💬	[2] GAD1, GAD2 💬 Type I diabetes mellitus × Name Full Name GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Divalproex sodium 💬 Type I diabetes mellitus × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 340. Type I diabetes mellitus × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
341	Type I diabetes mellitus 💬	[2] GAD1, GAD2 💬 Type I diabetes mellitus × Name Full Name GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproic acid 💬 Type I diabetes mellitus × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 340. Type I diabetes mellitus × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
342	Type I diabetes mellitus 💬	[2] GAD1, GAD2 💬 Type I diabetes mellitus × Name Full Name GAD1 glutamate decarboxylase 1 isoform GAD67 GAD2 glutamate decarboxylase 2	Valproate sodium 💬 Type I diabetes mellitus × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 340. Type I diabetes mellitus × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
343	Type II diabetes mellitus 💬	[1] CACNA1G 💬 Type II diabetes mellitus × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1	Divalproex sodium 💬 Type II diabetes mellitus × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 343. Type II diabetes mellitus × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
344	Type II diabetes mellitus 💬	[1] CACNA1G 💬 Type II diabetes mellitus × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1	Valproic acid 💬 Type II diabetes mellitus × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 343. Type II diabetes mellitus × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
345	Type II diabetes mellitus 💬	[1] CACNA1G 💬 Type II diabetes mellitus × Name Full Name CACNA1G voltage-dependent T-type calcium channel subunit alpha-1G isoform 1	Valproate sodium 💬 Type II diabetes mellitus × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 343. Type II diabetes mellitus × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
346	Tyrosine metabolism 💬	[1] MAOB 💬 Tyrosine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline mesylate 💬 Tyrosine metabolism × Name Other Names Rasagiline mesylate Rasagiline mesilate Azilect RASAGILINE	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 346. Tyrosine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
347	Tyrosine metabolism 💬	[1] MAOB 💬 Tyrosine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline 💬 Tyrosine metabolism × Name Other Names Rasagiline Azilect	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 346. Tyrosine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
348	Tyrosine metabolism 💬	[1] MAOB 💬 Tyrosine metabolism × Name Full Name MAOB amine oxidase [flavin-containing] B	Rasagiline tartrate 💬 Tyrosine metabolism × Name Other Names Rasagiline tartrate Rasagiline	Rasagiline	[4]  2 ,  5 ,  6 , 17 💬 346. Tyrosine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
349	Valine, leucine and isoleucine degradation 💬	[1] ABAT 💬 Valine, leucine and isoleucine degradation × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor	Divalproex sodium 💬 Valine, leucine and isoleucine degradation × Name Other Names Divalproex sodium Valproate semisodium Depakote DIVALPROEX SODIUM D/R DIVALPROEX SODIUM ER	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 349. Valine, leucine and isoleucine degradation × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
350	Valine, leucine and isoleucine degradation 💬	[1] ABAT 💬 Valine, leucine and isoleucine degradation × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor	Valproic acid 💬 Valine, leucine and isoleucine degradation × Name Other Names Valproic acid Depakene	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 349. Valine, leucine and isoleucine degradation × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
351	Valine, leucine and isoleucine degradation 💬	[1] ABAT 💬 Valine, leucine and isoleucine degradation × Name Full Name ABAT 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor	Valproate sodium 💬 Valine, leucine and isoleucine degradation × Name Other Names Valproate sodium Sodium valproate Depakene Selenica	Valproic acid	[11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬 349. Valine, leucine and isoleucine degradation × Disease ID Name  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;  5  Progressive supranuclear palsy;PSP; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 89 Lymphangioleiomyomatosis;LAM; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
352	Vascular smooth muscle contraction 💬	[3] ADRA1A, ADRA1B, ADRA1D 💬 Vascular smooth muscle contraction × Name Full Name ADRA1A alpha-1A adrenergic receptor isoform 1 ADRA1B alpha-1B adrenergic receptor ADRA1D alpha-1D adrenergic receptor	Droxidopa 💬 Vascular smooth muscle contraction × Name Other Names Droxidopa Dops Northera	Droxidopa	[5]  5 ,  6 , 17, 169, 170 💬 352. Vascular smooth muscle contraction × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 169 Menkes disease;Menkes syndrome; 170 Occipital horn syndrome;
353	Vascular smooth muscle contraction 💬	[2] ROCK1, ROCK2 💬 Vascular smooth muscle contraction × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Vascular smooth muscle contraction × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 353. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
354	Vascular smooth muscle contraction 💬	[2] ROCK1, ROCK2 💬 Vascular smooth muscle contraction × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Vascular smooth muscle contraction × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 353. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
355	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Salsalate 💬 VEGF signaling pathway × Name Other Names Salsalate Sasapyrine Disalcid	Salsalate	[1]  5  💬 355. VEGF signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
356	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Tolfenamic acid 💬 VEGF signaling pathway × Name Other Names Tolfenamic acid Clotam	Tolfenamic acid	[1]  5  💬 356. VEGF signaling pathway × Disease ID Name  5  Progressive supranuclear palsy;PSP;
357	Wnt signaling pathway 💬	[1] ROCK2 💬 Wnt signaling pathway × Name Full Name ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Wnt signaling pathway × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 357. Wnt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
358	Wnt signaling pathway 💬	[1] ROCK2 💬 Wnt signaling pathway × Name Full Name ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Wnt signaling pathway × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 357. Wnt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
359	Yersinia infection 💬	[2] ROCK1, ROCK2 💬 Yersinia infection × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil hydrochloride 💬 Yersinia infection × Name Other Names Fasudil hydrochloride Fasudil hydrochloride	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 359. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
360	Yersinia infection 💬	[2] ROCK1, ROCK2 💬 Yersinia infection × Name Full Name ROCK1 rho-associated protein kinase 1 ROCK2 rho-associated protein kinase 2 isoform 1	Fasudil 💬 Yersinia infection × Name Other Names Fasudil Fasudil	Fasudil	[5]  2 ,  5 ,  6 ,  7 , 51 💬 359. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  7  Corticobasal degeneration;Corticobasal syndrome;CBD; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;

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