Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Alzheimer disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Alzheimer disease × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 1. Alzheimer disease × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
2	Alzheimer disease 💬	[1] PSMB5 💬 Alzheimer disease × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Alzheimer disease × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 2. Alzheimer disease × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
3	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Alzheimer disease × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 3. Alzheimer disease × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
4	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amphetamine addiction × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Amphetamine addiction × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 4. Amphetamine addiction × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
5	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Amyotrophic lateral sclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Amyotrophic lateral sclerosis × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 5. Amyotrophic lateral sclerosis × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
6	Amyotrophic lateral sclerosis 💬	[1] PSMB5 💬 Amyotrophic lateral sclerosis × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Amyotrophic lateral sclerosis × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 6. Amyotrophic lateral sclerosis × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
7	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Arachidonic acid metabolism × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 7. Arachidonic acid metabolism × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
8	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Axon guidance × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Axon guidance × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 8. Axon guidance × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
9	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 B cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 B cell receptor signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 9. B cell receptor signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
10	Breast cancer 💬	[2] ESR1, PGR 💬 Breast cancer × Name Full Name ESR1 estrogen receptor 1 PGR progesterone receptor	Danazol 💬 Breast cancer × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 10. Breast cancer × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
11	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 C-type lectin receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 C-type lectin receptor signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 11. C-type lectin receptor signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
12	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 C-type lectin receptor signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 12. C-type lectin receptor signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
13	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Calcium signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Calcium signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 13. Calcium signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
14	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cellular senescence × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Cellular senescence × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 14. Cellular senescence × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
15	cGMP-PKG signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 cGMP-PKG signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 cGMP-PKG signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 15. cGMP-PKG signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
16	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 16. Chemical carcinogenesis - DNA adducts × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
17	Chemical carcinogenesis - receptor activation 💬	[3] AR, ESR1, PGR 💬 Chemical carcinogenesis - receptor activation × Name Full Name AR androgen receptor ESR1 estrogen receptor 1 PGR progesterone receptor	Danazol 💬 Chemical carcinogenesis - receptor activation × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 17. Chemical carcinogenesis - receptor activation × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
18	Complement and coagulation cascades 💬	[1] F8 💬 Complement and coagulation cascades × Name Full Name F8 coagulation factor VIII	Desmopressin 💬 Complement and coagulation cascades × Name Other Names Desmopressin Desmopressin (INN)	Desmopressin	[6]  6 , 64, 72, 75, 225, 288 💬 18. Complement and coagulation cascades × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 64 Thrombotic thrombocytopenic purpura;TTP; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 75 Cushing disease;Cushing; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
19	Complement and coagulation cascades 💬	[1] MASP2 💬 Complement and coagulation cascades × Name Full Name MASP2 mannan binding lectin serine peptidase 2	Narsoplimab 💬 Complement and coagulation cascades × Name Other Names Narsoplimab Narsoplimab (USAN)	Narsoplimab	[4] 64, 66, 109, 222 💬 19. Complement and coagulation cascades × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 109 Atypical hemolytic uremic syndrome;aHUS; 222 Primary nephrotic syndrome;
20	Complement and coagulation cascades 💬	[1] VWF 💬 Complement and coagulation cascades × Name Full Name VWF von Willebrand factor	Caplacizumab 💬 Complement and coagulation cascades × Name Other Names Caplacizumab Caplacizumab (USAN/INN) Caplacizumab (genetical recombination) (JAN) Caplacizumab-yhdp Cablivi (TN)	Caplacizumab	[1] 64 💬 20. Complement and coagulation cascades × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP;
21	Coronavirus disease - COVID-19 💬	[1] MASP2 💬 Coronavirus disease - COVID-19 × Name Full Name MASP2 mannan binding lectin serine peptidase 2	Narsoplimab 💬 Coronavirus disease - COVID-19 × Name Other Names Narsoplimab Narsoplimab (USAN)	Narsoplimab	[4] 64, 66, 109, 222 💬 21. Coronavirus disease - COVID-19 × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 109 Atypical hemolytic uremic syndrome;aHUS; 222 Primary nephrotic syndrome;
22	Coronavirus disease - COVID-19 💬	[1] VWF 💬 Coronavirus disease - COVID-19 × Name Full Name VWF von Willebrand factor	Caplacizumab 💬 Coronavirus disease - COVID-19 × Name Other Names Caplacizumab Caplacizumab (USAN/INN) Caplacizumab (genetical recombination) (JAN) Caplacizumab-yhdp Cablivi (TN)	Caplacizumab	[1] 64 💬 22. Coronavirus disease - COVID-19 × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP;
23	Cytokine-cytokine receptor interaction 💬	[1] MPL 💬 Cytokine-cytokine receptor interaction × Name Full Name MPL MPL proto-oncogene, thrombopoietin receptor	Romiplostim 💬 Cytokine-cytokine receptor interaction × Name Other Names Romiplostim Romiplostim (USAN/INN) Romiplostim (genetical recombination) (JAN) Nplate (TN) Romiplate (TN)	Romiplostim	[4] 60, 63, 64, 65 💬 23. Cytokine-cytokine receptor interaction × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency;
24	Dopaminergic synapse 💬	[3] PPP3CA, PPP3CB, PPP3CC 💬 Dopaminergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma	Cyclosporine 💬 Dopaminergic synapse × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 24. Dopaminergic synapse × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
25	ECM-receptor interaction 💬	[1] VWF 💬 ECM-receptor interaction × Name Full Name VWF von Willebrand factor	Caplacizumab 💬 ECM-receptor interaction × Name Other Names Caplacizumab Caplacizumab (USAN/INN) Caplacizumab (genetical recombination) (JAN) Caplacizumab-yhdp Cablivi (TN)	Caplacizumab	[1] 64 💬 25. ECM-receptor interaction × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP;
26	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬 Endocrine and other factor-regulated calcium reabsorption × Name Full Name ESR1 estrogen receptor 1	Danazol 💬 Endocrine and other factor-regulated calcium reabsorption × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 26. Endocrine and other factor-regulated calcium reabsorption × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
27	Endocrine resistance 💬	[1] ESR1 💬 Endocrine resistance × Name Full Name ESR1 estrogen receptor 1	Danazol 💬 Endocrine resistance × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 27. Endocrine resistance × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
28	Estrogen signaling pathway 💬	[2] ESR1, PGR 💬 Estrogen signaling pathway × Name Full Name ESR1 estrogen receptor 1 PGR progesterone receptor	Danazol 💬 Estrogen signaling pathway × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 28. Estrogen signaling pathway × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
29	Focal adhesion 💬	[1] VWF 💬 Focal adhesion × Name Full Name VWF von Willebrand factor	Caplacizumab 💬 Focal adhesion × Name Other Names Caplacizumab Caplacizumab (USAN/INN) Caplacizumab (genetical recombination) (JAN) Caplacizumab-yhdp Cablivi (TN)	Caplacizumab	[1] 64 💬 29. Focal adhesion × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP;
30	Glucagon signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glucagon signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Glucagon signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 30. Glucagon signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
31	Glutamatergic synapse 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Glutamatergic synapse × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Glutamatergic synapse × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 31. Glutamatergic synapse × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
32	Hematopoietic cell lineage 💬	[1] MS4A1 💬 Hematopoietic cell lineage × Name Full Name MS4A1 membrane spanning 4-domains A1	Rituximab 💬 Hematopoietic cell lineage × Name Other Names Rituximab Rituximab (USAN/INN) Rituximab (genetical recombination) (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 1] (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 2] (JAN) Rituximab-abbs Rituximab-pvvr Rituximab-arrx Rituxan (TN) Riabni (TN) Truximab (TN) RUXIENCE TRUXIMA	Rituximab	[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬 32. Hematopoietic cell lineage × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 19 Lysosomal storage disease;Lysosomal disease; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 36 Epidermolysis bullosa; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 52 Mixed connective tissue disease; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 83 Addison disease;Primary chronic adrenocortical insufficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 94 Primary sclerosing cholangitis;PSC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 162 Pemphigoid; 222 Primary nephrotic syndrome; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 296 Biliary atresia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
33	Human cytomegalovirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human cytomegalovirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Human cytomegalovirus infection × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 33. Human cytomegalovirus infection × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
34	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Human cytomegalovirus infection × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 34. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
35	Human immunodeficiency virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human immunodeficiency virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Human immunodeficiency virus 1 infection × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 35. Human immunodeficiency virus 1 infection × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
36	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Human papillomavirus infection × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 36. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
37	Human papillomavirus infection 💬	[1] VWF 💬 Human papillomavirus infection × Name Full Name VWF von Willebrand factor	Caplacizumab 💬 Human papillomavirus infection × Name Other Names Caplacizumab Caplacizumab (USAN/INN) Caplacizumab (genetical recombination) (JAN) Caplacizumab-yhdp Cablivi (TN)	Caplacizumab	[1] 64 💬 37. Human papillomavirus infection × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP;
38	Human T-cell leukemia virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Human T-cell leukemia virus 1 infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Human T-cell leukemia virus 1 infection × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 38. Human T-cell leukemia virus 1 infection × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
39	Huntington disease 💬	[1] PSMB5 💬 Huntington disease × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Huntington disease × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 39. Huntington disease × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
40	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 IL-17 signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 40. IL-17 signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
41	JAK-STAT signaling pathway 💬	[1] MPL 💬 JAK-STAT signaling pathway × Name Full Name MPL MPL proto-oncogene, thrombopoietin receptor	Romiplostim 💬 JAK-STAT signaling pathway × Name Other Names Romiplostim Romiplostim (USAN/INN) Romiplostim (genetical recombination) (JAN) Nplate (TN) Romiplate (TN)	Romiplostim	[4] 60, 63, 64, 65 💬 41. JAK-STAT signaling pathway × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency;
42	Kaposi sarcoma-associated herpesvirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 42. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
43	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 43. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
44	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Leishmaniasis × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 44. Leishmaniasis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
45	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Lipid and atherosclerosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Lipid and atherosclerosis × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 45. Lipid and atherosclerosis × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
46	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Long-term potentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Long-term potentiation × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 46. Long-term potentiation × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
47	MAPK signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 MAPK signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 MAPK signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 47. MAPK signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
48	Metabolic pathways 💬	[2] PTGS1, PTGS2 💬 Metabolic pathways × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Metabolic pathways × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 48. Metabolic pathways × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
49	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 MicroRNAs in cancer × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 49. MicroRNAs in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
50	Natural killer cell mediated cytotoxicity 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Natural killer cell mediated cytotoxicity × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Natural killer cell mediated cytotoxicity × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 50. Natural killer cell mediated cytotoxicity × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
51	Neuroactive ligand-receptor interaction 💬	[1] AVPR2 💬 Neuroactive ligand-receptor interaction × Name Full Name AVPR2 arginine vasopressin receptor 2	Desmopressin 💬 Neuroactive ligand-receptor interaction × Name Other Names Desmopressin Desmopressin (INN)	Desmopressin	[6]  6 , 64, 72, 75, 225, 288 💬 51. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 64 Thrombotic thrombocytopenic purpura;TTP; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 75 Cushing disease;Cushing; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
52	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Dexamethasone 💬 Neuroactive ligand-receptor interaction × Name Other Names Dexamethasone Dexamethasone (JP18/USP/INN) Decadron (TN) Maxidex (TN) DEXTENZA DEXYCU HEMADY OZURDEX DEXAMETHASONE 6-DAY DEXAMETHASONE INTENSOL TAPERDEX 12-DAY TAPERDEX 6-DAY TAPERDEX 7-DAY	Dexamethasone	[22] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299 💬 52. Neuroactive ligand-receptor interaction × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 16 Crow-Fukase syndrome;POEMS syndrome; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 70 Spinal stenosis;Extensive spinal canal stenosis; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 84 Sarcoidosis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 162 Pemphigoid; 222 Primary nephrotic syndrome; 235 Hypoparathyroidism;Accessory thyroid hypergasia disease; 257 Hepatic glycogenosis;Liver glycogenosis;Hepatic glycogen storage disease;Liver glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 296 Biliary atresia; 299 Cystic fibrosis;
53	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Methylprednisolone 💬 Neuroactive ligand-receptor interaction × Name Other Names Methylprednisolone Methylprednisolone (JP18/USP/INN) Medrol (TN) METHYLPRED DP	Methylprednisolone	[46]  2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 53. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 18 Spinocerebellar degeneration;SCD; 19 Lysosomal storage disease;Lysosomal disease; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 83 Addison disease;Primary chronic adrenocortical insufficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 145 West syndrome;Infantile spasm; 162 Pemphigoid; 164 Oculocutaneous albinism; 211 Hypoplastic left heart syndrome;HLHS; 220 Rapidly progressive glomerulonephritis; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia;
54	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Prednisolone 💬 Neuroactive ligand-receptor interaction × Name Other Names Prednisolone Prednisolone (JP18/USP/INN) Delta-cortef (TN)	Prednisolone	[42]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬 54. Neuroactive ligand-receptor interaction × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 75 Cushing disease;Cushing; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 145 West syndrome;Infantile spasm; 162 Pemphigoid; 222 Primary nephrotic syndrome; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 296 Biliary atresia; 299 Cystic fibrosis; 300 IgG4-related disease;
55	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Prednisone 💬 Neuroactive ligand-receptor interaction × Name Other Names Prednisone Prednisone (USP) Prednisone monohydrate Deltasone (TN) Meticorten (TN) Rayos (TN)	Prednisone	[45]  2 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬 55. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 19 Lysosomal storage disease;Lysosomal disease; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 299 Cystic fibrosis; 300 IgG4-related disease; 307 Canavan disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
56	Neutrophil extracellular trap formation 💬	[1] VWF 💬 Neutrophil extracellular trap formation × Name Full Name VWF von Willebrand factor	Caplacizumab 💬 Neutrophil extracellular trap formation × Name Other Names Caplacizumab Caplacizumab (USAN/INN) Caplacizumab (genetical recombination) (JAN) Caplacizumab-yhdp Cablivi (TN)	Caplacizumab	[1] 64 💬 56. Neutrophil extracellular trap formation × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP;
57	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 NF-kappa B signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 57. NF-kappa B signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
58	Oocyte meiosis 💬	[2] AR, PGR 💬 Oocyte meiosis × Name Full Name AR androgen receptor PGR progesterone receptor	Danazol 💬 Oocyte meiosis × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 58. Oocyte meiosis × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
59	Oocyte meiosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oocyte meiosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Oocyte meiosis × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 59. Oocyte meiosis × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
60	Osteoclast differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Osteoclast differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Osteoclast differentiation × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 60. Osteoclast differentiation × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
61	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Ovarian steroidogenesis × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 61. Ovarian steroidogenesis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
62	Oxytocin signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Oxytocin signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Oxytocin signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 62. Oxytocin signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
63	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Oxytocin signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 63. Oxytocin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
64	Parkinson disease 💬	[1] PSMB5 💬 Parkinson disease × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Parkinson disease × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 64. Parkinson disease × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
65	Pathways in cancer 💬	[2] AR, ESR1 💬 Pathways in cancer × Name Full Name AR androgen receptor ESR1 estrogen receptor 1	Danazol 💬 Pathways in cancer × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 65. Pathways in cancer × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
66	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Pathways in cancer × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 66. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
67	Pathways of neurodegeneration - multiple diseases 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 67. Pathways of neurodegeneration - multiple diseases × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
68	Pathways of neurodegeneration - multiple diseases 💬	[1] PSMB5 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 68. Pathways of neurodegeneration - multiple diseases × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
69	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 69. Pathways of neurodegeneration - multiple diseases × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
70	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 70. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
71	Phospholipase D signaling pathway 💬	[1] AVPR2 💬 Phospholipase D signaling pathway × Name Full Name AVPR2 arginine vasopressin receptor 2	Desmopressin 💬 Phospholipase D signaling pathway × Name Other Names Desmopressin Desmopressin (INN)	Desmopressin	[6]  6 , 64, 72, 75, 225, 288 💬 71. Phospholipase D signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 64 Thrombotic thrombocytopenic purpura;TTP; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 75 Cushing disease;Cushing; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
72	PI3K-Akt signaling pathway 💬	[1] VWF 💬 PI3K-Akt signaling pathway × Name Full Name VWF von Willebrand factor	Caplacizumab 💬 PI3K-Akt signaling pathway × Name Other Names Caplacizumab Caplacizumab (USAN/INN) Caplacizumab (genetical recombination) (JAN) Caplacizumab-yhdp Cablivi (TN)	Caplacizumab	[1] 64 💬 72. PI3K-Akt signaling pathway × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP;
73	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1	Aspirin 💬 Platelet activation × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 73. Platelet activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
74	Platelet activation 💬	[1] VWF 💬 Platelet activation × Name Full Name VWF von Willebrand factor	Caplacizumab 💬 Platelet activation × Name Other Names Caplacizumab Caplacizumab (USAN/INN) Caplacizumab (genetical recombination) (JAN) Caplacizumab-yhdp Cablivi (TN)	Caplacizumab	[1] 64 💬 74. Platelet activation × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP;
75	Prion disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Prion disease × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Prion disease × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 75. Prion disease × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
76	Prion disease 💬	[1] PSMB5 💬 Prion disease × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Prion disease × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 76. Prion disease × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
77	Progesterone-mediated oocyte maturation 💬	[1] PGR 💬 Progesterone-mediated oocyte maturation × Name Full Name PGR progesterone receptor	Danazol 💬 Progesterone-mediated oocyte maturation × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 77. Progesterone-mediated oocyte maturation × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
78	Prolactin signaling pathway 💬	[1] ESR1 💬 Prolactin signaling pathway × Name Full Name ESR1 estrogen receptor 1	Danazol 💬 Prolactin signaling pathway × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 78. Prolactin signaling pathway × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
79	Prostate cancer 💬	[1] AR 💬 Prostate cancer × Name Full Name AR androgen receptor	Danazol 💬 Prostate cancer × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 79. Prostate cancer × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
80	Proteasome 💬	[1] PSMB5 💬 Proteasome × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Proteasome × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 80. Proteasome × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
81	Proteoglycans in cancer 💬	[1] ESR1 💬 Proteoglycans in cancer × Name Full Name ESR1 estrogen receptor 1	Danazol 💬 Proteoglycans in cancer × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 81. Proteoglycans in cancer × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
82	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Regulation of lipolysis in adipocytes × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 82. Regulation of lipolysis in adipocytes × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
83	Renin secretion 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Renin secretion × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Renin secretion × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 83. Renin secretion × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
84	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Retrograde endocannabinoid signaling × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 84. Retrograde endocannabinoid signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
85	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Serotonergic synapse × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 85. Serotonergic synapse × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
86	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 Small cell lung cancer × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 86. Small cell lung cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
87	Spinocerebellar ataxia 💬	[1] PSMB5 💬 Spinocerebellar ataxia × Name Full Name PSMB5 proteasome 20S subunit beta 5	Bortezomib 💬 Spinocerebellar ataxia × Name Other Names Bortezomib Bortezomib (JAN/USAN/INN) Velcade (TN)	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 87. Spinocerebellar ataxia × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 222 Primary nephrotic syndrome; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
88	Staphylococcus aureus infection 💬	[1] MASP2 💬 Staphylococcus aureus infection × Name Full Name MASP2 mannan binding lectin serine peptidase 2	Narsoplimab 💬 Staphylococcus aureus infection × Name Other Names Narsoplimab Narsoplimab (USAN)	Narsoplimab	[4] 64, 66, 109, 222 💬 88. Staphylococcus aureus infection × Disease ID Name 64 Thrombotic thrombocytopenic purpura;TTP; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 109 Atypical hemolytic uremic syndrome;aHUS; 222 Primary nephrotic syndrome;
89	T cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 T cell receptor signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 T cell receptor signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 89. T cell receptor signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
90	Th1 and Th2 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th1 and Th2 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Th1 and Th2 cell differentiation × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 90. Th1 and Th2 cell differentiation × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
91	Th17 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Th17 cell differentiation × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Th17 cell differentiation × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 91. Th17 cell differentiation × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
92	Thyroid hormone signaling pathway 💬	[1] ESR1 💬 Thyroid hormone signaling pathway × Name Full Name ESR1 estrogen receptor 1	Danazol 💬 Thyroid hormone signaling pathway × Name Other Names Danazol Danazol (JP18/USP/INN) Danocrine (TN)	Danazol	[5] 60, 63, 64, 65, 285 💬 92. Thyroid hormone signaling pathway × Disease ID Name 60 Aplastic anemia; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 285 Fanconi anemia;
93	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 TNF signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 93. TNF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
94	Tuberculosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tuberculosis × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Tuberculosis × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 94. Tuberculosis × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
95	Vasopressin-regulated water reabsorption 💬	[1] AVPR2 💬 Vasopressin-regulated water reabsorption × Name Full Name AVPR2 arginine vasopressin receptor 2	Desmopressin 💬 Vasopressin-regulated water reabsorption × Name Other Names Desmopressin Desmopressin (INN)	Desmopressin	[6]  6 , 64, 72, 75, 225, 288 💬 95. Vasopressin-regulated water reabsorption × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 64 Thrombotic thrombocytopenic purpura;TTP; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH; 75 Cushing disease;Cushing; 225 Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
96	VEGF signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 VEGF signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 VEGF signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 96. VEGF signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;
97	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Aspirin 💬 VEGF signaling pathway × Name Other Names Aspirin Aspirin (JP18/USP) Aspalon (JAN) Acetylsalicylic acid Easprin (TN) Durlaza (TN)	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 97. VEGF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 22 Moyamoya disease;Occlusive disease in circle of Willis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 58 Hypertrophic cardiomyopathy;HCM; 64 Thrombotic thrombocytopenic purpura;TTP; 86 Pulmonary arterial hypertension;PAH; 97 Ulcerative colitis; 113 Muscular dystrophy; 158 Tuberous sclerosis;Tuberous sclerosis complex; 210 Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome; 231 Alpha-1-antitrypsin deficiency;AATD; 251 Urea cycle disorder;
98	Wnt signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Wnt signaling pathway × Name Full Name PPP3CA protein phosphatase 3 catalytic subunit alpha PPP3CB protein phosphatase 3 catalytic subunit beta PPP3CC protein phosphatase 3 catalytic subunit gamma PPP3R1 protein phosphatase 3 regulatory subunit B, alpha PPP3R2 protein phosphatase 3 regulatory subunit B, beta	Cyclosporine 💬 Wnt signaling pathway × Name Other Names Cyclosporine Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA RESTASIS MULTIDOSE VERKAZIA CYCLOSPORINE, MODFIED	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 98. Wnt signaling pathway × Disease ID Name 11 Myasthenia gravis;MG; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 58 Hypertrophic cardiomyopathy;HCM; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 90 Retinitis pigmentosa; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 302 Leber hereditary optic neuropathy; 326 Osteopetrosis;

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