Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
2 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
3 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
4 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
5 cAMP signaling pathway 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [5]  6 , 17, 78, 193, 233 💬
6 cAMP signaling pathway 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
7 cAMP signaling pathway 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
8 cAMP signaling pathway 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
9 cAMP signaling pathway 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
10 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone 💬 Testosterone [9]  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬
11 Circadian entrainment 💬
 [2] MTNR1A, MTNR1B 💬 Melatonin 💬 Melatonin [17]  2 ,  6 ,  8 , 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 202, 265 💬
12 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
13 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
14 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
15 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
16 Cushing syndrome 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
17 Cushing syndrome 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
18 Cushing syndrome 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
19 Cushing syndrome 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
20 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 Somatropin 💬 Somatotropin [28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
21 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 Somatropin 💬 Somatotropin [28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
22 Hormone signaling 💬
 [1] GHR 💬 Somatropin 💬 Somatotropin [28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
23 Hormone signaling 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [5]  6 , 17, 78, 193, 233 💬
24 Hormone signaling 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
25 Hormone signaling 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
26 Hormone signaling 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
27 Hormone signaling 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
28 Hormone signaling 💬
 [2] THRA, THRB 💬 Levothyroxine sodium 💬 Levothyroxine [3] 49, 78, 80 💬
29 Hormone signaling 💬
 [2] THRA, THRB 💬 Levothyroxine 💬 Levothyroxine [3] 49, 78, 80 💬
30 Hormone signaling 💬
 [2] THRA, THRB 💬 Levothyroxine sodium 💬 Levothyroxine [3] 49, 78, 80 💬
31 Insulin secretion 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [5]  6 , 17, 78, 193, 233 💬
32 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Somatropin 💬 Somatotropin [28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
33 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 Somatropin 💬 Somatotropin [28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
34 Neuroactive ligand-receptor interaction 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [5]  6 , 17, 78, 193, 233 💬
35 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
36 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
37 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
38 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
39 Neuroactive ligand-receptor interaction 💬
 [2] MTNR1A, MTNR1B 💬 Melatonin 💬 Melatonin [17]  2 ,  6 ,  8 , 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 202, 265 💬
40 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Hydrocortisone 💬 Hydrocortisone [11]  6 , 41, 46, 53, 75, 78, 81, 83, 97, 98, 299 💬
41 Neuroactive ligand-receptor interaction 💬
 [2] THRA, THRB 💬 Levothyroxine sodium 💬 Levothyroxine [3] 49, 78, 80 💬
42 Neuroactive ligand-receptor interaction 💬
 [2] THRA, THRB 💬 Levothyroxine 💬 Levothyroxine [3] 49, 78, 80 💬
43 Neuroactive ligand-receptor interaction 💬
 [2] THRA, THRB 💬 Levothyroxine sodium 💬 Levothyroxine [3] 49, 78, 80 💬
44 Oocyte meiosis 💬
 [1] AR 💬 Testosterone 💬 Testosterone [9]  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬
45 Ovarian steroidogenesis 💬
 [1] CYP19A 💬 Anastrozole 💬 Anastrozole [3] 78, 86, 193 💬
46 Pathways in cancer 💬
 [1] AR 💬 Testosterone 💬 Testosterone [9]  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬
47 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Somatropin 💬 Somatotropin [28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
48 Prostate cancer 💬
 [1] AR 💬 Testosterone 💬 Testosterone [9]  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬
49 Steroid hormone biosynthesis 💬
 [1] CYP19A 💬 Anastrozole 💬 Anastrozole [3] 78, 86, 193 💬
50 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 Levothyroxine sodium 💬 Levothyroxine [3] 49, 78, 80 💬
51 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 Levothyroxine 💬 Levothyroxine [3] 49, 78, 80 💬
52 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 Levothyroxine sodium 💬 Levothyroxine [3] 49, 78, 80 💬

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