Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Aldosterone synthesis and secretion 💬	[1] MC2R 💬 Aldosterone synthesis and secretion × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin 💬 Aldosterone synthesis and secretion × Name Other Names Corticotropin ACTH Acthar PURIFIED CORTROPHIN GEL	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 1. Aldosterone synthesis and secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
2	Aldosterone synthesis and secretion 💬	[1] MC2R 💬 Aldosterone synthesis and secretion × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin, repository 💬 Aldosterone synthesis and secretion × Name Other Names Corticotropin, repository Cortigel	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 1. Aldosterone synthesis and secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
3	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Alzheimer disease × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 3. Alzheimer disease × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
4	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Alzheimer disease × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 3. Alzheimer disease × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
5	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Alzheimer disease × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 3. Alzheimer disease × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
6	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Alzheimer disease × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 3. Alzheimer disease × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
7	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Alzheimer disease × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 3. Alzheimer disease × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
8	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Arachidonic acid metabolism × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 8. Arachidonic acid metabolism × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
9	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Arachidonic acid metabolism × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 8. Arachidonic acid metabolism × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
10	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Arachidonic acid metabolism × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 8. Arachidonic acid metabolism × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
11	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Arachidonic acid metabolism × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 8. Arachidonic acid metabolism × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
12	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Arachidonic acid metabolism × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 8. Arachidonic acid metabolism × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
13	Breast cancer 💬	[2] ESR1, ESR2 💬 Breast cancer × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol 💬 Breast cancer × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 13. Breast cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
14	Breast cancer 💬	[2] ESR1, ESR2 💬 Breast cancer × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol hemihydrate 💬 Breast cancer × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 13. Breast cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
15	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 C-type lectin receptor signaling pathway × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 15. C-type lectin receptor signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
16	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 C-type lectin receptor signaling pathway × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 15. C-type lectin receptor signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
17	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 C-type lectin receptor signaling pathway × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 15. C-type lectin receptor signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
18	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 C-type lectin receptor signaling pathway × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 15. C-type lectin receptor signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
19	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 C-type lectin receptor signaling pathway × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 15. C-type lectin receptor signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
20	cAMP signaling pathway 💬	[1] GLP1R 💬 cAMP signaling pathway × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Exenatide 💬 cAMP signaling pathway × Name Other Names Exenatide Byetta	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 20. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
21	cAMP signaling pathway 💬	[1] MC2R 💬 cAMP signaling pathway × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin 💬 cAMP signaling pathway × Name Other Names Corticotropin ACTH Acthar PURIFIED CORTROPHIN GEL	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 21. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
22	cAMP signaling pathway 💬	[1] MC2R 💬 cAMP signaling pathway × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin, repository 💬 cAMP signaling pathway × Name Other Names Corticotropin, repository Cortigel	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 21. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
23	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 23. Chemical carcinogenesis - DNA adducts × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
24	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 23. Chemical carcinogenesis - DNA adducts × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
25	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 23. Chemical carcinogenesis - DNA adducts × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
26	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 23. Chemical carcinogenesis - DNA adducts × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
27	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 23. Chemical carcinogenesis - DNA adducts × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
28	Chemical carcinogenesis - receptor activation 💬	[1] AR 💬 Chemical carcinogenesis - receptor activation × Name Full Name AR androgen receptor isoform 1	Testosterone 💬 Chemical carcinogenesis - receptor activation × Name Other Names Testosterone Androderm Androgel Axiron Striant Testim NATESTO VOGELXO TESTOPEL TESTOSTERONE GEL, 1%	Testosterone	[9]  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬 28. Chemical carcinogenesis - receptor activation × Disease ID Name  1  Spinal and bulbar muscular atrophy;Spinobulbar muscular atrophy;SBMA;Kennedy disease;Kennedy syndrome;Kennedy-Alter-Sung syndrome;  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 60 Aplastic anemia; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 265 Lipodystrophy;
29	Chemical carcinogenesis - receptor activation 💬	[2] ESR1, ESR2 💬 Chemical carcinogenesis - receptor activation × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol 💬 Chemical carcinogenesis - receptor activation × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 29. Chemical carcinogenesis - receptor activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
30	Chemical carcinogenesis - receptor activation 💬	[2] ESR1, ESR2 💬 Chemical carcinogenesis - receptor activation × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol hemihydrate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 29. Chemical carcinogenesis - receptor activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
31	Circadian entrainment 💬	[2] MTNR1A, MTNR1B 💬 Circadian entrainment × Name Full Name MTNR1A melatonin receptor type 1A MTNR1B melatonin receptor type 1B	Melatonin 💬 Circadian entrainment × Name Other Names Melatonin Melatonina Melatobel	Melatonin	[18]  2 ,  6 ,  8 , 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 159, 202, 265 💬 31. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 37 Generalised pustular psoriasis;GPP;Pustular psoriasis;Herpetic impetigo; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 86 Pulmonary arterial hypertension;PAH; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 159 Xeroderma pigmentosum;XP; 202 Smith-Magenis syndrome; 265 Lipodystrophy;
32	Cortisol synthesis and secretion 💬	[1] MC2R 💬 Cortisol synthesis and secretion × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin 💬 Cortisol synthesis and secretion × Name Other Names Corticotropin ACTH Acthar PURIFIED CORTROPHIN GEL	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 32. Cortisol synthesis and secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
33	Cortisol synthesis and secretion 💬	[1] MC2R 💬 Cortisol synthesis and secretion × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin, repository 💬 Cortisol synthesis and secretion × Name Other Names Corticotropin, repository Cortigel	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 32. Cortisol synthesis and secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
34	Cushing syndrome 💬	[1] MC2R 💬 Cushing syndrome × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin 💬 Cushing syndrome × Name Other Names Corticotropin ACTH Acthar PURIFIED CORTROPHIN GEL	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 34. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
35	Cushing syndrome 💬	[1] MC2R 💬 Cushing syndrome × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin, repository 💬 Cushing syndrome × Name Other Names Corticotropin, repository Cortigel	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 34. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
36	Efferocytosis 💬	[1] PTGS2 💬 Efferocytosis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Efferocytosis × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 36. Efferocytosis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
37	Efferocytosis 💬	[1] PTGS2 💬 Efferocytosis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Efferocytosis × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 36. Efferocytosis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
38	Efferocytosis 💬	[1] PTGS2 💬 Efferocytosis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Efferocytosis × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 36. Efferocytosis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
39	Efferocytosis 💬	[1] PTGS2 💬 Efferocytosis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Efferocytosis × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 36. Efferocytosis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
40	Efferocytosis 💬	[1] PTGS2 💬 Efferocytosis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Efferocytosis × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 36. Efferocytosis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
41	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬 Endocrine and other factor-regulated calcium reabsorption × Name Full Name ESR1 estrogen receptor isoform 1	Estradiol 💬 Endocrine and other factor-regulated calcium reabsorption × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 41. Endocrine and other factor-regulated calcium reabsorption × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
42	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬 Endocrine and other factor-regulated calcium reabsorption × Name Full Name ESR1 estrogen receptor isoform 1	Estradiol hemihydrate 💬 Endocrine and other factor-regulated calcium reabsorption × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 41. Endocrine and other factor-regulated calcium reabsorption × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
43	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬 Estrogen signaling pathway × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol 💬 Estrogen signaling pathway × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 43. Estrogen signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
44	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬 Estrogen signaling pathway × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol hemihydrate 💬 Estrogen signaling pathway × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 43. Estrogen signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
45	GnRH secretion 💬	[1] ESR2 💬 GnRH secretion × Name Full Name ESR2 estrogen receptor beta isoform 1	Estradiol 💬 GnRH secretion × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 45. GnRH secretion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
46	GnRH secretion 💬	[1] ESR2 💬 GnRH secretion × Name Full Name ESR2 estrogen receptor beta isoform 1	Estradiol hemihydrate 💬 GnRH secretion × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 45. GnRH secretion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
47	Hormone signaling 💬	[2] ESR1, ESR2 💬 Hormone signaling × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol 💬 Hormone signaling × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 47. Hormone signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
48	Hormone signaling 💬	[2] ESR1, ESR2 💬 Hormone signaling × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol hemihydrate 💬 Hormone signaling × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 47. Hormone signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
49	Hormone signaling 💬	[1] GLP1R 💬 Hormone signaling × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Exenatide 💬 Hormone signaling × Name Other Names Exenatide Byetta	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 49. Hormone signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
50	Hormone signaling 💬	[1] MC2R 💬 Hormone signaling × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin 💬 Hormone signaling × Name Other Names Corticotropin ACTH Acthar PURIFIED CORTROPHIN GEL	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 50. Hormone signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
51	Hormone signaling 💬	[1] MC2R 💬 Hormone signaling × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin, repository 💬 Hormone signaling × Name Other Names Corticotropin, repository Cortigel	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 50. Hormone signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
52	Hormone signaling 💬	[2] THRA, THRB 💬 Hormone signaling × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine sodium 💬 Hormone signaling × Name Other Names Levothyroxine sodium Levothyroxine sodium hydrate Levothroid Levoxyl Synthroid EUTHYROX THYQUIDITY TIROSINT UNITHROID	Levothyroxine	[3] 49, 78, 80 💬 52. Hormone signaling × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
53	Hormone signaling 💬	[2] THRA, THRB 💬 Hormone signaling × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine 💬 Hormone signaling × Name Other Names Levothyroxine Forthyron	Levothyroxine	[3] 49, 78, 80 💬 52. Hormone signaling × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
54	Hormone signaling 💬	[2] THRA, THRB 💬 Hormone signaling × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine sodium 💬 Hormone signaling × Name Other Names Levothyroxine sodium Levothyroxine sodium anhydrous	Levothyroxine	[3] 49, 78, 80 💬 52. Hormone signaling × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
55	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Human cytomegalovirus infection × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 55. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
56	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Human cytomegalovirus infection × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 55. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
57	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Human cytomegalovirus infection × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 55. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
58	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Human cytomegalovirus infection × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 55. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
59	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Human cytomegalovirus infection × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 55. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
60	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Human papillomavirus infection × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 60. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
61	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Human papillomavirus infection × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 60. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
62	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Human papillomavirus infection × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 60. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
63	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Human papillomavirus infection × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 60. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
64	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Human papillomavirus infection × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 60. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
65	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 IL-17 signaling pathway × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 65. IL-17 signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
66	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 IL-17 signaling pathway × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 65. IL-17 signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
67	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 IL-17 signaling pathway × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 65. IL-17 signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
68	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 IL-17 signaling pathway × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 65. IL-17 signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
69	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 IL-17 signaling pathway × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 65. IL-17 signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
70	Insulin secretion 💬	[1] GLP1R 💬 Insulin secretion × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Exenatide 💬 Insulin secretion × Name Other Names Exenatide Byetta	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 70. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
71	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 71. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
72	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 71. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
73	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 71. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
74	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 71. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
75	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 71. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
76	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Leishmaniasis × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 76. Leishmaniasis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
77	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Leishmaniasis × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 76. Leishmaniasis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
78	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Leishmaniasis × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 76. Leishmaniasis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
79	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Leishmaniasis × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 76. Leishmaniasis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
80	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Leishmaniasis × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 76. Leishmaniasis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
81	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 MicroRNAs in cancer × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 81. MicroRNAs in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
82	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 MicroRNAs in cancer × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 81. MicroRNAs in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
83	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 MicroRNAs in cancer × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 81. MicroRNAs in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
84	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 MicroRNAs in cancer × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 81. MicroRNAs in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
85	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 MicroRNAs in cancer × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 81. MicroRNAs in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
86	Neuroactive ligand-receptor interaction 💬	[1] GLP1R 💬 Neuroactive ligand-receptor interaction × Name Full Name GLP1R glucagon-like peptide 1 receptor precursor	Exenatide 💬 Neuroactive ligand-receptor interaction × Name Other Names Exenatide Byetta	Exenatide	[6]  6 , 17, 72, 78, 193, 233 💬 86. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 17 Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 193 Prader-Willi syndrome; 233 Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
87	Neuroactive ligand-receptor interaction 💬	[1] MC2R 💬 Neuroactive ligand-receptor interaction × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin 💬 Neuroactive ligand-receptor interaction × Name Other Names Corticotropin ACTH Acthar PURIFIED CORTROPHIN GEL	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 87. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
88	Neuroactive ligand-receptor interaction 💬	[1] MC2R 💬 Neuroactive ligand-receptor interaction × Name Full Name MC2R adrenocorticotropic hormone receptor	Corticotropin, repository 💬 Neuroactive ligand-receptor interaction × Name Other Names Corticotropin, repository Cortigel	Corticotropin	[10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬 87. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 84 Sarcoidosis; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome; 222 Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
89	Neuroactive ligand-receptor interaction 💬	[2] MTNR1A, MTNR1B 💬 Neuroactive ligand-receptor interaction × Name Full Name MTNR1A melatonin receptor type 1A MTNR1B melatonin receptor type 1B	Melatonin 💬 Neuroactive ligand-receptor interaction × Name Other Names Melatonin Melatonina Melatobel	Melatonin	[18]  2 ,  6 ,  8 , 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 159, 202, 265 💬 89. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;  8  Huntington disease;Huntington chorea;Huntington syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 37 Generalised pustular psoriasis;GPP;Pustular psoriasis;Herpetic impetigo; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 72 Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Disorders of antidiuretic hormone (ADH) secretion;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 86 Pulmonary arterial hypertension;PAH; 90 Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 149 Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome; 159 Xeroderma pigmentosum;XP; 202 Smith-Magenis syndrome; 265 Lipodystrophy;
90	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 glucocorticoid receptor isoform alpha	Hydrocortisone 💬 Neuroactive ligand-receptor interaction × Name Other Names Hydrocortisone HC Acticort Anusol HC Colocort Cortef Hytone Plenadren ALKINDI CORTENEMA KHINDIVI ALA-SCALP ALACORT ANUSOL HYDROCORTISONE CREAM HYDROCORTISONE RECTAL SUSPENSION PROCTO-MED HC PROCTOSOL-HC PROCTOZONE-HC TEXACORT	Hydrocortisone	[10]  6 , 41, 46, 53, 75, 78, 81, 83, 97, 299 💬 90. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy; 75 Cushing disease;Cushing syndrome; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency; 83 Addison disease;Primary chronic adrenocortical insufficiency; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 299 Cystic fibrosis;CF;
91	Neuroactive ligand-receptor interaction 💬	[2] THRA, THRB 💬 Neuroactive ligand-receptor interaction × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine sodium 💬 Neuroactive ligand-receptor interaction × Name Other Names Levothyroxine sodium Levothyroxine sodium hydrate Levothroid Levoxyl Synthroid EUTHYROX THYQUIDITY TIROSINT UNITHROID	Levothyroxine	[3] 49, 78, 80 💬 91. Neuroactive ligand-receptor interaction × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
92	Neuroactive ligand-receptor interaction 💬	[2] THRA, THRB 💬 Neuroactive ligand-receptor interaction × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine 💬 Neuroactive ligand-receptor interaction × Name Other Names Levothyroxine Forthyron	Levothyroxine	[3] 49, 78, 80 💬 91. Neuroactive ligand-receptor interaction × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
93	Neuroactive ligand-receptor interaction 💬	[2] THRA, THRB 💬 Neuroactive ligand-receptor interaction × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine sodium 💬 Neuroactive ligand-receptor interaction × Name Other Names Levothyroxine sodium Levothyroxine sodium anhydrous	Levothyroxine	[3] 49, 78, 80 💬 91. Neuroactive ligand-receptor interaction × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
94	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 NF-kappa B signaling pathway × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 94. NF-kappa B signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
95	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 NF-kappa B signaling pathway × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 94. NF-kappa B signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
96	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 NF-kappa B signaling pathway × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 94. NF-kappa B signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
97	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 NF-kappa B signaling pathway × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 94. NF-kappa B signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
98	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 NF-kappa B signaling pathway × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 94. NF-kappa B signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
99	Oocyte meiosis 💬	[1] AR 💬 Oocyte meiosis × Name Full Name AR androgen receptor isoform 1	Testosterone 💬 Oocyte meiosis × Name Other Names Testosterone Androderm Androgel Axiron Striant Testim NATESTO VOGELXO TESTOPEL TESTOSTERONE GEL, 1%	Testosterone	[9]  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬 99. Oocyte meiosis × Disease ID Name  1  Spinal and bulbar muscular atrophy;Spinobulbar muscular atrophy;SBMA;Kennedy disease;Kennedy syndrome;Kennedy-Alter-Sung syndrome;  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 60 Aplastic anemia; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 265 Lipodystrophy;
100	Ovarian steroidogenesis 💬	[1] CYP19A1 💬 Ovarian steroidogenesis × Name Full Name CYP19A1 aromatase	Anastrozole 💬 Ovarian steroidogenesis × Name Other Names Anastrozole Arimidex	Anastrozole	[3] 78, 86, 193 💬 100. Ovarian steroidogenesis × Disease ID Name 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 86 Pulmonary arterial hypertension;PAH; 193 Prader-Willi syndrome;
101	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Ovarian steroidogenesis × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 101. Ovarian steroidogenesis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
102	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Ovarian steroidogenesis × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 101. Ovarian steroidogenesis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
103	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Ovarian steroidogenesis × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 101. Ovarian steroidogenesis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
104	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Ovarian steroidogenesis × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 101. Ovarian steroidogenesis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
105	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Ovarian steroidogenesis × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 101. Ovarian steroidogenesis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
106	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Oxytocin signaling pathway × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 106. Oxytocin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
107	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Oxytocin signaling pathway × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 106. Oxytocin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
108	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Oxytocin signaling pathway × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 106. Oxytocin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
109	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Oxytocin signaling pathway × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 106. Oxytocin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
110	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Oxytocin signaling pathway × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 106. Oxytocin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
111	Pathways in cancer 💬	[1] AR 💬 Pathways in cancer × Name Full Name AR androgen receptor isoform 1	Testosterone 💬 Pathways in cancer × Name Other Names Testosterone Androderm Androgel Axiron Striant Testim NATESTO VOGELXO TESTOPEL TESTOSTERONE GEL, 1%	Testosterone	[9]  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬 111. Pathways in cancer × Disease ID Name  1  Spinal and bulbar muscular atrophy;Spinobulbar muscular atrophy;SBMA;Kennedy disease;Kennedy syndrome;Kennedy-Alter-Sung syndrome;  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 60 Aplastic anemia; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 265 Lipodystrophy;
112	Pathways in cancer 💬	[2] ESR1, ESR2 💬 Pathways in cancer × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol 💬 Pathways in cancer × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 112. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
113	Pathways in cancer 💬	[2] ESR1, ESR2 💬 Pathways in cancer × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol hemihydrate 💬 Pathways in cancer × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 112. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
114	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Pathways in cancer × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 114. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
115	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Pathways in cancer × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 114. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
116	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Pathways in cancer × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 114. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
117	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Pathways in cancer × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 114. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
118	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Pathways in cancer × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 114. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
119	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 119. Pathways of neurodegeneration - multiple diseases × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
120	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 119. Pathways of neurodegeneration - multiple diseases × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
121	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 119. Pathways of neurodegeneration - multiple diseases × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
122	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 119. Pathways of neurodegeneration - multiple diseases × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
123	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 119. Pathways of neurodegeneration - multiple diseases × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
124	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor	Diclofenac potassium 💬 Platelet activation × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 124. Platelet activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
125	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor	Diclofenac sodium 💬 Platelet activation × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 124. Platelet activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
126	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor	Diclofenac 💬 Platelet activation × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 124. Platelet activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
127	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor	Diclofenac diethylamine 💬 Platelet activation × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 124. Platelet activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
128	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor	Diclofenac epolamine 💬 Platelet activation × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 124. Platelet activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
129	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬 Prolactin signaling pathway × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol 💬 Prolactin signaling pathway × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 129. Prolactin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
130	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬 Prolactin signaling pathway × Name Full Name ESR1 estrogen receptor isoform 1 ESR2 estrogen receptor beta isoform 1	Estradiol hemihydrate 💬 Prolactin signaling pathway × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 129. Prolactin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
131	Prostate cancer 💬	[1] AR 💬 Prostate cancer × Name Full Name AR androgen receptor isoform 1	Testosterone 💬 Prostate cancer × Name Other Names Testosterone Androderm Androgel Axiron Striant Testim NATESTO VOGELXO TESTOPEL TESTOSTERONE GEL, 1%	Testosterone	[9]  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬 131. Prostate cancer × Disease ID Name  1  Spinal and bulbar muscular atrophy;Spinobulbar muscular atrophy;SBMA;Kennedy disease;Kennedy syndrome;Kennedy-Alter-Sung syndrome;  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 60 Aplastic anemia; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 265 Lipodystrophy;
132	Proteoglycans in cancer 💬	[1] ESR1 💬 Proteoglycans in cancer × Name Full Name ESR1 estrogen receptor isoform 1	Estradiol 💬 Proteoglycans in cancer × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 132. Proteoglycans in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
133	Proteoglycans in cancer 💬	[1] ESR1 💬 Proteoglycans in cancer × Name Full Name ESR1 estrogen receptor isoform 1	Estradiol hemihydrate 💬 Proteoglycans in cancer × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 132. Proteoglycans in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
134	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Regulation of lipolysis in adipocytes × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 134. Regulation of lipolysis in adipocytes × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
135	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Regulation of lipolysis in adipocytes × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 134. Regulation of lipolysis in adipocytes × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
136	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Regulation of lipolysis in adipocytes × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 134. Regulation of lipolysis in adipocytes × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
137	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Regulation of lipolysis in adipocytes × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 134. Regulation of lipolysis in adipocytes × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
138	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Regulation of lipolysis in adipocytes × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 134. Regulation of lipolysis in adipocytes × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
139	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Retrograde endocannabinoid signaling × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 139. Retrograde endocannabinoid signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
140	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Retrograde endocannabinoid signaling × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 139. Retrograde endocannabinoid signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
141	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Retrograde endocannabinoid signaling × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 139. Retrograde endocannabinoid signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
142	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Retrograde endocannabinoid signaling × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 139. Retrograde endocannabinoid signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
143	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Retrograde endocannabinoid signaling × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 139. Retrograde endocannabinoid signaling × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
144	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Serotonergic synapse × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 144. Serotonergic synapse × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
145	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Serotonergic synapse × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 144. Serotonergic synapse × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
146	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Serotonergic synapse × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 144. Serotonergic synapse × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
147	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Serotonergic synapse × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 144. Serotonergic synapse × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
148	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin G/H synthase 1 isoform 1 precursor PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Serotonergic synapse × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 144. Serotonergic synapse × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
149	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 Small cell lung cancer × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 149. Small cell lung cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
150	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 Small cell lung cancer × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 149. Small cell lung cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
151	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 Small cell lung cancer × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 149. Small cell lung cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
152	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 Small cell lung cancer × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 149. Small cell lung cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
153	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 Small cell lung cancer × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 149. Small cell lung cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
154	Steroid hormone biosynthesis 💬	[1] CYP19A1 💬 Steroid hormone biosynthesis × Name Full Name CYP19A1 aromatase	Anastrozole 💬 Steroid hormone biosynthesis × Name Other Names Anastrozole Arimidex	Anastrozole	[3] 78, 86, 193 💬 154. Steroid hormone biosynthesis × Disease ID Name 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 86 Pulmonary arterial hypertension;PAH; 193 Prader-Willi syndrome;
155	Thyroid hormone signaling pathway 💬	[1] ESR1 💬 Thyroid hormone signaling pathway × Name Full Name ESR1 estrogen receptor isoform 1	Estradiol 💬 Thyroid hormone signaling pathway × Name Other Names Estradiol Climara Divigel Estrace Estraderm Estrasorb Estring Estrogel Innofem Vagifem Vivelle MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL GEL ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 155. Thyroid hormone signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
156	Thyroid hormone signaling pathway 💬	[1] ESR1 💬 Thyroid hormone signaling pathway × Name Full Name ESR1 estrogen receptor isoform 1	Estradiol hemihydrate 💬 Thyroid hormone signaling pathway × Name Other Names Estradiol hemihydrate Estrasorb Vagifem ELESTRIN EVAMIST ESTRADIOL ESTRADIOL VAGINAL ESTRADIOL VAGINAL INSERTS	Estradiol	[9] 13, 46, 49, 65, 76, 78, 118, 226, 299 💬 155. Thyroid hormone signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Abnormal pituitary gonadotropin secretion;Central precocious puberty;Gonadotropin producing pituitary adenoma; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 118 Myelomeningocele;Myeloschisis;Myelocele;Myelocystocele;Syringomyelocele;Neural tube defects; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 299 Cystic fibrosis;CF;
157	Thyroid hormone signaling pathway 💬	[2] THRA, THRB 💬 Thyroid hormone signaling pathway × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine sodium 💬 Thyroid hormone signaling pathway × Name Other Names Levothyroxine sodium Levothyroxine sodium hydrate Levothroid Levoxyl Synthroid EUTHYROX THYQUIDITY TIROSINT UNITHROID	Levothyroxine	[3] 49, 78, 80 💬 157. Thyroid hormone signaling pathway × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
158	Thyroid hormone signaling pathway 💬	[2] THRA, THRB 💬 Thyroid hormone signaling pathway × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine 💬 Thyroid hormone signaling pathway × Name Other Names Levothyroxine Forthyron	Levothyroxine	[3] 49, 78, 80 💬 157. Thyroid hormone signaling pathway × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
159	Thyroid hormone signaling pathway 💬	[2] THRA, THRB 💬 Thyroid hormone signaling pathway × Name Full Name THRA thyroid hormone receptor alpha isoform 2 THRB thyroid hormone receptor beta isoform a	Levothyroxine sodium 💬 Thyroid hormone signaling pathway × Name Other Names Levothyroxine sodium Levothyroxine sodium anhydrous	Levothyroxine	[3] 49, 78, 80 💬 157. Thyroid hormone signaling pathway × Disease ID Name 49 Systemic lupus erythematosus;SLE; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 80 Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
160	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 TNF signaling pathway × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 160. TNF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
161	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 TNF signaling pathway × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 160. TNF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
162	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 TNF signaling pathway × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 160. TNF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
163	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 TNF signaling pathway × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 160. TNF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
164	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 TNF signaling pathway × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 160. TNF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
165	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac potassium 💬 VEGF signaling pathway × Name Other Names Diclofenac potassium Cambia Cataflam Zipsor LOFENA	Diclofenac	[5] 13, 34, 46, 78, 271 💬 165. VEGF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
166	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac sodium 💬 VEGF signaling pathway × Name Other Names Diclofenac sodium Solaraze Voltaren	Diclofenac	[5] 13, 34, 46, 78, 271 💬 165. VEGF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
167	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac 💬 VEGF signaling pathway × Name Other Names Diclofenac Solaraze Zorvolex	Diclofenac	[5] 13, 34, 46, 78, 271 💬 165. VEGF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
168	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac diethylamine 💬 VEGF signaling pathway × Name Other Names Diclofenac diethylamine Voltaren Emulgel	Diclofenac	[5] 13, 34, 46, 78, 271 💬 165. VEGF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
169	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin G/H synthase 2 precursor	Diclofenac epolamine 💬 VEGF signaling pathway × Name Other Names Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine Flector LICART DICLOX PATCH 30CT	Diclofenac	[5] 13, 34, 46, 78, 271 💬 165. VEGF signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 78 Hypopituitarism;Anterior pituitary hypothyroidism;PRL deficiency; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;

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