Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Metabolic pathways 💬

[1] ABAT 💬

Vigabatrin 💬

Vigabatrin

[2] 145, 158 💬

Metabolic pathways 💬

[4] ABAT, ALDH5A1, GAD1, GAD2 💬

Valproic acid 💬

Valproic acid

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Metabolic pathways 💬

[3] ADH1A, ADH1B, ADH1C 💬

Fomepizole 💬

Fomepizole

[1] 301 💬

Metabolic pathways 💬

[1] ALAS1 💬

Givosiran 💬

Givosiran

[1] 254 💬

Metabolic pathways 💬

[2] ALAS1, ALAS2 💬

Hemin 💬

Hemin

[1] 254 💬

Metabolic pathways 💬

[1] ALOX5 💬

Oxatomide 💬

Oxatomide

[1] 113 💬

Metabolic pathways 💬

[1] ALOX5 💬

Zileuton 💬

Zileuton

[3] 85, 160, 164 💬

Metabolic pathways 💬

[1] ALPL 💬

Asfotase alfa 💬

Asfotase alfa

[1] 172 💬

Metabolic pathways 💬

[5] AMY2A, AMY2B, GAA, GANC, MGAM 💬

Acarbose 💬

Acarbose

[1] 298 💬

Metabolic pathways 💬

[1] ANPEP 💬

Ubenimex 💬

Ubenimex

[1] 86 💬

Metabolic pathways 💬

[1] AOC3 💬

Hydralazine 💬

Hydralazine

[1] 67 💬

Metabolic pathways 💬

[1] ARSB 💬

Galsulfase 💬

Galsulfase

[1] 19 💬

Metabolic pathways 💬

[2] ATP4A, ATP4B 💬

Dexlansoprazole 💬

Dexlansoprazole

[1] 98 💬

Metabolic pathways 💬

[2] ATP4A, ATP4B 💬

Esomeprazole 💬

Esomeprazole

[8] 13, 46, 86, 98, 107, 113, 298, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
86	Pulmonary arterial hypertension;PAH;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Metabolic pathways 💬

[2] ATP4A, ATP4B 💬

Lansoprazole 💬

Lansoprazole

[7] 63, 71, 85, 98, 166, 222, 299 💬

Disease ID	Name
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
71	Idiopathic osteonecrosis of the femoral head;Idiopathic femoral head necrosis;
85	Idiopathic interstitial pneumonia;IIPs;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
166	Pseudoxanthoma elasticum;PXE;
222	Primary nephrotic syndrome;
299	Cystic fibrosis;

Metabolic pathways 💬

[2] ATP4A, ATP4B 💬

Omeprazole 💬

Omeprazole

[14] 6 , 8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
282	Congenital dyserythropoietic anemia;CDA;
294	Congenital diaphragmatic hernia;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Metabolic pathways 💬

[2] ATP4A, ATP4B 💬

Pantoprazole 💬

Pantoprazole

[2] 13, 65 💬

Metabolic pathways 💬

[2] ATP4A, ATP4B 💬

Rabeprazole 💬

Rabeprazole

[2] 2 , 51 💬

Metabolic pathways 💬

[2] ATP4A, ATP4B 💬

Vonoprazan 💬

Vonoprazan

[2] 63, 98 💬

Disease ID	Name
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;

Metabolic pathways 💬

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Metabolic pathways 💬

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Dichlorphenamide 💬

Diclofenamide

[1] 114 💬

Metabolic pathways 💬

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Dorzolamide 💬

Dorzolamide

[1] 90 💬

Metabolic pathways 💬

[2] CA2, CA4 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Metabolic pathways 💬

[1] CD38 💬

Daratumumab 💬

Daratumumab

[5] 13, 28, 48, 49, 63 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
48	Primary antiphospholipid syndrome;Primary antiphospholipid antibody syndrome;Primary APS;PAPS;
49	Systemic lupus erythematosus;SLE;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;

Metabolic pathways 💬

[1] CD38 💬

Isatuximab 💬

Isatuximab

[3] 28, 61, 283 💬

Metabolic pathways 💬

[1] CD38 💬

Mezagitamab 💬

Mezagitamab

[2] 63, 66 💬

Metabolic pathways 💬

[1] COMT 💬

Entacapone 💬

Entacapone

[2] 6 , 17 💬

Metabolic pathways 💬

[1] COMT 💬

Opicapone 💬

Opicapone

[1] 6 💬

Metabolic pathways 💬

[1] COMT 💬

Tolcapone 💬

Tolcapone

[3] 6 , 28, 127 💬

Metabolic pathways 💬

[1] CPS1 💬

Carglumic acid 💬

Carglumic acid

[3] 245, 246, 251 💬

Metabolic pathways 💬

[3] CYP11A1, CYP11B1, CYP17A1 💬

Levoketoconazole 💬

Levoketoconazole

[1] 75 💬

Metabolic pathways 💬

[1] CYP11B1 💬

Metyrapone 💬

Metyrapone

[1] 75 💬

Metabolic pathways 💬

[1] CYP11B2 💬

Osilodrostat 💬

Osilodrostat

[1] 75 💬

Metabolic pathways 💬

[1] CYP17A1 💬

Ketoconazole 💬

Ketoconazole

[3] 8 , 13, 75 💬

Metabolic pathways 💬

[1] CYP19A1 💬

Anastrozole 💬

Anastrozole

[3] 78, 86, 193 💬

Metabolic pathways 💬

[1] CYP19A1 💬

Letrozole 💬

Letrozole

[2] 81, 89 💬

Metabolic pathways 💬

[1] DDC 💬

Benserazide 💬

Benserazide

[1] 6 💬

Metabolic pathways 💬

[1] DDC 💬

Carbidopa 💬

Carbidopa

[7] 6 , 13, 17, 90, 140, 164, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
90	Retinitis pigmentosa;
140	Dorabe syndrome;Dravet syndrome;
164	Oculocutaneous albinism;
201	Angelman syndrome;

Metabolic pathways 💬

[2] DHFR, DHFR2 💬

Methotrexate 💬

Methotrexate

[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
84	Sarcoidosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
164	Oculocutaneous albinism;
172	Hypophosphatasia;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Metabolic pathways 💬

[1] DHODH 💬

Leflunomide 💬

Leflunomide

[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis;MG;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
224	Purpura nephritis;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

Metabolic pathways 💬

[1] DHODH 💬

Teriflunomide 💬

Teriflunomide

[3] 13, 25, 26 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;

Metabolic pathways 💬

[3] DNMT1, DNMT3A, DNMT3B 💬

Decitabine 💬

Decitabine

[3] 13, 60, 63 💬

Metabolic pathways 💬

[1] ENPP2 💬

Ziritaxestat 💬

Ziritaxestat

[2] 51, 85 💬

Metabolic pathways 💬

[1] FDPS 💬

Alendronic acid 💬

Alendronic acid

[7] 19, 41, 46, 50, 271, 274, 299 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
274	Osteogenesis Imperfecta;
299	Cystic fibrosis;

Metabolic pathways 💬

[1] FDPS 💬

Pamidronic acid 💬

Pamidronic acid

[3] 270, 271, 274 💬

Metabolic pathways 💬

[1] FDPS 💬

Risedronic acid 💬

Risedronic acid

[9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
274	Osteogenesis Imperfecta;

Metabolic pathways 💬

[1] FDPS 💬

Zoledronic acid 💬

Zoledronic acid

[13] 5 , 6 , 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
270	Chronic recurrent multifocal osteomyelitis;
274	Osteogenesis Imperfecta;
299	Cystic fibrosis;
333	Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;

Metabolic pathways 💬

[1] FDPS 💬

Zoledronic acid 💬

Zoledronic acid

[13] 5 , 6 , 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
270	Chronic recurrent multifocal osteomyelitis;
274	Osteogenesis Imperfecta;
299	Cystic fibrosis;
333	Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;

Metabolic pathways 💬

[1] GAA 💬

Alglucosidase alfa 💬

Alglucosidase alfa

[1] 256 💬

Metabolic pathways 💬

[1] GAA 💬

Avalglucosidase alfa 💬

Avalglucosidase alfa

[1] 256 💬

Metabolic pathways 💬

[1] GAA 💬

Cipaglucosidase alfa 💬

Cipaglucosidase alfa

[1] 256 💬

Metabolic pathways 💬

[1] GAA 💬

Duvoglustat 💬

Duvoglustat

[1] 256 💬

Metabolic pathways 💬

[1] GALNS 💬

Elosulfase alfa 💬

Elosulfase alfa

[1] 19 💬

Metabolic pathways 💬

[1] GBA1 💬

Alglucerase 💬

Alglucerase

[1] 19 💬

Metabolic pathways 💬

[1] GBA1 💬

Imiglucerase 💬

Imiglucerase

[1] 19 💬

Metabolic pathways 💬

[1] GBA1 💬

Taliglucerase alfa 💬

Taliglucerase alfa

[1] 19 💬

Metabolic pathways 💬

[1] GBA1 💬

Velaglucerase alfa 💬

Velaglucerase alfa

[1] 19 💬

Metabolic pathways 💬

[1] GLA 💬

Agalsidase alfa 💬

Agalsidase alfa

[1] 19 💬

Metabolic pathways 💬

[1] GLA 💬

Agalsidase beta 💬

Agalsidase beta

[1] 19 💬

Metabolic pathways 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

Amyl Nitrite

[1] 58 💬

Metabolic pathways 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Riociguat 💬

Riociguat

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

Metabolic pathways 💬

[1] GUCY2C 💬

Linaclotide 💬

Linaclotide

[2] 6 , 97 💬

Metabolic pathways 💬

[1] GUSB 💬

Vestronidase alfa 💬

Vestronidase alfa

[1] 19 💬

Metabolic pathways 💬

[1] HAO1 💬

Lumasiran 💬

Lumasiran

[1] 234 💬

Metabolic pathways 💬

[1] HMGCR 💬

Atorvastatin 💬

Atorvastatin

[19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
79	Homozygous familial hypercholesterolemia;
84	Sarcoidosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
160	Congenital ichthyosis;
222	Primary nephrotic syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
265	Lipodystrophy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
297	Alagille syndrome;
299	Cystic fibrosis;

Metabolic pathways 💬

[1] HMGCR 💬

Fluvastatin 💬

Fluvastatin

[3] 79, 218, 222 💬

Metabolic pathways 💬

[1] HMGCR 💬

Lovastatin 💬

Lovastatin

[11] 6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
79	Homozygous familial hypercholesterolemia;
156	Rett syndrome;
160	Congenital ichthyosis;
195	Noonan syndrome;
206	Fragile X syndrome;
263	Cerebrotendinous xanthomatosis;27-hydroxylase deficiency;CYP27 deficiency;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
310	Congenital anomalies syndrome;

Metabolic pathways 💬

[1] HMGCR 💬

Pravastatin 💬

Pravastatin

[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
79	Homozygous familial hypercholesterolemia;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
265	Lipodystrophy;
333	Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;

Metabolic pathways 💬

[1] HMGCR 💬

Rosuvastatin 💬

Rosuvastatin

[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
18	Spinocerebellar degeneration;SCD;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
56	Behcet disease;Behçet disease;BD;
79	Homozygous familial hypercholesterolemia;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Cystic fibrosis;

Metabolic pathways 💬

[1] HMGCR 💬

Simvastatin 💬

Simvastatin

[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
79	Homozygous familial hypercholesterolemia;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
94	Primary sclerosing cholangitis;PSC;
158	Tuberous sclerosis;Tuberous sclerosis complex;
160	Congenital ichthyosis;
162	Pemphigoid;
195	Noonan syndrome;
265	Lipodystrophy;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;
310	Congenital anomalies syndrome;

Metabolic pathways 💬

[2] HMOX1, HMOX2 💬

Stannsoporfin 💬

Stannsoporfin

[1] 254 💬

Metabolic pathways 💬

[1] HPD 💬

Nitisinone 💬

Nitisinone

[3] 6 , 164, 241 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
164	Oculocutaneous albinism;
241	Hypertyrosinemia type I;Tyrosinemia type I;Tyrosinemia I;Hereditary tyrosinemia, Type I;Fumarylacetoacetate hydrolase deficiency;FAH deficiency;

Metabolic pathways 💬

[1] HPRT1 💬

Mercaptopurine 💬

Mercaptopurine

[4] 65, 96, 97, 164 💬

Metabolic pathways 💬

[1] HPRT1 💬

Mercaptopurine 💬

Mercaptopurine

[4] 65, 96, 97, 164 💬

Metabolic pathways 💬

[1] HPRT1 💬

Tioguanine 💬

Tioguanine

[2] 13, 37 💬

Metabolic pathways 💬

[1] IDS 💬

Idursulfase 💬

Idursulfase

[1] 19 💬

Metabolic pathways 💬

[1] IDS 💬

Idursulfase beta 💬

Idursulfase beta

[1] 19 💬

Metabolic pathways 💬

[1] IDS 💬

Pabinafusp alfa 💬

Pabinafusp alfa

[1] 19 💬

Metabolic pathways 💬

[1] IDUA 💬

Laronidase 💬

Laronidase

[2] 19, 256 💬

Metabolic pathways 💬

[2] IMPDH1, IMPDH2 💬

Mizoribine 💬

Mizoribine

[8] 46, 49, 51, 53, 66, 94, 222, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
94	Primary sclerosing cholangitis;PSC;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Metabolic pathways 💬

[2] IMPDH1, IMPDH2 💬

Mycophenolate mofetil 💬

Mycophenolate mofetil

[34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

Metabolic pathways 💬

[2] IMPDH1, IMPDH2 💬

Mycophenolic acid 💬

Mycophenolic acid

[36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

Metabolic pathways 💬

[1] MAOA 💬

Moclobemide 💬

Moclobemide

[1] 6 💬

Metabolic pathways 💬

[2] MAOA, MAOB 💬

Iproniazid 💬

Iproniazid

[1] 6 💬

Metabolic pathways 💬

[2] MAOA, MAOB 💬

Phenelzine 💬

Phenelzine

[1] 6 💬

Metabolic pathways 💬

[2] MAOA, MAOB 💬

Phentermine 💬

Phentermine

[1] 97 💬

Metabolic pathways 💬

[1] MAOB 💬

Rasagiline 💬

Rasagiline

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

Metabolic pathways 💬

[1] MAOB 💬

Rasagiline tartrate 💬

Rasagiline

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

Metabolic pathways 💬

[1] MAOB 💬

Safinamide 💬

Safinamide

[2] 6 , 17 💬

Metabolic pathways 💬

[1] MAOB 💬

Selegiline 💬

Selegiline

[1] 6 💬

Metabolic pathways 💬

[1] NPR1 💬

Nesiritide 💬

Nesiritide

[2] 46, 58 💬

Metabolic pathways 💬

[2] NPR1, NPR2 💬

Erythrityl tetranitrate 💬

Erythrityl tetranitrate

[1] 46 💬

Metabolic pathways 💬

[1] NPR2 💬

Vosoritide 💬

Vosoritide

[1] 276 💬

Metabolic pathways 💬

[2] NQO1, VKORC1 💬

Warfarin 💬

Warfarin

[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
91	Budd-Chiari syndrome;BCS;

Metabolic pathways 💬

[1] ODC1 💬

Eflornithine 💬

Eflornithine

[1] 65 💬

Metabolic pathways 💬

[1] PAH 💬

Pegvaliase 💬

Pegvaliase

[1] 240 💬

Metabolic pathways 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Aminophylline 💬

Aminophylline

[1] 63 💬

Metabolic pathways 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Bucladesine 💬

Bucladesine

[1] 246 💬

Metabolic pathways 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Flavoxate 💬

Flavoxate

[1] 226 💬

100

Metabolic pathways 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Theophylline 💬

Theophylline

[2] 236, 299 💬

101

Metabolic pathways 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Theophylline 💬

Theophylline

[2] 236, 299 💬

102

Metabolic pathways 💬

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

103

Metabolic pathways 💬

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

104

Metabolic pathways 💬

[2] PDE3A, PDE3B 💬

Cilostazol 💬

Cilostazol

[3] 46, 51, 70 💬

105

Metabolic pathways 💬

[2] PDE3A, PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

106

Metabolic pathways 💬

[2] PDE3A, PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

107

Metabolic pathways 💬

[6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

108

Metabolic pathways 💬

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Apremilast 💬

Apremilast

[7] 46, 50, 56, 97, 107, 162, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
56	Behcet disease;Behçet disease;BD;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

109

Metabolic pathways 💬

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Roflumilast 💬

Roflumilast

[4] 84, 97, 206, 299 💬

110

Metabolic pathways 💬

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Rolipram 💬

Rolipram

[2] 8 , 13 💬

111

Metabolic pathways 💬

[2] PDE4A, PDE5A 💬

Dipyridamole 💬

Dipyridamole

[6] 46, 49, 51, 66, 96, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
224	Purpura nephritis;

112

Metabolic pathways 💬

[1] PDE4D 💬

Zatolmilast 💬

Zatolmilast

[1] 206 💬

113

Metabolic pathways 💬

[1] PDE5A 💬

Sildenafil 💬

Sildenafil

[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
294	Congenital diaphragmatic hernia;
299	Cystic fibrosis;
301	Macular dystrophy;

114

Metabolic pathways 💬

[1] PDE5A 💬

Tadalafil 💬

Tadalafil

[7] 6 , 51, 75, 84, 86, 113, 210 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

115

Metabolic pathways 💬

[1] PDE5A 💬

Udenafil 💬

Udenafil

[2] 86, 210 💬

116

Metabolic pathways 💬

[1] PDE5A 💬

Vardenafil 💬

Vardenafil

[3] 13, 86, 299 💬

117

Metabolic pathways 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

118

Metabolic pathways 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

119

Metabolic pathways 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

120

Metabolic pathways 💬

[3] PTGES, PTGS1, PTGS2 💬

Aceclofenac 💬

Aceclofenac

[1] 46 💬

121

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Acetaminophen 💬

Acetaminophen

[15] 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
337	Homocystinuria;

122

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Aspirin 💬

Acetylsalicylic acid

[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
64	Thrombotic thrombocytopenic purpura;TTP;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
158	Tuberous sclerosis;Tuberous sclerosis complex;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
231	Alpha-1-antitrypsin deficiency;AATD;
251	Urea cycle disorder;

123

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Diclofenac 💬

Diclofenac

[5] 13, 34, 46, 78, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

124

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

125

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Ibuprofen 💬

Ibuprofen

[7] 13, 46, 65, 107, 113, 271, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Cystic fibrosis;

126

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Indomethacin 💬

Indomethacin

[3] 225, 271, 298 💬

Disease ID	Name
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
298	Hereditary pancreatitis;Chronic pancreatitis;

127

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Ketoprofen 💬

Ketoprofen

[1] 46 💬

128

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Ketorolac 💬

Ketorolac

[2] 70, 226 💬

129

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Loxoprofen 💬

Loxoprofen

[2] 46, 271 💬

130

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Naproxen 💬

Naproxen

[4] 13, 46, 107, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

131

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Salsalate 💬

Salsalate

[1] 5 💬

132

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Sulindac 💬

Sulindac

[1] 206 💬

133

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Tolfenamic acid 💬

Tolfenamic acid

[1] 5 💬

134

Metabolic pathways 💬

[1] PTGS2 💬

Celecoxib 💬

Celecoxib

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

135

Metabolic pathways 💬

[1] PTGS2 💬

Diflunisal 💬

Diflunisal

[1] 28 💬

136

Metabolic pathways 💬

[1] PTGS2 💬

Etodolac 💬

Etodolac

[1] 46 💬

137

Metabolic pathways 💬

[1] PTGS2 💬

Etoricoxib 💬

Etoricoxib

[2] 46, 271 💬

138

Metabolic pathways 💬

[1] PTGS2 💬

Lumiracoxib 💬

Lumiracoxib

[1] 46 💬

139

Metabolic pathways 💬

[1] PTGS2 💬

Meloxicam 💬

Meloxicam

[4] 46, 49, 271, 296 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
296	Biliary atresia;

140

Metabolic pathways 💬

[1] PTGS2 💬

Nimesulide 💬

Nimesulide

[1] 46 💬

141

Metabolic pathways 💬

[1] PTGS2 💬

Parecoxib 💬

Parecoxib

[2] 46, 271 💬

142

Metabolic pathways 💬

[1] PTGS2 💬

Rofecoxib 💬

Rofecoxib

[1] 46 💬

143

Metabolic pathways 💬

[1] PTGS2 💬

Valdecoxib 💬

Valdecoxib

[1] 46 💬

144

Metabolic pathways 💬

[1] RRM1 💬

Cladribine 💬

Cladribine

[3] 11, 13, 94 💬

145

Metabolic pathways 💬

[1] RRM1 💬

Clofarabine 💬

Clofarabine

[5] 19, 20, 60, 234, 326 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
60	Aplastic anemia;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
326	Osteopetrosis;

146

Metabolic pathways 💬

[1] RRM1 💬

Fludarabine 💬

Fludarabine

[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;

147

Metabolic pathways 💬

[1] RRM2 💬

Hydroxyurea 💬

Hydroxyurea

[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
284	Diamond-Blackfan anemia;

148

Metabolic pathways 💬

[1] SMPD1 💬

Olipudase alfa 💬

Olipudase alfa

[1] 19 💬

149

Metabolic pathways 💬

[2] SRD5A1, SRD5A2 💬

Dutasteride 💬

Dutasteride

[2] 1 , 2 💬

150

Metabolic pathways 💬

[1] SRD5A2 💬

Finasteride 💬

Finasteride

[1] 6 💬

151

Metabolic pathways 💬

[2] TPH1, TPH2 💬

Telotristat 💬

Telotristat

[1] 97 💬

152

Metabolic pathways 💬

[1] TPO 💬

Methimazole 💬

Methimazole

[1] 50 💬

153

Metabolic pathways 💬

[1] TYMS 💬

Tegafur 💬

Tegafur

[1] 46 💬

154

Metabolic pathways 💬

[1] UGCG 💬

Eliglustat 💬

Eliglustat

[1] 19 💬

155

Metabolic pathways 💬

[1] UGCG 💬

Lucerastat 💬

Lucerastat

[1] 19 💬

156

Metabolic pathways 💬

[1] UGCG 💬

Miglustat 💬

Miglustat

[3] 19, 256, 299 💬

157

Metabolic pathways 💬

[1] UGCG 💬

Venglustat 💬

Venglustat

[3] 6 , 19, 67 💬

158

Metabolic pathways 💬

[1] VKORC1 💬

Phenindione 💬

Phenindione

[1] 65 💬

159

Metabolic pathways 💬

[1] XDH 💬

Allopurinol 💬

Allopurinol

[7] 6 , 46, 57, 60, 66, 96, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

160

Metabolic pathways 💬

[1] XDH 💬

Febuxostat 💬

Febuxostat

[3] 2 , 6 , 13 💬