Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 NOD-like receptor signaling pathway 💬
 [1] BCL2 💬 Obatoclax mesylate 💬 Obatoclax [1] 60 💬
2 NOD-like receptor signaling pathway 💬
 [1] BCL2 💬 Sonrotoclax 💬 Sonrotoclax [1] 28 💬
3 NOD-like receptor signaling pathway 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [2] 28, 85 💬
4 NOD-like receptor signaling pathway 💬
 [1] CASR 💬 Cinacalcet 💬 Cinacalcet [1] 238 💬
5 NOD-like receptor signaling pathway 💬
 [1] CASR 💬 Cinacalcet hydrochloride 💬 Cinacalcet [1] 238 💬
6 NOD-like receptor signaling pathway 💬
 [4] CCL2, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [12] 13, 34, 40, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
7 NOD-like receptor signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Rontalizumab 💬 Rontalizumab [1] 49 💬
8 NOD-like receptor signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Sifalimumab 💬 Sifalimumab [1] 49 💬
9 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Anifrolumab 💬 Anifrolumab [6] 46, 48, 49, 50, 51, 53 💬
10 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta 💬 Human interferon beta [2] 13, 26 💬
11 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa 💬 Interferon alfa [5] 25, 26, 28, 56, 96 💬
12 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2a 💬 Interferon alfa-2a [1] 56 💬
13 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2b 💬 Interferon alfa-2b [2] 25, 26 💬
14 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1a 💬 Interferon beta-1a [5] 13, 14, 26, 96, 97 💬
15 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1b 💬 Interferon beta-1b [1] 13 💬
16 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Peginterferon alfa-2a 💬 Peginterferon alfa-2a [1] 222 💬
17 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a [1] 13 💬
18 NOD-like receptor signaling pathway 💬
 [1] IFNB1 💬 Dazukibart 💬 Dazukibart [1] 50 💬
19 NOD-like receptor signaling pathway 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [11] 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
20 NOD-like receptor signaling pathway 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
21 NOD-like receptor signaling pathway 💬
 [1] IL1B 💬 Lutikizumab 💬 Lutikizumab [3] 46, 96, 97 💬
22 NOD-like receptor signaling pathway 💬
 [1] IL1B 💬 Rilonacept 💬 Rilonacept [5] 51, 84, 106, 107, 266 💬
23 NOD-like receptor signaling pathway 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
24 NOD-like receptor signaling pathway 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
25 NOD-like receptor signaling pathway 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
26 NOD-like receptor signaling pathway 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
27 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Abrocitinib 💬 Abrocitinib [3] 39, 84, 162 💬
28 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Baricitinib 💬 Baricitinib [24]  2 , 13, 40, 41, 46, 49, 50, 51, 53, 54, 56, 63, 65, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
29 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Filgotinib 💬 Filgotinib [10] 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
30 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Golidocitinib 💬 Golidocitinib [1] 60 💬
31 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Gusacitinib 💬 Gusacitinib [1] 49 💬
32 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Itacitinib 💬 Itacitinib [4] 46, 51, 97, 228 💬
33 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Itacitinib adipate 💬 Itacitinib [4] 46, 51, 97, 228 💬
34 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Ivarmacitinib 💬 Ivarmacitinib [6] 40, 46, 51, 56, 271, 300 💬
35 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Ivarmacitinib sulfate 💬 Ivarmacitinib [6] 40, 46, 51, 56, 271, 300 💬
36 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Peficitinib 💬 Peficitinib [1] 46 💬
37 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Ruxolitinib 💬 Ruxolitinib [7] 13, 15, 50, 60, 65, 228, 331 💬
38 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Ruxolitinib phosphate 💬 Ruxolitinib [7] 13, 15, 50, 60, 65, 228, 331 💬
39 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Upadacitinib 💬 Upadacitinib [12] 40, 41, 46, 49, 53, 55, 63, 96, 97, 98, 107, 271 💬
40 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Upadacitinib tartrate 💬 Upadacitinib [12] 40, 41, 46, 49, 53, 55, 63, 96, 97, 98, 107, 271 💬
41 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 Upadacitinib hydrate 💬 Upadacitinib [12] 40, 41, 46, 49, 53, 55, 63, 96, 97, 98, 107, 271 💬
42 NOD-like receptor signaling pathway 💬
 [2] JAK1, TYK2 💬 Brepocitinib 💬 Brepocitinib [5] 49, 50, 84, 96, 97 💬
43 NOD-like receptor signaling pathway 💬
 [2] JAK1, TYK2 💬 Delgocitinib 💬 Delgocitinib [1] 50 💬
44 NOD-like receptor signaling pathway 💬
 [2] JAK1, TYK2 💬 Filgotinib maleate 💬 Filgotinib [10] 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
45 NOD-like receptor signaling pathway 💬
 [2] JAK1, TYK2 💬 Tofacitinib citrate 💬 Tofacitinib [23]  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 56, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
46 NOD-like receptor signaling pathway 💬
 [2] JAK1, TYK2 💬 Tofacitinib 💬 Tofacitinib [23]  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 56, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
47 NOD-like receptor signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
48 NOD-like receptor signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
49 NOD-like receptor signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [7] 46, 49, 51, 53, 63, 271, 300 💬
50 NOD-like receptor signaling pathway 💬
 [1] NLRP3 💬 Usnoflast 💬 Usnoflast [1]  2  💬
51 NOD-like receptor signaling pathway 💬
 [1] PRKCD 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
52 NOD-like receptor signaling pathway 💬
 [1] PRKCD 💬 Sotrastaurin acetate 💬 Sotrastaurin [1] 97 💬
53 NOD-like receptor signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
54 NOD-like receptor signaling pathway 💬
 [1] RIPK1 💬 Eclitasertib 💬 SAR443122 [1] 97 💬
55 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [22] 19, 37, 38, 40, 41, 46, 55, 56, 84, 90, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
56 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [10] 37, 40, 46, 48, 49, 96, 97, 107, 226, 271 💬
57 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
58 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
59 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 162, 164, 223, 269, 270, 271 💬
60 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [9] 16, 26, 28, 34, 49, 56, 284, 300, 331 💬
61 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
62 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
63 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [22]  2 , 16, 20, 28, 49, 51, 53, 56, 63, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
64 NOD-like receptor signaling pathway 💬
 [1] TYK2 💬 Deucravacitinib 💬 Deucravacitinib [10] 36, 37, 40, 49, 53, 84, 96, 97, 160, 269 💬
65 NOD-like receptor signaling pathway 💬
 [1] TYK2 💬 Envudeucitinib 💬 Envudeucitinib [1] 49 💬
66 NOD-like receptor signaling pathway 💬
 [1] TYK2 💬 Zasocitinib 💬 Zasocitinib [2] 96, 97 💬