Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Pathogenic Escherichia coli infection 💬
 [1] ABL1 💬 Imatinib mesylate 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
2 Pathogenic Escherichia coli infection 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
3 Pathogenic Escherichia coli infection 💬
 [1] ABL1 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
4 Pathogenic Escherichia coli infection 💬
 [3] ABL1, FYN, SRC 💬 Dasatinib 💬 Dasatinib [3] 13, 51, 85 💬
5 Pathogenic Escherichia coli infection 💬
 [3] ABL1, FYN, SRC 💬 Dasatinib 💬 Dasatinib [3] 13, 51, 85 💬
6 Pathogenic Escherichia coli infection 💬
 [2] ABL1, SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
7 Pathogenic Escherichia coli infection 💬
 [2] ABL1, SRC 💬 Bosutinib hydrate 💬 Bosutinib [2]  2 , 67 💬
8 Pathogenic Escherichia coli infection 💬
 [2] ABL1, SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
9 Pathogenic Escherichia coli infection 💬
 [1] CASP9 💬 Rimiducid 💬 Rimiducid [7] 19, 49, 60, 65, 284, 285, 326 💬
10 Pathogenic Escherichia coli infection 💬
 [1] F2 💬 Dabigatran 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
11 Pathogenic Escherichia coli infection 💬
 [1] F2 💬 Dabigatran etexilate mesylate 💬 Dabigatran etexilate [2] 51, 75 💬
12 Pathogenic Escherichia coli infection 💬
 [1] F2 💬 Dabigatran etexilate 💬 Dabigatran etexilate [2] 51, 75 💬
13 Pathogenic Escherichia coli infection 💬
 [1] F2 💬 Thrombomodulin alfa 💬 Thrombomodulin Alfa [1] 85 💬
14 Pathogenic Escherichia coli infection 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [11] 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
15 Pathogenic Escherichia coli infection 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
16 Pathogenic Escherichia coli infection 💬
 [1] IL1B 💬 Lutikizumab 💬 Lutikizumab [3] 46, 96, 97 💬
17 Pathogenic Escherichia coli infection 💬
 [1] IL1B 💬 Rilonacept 💬 Rilonacept [5] 51, 84, 106, 107, 266 💬
18 Pathogenic Escherichia coli infection 💬
 [3] IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [12] 13, 34, 40, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
19 Pathogenic Escherichia coli infection 💬
 [1] IL1R1 💬 Anakinra 💬 Anakinra [22]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 57, 84, 86, 97, 106, 107, 149, 153, 266, 299 💬
20 Pathogenic Escherichia coli infection 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
21 Pathogenic Escherichia coli infection 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
22 Pathogenic Escherichia coli infection 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
23 Pathogenic Escherichia coli infection 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
24 Pathogenic Escherichia coli infection 💬
 [1] ITGB1 💬 Bexotegrast 💬 Bexotegrast [1] 94 💬
25 Pathogenic Escherichia coli infection 💬
 [1] ITGB1 💬 Carotegrast methyl 💬 Carotegrast methyl [1] 97 💬
26 Pathogenic Escherichia coli infection 💬
 [1] LPAR1 💬 Admilparant 💬 BMS-986278 [1] 85 💬
27 Pathogenic Escherichia coli infection 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
28 Pathogenic Escherichia coli infection 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
29 Pathogenic Escherichia coli infection 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [7] 46, 49, 51, 53, 63, 271, 300 💬
30 Pathogenic Escherichia coli infection 💬
 [1] NLRP3 💬 Usnoflast 💬 Usnoflast [1]  2  💬
31 Pathogenic Escherichia coli infection 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
32 Pathogenic Escherichia coli infection 💬
 [1] RIPK1 💬 Eclitasertib 💬 SAR443122 [1] 97 💬
33 Pathogenic Escherichia coli infection 💬
 [2] ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil [5]  2 ,  5 ,  6 ,  7 , 51 💬
34 Pathogenic Escherichia coli infection 💬
 [2] ROCK1, ROCK2 💬 Fasudil 💬 Fasudil [5]  2 ,  5 ,  6 ,  7 , 51 💬
35 Pathogenic Escherichia coli infection 💬
 [1] ROCK2 💬 Belumosudil 💬 Belumosudil [3] 51, 85, 228 💬
36 Pathogenic Escherichia coli infection 💬
 [1] ROCK2 💬 Belumosudil mesylate 💬 Belumosudil [3] 51, 85, 228 💬
37 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [22] 19, 37, 38, 40, 41, 46, 55, 56, 84, 90, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
38 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [10] 37, 40, 46, 48, 49, 96, 97, 107, 226, 271 💬
39 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
40 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
41 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 162, 164, 223, 269, 270, 271 💬
42 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [9] 16, 26, 28, 34, 49, 56, 284, 300, 331 💬
43 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
44 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
45 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [22]  2 , 16, 20, 28, 49, 51, 53, 56, 63, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
46 Pathogenic Escherichia coli infection 💬
 [1] TNFRSF1A 💬 Balinatunfib 💬 Balinatunfib [2] 96, 97 💬
47 Pathogenic Escherichia coli infection 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Belantamab mafodotin 💬 Belantamab mafodotin [2] 28, 63 💬
48 Pathogenic Escherichia coli infection 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Brentuximab vedotin 💬 Brentuximab vedotin [2] 49, 51 💬
49 Pathogenic Escherichia coli infection 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Colchicine 💬 Colchicine [9]  2 , 42, 46, 50, 56, 93, 97, 210, 266 💬
50 Pathogenic Escherichia coli infection 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Paclitaxel 💬 Paclitaxel [2] 46, 85 💬
51 Pathogenic Escherichia coli infection 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vinblastine sulfate 💬 Vinblastine [3] 34, 63, 65 💬
52 Pathogenic Escherichia coli infection 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vinblastine 💬 Vinblastine [3] 34, 63, 65 💬
53 Pathogenic Escherichia coli infection 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vincristine sulfate 💬 Vincristine [5] 26, 34, 63, 65, 331 💬
54 Pathogenic Escherichia coli infection 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vincristine 💬 Vincristine [5] 26, 34, 63, 65, 331 💬