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Target Gene/Pathway Pathway / Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Proximal tubule bicarbonate reclamation 💬

[4] ATP1A, ATP1A, ATP1A, ATP1A 💬

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

2

Proximal tubule bicarbonate reclamation 💬

[4] ATP1A, ATP1A, ATP1A, ATP1A 💬

[1] 299 💬

3

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Acetazolamide 💬

[6] 13, 90, 115, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
90	Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy;
115	Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

4

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Acetazolamide sodium 💬

[6] 13, 90, 115, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
90	Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy;
115	Hereditary periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

5

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Dichlorphenamide 💬

[1] 114 💬

Disease ID	Name
114	Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Autosomal-dominant myotonia congenita;Becker disease;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia;

6

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Dorzolamide hydrochloride 💬

[1] 90 💬

7

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Dorzolamide 💬

[1] 90 💬

8

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Topiramate 💬

[5] 6 , 140, 144, 156, 193 💬

9

Proximal tubule bicarbonate reclamation 💬

[1] SLC9A3 💬

[2] 6 , 299 💬

10

Proximal tubule bicarbonate reclamation 💬

[1] SLC9A3 💬

Tenapanor hydrochloride 💬

[2] 6 , 299 💬