Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 B cell receptor signaling pathway 💬
 [1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬
2 B cell receptor signaling pathway 💬
 [1] BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib [2] 46, 61 💬
3 B cell receptor signaling pathway 💬
 [1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬
4 B cell receptor signaling pathway 💬
 [1] BTK 💬 Elsubrutinib 💬 Elsubrutinib [1] 49 💬
5 B cell receptor signaling pathway 💬
 [1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬
6 B cell receptor signaling pathway 💬
 [1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬
7 B cell receptor signaling pathway 💬
 [1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬
8 B cell receptor signaling pathway 💬
 [1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
9 B cell receptor signaling pathway 💬
 [1] BTK 💬 Pirtobrutinib 💬 Pirtobrutinib [1] 13 💬
10 B cell receptor signaling pathway 💬
 [1] BTK 💬 Remibrutinib 💬 Remibrutinib [3] 11, 13, 53 💬
11 B cell receptor signaling pathway 💬
 [1] BTK 💬 Rilzabrutinib 💬 Rilzabrutinib [5] 35, 61, 63, 222, 300 💬
12 B cell receptor signaling pathway 💬
 [1] BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib [2] 46, 53 💬
13 B cell receptor signaling pathway 💬
 [1] BTK 💬 Tirabrutinib 💬 Tirabrutinib [2] 46, 53 💬
14 B cell receptor signaling pathway 💬
 [1] BTK 💬 Tolebrutinib 💬 Tolebrutinib [2] 11, 13 💬
15 B cell receptor signaling pathway 💬
 [1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [6] 13, 61, 63, 222, 300, 331 💬
16 Epstein-Barr virus infection 💬
 [1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬
17 Epstein-Barr virus infection 💬
 [1] BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib [2] 46, 61 💬
18 Epstein-Barr virus infection 💬
 [1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬
19 Epstein-Barr virus infection 💬
 [1] BTK 💬 Elsubrutinib 💬 Elsubrutinib [1] 49 💬
20 Epstein-Barr virus infection 💬
 [1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬
21 Epstein-Barr virus infection 💬
 [1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬
22 Epstein-Barr virus infection 💬
 [1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬
23 Epstein-Barr virus infection 💬
 [1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
24 Epstein-Barr virus infection 💬
 [1] BTK 💬 Pirtobrutinib 💬 Pirtobrutinib [1] 13 💬
25 Epstein-Barr virus infection 💬
 [1] BTK 💬 Remibrutinib 💬 Remibrutinib [3] 11, 13, 53 💬
26 Epstein-Barr virus infection 💬
 [1] BTK 💬 Rilzabrutinib 💬 Rilzabrutinib [5] 35, 61, 63, 222, 300 💬
27 Epstein-Barr virus infection 💬
 [1] BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib [2] 46, 53 💬
28 Epstein-Barr virus infection 💬
 [1] BTK 💬 Tirabrutinib 💬 Tirabrutinib [2] 46, 53 💬
29 Epstein-Barr virus infection 💬
 [1] BTK 💬 Tolebrutinib 💬 Tolebrutinib [2] 11, 13 💬
30 Epstein-Barr virus infection 💬
 [1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [6] 13, 61, 63, 222, 300, 331 💬
31 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬
32 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib [2] 46, 61 💬
33 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬
34 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Elsubrutinib 💬 Elsubrutinib [1] 49 💬
35 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬
36 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬
37 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬
38 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
39 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Pirtobrutinib 💬 Pirtobrutinib [1] 13 💬
40 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Remibrutinib 💬 Remibrutinib [3] 11, 13, 53 💬
41 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Rilzabrutinib 💬 Rilzabrutinib [5] 35, 61, 63, 222, 300 💬
42 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib [2] 46, 53 💬
43 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Tirabrutinib 💬 Tirabrutinib [2] 46, 53 💬
44 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Tolebrutinib 💬 Tolebrutinib [2] 11, 13 💬
45 Fc epsilon RI signaling pathway 💬
 [1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [6] 13, 61, 63, 222, 300, 331 💬
46 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬
47 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib [2] 46, 61 💬
48 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬
49 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Elsubrutinib 💬 Elsubrutinib [1] 49 💬
50 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬
51 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬
52 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬
53 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
54 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Pirtobrutinib 💬 Pirtobrutinib [1] 13 💬
55 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Remibrutinib 💬 Remibrutinib [3] 11, 13, 53 💬
56 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Rilzabrutinib 💬 Rilzabrutinib [5] 35, 61, 63, 222, 300 💬
57 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib [2] 46, 53 💬
58 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Tirabrutinib 💬 Tirabrutinib [2] 46, 53 💬
59 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Tolebrutinib 💬 Tolebrutinib [2] 11, 13 💬
60 NF-kappa B signaling pathway 💬
 [1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [6] 13, 61, 63, 222, 300, 331 💬
61 Osteoclast differentiation 💬
 [1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬
62 Osteoclast differentiation 💬
 [1] BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib [2] 46, 61 💬
63 Osteoclast differentiation 💬
 [1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬
64 Osteoclast differentiation 💬
 [1] BTK 💬 Elsubrutinib 💬 Elsubrutinib [1] 49 💬
65 Osteoclast differentiation 💬
 [1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬
66 Osteoclast differentiation 💬
 [1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬
67 Osteoclast differentiation 💬
 [1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬
68 Osteoclast differentiation 💬
 [1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
69 Osteoclast differentiation 💬
 [1] BTK 💬 Pirtobrutinib 💬 Pirtobrutinib [1] 13 💬
70 Osteoclast differentiation 💬
 [1] BTK 💬 Remibrutinib 💬 Remibrutinib [3] 11, 13, 53 💬
71 Osteoclast differentiation 💬
 [1] BTK 💬 Rilzabrutinib 💬 Rilzabrutinib [5] 35, 61, 63, 222, 300 💬
72 Osteoclast differentiation 💬
 [1] BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib [2] 46, 53 💬
73 Osteoclast differentiation 💬
 [1] BTK 💬 Tirabrutinib 💬 Tirabrutinib [2] 46, 53 💬
74 Osteoclast differentiation 💬
 [1] BTK 💬 Tolebrutinib 💬 Tolebrutinib [2] 11, 13 💬
75 Osteoclast differentiation 💬
 [1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [6] 13, 61, 63, 222, 300, 331 💬
76 Platelet activation 💬
 [1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬
77 Platelet activation 💬
 [1] BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib [2] 46, 61 💬
78 Platelet activation 💬
 [1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬
79 Platelet activation 💬
 [1] BTK 💬 Elsubrutinib 💬 Elsubrutinib [1] 49 💬
80 Platelet activation 💬
 [1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬
81 Platelet activation 💬
 [1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬
82 Platelet activation 💬
 [1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬
83 Platelet activation 💬
 [1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
84 Platelet activation 💬
 [1] BTK 💬 Pirtobrutinib 💬 Pirtobrutinib [1] 13 💬
85 Platelet activation 💬
 [1] BTK 💬 Remibrutinib 💬 Remibrutinib [3] 11, 13, 53 💬
86 Platelet activation 💬
 [1] BTK 💬 Rilzabrutinib 💬 Rilzabrutinib [5] 35, 61, 63, 222, 300 💬
87 Platelet activation 💬
 [1] BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib [2] 46, 53 💬
88 Platelet activation 💬
 [1] BTK 💬 Tirabrutinib 💬 Tirabrutinib [2] 46, 53 💬
89 Platelet activation 💬
 [1] BTK 💬 Tolebrutinib 💬 Tolebrutinib [2] 11, 13 💬
90 Platelet activation 💬
 [1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [6] 13, 61, 63, 222, 300, 331 💬
91 Primary immunodeficiency 💬
 [1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬
92 Primary immunodeficiency 💬
 [1] BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib [2] 46, 61 💬
93 Primary immunodeficiency 💬
 [1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬
94 Primary immunodeficiency 💬
 [1] BTK 💬 Elsubrutinib 💬 Elsubrutinib [1] 49 💬
95 Primary immunodeficiency 💬
 [1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬
96 Primary immunodeficiency 💬
 [1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬
97 Primary immunodeficiency 💬
 [1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬
98 Primary immunodeficiency 💬
 [1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
99 Primary immunodeficiency 💬
 [1] BTK 💬 Pirtobrutinib 💬 Pirtobrutinib [1] 13 💬
100 Primary immunodeficiency 💬
 [1] BTK 💬 Remibrutinib 💬 Remibrutinib [3] 11, 13, 53 💬
101 Primary immunodeficiency 💬
 [1] BTK 💬 Rilzabrutinib 💬 Rilzabrutinib [5] 35, 61, 63, 222, 300 💬
102 Primary immunodeficiency 💬
 [1] BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib [2] 46, 53 💬
103 Primary immunodeficiency 💬
 [1] BTK 💬 Tirabrutinib 💬 Tirabrutinib [2] 46, 53 💬
104 Primary immunodeficiency 💬
 [1] BTK 💬 Tolebrutinib 💬 Tolebrutinib [2] 11, 13 💬
105 Primary immunodeficiency 💬
 [1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [6] 13, 61, 63, 222, 300, 331 💬

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