Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	AGE-RAGE signaling pathway in diabetic complications 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 AGE-RAGE signaling pathway in diabetic complications × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
2	Bladder cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Bladder cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
3	Breast cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Breast cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
4	Cell cycle 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Cell cycle × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
5	Cellular senescence 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Cellular senescence × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
6	Chronic myeloid leukemia 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Chronic myeloid leukemia × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
7	Cushing syndrome 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Cushing syndrome × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
8	Epstein-Barr virus infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Epstein-Barr virus infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
9	Glioma 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Glioma × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
10	Hepatitis C 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Hepatitis C × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
11	Hepatocellular carcinoma 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Hepatocellular carcinoma × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
12	Human cytomegalovirus infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Human cytomegalovirus infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
13	Human papillomavirus infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Human papillomavirus infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
14	Human T-cell leukemia virus 1 infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
15	Influenza A 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Influenza A × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
16	Kaposi sarcoma-associated herpesvirus infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
17	Measles 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Measles × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
18	Melanoma 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Melanoma × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
19	Non-small cell lung cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Non-small cell lung cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
20	p53 signaling pathway 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 p53 signaling pathway × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
21	Pancreatic cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Pancreatic cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
22	Pathways in cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Pathways in cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
23	PI3K-Akt signaling pathway 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 PI3K-Akt signaling pathway × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
24	Small cell lung cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Small cell lung cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
25	T cell receptor signaling pathway 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 T cell receptor signaling pathway × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
26	Tight junction 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Tight junction × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
27	Viral carcinogenesis 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Viral carcinogenesis × Name Other Names Abemaciclib Abemaciclib (JAN/USAN/INN) Verzenio (TN) VERZENIO	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;

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