Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	AGE-RAGE signaling pathway in diabetic complications 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 AGE-RAGE signaling pathway in diabetic complications × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
2	Bladder cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Bladder cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
3	Breast cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Breast cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
4	Cell cycle 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Cell cycle × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
5	Cellular senescence 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Cellular senescence × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
6	Chronic myeloid leukemia 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Chronic myeloid leukemia × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
7	Cushing syndrome 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Cushing syndrome × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
8	Endocrine resistance 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Endocrine resistance × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
9	Epstein-Barr virus infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Epstein-Barr virus infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
10	Glioma 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Glioma × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
11	Hepatitis C 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Hepatitis C × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
12	Hepatocellular carcinoma 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Hepatocellular carcinoma × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
13	Human cytomegalovirus infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Human cytomegalovirus infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
14	Human papillomavirus infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Human papillomavirus infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
15	Human T-cell leukemia virus 1 infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
16	Influenza A 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Influenza A × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
17	Kaposi sarcoma-associated herpesvirus infection 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
18	Measles 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Measles × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
19	Melanoma 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Melanoma × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
20	Non-small cell lung cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Non-small cell lung cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
21	p53 signaling pathway 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 p53 signaling pathway × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
22	Pancreatic cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Pancreatic cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
23	Pathways in cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Pathways in cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
24	PI3K-Akt signaling pathway 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 PI3K-Akt signaling pathway × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
25	Small cell lung cancer 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Small cell lung cancer × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
26	T cell receptor signaling pathway 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 T cell receptor signaling pathway × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
27	Tight junction 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Tight junction × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;
28	Viral carcinogenesis 💬	[1] CDK4 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name CDK4 cyclin dependent kinase 4	Abemaciclib 💬 Viral carcinogenesis × Name Other Names Abemaciclib Abemaciclib (JAN/USAN) Verzenio (TN)	Abemaciclib	[1] 34 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 34 Neurofibromatosis;

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