Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Calcium signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [8] 51, 66, 84, 85, 86, 88, 210, 211 💬
2 Calcium signaling pathway 💬
 [1] EDNRA 💬 Atrasentan hydrochloride 💬 Atrasentan [3] 66, 218, 222 💬
3 Calcium signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
4 Calcium signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
5 Calcium signaling pathway 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
6 Calcium signaling pathway 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬
7 Calcium signaling pathway 💬
 [1] EDNRA 💬 Sitaxentan sodium 💬 Sitaxentan [1] 86 💬
8 Calcium signaling pathway 💬
 [1] EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
9 Calcium signaling pathway 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬
10 cAMP signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [8] 51, 66, 84, 85, 86, 88, 210, 211 💬
11 cAMP signaling pathway 💬
 [1] EDNRA 💬 Atrasentan hydrochloride 💬 Atrasentan [3] 66, 218, 222 💬
12 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
13 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
14 cAMP signaling pathway 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
15 cAMP signaling pathway 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬
16 cAMP signaling pathway 💬
 [1] EDNRA 💬 Sitaxentan sodium 💬 Sitaxentan [1] 86 💬
17 cAMP signaling pathway 💬
 [1] EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
18 cAMP signaling pathway 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬
19 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [8] 51, 66, 84, 85, 86, 88, 210, 211 💬
20 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Atrasentan hydrochloride 💬 Atrasentan [3] 66, 218, 222 💬
21 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
22 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
23 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
24 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬
25 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Sitaxentan sodium 💬 Sitaxentan [1] 86 💬
26 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
27 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬
28 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [8] 51, 66, 84, 85, 86, 88, 210, 211 💬
29 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Atrasentan hydrochloride 💬 Atrasentan [3] 66, 218, 222 💬
30 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
31 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
32 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
33 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬
34 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Sitaxentan sodium 💬 Sitaxentan [1] 86 💬
35 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
36 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬
37 Pathways in cancer 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [8] 51, 66, 84, 85, 86, 88, 210, 211 💬
38 Pathways in cancer 💬
 [1] EDNRA 💬 Atrasentan hydrochloride 💬 Atrasentan [3] 66, 218, 222 💬
39 Pathways in cancer 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
40 Pathways in cancer 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
41 Pathways in cancer 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
42 Pathways in cancer 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬
43 Pathways in cancer 💬
 [1] EDNRA 💬 Sitaxentan sodium 💬 Sitaxentan [1] 86 💬
44 Pathways in cancer 💬
 [1] EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
45 Pathways in cancer 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬
46 Renin secretion 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [8] 51, 66, 84, 85, 86, 88, 210, 211 💬
47 Renin secretion 💬
 [1] EDNRA 💬 Atrasentan hydrochloride 💬 Atrasentan [3] 66, 218, 222 💬
48 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
49 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
50 Renin secretion 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
51 Renin secretion 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬
52 Renin secretion 💬
 [1] EDNRA 💬 Sitaxentan sodium 💬 Sitaxentan [1] 86 💬
53 Renin secretion 💬
 [1] EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
54 Renin secretion 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬
55 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [8] 51, 66, 84, 85, 86, 88, 210, 211 💬
56 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Atrasentan hydrochloride 💬 Atrasentan [3] 66, 218, 222 💬
57 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
58 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
59 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
60 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬
61 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Sitaxentan sodium 💬 Sitaxentan [1] 86 💬
62 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
63 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬

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