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Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Cadherin signaling 💬

[1] GABRA5 💬

Alogabat 💬

Alogabat

[1] 201 💬

Cadherin signaling 💬

[1] GABRA5 💬

Alprazolam 💬

Alprazolam

[2] 8 , 75 💬

Cadherin signaling 💬

[1] GABRA5 💬

Clobazam 💬

Clobazam

[2] 140, 144 💬

Cadherin signaling 💬

[1] GABRA5 💬

Clonazepam 💬

Clonazepam

[1] 6 💬

Cadherin signaling 💬

[1] GABRA5 💬

Diazepam 💬

Diazepam

[3] 46, 155, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
298	Hereditary pancreatitis;Chronic pancreatitis;

Cadherin signaling 💬

[1] GABRA5 💬

Eszopiclone 💬

Eszopiclone

[3] 6 , 13, 46 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Cadherin signaling 💬

[1] GABRA5 💬

Flumazenil 💬

Flumazenil

[5] 6 , 13, 17, 18, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
206	Fragile X syndrome;

Cadherin signaling 💬

[1] GABRA5 💬

Fospropofol disodium 💬

Fospropofol

[1] 226 💬

Cadherin signaling 💬

[1] GABRA5 💬

Gaboxadol 💬

Gaboxadol

[2] 201, 206 💬

Cadherin signaling 💬

[1] GABRA5 💬

Ganaxolone 💬

Ganaxolone

[4] 145, 152, 158, 206 💬

Disease ID	Name
145	West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome;
152	PCDH19-related syndrome;PCDH19-related epilepsy syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19 related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
206	Fragile X syndrome;

Cadherin signaling 💬

[1] GABRA5 💬

Lorazepam 💬

Lorazepam

[2] 36, 231 💬

Cadherin signaling 💬

[1] GABRA5 💬

Midazolam 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Cadherin signaling 💬

[1] GABRA5 💬

Midazolam hydrochloride 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Cadherin signaling 💬

[1] GABRA5 💬

Midazolam maleate 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Cadherin signaling 💬

[1] GABRA5 💬

Nitrazepam 💬

Nitrazepam

[1] 145 💬

Cadherin signaling 💬

[1] GABRA5 💬

Propofol 💬

Propofol

[10] 3 , 6 , 21, 22, 34, 46, 70, 97, 98, 296 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;
296	Biliary atresia;

Cadherin signaling 💬

[1] GABRA5 💬

Remimazolam besylate 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

Cadherin signaling 💬

[1] GABRA5 💬

Remimazolam 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

Cadherin signaling 💬

[1] GABRA5 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

Cadherin signaling 💬

[1] GABRA5 💬

Zolpidem tartrate 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Cadherin signaling 💬

[1] GABRA5 💬

Zolpidem 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Cadherin signaling 💬

[1] GABRA5 💬

Zopiclone 💬

Zopiclone

[1] 6 💬

GABAergic synapse 💬

[1] GABRA5 💬

Alogabat 💬

Alogabat

[1] 201 💬

GABAergic synapse 💬

[1] GABRA5 💬

Alprazolam 💬

Alprazolam

[2] 8 , 75 💬

GABAergic synapse 💬

[1] GABRA5 💬

Clobazam 💬

Clobazam

[2] 140, 144 💬

GABAergic synapse 💬

[1] GABRA5 💬

Clonazepam 💬

Clonazepam

[1] 6 💬

GABAergic synapse 💬

[1] GABRA5 💬

Diazepam 💬

Diazepam

[3] 46, 155, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
298	Hereditary pancreatitis;Chronic pancreatitis;

GABAergic synapse 💬

[1] GABRA5 💬

Eszopiclone 💬

Eszopiclone

[3] 6 , 13, 46 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

GABAergic synapse 💬

[1] GABRA5 💬

Flumazenil 💬

Flumazenil

[5] 6 , 13, 17, 18, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
206	Fragile X syndrome;

GABAergic synapse 💬

[1] GABRA5 💬

Fospropofol disodium 💬

Fospropofol

[1] 226 💬

GABAergic synapse 💬

[1] GABRA5 💬

Gaboxadol 💬

Gaboxadol

[2] 201, 206 💬

GABAergic synapse 💬

[1] GABRA5 💬

Ganaxolone 💬

Ganaxolone

[4] 145, 152, 158, 206 💬

Disease ID	Name
145	West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome;
152	PCDH19-related syndrome;PCDH19-related epilepsy syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19 related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
206	Fragile X syndrome;

GABAergic synapse 💬

[1] GABRA5 💬

Lorazepam 💬

Lorazepam

[2] 36, 231 💬

GABAergic synapse 💬

[1] GABRA5 💬

Midazolam 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

GABAergic synapse 💬

[1] GABRA5 💬

Midazolam hydrochloride 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

GABAergic synapse 💬

[1] GABRA5 💬

Midazolam maleate 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

GABAergic synapse 💬

[1] GABRA5 💬

Nitrazepam 💬

Nitrazepam

[1] 145 💬

GABAergic synapse 💬

[1] GABRA5 💬

Propofol 💬

Propofol

[10] 3 , 6 , 21, 22, 34, 46, 70, 97, 98, 296 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;
296	Biliary atresia;

GABAergic synapse 💬

[1] GABRA5 💬

Remimazolam besylate 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

GABAergic synapse 💬

[1] GABRA5 💬

Remimazolam 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

GABAergic synapse 💬

[1] GABRA5 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

GABAergic synapse 💬

[1] GABRA5 💬

Zolpidem tartrate 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

GABAergic synapse 💬

[1] GABRA5 💬

Zolpidem 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

GABAergic synapse 💬

[1] GABRA5 💬

Zopiclone 💬

Zopiclone

[1] 6 💬

Morphine addiction 💬

[1] GABRA5 💬

Alogabat 💬

Alogabat

[1] 201 💬

Morphine addiction 💬

[1] GABRA5 💬

Alprazolam 💬

Alprazolam

[2] 8 , 75 💬

Morphine addiction 💬

[1] GABRA5 💬

Clobazam 💬

Clobazam

[2] 140, 144 💬

Morphine addiction 💬

[1] GABRA5 💬

Clonazepam 💬

Clonazepam

[1] 6 💬

Morphine addiction 💬

[1] GABRA5 💬

Diazepam 💬

Diazepam

[3] 46, 155, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
298	Hereditary pancreatitis;Chronic pancreatitis;

Morphine addiction 💬

[1] GABRA5 💬

Eszopiclone 💬

Eszopiclone

[3] 6 , 13, 46 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Morphine addiction 💬

[1] GABRA5 💬

Flumazenil 💬

Flumazenil

[5] 6 , 13, 17, 18, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
206	Fragile X syndrome;

Morphine addiction 💬

[1] GABRA5 💬

Fospropofol disodium 💬

Fospropofol

[1] 226 💬

Morphine addiction 💬

[1] GABRA5 💬

Gaboxadol 💬

Gaboxadol

[2] 201, 206 💬

Morphine addiction 💬

[1] GABRA5 💬

Ganaxolone 💬

Ganaxolone

[4] 145, 152, 158, 206 💬

Disease ID	Name
145	West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome;
152	PCDH19-related syndrome;PCDH19-related epilepsy syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19 related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
206	Fragile X syndrome;

Morphine addiction 💬

[1] GABRA5 💬

Lorazepam 💬

Lorazepam

[2] 36, 231 💬

Morphine addiction 💬

[1] GABRA5 💬

Midazolam 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Morphine addiction 💬

[1] GABRA5 💬

Midazolam hydrochloride 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Morphine addiction 💬

[1] GABRA5 💬

Midazolam maleate 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Morphine addiction 💬

[1] GABRA5 💬

Nitrazepam 💬

Nitrazepam

[1] 145 💬

Morphine addiction 💬

[1] GABRA5 💬

Propofol 💬

Propofol

[10] 3 , 6 , 21, 22, 34, 46, 70, 97, 98, 296 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;
296	Biliary atresia;

Morphine addiction 💬

[1] GABRA5 💬

Remimazolam besylate 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

Morphine addiction 💬

[1] GABRA5 💬

Remimazolam 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

Morphine addiction 💬

[1] GABRA5 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

Morphine addiction 💬

[1] GABRA5 💬

Zolpidem tartrate 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Morphine addiction 💬

[1] GABRA5 💬

Zolpidem 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Morphine addiction 💬

[1] GABRA5 💬

Zopiclone 💬

Zopiclone

[1] 6 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Alogabat 💬

Alogabat

[1] 201 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Alprazolam 💬

Alprazolam

[2] 8 , 75 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Clobazam 💬

Clobazam

[2] 140, 144 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Clonazepam 💬

Clonazepam

[1] 6 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Diazepam 💬

Diazepam

[3] 46, 155, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
298	Hereditary pancreatitis;Chronic pancreatitis;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Eszopiclone 💬

Eszopiclone

[3] 6 , 13, 46 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Flumazenil 💬

Flumazenil

[5] 6 , 13, 17, 18, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
206	Fragile X syndrome;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Fospropofol disodium 💬

Fospropofol

[1] 226 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Gaboxadol 💬

Gaboxadol

[2] 201, 206 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Ganaxolone 💬

Ganaxolone

[4] 145, 152, 158, 206 💬

Disease ID	Name
145	West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome;
152	PCDH19-related syndrome;PCDH19-related epilepsy syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19 related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
206	Fragile X syndrome;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Lorazepam 💬

Lorazepam

[2] 36, 231 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Midazolam 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Midazolam hydrochloride 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Midazolam maleate 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Nitrazepam 💬

Nitrazepam

[1] 145 💬

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Propofol 💬

Propofol

[10] 3 , 6 , 21, 22, 34, 46, 70, 97, 98, 296 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;
296	Biliary atresia;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Remimazolam besylate 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Remimazolam 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Zolpidem tartrate 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Zolpidem 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Neuroactive ligand signaling 💬

[1] GABRA5 💬

Zopiclone 💬

Zopiclone

[1] 6 💬

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Alogabat 💬

Alogabat

[1] 201 💬

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Alprazolam 💬

Alprazolam

[2] 8 , 75 💬

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Clobazam 💬

Clobazam

[2] 140, 144 💬

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Clonazepam 💬

Clonazepam

[1] 6 💬

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Diazepam 💬

Diazepam

[3] 46, 155, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
298	Hereditary pancreatitis;Chronic pancreatitis;

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Eszopiclone 💬

Eszopiclone

[3] 6 , 13, 46 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Flumazenil 💬

Flumazenil

[5] 6 , 13, 17, 18, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
206	Fragile X syndrome;

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Fospropofol disodium 💬

Fospropofol

[1] 226 💬

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Gaboxadol 💬

Gaboxadol

[2] 201, 206 💬

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Ganaxolone 💬

Ganaxolone

[4] 145, 152, 158, 206 💬

Disease ID	Name
145	West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome;
152	PCDH19-related syndrome;PCDH19-related epilepsy syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19 related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
206	Fragile X syndrome;

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Lorazepam 💬

Lorazepam

[2] 36, 231 💬

100

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Midazolam 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

101

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Midazolam hydrochloride 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

102

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Midazolam maleate 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

103

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Nitrazepam 💬

Nitrazepam

[1] 145 💬

104

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Propofol 💬

Propofol

[10] 3 , 6 , 21, 22, 34, 46, 70, 97, 98, 296 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;
296	Biliary atresia;

105

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Remimazolam besylate 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

106

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Remimazolam 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

107

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

108

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Zolpidem tartrate 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

109

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Zolpidem 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

110

Neuroactive ligand-receptor interaction 💬

[1] GABRA5 💬

Zopiclone 💬

Zopiclone

[1] 6 💬

111

Nicotine addiction 💬

[1] GABRA5 💬

Alogabat 💬

Alogabat

[1] 201 💬

112

Nicotine addiction 💬

[1] GABRA5 💬

Alprazolam 💬

Alprazolam

[2] 8 , 75 💬

113

Nicotine addiction 💬

[1] GABRA5 💬

Clobazam 💬

Clobazam

[2] 140, 144 💬

114

Nicotine addiction 💬

[1] GABRA5 💬

Clonazepam 💬

Clonazepam

[1] 6 💬

115

Nicotine addiction 💬

[1] GABRA5 💬

Diazepam 💬

Diazepam

[3] 46, 155, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
298	Hereditary pancreatitis;Chronic pancreatitis;

116

Nicotine addiction 💬

[1] GABRA5 💬

Eszopiclone 💬

Eszopiclone

[3] 6 , 13, 46 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

117

Nicotine addiction 💬

[1] GABRA5 💬

Flumazenil 💬

Flumazenil

[5] 6 , 13, 17, 18, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
206	Fragile X syndrome;

118

Nicotine addiction 💬

[1] GABRA5 💬

Fospropofol disodium 💬

Fospropofol

[1] 226 💬

119

Nicotine addiction 💬

[1] GABRA5 💬

Gaboxadol 💬

Gaboxadol

[2] 201, 206 💬

120

Nicotine addiction 💬

[1] GABRA5 💬

Ganaxolone 💬

Ganaxolone

[4] 145, 152, 158, 206 💬

Disease ID	Name
145	West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome;
152	PCDH19-related syndrome;PCDH19-related epilepsy syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19 related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
206	Fragile X syndrome;

121

Nicotine addiction 💬

[1] GABRA5 💬

Lorazepam 💬

Lorazepam

[2] 36, 231 💬

122

Nicotine addiction 💬

[1] GABRA5 💬

Midazolam 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

123

Nicotine addiction 💬

[1] GABRA5 💬

Midazolam hydrochloride 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

124

Nicotine addiction 💬

[1] GABRA5 💬

Midazolam maleate 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

125

Nicotine addiction 💬

[1] GABRA5 💬

Nitrazepam 💬

Nitrazepam

[1] 145 💬

126

Nicotine addiction 💬

[1] GABRA5 💬

Propofol 💬

Propofol

[10] 3 , 6 , 21, 22, 34, 46, 70, 97, 98, 296 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;
296	Biliary atresia;

127

Nicotine addiction 💬

[1] GABRA5 💬

Remimazolam besylate 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

128

Nicotine addiction 💬

[1] GABRA5 💬

Remimazolam 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

129

Nicotine addiction 💬

[1] GABRA5 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

130

Nicotine addiction 💬

[1] GABRA5 💬

Zolpidem tartrate 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

131

Nicotine addiction 💬

[1] GABRA5 💬

Zolpidem 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

132

Nicotine addiction 💬

[1] GABRA5 💬

Zopiclone 💬

Zopiclone

[1] 6 💬

133

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Alogabat 💬

Alogabat

[1] 201 💬

134

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Alprazolam 💬

Alprazolam

[2] 8 , 75 💬

135

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Clobazam 💬

Clobazam

[2] 140, 144 💬

136

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Clonazepam 💬

Clonazepam

[1] 6 💬

137

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Diazepam 💬

Diazepam

[3] 46, 155, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
298	Hereditary pancreatitis;Chronic pancreatitis;

138

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Eszopiclone 💬

Eszopiclone

[3] 6 , 13, 46 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

139

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Flumazenil 💬

Flumazenil

[5] 6 , 13, 17, 18, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
206	Fragile X syndrome;

140

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Fospropofol disodium 💬

Fospropofol

[1] 226 💬

141

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Gaboxadol 💬

Gaboxadol

[2] 201, 206 💬

142

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Ganaxolone 💬

Ganaxolone

[4] 145, 152, 158, 206 💬

Disease ID	Name
145	West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome;
152	PCDH19-related syndrome;PCDH19-related epilepsy syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19 related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
206	Fragile X syndrome;

143

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Lorazepam 💬

Lorazepam

[2] 36, 231 💬

144

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Midazolam 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

145

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Midazolam hydrochloride 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

146

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Midazolam maleate 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

147

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Nitrazepam 💬

Nitrazepam

[1] 145 💬

148

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Propofol 💬

Propofol

[10] 3 , 6 , 21, 22, 34, 46, 70, 97, 98, 296 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;
296	Biliary atresia;

149

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Remimazolam besylate 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

150

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Remimazolam 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

151

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

152

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Zolpidem tartrate 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

153

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Zolpidem 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

154

Retrograde endocannabinoid signaling 💬

[1] GABRA5 💬

Zopiclone 💬

Zopiclone

[1] 6 💬

155

Taste transduction 💬

[1] GABRA5 💬

Alogabat 💬

Alogabat

[1] 201 💬

156

Taste transduction 💬

[1] GABRA5 💬

Alprazolam 💬

Alprazolam

[2] 8 , 75 💬

157

Taste transduction 💬

[1] GABRA5 💬

Clobazam 💬

Clobazam

[2] 140, 144 💬

158

Taste transduction 💬

[1] GABRA5 💬

Clonazepam 💬

Clonazepam

[1] 6 💬

159

Taste transduction 💬

[1] GABRA5 💬

Diazepam 💬

Diazepam

[3] 46, 155, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
298	Hereditary pancreatitis;Chronic pancreatitis;

160

Taste transduction 💬

[1] GABRA5 💬

Eszopiclone 💬

Eszopiclone

[3] 6 , 13, 46 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

161

Taste transduction 💬

[1] GABRA5 💬

Flumazenil 💬

Flumazenil

[5] 6 , 13, 17, 18, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
206	Fragile X syndrome;

162

Taste transduction 💬

[1] GABRA5 💬

Fospropofol disodium 💬

Fospropofol

[1] 226 💬

163

Taste transduction 💬

[1] GABRA5 💬

Gaboxadol 💬

Gaboxadol

[2] 201, 206 💬

164

Taste transduction 💬

[1] GABRA5 💬

Ganaxolone 💬

Ganaxolone

[4] 145, 152, 158, 206 💬

Disease ID	Name
145	West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome;
152	PCDH19-related syndrome;PCDH19-related epilepsy syndrome;PCDH19 Epilepsy;Epilepsy and mental retardation limited to females;PCDH19 female pediatric epilepsy;PCDH19 related epilepsy;Protocadherin 19 (PCDH19)-related epilepsy;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
206	Fragile X syndrome;

165

Taste transduction 💬

[1] GABRA5 💬

Lorazepam 💬

Lorazepam

[2] 36, 231 💬

166

Taste transduction 💬

[1] GABRA5 💬

Midazolam 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

167

Taste transduction 💬

[1] GABRA5 💬

Midazolam hydrochloride 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

168

Taste transduction 💬

[1] GABRA5 💬

Midazolam maleate 💬

Midazolam

[14] 2 , 3 , 6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
231	Alpha-1-antitrypsin deficiency;AATD;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;CF;

169

Taste transduction 💬

[1] GABRA5 💬

Nitrazepam 💬

Nitrazepam

[1] 145 💬

170

Taste transduction 💬

[1] GABRA5 💬

Propofol 💬

Propofol

[10] 3 , 6 , 21, 22, 34, 46, 70, 97, 98, 296 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;
296	Biliary atresia;

171

Taste transduction 💬

[1] GABRA5 💬

Remimazolam besylate 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

172

Taste transduction 💬

[1] GABRA5 💬

Remimazolam 💬

Remimazolam

[3] 6 , 22, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
22	Moyamoya disease;Occlusive disease in circle of Willis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

173

Taste transduction 💬

[1] GABRA5 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

174

Taste transduction 💬

[1] GABRA5 💬

Zolpidem tartrate 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

175

Taste transduction 💬

[1] GABRA5 💬

Zolpidem 💬

Zolpidem

[3] 5 , 6 , 46 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;

176

Taste transduction 💬

[1] GABRA5 💬

Zopiclone 💬

Zopiclone

[1] 6 💬