Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adherens junction 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Adherens junction × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 1. Adherens junction × Disease ID Name 232 Carney complex;
2	Adherens junction 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Adherens junction × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 2. Adherens junction × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
3	Adherens junction 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Adherens junction × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 3. Adherens junction × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
4	AMPK signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 AMPK signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 4. AMPK signaling pathway × Disease ID Name 232 Carney complex;
5	AMPK signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 AMPK signaling pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 5. AMPK signaling pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
6	AMPK signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 AMPK signaling pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 6. AMPK signaling pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
7	Autophagy - animal 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Autophagy - animal × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 7. Autophagy - animal × Disease ID Name 232 Carney complex;
8	Autophagy - animal 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Autophagy - animal × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 8. Autophagy - animal × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
9	Autophagy - animal 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Autophagy - animal × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 9. Autophagy - animal × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
10	Breast cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Breast cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 10. Breast cancer × Disease ID Name 232 Carney complex;
11	Breast cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Breast cancer × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 11. Breast cancer × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
12	Breast cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Breast cancer × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 12. Breast cancer × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
13	EGFR tyrosine kinase inhibitor resistance 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 13. EGFR tyrosine kinase inhibitor resistance × Disease ID Name 232 Carney complex;
14	EGFR tyrosine kinase inhibitor resistance 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 14. EGFR tyrosine kinase inhibitor resistance × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
15	EGFR tyrosine kinase inhibitor resistance 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 15. EGFR tyrosine kinase inhibitor resistance × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
16	Endocrine resistance 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Endocrine resistance × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 16. Endocrine resistance × Disease ID Name 232 Carney complex;
17	Endocrine resistance 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Endocrine resistance × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 17. Endocrine resistance × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
18	Endocrine resistance 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Endocrine resistance × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 18. Endocrine resistance × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
19	Endocytosis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Endocytosis × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 19. Endocytosis × Disease ID Name 232 Carney complex;
20	Endocytosis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Endocytosis × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 20. Endocytosis × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
21	Endocytosis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Endocytosis × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 21. Endocytosis × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
22	Focal adhesion 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Focal adhesion × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 22. Focal adhesion × Disease ID Name 232 Carney complex;
23	Focal adhesion 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Focal adhesion × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 23. Focal adhesion × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
24	Focal adhesion 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Focal adhesion × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 24. Focal adhesion × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
25	FoxO signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 FoxO signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 25. FoxO signaling pathway × Disease ID Name 232 Carney complex;
26	FoxO signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 FoxO signaling pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 26. FoxO signaling pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
27	FoxO signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 FoxO signaling pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 27. FoxO signaling pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
28	Glioma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Glioma × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 28. Glioma × Disease ID Name 232 Carney complex;
29	Glioma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Glioma × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 29. Glioma × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
30	Glioma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Glioma × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 30. Glioma × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
31	Hepatocellular carcinoma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Hepatocellular carcinoma × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 31. Hepatocellular carcinoma × Disease ID Name 232 Carney complex;
32	Hepatocellular carcinoma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Hepatocellular carcinoma × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 32. Hepatocellular carcinoma × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
33	Hepatocellular carcinoma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Hepatocellular carcinoma × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 33. Hepatocellular carcinoma × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
34	HIF-1 signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 HIF-1 signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 34. HIF-1 signaling pathway × Disease ID Name 232 Carney complex;
35	HIF-1 signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 HIF-1 signaling pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 35. HIF-1 signaling pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
36	HIF-1 signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 HIF-1 signaling pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 36. HIF-1 signaling pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
37	Long-term depression 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Long-term depression × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 37. Long-term depression × Disease ID Name 232 Carney complex;
38	Long-term depression 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Long-term depression × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 38. Long-term depression × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
39	Long-term depression 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Long-term depression × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 39. Long-term depression × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
40	Longevity regulating pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Longevity regulating pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 40. Longevity regulating pathway × Disease ID Name 232 Carney complex;
41	Longevity regulating pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Longevity regulating pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 41. Longevity regulating pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
42	Longevity regulating pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Longevity regulating pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 42. Longevity regulating pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
43	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Longevity regulating pathway - multiple species × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 43. Longevity regulating pathway - multiple species × Disease ID Name 232 Carney complex;
44	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Longevity regulating pathway - multiple species × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 44. Longevity regulating pathway - multiple species × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
45	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Longevity regulating pathway - multiple species × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 45. Longevity regulating pathway - multiple species × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
46	MAPK signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 MAPK signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 46. MAPK signaling pathway × Disease ID Name 232 Carney complex;
47	MAPK signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 MAPK signaling pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 47. MAPK signaling pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
48	MAPK signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 MAPK signaling pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 48. MAPK signaling pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
49	Melanoma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Melanoma × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 49. Melanoma × Disease ID Name 232 Carney complex;
50	Melanoma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Melanoma × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 50. Melanoma × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
51	Melanoma 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Melanoma × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 51. Melanoma × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
52	mTOR signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 mTOR signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 52. mTOR signaling pathway × Disease ID Name 232 Carney complex;
53	mTOR signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 mTOR signaling pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 53. mTOR signaling pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
54	mTOR signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 mTOR signaling pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 54. mTOR signaling pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
55	Oocyte meiosis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Oocyte meiosis × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 55. Oocyte meiosis × Disease ID Name 232 Carney complex;
56	Oocyte meiosis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Oocyte meiosis × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 56. Oocyte meiosis × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
57	Oocyte meiosis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Oocyte meiosis × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 57. Oocyte meiosis × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
58	Ovarian steroidogenesis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Ovarian steroidogenesis × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 58. Ovarian steroidogenesis × Disease ID Name 232 Carney complex;
59	Ovarian steroidogenesis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Ovarian steroidogenesis × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 59. Ovarian steroidogenesis × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
60	Ovarian steroidogenesis 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Ovarian steroidogenesis × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 60. Ovarian steroidogenesis × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
61	Pathways in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Pathways in cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 61. Pathways in cancer × Disease ID Name 232 Carney complex;
62	Pathways in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Pathways in cancer × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 62. Pathways in cancer × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
63	Pathways in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Pathways in cancer × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 63. Pathways in cancer × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
64	PI3K-Akt signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 PI3K-Akt signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 64. PI3K-Akt signaling pathway × Disease ID Name 232 Carney complex;
65	PI3K-Akt signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 PI3K-Akt signaling pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 65. PI3K-Akt signaling pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
66	PI3K-Akt signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 PI3K-Akt signaling pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 66. PI3K-Akt signaling pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
67	Progesterone-mediated oocyte maturation 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 67. Progesterone-mediated oocyte maturation × Disease ID Name 232 Carney complex;
68	Progesterone-mediated oocyte maturation 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Progesterone-mediated oocyte maturation × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 68. Progesterone-mediated oocyte maturation × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
69	Progesterone-mediated oocyte maturation 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Progesterone-mediated oocyte maturation × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 69. Progesterone-mediated oocyte maturation × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
70	Prostate cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Prostate cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 70. Prostate cancer × Disease ID Name 232 Carney complex;
71	Prostate cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Prostate cancer × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 71. Prostate cancer × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
72	Prostate cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Prostate cancer × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 72. Prostate cancer × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
73	Proteoglycans in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Proteoglycans in cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 73. Proteoglycans in cancer × Disease ID Name 232 Carney complex;
74	Proteoglycans in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Proteoglycans in cancer × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 74. Proteoglycans in cancer × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
75	Proteoglycans in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Proteoglycans in cancer × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 75. Proteoglycans in cancer × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
76	Rap1 signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Rap1 signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 76. Rap1 signaling pathway × Disease ID Name 232 Carney complex;
77	Rap1 signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Rap1 signaling pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 77. Rap1 signaling pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
78	Rap1 signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Rap1 signaling pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 78. Rap1 signaling pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
79	Ras signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Ras signaling pathway × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 79. Ras signaling pathway × Disease ID Name 232 Carney complex;
80	Ras signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Ras signaling pathway × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 80. Ras signaling pathway × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
81	Ras signaling pathway 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Ras signaling pathway × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 81. Ras signaling pathway × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
82	Signaling pathways regulating pluripotency of stem cells 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 82. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 232 Carney complex;
83	Signaling pathways regulating pluripotency of stem cells 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 83. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
84	Signaling pathways regulating pluripotency of stem cells 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 84. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;
85	Transcriptional misregulation in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Linsitinib 💬 Transcriptional misregulation in cancer × Name Other Names Linsitinib Linsitinib (USAN/INN)	Linsitinib	[1] 232 💬 85. Transcriptional misregulation in cancer × Disease ID Name 232 Carney complex;
86	Transcriptional misregulation in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Mecasermin 💬 Transcriptional misregulation in cancer × Name Other Names Mecasermin Mecasermin (USAN/INN) Mecasermin (genetical recombination) (JAN) Increlex (TN) Myotrophin (TN)	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 86. Transcriptional misregulation in cancer × Disease ID Name 65 Primary immunodeficiency; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;Terminal ileitis; 168 Ehlers-Danlos syndrome;EDS; 265 Lipodystrophy; 299 Cystic fibrosis;
87	Transcriptional misregulation in cancer 💬	[1] IGF1R 💬 Adherens junction × Name Full Name IGF1R insulin like growth factor 1 receptor	Teprotumumab 💬 Transcriptional misregulation in cancer × Name Other Names Teprotumumab Teprotumumab (USAN/INN) Teprotumumab-trbw Tepezza (TN)	Teprotumumab	[1] 51 💬 87. Transcriptional misregulation in cancer × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc;

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