Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Coronavirus disease - COVID-19 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
2 Coronavirus disease - COVID-19 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
3 Coronavirus disease - COVID-19 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
4 Cytokine-cytokine receptor interaction 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
5 Cytokine-cytokine receptor interaction 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
6 Cytokine-cytokine receptor interaction 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
7 Hematopoietic cell lineage 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
8 Hematopoietic cell lineage 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
9 Hematopoietic cell lineage 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
10 HIF-1 signaling pathway 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
11 HIF-1 signaling pathway 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
12 HIF-1 signaling pathway 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
13 Human cytomegalovirus infection 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
14 Human cytomegalovirus infection 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
15 Human cytomegalovirus infection 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
16 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
17 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
18 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
19 Non-alcoholic fatty liver disease 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
20 Non-alcoholic fatty liver disease 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
21 Non-alcoholic fatty liver disease 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
22 Pathways in cancer 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
23 Pathways in cancer 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
24 Pathways in cancer 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
25 PI3K-Akt signaling pathway 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
26 PI3K-Akt signaling pathway 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
27 PI3K-Akt signaling pathway 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
28 Th17 cell differentiation 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
29 Th17 cell differentiation 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
30 Th17 cell differentiation 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
31 Viral protein interaction with cytokine and cytokine receptor 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
32 Viral protein interaction with cytokine and cytokine receptor 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [4] 11, 13, 86, 113 💬
33 Viral protein interaction with cytokine and cytokine receptor 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [24]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬

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