Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Acute myeloid leukemia × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 1. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
2	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Acute myeloid leukemia × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 2. Acute myeloid leukemia × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
3	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Acute myeloid leukemia × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 2. Acute myeloid leukemia × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
4	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Acute myeloid leukemia × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 4. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
5	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Acute myeloid leukemia × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 5. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
6	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Acute myeloid leukemia × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 5. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
7	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Acute myeloid leukemia × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 7. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
8	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Acute myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 7. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
9	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Alcoholism × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 9. Alcoholism × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
10	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Alcoholism × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 10. Alcoholism × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
11	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Alcoholism × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 10. Alcoholism × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
12	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Alcoholism × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 12. Alcoholism × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
13	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Alcoholism × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 13. Alcoholism × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
14	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Alcoholism × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 13. Alcoholism × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
15	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Alcoholism × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 15. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
16	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Alcoholism × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 15. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
17	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Alzheimer disease × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 17. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
18	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Alzheimer disease × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 18. Alzheimer disease × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
19	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Alzheimer disease × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 18. Alzheimer disease × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
20	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Alzheimer disease × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 20. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
21	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Alzheimer disease × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 21. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
22	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Alzheimer disease × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 21. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
23	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Alzheimer disease × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
24	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Alzheimer disease × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
25	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Apelin signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 25. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
26	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Apelin signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 26. Apelin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
27	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Apelin signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 26. Apelin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
28	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Apelin signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 28. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
29	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Apelin signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 29. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
30	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Apelin signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 29. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
31	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Apelin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 31. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
32	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Apelin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 31. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
33	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Apoptosis × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 33. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
34	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Apoptosis × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 34. Apoptosis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
35	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Apoptosis × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 34. Apoptosis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
36	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Apoptosis × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 36. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
37	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Apoptosis × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 37. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
38	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Apoptosis × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 37. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
39	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Apoptosis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 39. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
40	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Apoptosis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 39. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
41	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Autophagy - animal × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 41. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
42	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Autophagy - animal × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 42. Autophagy - animal × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
43	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Autophagy - animal × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 42. Autophagy - animal × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
44	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Autophagy - animal × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 44. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
45	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Autophagy - animal × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 45. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Autophagy - animal × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 45. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
47	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Autophagy - animal × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 47. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
48	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Autophagy - animal × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 47. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
49	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 B cell receptor signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 49. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
50	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 B cell receptor signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 50. B cell receptor signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
51	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 B cell receptor signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 50. B cell receptor signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
52	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 B cell receptor signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 52. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
53	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 B cell receptor signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 53. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
54	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 B cell receptor signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 53. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
55	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 B cell receptor signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 55. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
56	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 B cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 55. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
57	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Bladder cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 57. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
58	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Bladder cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 58. Bladder cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
59	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Bladder cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 58. Bladder cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
60	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Bladder cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 60. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
61	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Bladder cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 61. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
62	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Bladder cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 61. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
63	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Bladder cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 63. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
64	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Bladder cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 63. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
65	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Breast cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 65. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
66	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Breast cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 66. Breast cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
67	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Breast cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 66. Breast cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
68	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Breast cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 68. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
69	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Breast cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 69. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
70	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Breast cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 69. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
71	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Breast cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 71. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
72	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Breast cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 71. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
73	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 cAMP signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 73. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
74	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 cAMP signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 74. cAMP signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
75	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 cAMP signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 74. cAMP signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
76	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 cAMP signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 76. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
77	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 cAMP signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 77. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
78	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 cAMP signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 77. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
79	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 cAMP signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 79. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
80	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 cAMP signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 79. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
81	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Cellular senescence × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 81. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
82	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Cellular senescence × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 82. Cellular senescence × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
83	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Cellular senescence × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 82. Cellular senescence × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
84	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Cellular senescence × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 84. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
85	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Cellular senescence × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 85. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
86	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Cellular senescence × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 85. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
87	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Cellular senescence × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 87. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
88	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Cellular senescence × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 87. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
89	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Central carbon metabolism in cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 89. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
90	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Central carbon metabolism in cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 90. Central carbon metabolism in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
91	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Central carbon metabolism in cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 90. Central carbon metabolism in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
92	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Central carbon metabolism in cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 92. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
93	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Central carbon metabolism in cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 93. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
94	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Central carbon metabolism in cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 93. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
95	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Central carbon metabolism in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 95. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
96	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Central carbon metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 95. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
97	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 cGMP-PKG signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 97. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
98	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 cGMP-PKG signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 98. cGMP-PKG signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
99	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 cGMP-PKG signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 98. cGMP-PKG signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
100	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 cGMP-PKG signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 100. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
101	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 cGMP-PKG signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 101. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
102	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 cGMP-PKG signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 101. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
103	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 103. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
104	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 103. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
105	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 105. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
106	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 106. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
107	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 106. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
108	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 108. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
109	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 109. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
110	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 109. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
111	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 111. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
112	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 111. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
113	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 113. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
114	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 114. Chemical carcinogenesis - receptor activation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
115	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 114. Chemical carcinogenesis - receptor activation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
116	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 116. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
117	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 117. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
118	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 117. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
119	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
120	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
121	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Chemokine signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 121. Chemokine signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
122	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Chemokine signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 122. Chemokine signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
123	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Chemokine signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 122. Chemokine signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
124	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Chemokine signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 124. Chemokine signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
125	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Chemokine signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 125. Chemokine signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
126	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Chemokine signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 125. Chemokine signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
127	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Chemokine signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 127. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
128	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Chemokine signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 127. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
129	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Choline metabolism in cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 129. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
130	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Choline metabolism in cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 130. Choline metabolism in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
131	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Choline metabolism in cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 130. Choline metabolism in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
132	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Choline metabolism in cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 132. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
133	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Choline metabolism in cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 133. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
134	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Choline metabolism in cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 133. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
135	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Choline metabolism in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 135. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
136	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Choline metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 135. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
137	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Cholinergic synapse × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 137. Cholinergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
138	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Cholinergic synapse × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 138. Cholinergic synapse × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
139	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Cholinergic synapse × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 138. Cholinergic synapse × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
140	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Cholinergic synapse × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 140. Cholinergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
141	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Cholinergic synapse × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 141. Cholinergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
142	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Cholinergic synapse × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 141. Cholinergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
143	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Cholinergic synapse × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 143. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
144	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Cholinergic synapse × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 143. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
145	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Chronic myeloid leukemia × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 145. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
146	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Chronic myeloid leukemia × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 146. Chronic myeloid leukemia × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
147	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Chronic myeloid leukemia × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 146. Chronic myeloid leukemia × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
148	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Chronic myeloid leukemia × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 148. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
149	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Chronic myeloid leukemia × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 149. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
150	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Chronic myeloid leukemia × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 149. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
151	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Chronic myeloid leukemia × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 151. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
152	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Chronic myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 151. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
153	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Colorectal cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 153. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
154	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Colorectal cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 154. Colorectal cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
155	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Colorectal cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 154. Colorectal cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
156	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Colorectal cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 156. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
157	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Colorectal cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 157. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
158	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Colorectal cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 157. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
159	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Colorectal cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 159. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
160	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Colorectal cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 159. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
161	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Cushing syndrome × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 161. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
162	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Cushing syndrome × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 162. Cushing syndrome × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
163	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Cushing syndrome × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 162. Cushing syndrome × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
164	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Cushing syndrome × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 164. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
165	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Cushing syndrome × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 165. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
166	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Cushing syndrome × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 165. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
167	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Cushing syndrome × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
168	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Cushing syndrome × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
169	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Efferocytosis × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 169. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
170	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Efferocytosis × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 170. Efferocytosis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
171	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Efferocytosis × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 170. Efferocytosis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
172	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Efferocytosis × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 172. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
173	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Efferocytosis × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 173. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
174	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Efferocytosis × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 173. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
175	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Efferocytosis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 175. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
176	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Efferocytosis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 175. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
177	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Endometrial cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 177. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
178	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Endometrial cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 178. Endometrial cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
179	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Endometrial cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 178. Endometrial cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
180	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Endometrial cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 180. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
181	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Endometrial cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 181. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
182	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Endometrial cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 181. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
183	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Endometrial cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 183. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
184	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Endometrial cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 183. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
185	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 ErbB signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 185. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
186	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 ErbB signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 186. ErbB signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
187	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 ErbB signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 186. ErbB signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
188	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 ErbB signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 188. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
189	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 ErbB signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 189. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
190	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 ErbB signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 189. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
191	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 ErbB signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
192	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 ErbB signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
193	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Estrogen signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 193. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
194	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Estrogen signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 194. Estrogen signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
195	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Estrogen signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 194. Estrogen signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
196	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Estrogen signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 196. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
197	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Estrogen signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 197. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
198	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Estrogen signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 197. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
199	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Estrogen signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 199. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
200	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Estrogen signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 199. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
201	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Fc epsilon RI signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 201. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
202	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Fc epsilon RI signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 202. Fc epsilon RI signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
203	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Fc epsilon RI signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 202. Fc epsilon RI signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
204	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Fc epsilon RI signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 204. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
205	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Fc epsilon RI signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 205. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
206	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Fc epsilon RI signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 205. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
207	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 207. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
208	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 207. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
209	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Fc gamma R-mediated phagocytosis × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 209. Fc gamma R-mediated phagocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
210	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Fc gamma R-mediated phagocytosis × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 210. Fc gamma R-mediated phagocytosis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
211	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Fc gamma R-mediated phagocytosis × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 210. Fc gamma R-mediated phagocytosis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
212	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Fc gamma R-mediated phagocytosis × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 212. Fc gamma R-mediated phagocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
213	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Fc gamma R-mediated phagocytosis × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 213. Fc gamma R-mediated phagocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
214	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Fc gamma R-mediated phagocytosis × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 213. Fc gamma R-mediated phagocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
215	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Fc gamma R-mediated phagocytosis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 215. Fc gamma R-mediated phagocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
216	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Fc gamma R-mediated phagocytosis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 215. Fc gamma R-mediated phagocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
217	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Focal adhesion × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 217. Focal adhesion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
218	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Focal adhesion × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 218. Focal adhesion × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
219	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Focal adhesion × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 218. Focal adhesion × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
220	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Focal adhesion × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 220. Focal adhesion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
221	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Focal adhesion × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 221. Focal adhesion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
222	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Focal adhesion × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 221. Focal adhesion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
223	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Focal adhesion × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 223. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
224	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Focal adhesion × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 223. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
225	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 FoxO signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 225. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
226	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 FoxO signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 226. FoxO signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
227	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 FoxO signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 226. FoxO signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
228	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 FoxO signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 228. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
229	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 FoxO signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 229. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
230	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 FoxO signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 229. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
231	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 FoxO signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 231. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
232	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 FoxO signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 231. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
233	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Gap junction × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 233. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
234	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Gap junction × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 234. Gap junction × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
235	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Gap junction × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 234. Gap junction × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
236	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Gap junction × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 236. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
237	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Gap junction × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 237. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
238	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Gap junction × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 237. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
239	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Gap junction × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 239. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
240	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Gap junction × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 239. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
241	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Gastric cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 241. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
242	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Gastric cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 242. Gastric cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
243	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Gastric cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 242. Gastric cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
244	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Gastric cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 244. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
245	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Gastric cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 245. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
246	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Gastric cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 245. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
247	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Gastric cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 247. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
248	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Gastric cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 247. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
249	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Glioma × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 249. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
250	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Glioma × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 250. Glioma × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
251	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Glioma × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 250. Glioma × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
252	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Glioma × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 252. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
253	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Glioma × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 253. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
254	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Glioma × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 253. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
255	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Glioma × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 255. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
256	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Glioma × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 255. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
257	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 GnRH secretion × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 257. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
258	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 GnRH secretion × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 258. GnRH secretion × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
259	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 GnRH secretion × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 258. GnRH secretion × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
260	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 GnRH secretion × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 260. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
261	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 GnRH secretion × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 261. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
262	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 GnRH secretion × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 261. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
263	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 GnRH secretion × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 263. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
264	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 GnRH secretion × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 263. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
265	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 GnRH signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 265. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
266	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 GnRH signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 266. GnRH signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
267	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 GnRH signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 266. GnRH signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
268	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 GnRH signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 268. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
269	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 GnRH signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 269. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
270	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 GnRH signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 269. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
271	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 GnRH signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 271. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
272	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 GnRH signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 271. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
273	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 273. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
274	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 274. Growth hormone synthesis, secretion and action × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
275	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Growth hormone synthesis, secretion and action × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 274. Growth hormone synthesis, secretion and action × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
276	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 276. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
277	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 277. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
278	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Growth hormone synthesis, secretion and action × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 277. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
279	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 279. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
280	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 279. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
281	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Hepatitis B × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 281. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
282	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Hepatitis B × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 282. Hepatitis B × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
283	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Hepatitis B × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 282. Hepatitis B × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
284	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Hepatitis B × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 284. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
285	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Hepatitis B × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 285. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
286	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Hepatitis B × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 285. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
287	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Hepatitis B × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 287. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
288	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Hepatitis B × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 287. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
289	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Hepatitis C × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 289. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
290	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Hepatitis C × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 290. Hepatitis C × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
291	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Hepatitis C × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 290. Hepatitis C × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
292	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Hepatitis C × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 292. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
293	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Hepatitis C × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 293. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
294	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Hepatitis C × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 293. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
295	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Hepatitis C × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 295. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
296	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Hepatitis C × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 295. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
297	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Hepatocellular carcinoma × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 297. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
298	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Hepatocellular carcinoma × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 298. Hepatocellular carcinoma × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
299	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Hepatocellular carcinoma × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 298. Hepatocellular carcinoma × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
300	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Hepatocellular carcinoma × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 300. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
301	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Hepatocellular carcinoma × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 301. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
302	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Hepatocellular carcinoma × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 301. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
303	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Hepatocellular carcinoma × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 303. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
304	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Hepatocellular carcinoma × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 303. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
305	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 HIF-1 signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 305. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
306	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 HIF-1 signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 306. HIF-1 signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
307	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 HIF-1 signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 306. HIF-1 signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
308	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 HIF-1 signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 308. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
309	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 HIF-1 signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 309. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
310	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 HIF-1 signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 309. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
311	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 HIF-1 signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 311. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
312	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 HIF-1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 311. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
313	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Human cytomegalovirus infection × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 313. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
314	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Human cytomegalovirus infection × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 314. Human cytomegalovirus infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
315	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Human cytomegalovirus infection × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 314. Human cytomegalovirus infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
316	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Human cytomegalovirus infection × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 316. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
317	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Human cytomegalovirus infection × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 317. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
318	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Human cytomegalovirus infection × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 317. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
319	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Human cytomegalovirus infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 319. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
320	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Human cytomegalovirus infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 319. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
321	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 321. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
322	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 322. Human immunodeficiency virus 1 infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
323	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Human immunodeficiency virus 1 infection × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 322. Human immunodeficiency virus 1 infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
324	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 324. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
325	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 325. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
326	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Human immunodeficiency virus 1 infection × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 325. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
327	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 327. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
328	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 327. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
329	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Human papillomavirus infection × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 329. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
330	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Human papillomavirus infection × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 330. Human papillomavirus infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
331	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Human papillomavirus infection × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 330. Human papillomavirus infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
332	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Human papillomavirus infection × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 332. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
333	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Human papillomavirus infection × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 333. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
334	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Human papillomavirus infection × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 333. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
335	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Human papillomavirus infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 335. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
336	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Human papillomavirus infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 335. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
337	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 337. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
338	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 338. Human T-cell leukemia virus 1 infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
339	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Human T-cell leukemia virus 1 infection × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 338. Human T-cell leukemia virus 1 infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
340	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 340. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
341	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 341. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
342	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Human T-cell leukemia virus 1 infection × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 341. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
343	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 343. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
344	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 343. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
345	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Influenza A × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 345. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
346	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Influenza A × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 346. Influenza A × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
347	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Influenza A × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 346. Influenza A × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
348	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Influenza A × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 348. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
349	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Influenza A × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 349. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
350	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Influenza A × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 349. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
351	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Influenza A × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 351. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
352	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Influenza A × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 351. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
353	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Insulin signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 353. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
354	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Insulin signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 354. Insulin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
355	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Insulin signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 354. Insulin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
356	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Insulin signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 356. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
357	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Insulin signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 357. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
358	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Insulin signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 357. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
359	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Insulin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 359. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
360	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Insulin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 359. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
361	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 361. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
362	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 362. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
363	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 362. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
364	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 364. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
365	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 365. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
366	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 365. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
367	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 367. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
368	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 367. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
369	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Long-term depression × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 369. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
370	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Long-term depression × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 370. Long-term depression × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
371	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Long-term depression × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 370. Long-term depression × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
372	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Long-term depression × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 372. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
373	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Long-term depression × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 373. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
374	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Long-term depression × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 373. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
375	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Long-term depression × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 375. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
376	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Long-term depression × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 375. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
377	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Long-term potentiation × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 377. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
378	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Long-term potentiation × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 378. Long-term potentiation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
379	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Long-term potentiation × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 378. Long-term potentiation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
380	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Long-term potentiation × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 380. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
381	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Long-term potentiation × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 381. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
382	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Long-term potentiation × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 381. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
383	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Long-term potentiation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 383. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
384	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Long-term potentiation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 383. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
385	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 MAPK signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 385. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
386	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 MAPK signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 386. MAPK signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
387	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 MAPK signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 386. MAPK signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
388	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 MAPK signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 388. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
389	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 MAPK signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 389. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
390	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 MAPK signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 389. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
391	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 MAPK signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 391. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
392	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 MAPK signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 391. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
393	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Melanogenesis × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 393. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
394	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Melanogenesis × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 394. Melanogenesis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
395	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Melanogenesis × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 394. Melanogenesis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
396	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Melanogenesis × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 396. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
397	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Melanogenesis × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 397. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
398	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Melanogenesis × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 397. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
399	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Melanogenesis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 399. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
400	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Melanogenesis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 399. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
401	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Melanoma × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 401. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
402	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Melanoma × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 402. Melanoma × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
403	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Melanoma × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 402. Melanoma × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
404	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Melanoma × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 404. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
405	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Melanoma × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 405. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
406	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Melanoma × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 405. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
407	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Melanoma × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 407. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
408	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Melanoma × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 407. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
409	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 MicroRNAs in cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 409. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
410	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 MicroRNAs in cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 410. MicroRNAs in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
411	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 MicroRNAs in cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 410. MicroRNAs in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
412	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 MicroRNAs in cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 412. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
413	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 MicroRNAs in cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 413. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
414	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 MicroRNAs in cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 413. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
415	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 MicroRNAs in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 415. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
416	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 MicroRNAs in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 415. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
417	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 mTOR signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 417. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
418	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 mTOR signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 418. mTOR signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
419	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 mTOR signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 418. mTOR signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
420	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 mTOR signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 420. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
421	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 mTOR signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 421. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
422	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 mTOR signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 421. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
423	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 mTOR signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 423. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
424	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 mTOR signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 423. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
425	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 425. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
426	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 426. Natural killer cell mediated cytotoxicity × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
427	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Natural killer cell mediated cytotoxicity × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 426. Natural killer cell mediated cytotoxicity × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
428	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 428. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
429	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 429. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
430	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Natural killer cell mediated cytotoxicity × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 429. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
431	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 431. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
432	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 431. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
433	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Neurotrophin signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 433. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
434	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Neurotrophin signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 434. Neurotrophin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
435	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Neurotrophin signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 434. Neurotrophin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
436	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Neurotrophin signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 436. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
437	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Neurotrophin signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 437. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
438	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Neurotrophin signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 437. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
439	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Neurotrophin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 439. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
440	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Neurotrophin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 439. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
441	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Neutrophil extracellular trap formation × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 441. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
442	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Neutrophil extracellular trap formation × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 442. Neutrophil extracellular trap formation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
443	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Neutrophil extracellular trap formation × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 442. Neutrophil extracellular trap formation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
444	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Neutrophil extracellular trap formation × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 444. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
445	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Neutrophil extracellular trap formation × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 445. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
446	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Neutrophil extracellular trap formation × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 445. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
447	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 447. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
448	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 447. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
449	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Non-small cell lung cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 449. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
450	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Non-small cell lung cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 450. Non-small cell lung cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
451	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Non-small cell lung cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 450. Non-small cell lung cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
452	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Non-small cell lung cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 452. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
453	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Non-small cell lung cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 453. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
454	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Non-small cell lung cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 453. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
455	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Non-small cell lung cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 455. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
456	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Non-small cell lung cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 455. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
457	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Oocyte meiosis × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 457. Oocyte meiosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
458	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Oocyte meiosis × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 458. Oocyte meiosis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
459	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Oocyte meiosis × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 458. Oocyte meiosis × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
460	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Oocyte meiosis × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 460. Oocyte meiosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
461	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Oocyte meiosis × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 461. Oocyte meiosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
462	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Oocyte meiosis × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 461. Oocyte meiosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
463	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Oocyte meiosis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 463. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
464	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Oocyte meiosis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 463. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
465	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Osteoclast differentiation × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 465. Osteoclast differentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
466	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Osteoclast differentiation × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 466. Osteoclast differentiation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
467	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Osteoclast differentiation × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 466. Osteoclast differentiation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
468	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Osteoclast differentiation × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 468. Osteoclast differentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
469	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Osteoclast differentiation × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 469. Osteoclast differentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
470	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Osteoclast differentiation × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 469. Osteoclast differentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
471	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Osteoclast differentiation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 471. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
472	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Osteoclast differentiation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 471. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
473	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Oxytocin signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 473. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
474	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Oxytocin signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 474. Oxytocin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
475	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Oxytocin signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 474. Oxytocin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
476	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Oxytocin signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 476. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
477	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Oxytocin signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 477. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
478	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Oxytocin signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 477. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
479	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Oxytocin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 479. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
480	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Oxytocin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 479. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
481	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Pancreatic cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 481. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
482	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Pancreatic cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 482. Pancreatic cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
483	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Pancreatic cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 482. Pancreatic cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
484	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Pancreatic cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 484. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
485	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Pancreatic cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 485. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
486	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Pancreatic cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 485. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
487	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Pancreatic cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 487. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
488	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Pancreatic cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 487. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
489	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 489. Parathyroid hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
490	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 490. Parathyroid hormone synthesis, secretion and action × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
491	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 490. Parathyroid hormone synthesis, secretion and action × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
492	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 492. Parathyroid hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
493	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 493. Parathyroid hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
494	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 493. Parathyroid hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
495	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 495. Parathyroid hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
496	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 495. Parathyroid hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
497	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Pathways in cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 497. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
498	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Pathways in cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 498. Pathways in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
499	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Pathways in cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 498. Pathways in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
500	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Pathways in cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 500. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
501	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Pathways in cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 501. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
502	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Pathways in cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 501. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
503	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Pathways in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 503. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
504	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Pathways in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 503. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
505	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 505. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
506	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 506. Pathways of neurodegeneration - multiple diseases × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
507	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 506. Pathways of neurodegeneration - multiple diseases × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
508	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 508. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
509	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 509. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
510	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 509. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
511	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 511. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
512	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 511. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
513	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 513. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
514	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 514. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
515	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 514. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
516	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 516. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
517	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 517. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
518	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 517. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
519	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 519. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
520	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 519. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
521	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Phospholipase D signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 521. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
522	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Phospholipase D signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 522. Phospholipase D signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
523	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Phospholipase D signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 522. Phospholipase D signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
524	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Phospholipase D signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 524. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
525	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Phospholipase D signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 525. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
526	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Phospholipase D signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 525. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
527	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Phospholipase D signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 527. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
528	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Phospholipase D signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 527. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
529	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 PI3K-Akt signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 529. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
530	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 PI3K-Akt signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 530. PI3K-Akt signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
531	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 PI3K-Akt signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 530. PI3K-Akt signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
532	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 PI3K-Akt signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 532. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
533	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 PI3K-Akt signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 533. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
534	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 PI3K-Akt signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 533. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
535	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 535. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
536	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 535. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
537	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 537. Progesterone-mediated oocyte maturation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
538	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 538. Progesterone-mediated oocyte maturation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
539	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Progesterone-mediated oocyte maturation × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 538. Progesterone-mediated oocyte maturation × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
540	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 540. Progesterone-mediated oocyte maturation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
541	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 541. Progesterone-mediated oocyte maturation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
542	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Progesterone-mediated oocyte maturation × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 541. Progesterone-mediated oocyte maturation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
543	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 543. Progesterone-mediated oocyte maturation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
544	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Progesterone-mediated oocyte maturation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 543. Progesterone-mediated oocyte maturation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
545	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Prolactin signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 545. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
546	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Prolactin signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 546. Prolactin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
547	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Prolactin signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 546. Prolactin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
548	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Prolactin signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 548. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
549	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Prolactin signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 549. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
550	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Prolactin signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 549. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
551	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Prolactin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 551. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
552	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Prolactin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 551. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
553	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Prostate cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 553. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
554	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Prostate cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 554. Prostate cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
555	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Prostate cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 554. Prostate cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
556	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Prostate cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 556. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
557	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Prostate cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 557. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
558	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Prostate cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 557. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
559	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Prostate cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 559. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
560	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Prostate cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 559. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
561	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Proteoglycans in cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 561. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
562	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Proteoglycans in cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 562. Proteoglycans in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
563	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Proteoglycans in cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 562. Proteoglycans in cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
564	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Proteoglycans in cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 564. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
565	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Proteoglycans in cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 565. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
566	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Proteoglycans in cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 565. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
567	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Proteoglycans in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 567. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
568	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Proteoglycans in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 567. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
569	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Rap1 signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 569. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
570	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Rap1 signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 570. Rap1 signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
571	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Rap1 signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 570. Rap1 signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
572	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Rap1 signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 572. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
573	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Rap1 signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 573. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
574	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Rap1 signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 573. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
575	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Rap1 signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 575. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
576	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Rap1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 575. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
577	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Ras signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 577. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
578	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Ras signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 578. Ras signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
579	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Ras signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 578. Ras signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
580	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Ras signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 580. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
581	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Ras signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 581. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
582	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Ras signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 581. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
583	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Ras signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 583. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
584	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Ras signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 583. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
585	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Regulation of actin cytoskeleton × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 585. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
586	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Regulation of actin cytoskeleton × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 586. Regulation of actin cytoskeleton × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
587	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Regulation of actin cytoskeleton × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 586. Regulation of actin cytoskeleton × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
588	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Regulation of actin cytoskeleton × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 588. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
589	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Regulation of actin cytoskeleton × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 589. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
590	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Regulation of actin cytoskeleton × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 589. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
591	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 591. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
592	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 591. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
593	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Relaxin signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 593. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
594	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Relaxin signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 594. Relaxin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
595	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Relaxin signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 594. Relaxin signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
596	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Relaxin signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 596. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
597	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Relaxin signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 597. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
598	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Relaxin signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 597. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
599	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Relaxin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 599. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
600	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Relaxin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 599. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
601	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Renal cell carcinoma × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 601. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
602	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Renal cell carcinoma × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 602. Renal cell carcinoma × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
603	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Renal cell carcinoma × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 602. Renal cell carcinoma × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
604	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Renal cell carcinoma × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 604. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
605	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Renal cell carcinoma × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 605. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
606	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Renal cell carcinoma × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 605. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
607	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Renal cell carcinoma × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 607. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
608	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Renal cell carcinoma × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 607. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
609	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Salmonella infection × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 609. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
610	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Salmonella infection × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 610. Salmonella infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
611	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Salmonella infection × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 610. Salmonella infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
612	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Salmonella infection × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 612. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
613	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Salmonella infection × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 613. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
614	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Salmonella infection × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 613. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
615	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Salmonella infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 615. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
616	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Salmonella infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 615. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
617	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Serotonergic synapse × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 617. Serotonergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
618	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Serotonergic synapse × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 618. Serotonergic synapse × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
619	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Serotonergic synapse × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 618. Serotonergic synapse × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
620	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Serotonergic synapse × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 620. Serotonergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
621	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Serotonergic synapse × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 621. Serotonergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
622	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Serotonergic synapse × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 621. Serotonergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
623	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Serotonergic synapse × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 623. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
624	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Serotonergic synapse × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 623. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
625	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 625. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
626	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 626. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
627	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 626. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
628	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 628. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
629	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 629. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
630	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 629. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
631	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 631. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
632	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 631. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
633	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Sphingolipid signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 633. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
634	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Sphingolipid signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 634. Sphingolipid signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
635	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Sphingolipid signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 634. Sphingolipid signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
636	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Sphingolipid signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 636. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
637	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Sphingolipid signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 637. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
638	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Sphingolipid signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 637. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
639	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Sphingolipid signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 639. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
640	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Sphingolipid signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 639. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
641	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 T cell receptor signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 641. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
642	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 T cell receptor signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 642. T cell receptor signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
643	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 T cell receptor signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 642. T cell receptor signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
644	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 T cell receptor signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 644. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
645	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 T cell receptor signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 645. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
646	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 T cell receptor signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 645. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
647	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 T cell receptor signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 647. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
648	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 T cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 647. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
649	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Thyroid cancer × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 649. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
650	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Thyroid cancer × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 650. Thyroid cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
651	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Thyroid cancer × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 650. Thyroid cancer × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
652	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Thyroid cancer × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 652. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
653	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Thyroid cancer × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 653. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
654	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Thyroid cancer × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 653. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
655	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Thyroid cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 655. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
656	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Thyroid cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 655. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
657	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Thyroid hormone signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 657. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
658	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Thyroid hormone signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 658. Thyroid hormone signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
659	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Thyroid hormone signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 658. Thyroid hormone signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
660	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Thyroid hormone signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 660. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
661	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Thyroid hormone signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 661. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
662	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Thyroid hormone signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 661. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
663	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 663. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
664	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 663. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
665	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 TNF signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 665. TNF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
666	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 TNF signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 666. TNF signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
667	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 TNF signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 666. TNF signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
668	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 TNF signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 668. TNF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
669	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 TNF signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 669. TNF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
670	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 TNF signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 669. TNF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
671	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 TNF signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 671. TNF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
672	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 TNF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 671. TNF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
673	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Toll-like receptor signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 673. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
674	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Toll-like receptor signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 674. Toll-like receptor signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
675	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Toll-like receptor signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 674. Toll-like receptor signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
676	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Toll-like receptor signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 676. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
677	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Toll-like receptor signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 677. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
678	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Toll-like receptor signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 677. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
679	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 679. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
680	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 679. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
681	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Vascular smooth muscle contraction × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 681. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
682	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Vascular smooth muscle contraction × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 682. Vascular smooth muscle contraction × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
683	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Vascular smooth muscle contraction × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 682. Vascular smooth muscle contraction × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
684	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Vascular smooth muscle contraction × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 684. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
685	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Vascular smooth muscle contraction × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 685. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
686	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Vascular smooth muscle contraction × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 685. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
687	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Vascular smooth muscle contraction × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 687. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
688	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Vascular smooth muscle contraction × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 687. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
689	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 VEGF signaling pathway × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 689. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
690	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 VEGF signaling pathway × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 690. VEGF signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
691	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 VEGF signaling pathway × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 690. VEGF signaling pathway × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
692	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 VEGF signaling pathway × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 692. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
693	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 VEGF signaling pathway × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 693. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
694	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 VEGF signaling pathway × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 693. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
695	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 VEGF signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 695. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
696	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 VEGF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 695. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
697	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Binimetinib 💬 Yersinia infection × Name Other Names Binimetinib Binimetinib (JAN/USAN/INN) Mektovi (TN) MEKTOVI	Binimetinib	[1] 34 💬 697. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
698	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib 💬 Yersinia infection × Name Other Names Cobimetinib Cobimetinib (USAN/INN)	Cobimetinib	[1] 280 💬 698. Yersinia infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
699	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Cobimetinib fumarate 💬 Yersinia infection × Name Other Names Cobimetinib fumarate Cobimetinib fumarate (USAN) Cobimetinib hemifumarate Cotellic (TN) COTELLIC	Cobimetinib	[1] 280 💬 698. Yersinia infection × Disease ID Name 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
700	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Mirdametinib 💬 Yersinia infection × Name Other Names Mirdametinib Mirdametinib (USAN) Gomekli (TN) GOMEKLI	Mirdametinib	[4] 34, 278, 279, 280 💬 700. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
701	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib 💬 Yersinia infection × Name Other Names Selumetinib Selumetinib (USAN/INN)	Selumetinib	[1] 34 💬 701. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
702	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Selumetinib sulfate 💬 Yersinia infection × Name Other Names Selumetinib sulfate Selumetinib sulfate (JAN/USAN) Koselugo (TN) KOSELUGO	Selumetinib	[1] 34 💬 701. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
703	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Yersinia infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 703. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
704	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Yersinia infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 703. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

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