Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Acute myeloid leukemia × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 1. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
2	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Acute myeloid leukemia × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 2. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
3	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Acute myeloid leukemia × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 3. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
4	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Acute myeloid leukemia × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 3. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
5	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Acute myeloid leukemia × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 5. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
6	Acute myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Acute myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 5. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
7	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Alcoholism × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 7. Alcoholism × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
8	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Alcoholism × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 8. Alcoholism × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
9	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Alcoholism × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 9. Alcoholism × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
10	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Alcoholism × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 9. Alcoholism × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
11	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Alcoholism × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 11. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
12	Alcoholism 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Alcoholism × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 11. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
13	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Alzheimer disease × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 13. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
14	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Alzheimer disease × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 14. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
15	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Alzheimer disease × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 15. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
16	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Alzheimer disease × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 15. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
17	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Alzheimer disease × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 17. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
18	Alzheimer disease 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Alzheimer disease × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 17. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
19	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Apelin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 19. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
20	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Apelin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 20. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
21	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Apelin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 21. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
22	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Apelin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 21. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
23	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Apelin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
24	Apelin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Apelin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
25	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Apoptosis × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 25. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
26	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Apoptosis × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 26. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
27	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Apoptosis × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 27. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
28	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Apoptosis × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 27. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
29	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Apoptosis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 29. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
30	Apoptosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Apoptosis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 29. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
31	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Autophagy - animal × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 31. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
32	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Autophagy - animal × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 32. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
33	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Autophagy - animal × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 33. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
34	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Autophagy - animal × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 33. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
35	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Autophagy - animal × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 35. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
36	Autophagy - animal 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Autophagy - animal × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 35. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
37	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 B cell receptor signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 37. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
38	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 B cell receptor signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 38. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
39	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 B cell receptor signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 39. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
40	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 B cell receptor signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 39. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
41	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 B cell receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 41. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
42	B cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 B cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 41. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
43	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Bladder cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 43. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
44	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Bladder cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 44. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
45	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Bladder cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 45. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Bladder cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 45. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
47	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Bladder cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 47. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
48	Bladder cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Bladder cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 47. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
49	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Breast cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 49. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
50	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Breast cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 50. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
51	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Breast cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 51. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
52	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Breast cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 51. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
53	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Breast cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 53. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
54	Breast cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Breast cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 53. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
55	Cadherin signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Cadherin signaling × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 55. Cadherin signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
56	Cadherin signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Cadherin signaling × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 56. Cadherin signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
57	Cadherin signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Cadherin signaling × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 57. Cadherin signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
58	Cadherin signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Cadherin signaling × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 57. Cadherin signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
59	Cadherin signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Cadherin signaling × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 59. Cadherin signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
60	Cadherin signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Cadherin signaling × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 59. Cadherin signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
61	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 cAMP signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 61. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
62	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 cAMP signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 62. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
63	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 cAMP signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 63. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
64	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 cAMP signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 63. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
65	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 cAMP signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 65. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
66	cAMP signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 cAMP signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 65. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
67	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Cellular senescence × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 67. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
68	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Cellular senescence × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 68. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
69	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Cellular senescence × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 69. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
70	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Cellular senescence × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 69. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
71	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Cellular senescence × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 71. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
72	Cellular senescence 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Cellular senescence × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 71. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
73	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Central carbon metabolism in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 73. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
74	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Central carbon metabolism in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 74. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
75	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Central carbon metabolism in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 75. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
76	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Central carbon metabolism in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 75. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
77	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Central carbon metabolism in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 77. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
78	Central carbon metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Central carbon metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 77. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
79	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 cGMP-PKG signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 79. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
80	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 cGMP-PKG signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 80. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
81	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 cGMP-PKG signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 81. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
82	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 cGMP-PKG signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 81. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
83	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 83. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
84	cGMP-PKG signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 83. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
85	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 85. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
86	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 86. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
87	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 87. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
88	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 87. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
89	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 89. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
90	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 89. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
91	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 91. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
92	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 92. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
93	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 93. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
94	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 93. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
95	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 95. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
96	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 95. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
97	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Chemokine signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 97. Chemokine signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
98	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Chemokine signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 98. Chemokine signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
99	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Chemokine signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 99. Chemokine signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
100	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Chemokine signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 99. Chemokine signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
101	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Chemokine signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 101. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
102	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Chemokine signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 101. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
103	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Choline metabolism in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 103. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
104	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Choline metabolism in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 104. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
105	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Choline metabolism in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 105. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
106	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Choline metabolism in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 105. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
107	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Choline metabolism in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 107. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
108	Choline metabolism in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Choline metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 107. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
109	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Cholinergic synapse × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 109. Cholinergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
110	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Cholinergic synapse × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 110. Cholinergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
111	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Cholinergic synapse × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 111. Cholinergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
112	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Cholinergic synapse × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 111. Cholinergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
113	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Cholinergic synapse × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 113. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
114	Cholinergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Cholinergic synapse × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 113. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
115	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Chronic myeloid leukemia × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 115. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
116	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Chronic myeloid leukemia × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 116. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
117	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Chronic myeloid leukemia × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 117. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
118	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Chronic myeloid leukemia × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 117. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
119	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Chronic myeloid leukemia × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
120	Chronic myeloid leukemia 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Chronic myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
121	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Colorectal cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 121. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
122	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Colorectal cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 122. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
123	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Colorectal cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 123. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
124	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Colorectal cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 123. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
125	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Colorectal cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 125. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
126	Colorectal cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Colorectal cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 125. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
127	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Cushing syndrome × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 127. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
128	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Cushing syndrome × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 128. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
129	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Cushing syndrome × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 129. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
130	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Cushing syndrome × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 129. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
131	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Cushing syndrome × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 131. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
132	Cushing syndrome 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Cushing syndrome × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 131. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
133	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Efferocytosis × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 133. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
134	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Efferocytosis × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 134. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
135	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Efferocytosis × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 135. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
136	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Efferocytosis × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 135. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
137	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Efferocytosis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 137. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
138	Efferocytosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Efferocytosis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 137. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
139	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Endometrial cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 139. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
140	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Endometrial cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 140. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
141	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Endometrial cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 141. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
142	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Endometrial cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 141. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
143	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Endometrial cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 143. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
144	Endometrial cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Endometrial cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 143. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
145	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 ErbB signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 145. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
146	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 ErbB signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 146. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
147	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 ErbB signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 147. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
148	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 ErbB signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 147. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
149	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 ErbB signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 149. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
150	ErbB signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 ErbB signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 149. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
151	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Estrogen signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 151. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
152	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Estrogen signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 152. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
153	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Estrogen signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 153. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
154	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Estrogen signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 153. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
155	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Estrogen signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 155. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
156	Estrogen signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Estrogen signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 155. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
157	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Fc epsilon RI signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 157. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
158	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Fc epsilon RI signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 158. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
159	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Fc epsilon RI signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 159. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
160	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Fc epsilon RI signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 159. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
161	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 161. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
162	Fc epsilon RI signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 161. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
163	Fc gamma R-mediated phagosome formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Fc gamma R-mediated phagosome formation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 163. Fc gamma R-mediated phagosome formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
164	Fc gamma R-mediated phagosome formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Fc gamma R-mediated phagosome formation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 164. Fc gamma R-mediated phagosome formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
165	Fc gamma R-mediated phagosome formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Fc gamma R-mediated phagosome formation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 165. Fc gamma R-mediated phagosome formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
166	Fc gamma R-mediated phagosome formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Fc gamma R-mediated phagosome formation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 165. Fc gamma R-mediated phagosome formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
167	Fc gamma R-mediated phagosome formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Fc gamma R-mediated phagosome formation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Fc gamma R-mediated phagosome formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
168	Fc gamma R-mediated phagosome formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Fc gamma R-mediated phagosome formation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Fc gamma R-mediated phagosome formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
169	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Focal adhesion × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 169. Focal adhesion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
170	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Focal adhesion × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 170. Focal adhesion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
171	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Focal adhesion × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 171. Focal adhesion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
172	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Focal adhesion × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 171. Focal adhesion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
173	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Focal adhesion × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 173. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
174	Focal adhesion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Focal adhesion × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 173. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
175	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 FoxO signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 175. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
176	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 FoxO signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 176. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
177	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 FoxO signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 177. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
178	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 FoxO signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 177. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
179	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 FoxO signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 179. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
180	FoxO signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 FoxO signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 179. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
181	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Gap junction × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 181. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
182	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Gap junction × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 182. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
183	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Gap junction × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 183. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
184	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Gap junction × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 183. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
185	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Gap junction × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 185. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
186	Gap junction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Gap junction × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 185. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
187	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Gastric cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 187. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
188	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Gastric cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 188. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
189	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Gastric cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 189. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
190	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Gastric cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 189. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
191	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Gastric cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
192	Gastric cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Gastric cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
193	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Glioma × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 193. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
194	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Glioma × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 194. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
195	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Glioma × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 195. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
196	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Glioma × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 195. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
197	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Glioma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 197. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
198	Glioma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Glioma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 197. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
199	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 GnRH secretion × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 199. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
200	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 GnRH secretion × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 200. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
201	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 GnRH secretion × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 201. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
202	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 GnRH secretion × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 201. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
203	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 GnRH secretion × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 203. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
204	GnRH secretion 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 GnRH secretion × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 203. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
205	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 GnRH signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 205. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
206	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 GnRH signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 206. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
207	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 GnRH signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 207. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
208	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 GnRH signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 207. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
209	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 GnRH signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 209. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
210	GnRH signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 GnRH signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 209. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
211	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 211. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
212	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 212. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
213	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 213. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
214	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Growth hormone synthesis, secretion and action × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 213. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
215	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 215. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
216	Growth hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 215. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
217	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Hepatitis B × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 217. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
218	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Hepatitis B × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 218. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
219	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Hepatitis B × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 219. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
220	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Hepatitis B × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 219. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
221	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Hepatitis B × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 221. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
222	Hepatitis B 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatitis B × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 221. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
223	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Hepatitis C × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 223. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
224	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Hepatitis C × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 224. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
225	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Hepatitis C × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 225. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
226	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Hepatitis C × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 225. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
227	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Hepatitis C × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 227. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
228	Hepatitis C 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatitis C × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 227. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
229	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Hepatocellular carcinoma × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 229. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
230	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Hepatocellular carcinoma × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 230. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
231	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Hepatocellular carcinoma × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 231. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
232	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Hepatocellular carcinoma × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 231. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
233	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Hepatocellular carcinoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 233. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
234	Hepatocellular carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatocellular carcinoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 233. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
235	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 HIF-1 signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 235. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
236	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 HIF-1 signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 236. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
237	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 HIF-1 signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 237. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
238	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 HIF-1 signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 237. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
239	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 HIF-1 signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 239. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
240	HIF-1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 HIF-1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 239. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
241	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Human cytomegalovirus infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 241. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
242	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Human cytomegalovirus infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 242. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
243	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Human cytomegalovirus infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 243. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
244	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Human cytomegalovirus infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 243. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
245	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Human cytomegalovirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 245. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
246	Human cytomegalovirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Human cytomegalovirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 245. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
247	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 247. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
248	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 248. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
249	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 249. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
250	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Human immunodeficiency virus 1 infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 249. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
251	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 251. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
252	Human immunodeficiency virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 251. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
253	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Human papillomavirus infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 253. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
254	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Human papillomavirus infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 254. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
255	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Human papillomavirus infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 255. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
256	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Human papillomavirus infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 255. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
257	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Human papillomavirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 257. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
258	Human papillomavirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Human papillomavirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 257. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
259	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 259. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
260	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 260. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
261	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 261. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
262	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Human T-cell leukemia virus 1 infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 261. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
263	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 263. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
264	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 263. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
265	IgSF CAM signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 IgSF CAM signaling × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 265. IgSF CAM signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
266	IgSF CAM signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 IgSF CAM signaling × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 266. IgSF CAM signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
267	IgSF CAM signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 IgSF CAM signaling × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 267. IgSF CAM signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
268	IgSF CAM signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 IgSF CAM signaling × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 267. IgSF CAM signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
269	IgSF CAM signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 IgSF CAM signaling × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 269. IgSF CAM signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
270	IgSF CAM signaling 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 IgSF CAM signaling × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 269. IgSF CAM signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
271	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Influenza A × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 271. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
272	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Influenza A × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 272. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
273	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Influenza A × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 273. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
274	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Influenza A × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 273. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
275	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Influenza A × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 275. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
276	Influenza A 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Influenza A × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 275. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
277	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Insulin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 277. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
278	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Insulin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 278. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
279	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Insulin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 279. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
280	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Insulin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 279. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
281	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Insulin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 281. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
282	Insulin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Insulin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 281. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
283	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 283. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
284	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 284. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
285	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 285. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
286	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 285. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
287	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 287. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
288	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 287. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
289	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Long-term depression × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 289. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
290	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Long-term depression × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 290. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
291	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Long-term depression × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 291. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
292	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Long-term depression × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 291. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
293	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Long-term depression × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 293. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
294	Long-term depression 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Long-term depression × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 293. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
295	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Long-term potentiation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 295. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
296	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Long-term potentiation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 296. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
297	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Long-term potentiation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 297. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
298	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Long-term potentiation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 297. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
299	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Long-term potentiation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 299. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
300	Long-term potentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Long-term potentiation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 299. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
301	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 MAPK signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 301. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
302	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 MAPK signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 302. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
303	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 MAPK signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 303. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
304	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 MAPK signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 303. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
305	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 MAPK signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 305. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
306	MAPK signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 MAPK signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 305. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
307	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Melanogenesis × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 307. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
308	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Melanogenesis × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 308. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
309	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Melanogenesis × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 309. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
310	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Melanogenesis × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 309. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
311	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Melanogenesis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 311. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
312	Melanogenesis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Melanogenesis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 311. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
313	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Melanoma × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 313. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
314	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Melanoma × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 314. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
315	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Melanoma × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 315. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
316	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Melanoma × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 315. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
317	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Melanoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 317. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
318	Melanoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Melanoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 317. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
319	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 MicroRNAs in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 319. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
320	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 MicroRNAs in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 320. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
321	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 MicroRNAs in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 321. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
322	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 MicroRNAs in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 321. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
323	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 MicroRNAs in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 323. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
324	MicroRNAs in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 MicroRNAs in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 323. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
325	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 mTOR signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 325. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
326	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 mTOR signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 326. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
327	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 mTOR signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 327. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
328	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 mTOR signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 327. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
329	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 mTOR signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 329. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
330	mTOR signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 mTOR signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 329. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
331	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 331. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
332	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 332. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
333	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 333. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
334	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Natural killer cell mediated cytotoxicity × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 333. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
335	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 335. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
336	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 335. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
337	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Neurotrophin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 337. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
338	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Neurotrophin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 338. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
339	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Neurotrophin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 339. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
340	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Neurotrophin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 339. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
341	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Neurotrophin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 341. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
342	Neurotrophin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Neurotrophin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 341. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
343	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Neutrophil extracellular trap formation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 343. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
344	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Neutrophil extracellular trap formation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 344. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
345	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Neutrophil extracellular trap formation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 345. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
346	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Neutrophil extracellular trap formation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 345. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
347	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 347. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
348	Neutrophil extracellular trap formation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 347. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
349	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Non-small cell lung cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 349. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
350	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Non-small cell lung cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 350. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
351	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Non-small cell lung cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 351. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
352	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Non-small cell lung cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 351. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
353	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Non-small cell lung cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 353. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
354	Non-small cell lung cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Non-small cell lung cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 353. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
355	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Oocyte meiosis × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 355. Oocyte meiosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
356	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Oocyte meiosis × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 356. Oocyte meiosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
357	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Oocyte meiosis × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 357. Oocyte meiosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
358	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Oocyte meiosis × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 357. Oocyte meiosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
359	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Oocyte meiosis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 359. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
360	Oocyte meiosis 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Oocyte meiosis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 359. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
361	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Osteoclast differentiation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 361. Osteoclast differentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
362	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Osteoclast differentiation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 362. Osteoclast differentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
363	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Osteoclast differentiation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 363. Osteoclast differentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
364	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Osteoclast differentiation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 363. Osteoclast differentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
365	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Osteoclast differentiation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 365. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
366	Osteoclast differentiation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Osteoclast differentiation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 365. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
367	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Oxytocin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 367. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
368	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Oxytocin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 368. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
369	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Oxytocin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 369. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
370	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Oxytocin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 369. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
371	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Oxytocin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 371. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
372	Oxytocin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Oxytocin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 371. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
373	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Pancreatic cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 373. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
374	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Pancreatic cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 374. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
375	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Pancreatic cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 375. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
376	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Pancreatic cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 375. Pancreatic cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
377	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Pancreatic cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 377. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
378	Pancreatic cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Pancreatic cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 377. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
379	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 379. Parathyroid hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
380	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 380. Parathyroid hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
381	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 381. Parathyroid hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
382	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 381. Parathyroid hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
383	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 383. Parathyroid hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
384	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 383. Parathyroid hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
385	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Pathways in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 385. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
386	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Pathways in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 386. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
387	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Pathways in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 387. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
388	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Pathways in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 387. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
389	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Pathways in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 389. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
390	Pathways in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Pathways in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 389. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
391	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 391. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
392	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 392. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
393	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 393. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
394	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 393. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
395	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 395. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
396	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 395. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
397	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 397. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
398	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 398. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
399	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 399. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
400	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 399. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
401	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 401. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
402	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 401. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
403	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Phospholipase D signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 403. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
404	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Phospholipase D signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 404. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
405	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Phospholipase D signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 405. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
406	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Phospholipase D signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 405. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
407	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Phospholipase D signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 407. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
408	Phospholipase D signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Phospholipase D signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 407. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
409	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 PI3K-Akt signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 409. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
410	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 PI3K-Akt signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 410. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
411	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 PI3K-Akt signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 411. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
412	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 PI3K-Akt signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 411. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
413	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 413. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
414	PI3K-Akt signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 413. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
415	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 415. Progesterone-mediated oocyte maturation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
416	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 416. Progesterone-mediated oocyte maturation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
417	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 417. Progesterone-mediated oocyte maturation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
418	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Progesterone-mediated oocyte maturation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 417. Progesterone-mediated oocyte maturation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
419	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 419. Progesterone-mediated oocyte maturation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
420	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Progesterone-mediated oocyte maturation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 419. Progesterone-mediated oocyte maturation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
421	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Prolactin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 421. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
422	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Prolactin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 422. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
423	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Prolactin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 423. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
424	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Prolactin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 423. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
425	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Prolactin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 425. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
426	Prolactin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Prolactin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 425. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
427	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Prostate cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 427. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
428	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Prostate cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 428. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
429	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Prostate cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 429. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
430	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Prostate cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 429. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
431	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Prostate cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 431. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
432	Prostate cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Prostate cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 431. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
433	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Proteoglycans in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 433. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
434	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Proteoglycans in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 434. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
435	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Proteoglycans in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 435. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
436	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Proteoglycans in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 435. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
437	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Proteoglycans in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 437. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
438	Proteoglycans in cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Proteoglycans in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 437. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
439	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Rap1 signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 439. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
440	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Rap1 signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 440. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
441	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Rap1 signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 441. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
442	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Rap1 signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 441. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
443	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Rap1 signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 443. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
444	Rap1 signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Rap1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 443. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
445	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Ras signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 445. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
446	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Ras signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 446. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
447	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Ras signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 447. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
448	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Ras signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 447. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
449	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Ras signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 449. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
450	Ras signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Ras signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 449. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
451	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Regulation of actin cytoskeleton × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 451. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
452	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Regulation of actin cytoskeleton × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 452. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
453	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Regulation of actin cytoskeleton × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 453. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
454	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Regulation of actin cytoskeleton × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 453. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
455	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 455. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
456	Regulation of actin cytoskeleton 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 455. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
457	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Relaxin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 457. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
458	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Relaxin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 458. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
459	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Relaxin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 459. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
460	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Relaxin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 459. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
461	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Relaxin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 461. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
462	Relaxin signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Relaxin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 461. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
463	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Renal cell carcinoma × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 463. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
464	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Renal cell carcinoma × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 464. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
465	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Renal cell carcinoma × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 465. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
466	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Renal cell carcinoma × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 465. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
467	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Renal cell carcinoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 467. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
468	Renal cell carcinoma 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Renal cell carcinoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 467. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
469	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Salmonella infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 469. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
470	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Salmonella infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 470. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
471	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Salmonella infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 471. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
472	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Salmonella infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 471. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
473	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Salmonella infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 473. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
474	Salmonella infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Salmonella infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 473. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
475	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Serotonergic synapse × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 475. Serotonergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
476	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Serotonergic synapse × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 476. Serotonergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
477	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Serotonergic synapse × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 477. Serotonergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
478	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Serotonergic synapse × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 477. Serotonergic synapse × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
479	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Serotonergic synapse × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 479. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
480	Serotonergic synapse 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Serotonergic synapse × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 479. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
481	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 481. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
482	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 482. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
483	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 483. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
484	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 483. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
485	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 485. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
486	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 485. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
487	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Sphingolipid signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 487. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
488	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Sphingolipid signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 488. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
489	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Sphingolipid signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 489. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
490	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Sphingolipid signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 489. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
491	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Sphingolipid signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 491. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
492	Sphingolipid signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Sphingolipid signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 491. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
493	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 T cell receptor signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 493. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
494	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 T cell receptor signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 494. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
495	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 T cell receptor signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 495. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
496	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 T cell receptor signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 495. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
497	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 T cell receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 497. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
498	T cell receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 T cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 497. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
499	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Thyroid cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 499. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
500	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Thyroid cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 500. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
501	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Thyroid cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 501. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
502	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Thyroid cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 501. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
503	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Thyroid cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 503. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
504	Thyroid cancer 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Thyroid cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 503. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
505	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Thyroid hormone signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 505. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
506	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Thyroid hormone signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 506. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
507	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Thyroid hormone signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 507. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
508	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Thyroid hormone signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 507. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
509	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 509. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
510	Thyroid hormone signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 509. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
511	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 TNF signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 511. TNF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
512	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 TNF signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 512. TNF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
513	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 TNF signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 513. TNF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
514	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 TNF signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 513. TNF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
515	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 TNF signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 515. TNF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
516	TNF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 TNF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 515. TNF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
517	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Toll-like receptor signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 517. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
518	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Toll-like receptor signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 518. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
519	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Toll-like receptor signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 519. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
520	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Toll-like receptor signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 519. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
521	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 521. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
522	Toll-like receptor signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 521. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
523	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Vascular smooth muscle contraction × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 523. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
524	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Vascular smooth muscle contraction × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 524. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
525	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Vascular smooth muscle contraction × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 525. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
526	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Vascular smooth muscle contraction × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 525. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
527	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Vascular smooth muscle contraction × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 527. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
528	Vascular smooth muscle contraction 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Vascular smooth muscle contraction × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 527. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
529	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 VEGF signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 529. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
530	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 VEGF signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 530. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
531	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 VEGF signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 531. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
532	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 VEGF signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 531. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
533	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 VEGF signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 533. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
534	VEGF signaling pathway 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 VEGF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 533. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
535	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Binimetinib 💬 Yersinia infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 535. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
536	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Mirdametinib 💬 Yersinia infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 536. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
537	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib 💬 Yersinia infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 537. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
538	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Selumetinib sulfate 💬 Yersinia infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 537. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
539	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Yersinia infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 539. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
540	Yersinia infection 💬	[1] MAP2K1 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Yersinia infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 539. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

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