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Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Apelin signaling pathway 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Apelin signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Apelin signaling pathway 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Apelin signaling pathway 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Apelin signaling pathway 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

cAMP signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

cAMP signaling pathway 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

cAMP signaling pathway 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

cAMP signaling pathway 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

cAMP signaling pathway 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

cGMP-PKG signaling pathway 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Glucagon signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Glucagon signaling pathway 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Glucagon signaling pathway 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Glucagon signaling pathway 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Glucagon signaling pathway 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Insulin signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Insulin signaling pathway 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Insulin signaling pathway 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Insulin signaling pathway 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

Morphine addiction 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

Morphine addiction 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

Morphine addiction 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

Morphine addiction 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Morphine addiction 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Morphine addiction 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

Morphine addiction 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Morphine addiction 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

Morphine addiction 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

Morphine addiction 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

Morphine addiction 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

Morphine addiction 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

Morphine addiction 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

Morphine addiction 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Morphine addiction 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Morphine addiction 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

100

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

101

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

102

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

103

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

104

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

105

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

106

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

107

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

108

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

109

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

110

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

111

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

112

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

113

Purine metabolism 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

114

Purine metabolism 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

115

Purine metabolism 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

116

Purine metabolism 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

117

Purine metabolism 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

118

Purine metabolism 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

119

Purine metabolism 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

120

Purine metabolism 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

121

Purine metabolism 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

122

Purine metabolism 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

123

Purine metabolism 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

124

Purine metabolism 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

125

Purine metabolism 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

126

Purine metabolism 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

127

Purine metabolism 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

128

Purine metabolism 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

129

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

130

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

131

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

132

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

133

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

134

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

135

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

136

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Flavoxate hydrochloride 💬

Flavoxate

[1] 226 💬

137

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

138

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

139

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

140

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

141

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Milrinone lactate 💬

Milrinone

[1] 294 💬

142

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

143

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

144

Regulation of lipolysis in adipocytes 💬

[1] PDE3B 💬

Theophylline sodium glycinate 💬

Theophylline

[2] 236, 299 💬

145

Renin secretion 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

146

Renin secretion 💬

[1] PDE3B 💬

Aminophylline dihydrate 💬

Aminophylline

[1] 63 💬

147

Renin secretion 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

148

Renin secretion 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

149

Renin secretion 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

150

Renin secretion 💬

[1] PDE3B 💬

Caffeine citrate 💬

Caffeine

[8] 2 , 6 , 13, 21, 46, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
265	Lipodystrophy;

151

Renin secretion 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[5] 6 , 46, 51, 70, 124 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;