Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 cAMP signaling pathway 💬
 [1] PDE4 💬 Dipyridamole 💬 Dipyridamole [5] 46, 51, 66, 96, 224 💬
2 cAMP signaling pathway 💬
 [1] PDE4 💬 Zatolmilast 💬 Zatolmilast [1] 206 💬
3 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Apremilast 💬 Apremilast [8] 36, 46, 50, 56, 97, 107, 162, 271 💬
4 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
5 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Rolipram 💬 Rolipram [2]  8 , 13 💬
6 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
7 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Bucladesine 💬 Bucladesine [1] 246 💬
8 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
9 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine citrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
10 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Aminophylline dihydrate 💬 Aminophylline [1] 63 💬
11 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Flavoxate hydrochloride 💬 Flavoxate [1] 226 💬
12 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Roflumilast 💬 Roflumilast [4] 84, 97, 206, 299 💬
13 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Aminophylline 💬 Aminophylline [1] 63 💬
14 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Flavoxate 💬 Flavoxate [1] 226 💬
15 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
16 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
17 cAMP signaling pathway 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
18 Morphine addiction 💬
 [1] PDE4 💬 Dipyridamole 💬 Dipyridamole [5] 46, 51, 66, 96, 224 💬
19 Morphine addiction 💬
 [1] PDE4 💬 Zatolmilast 💬 Zatolmilast [1] 206 💬
20 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Aminophylline dihydrate 💬 Aminophylline [1] 63 💬
21 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
22 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
23 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
24 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine citrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
25 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Flavoxate 💬 Flavoxate [1] 226 💬
26 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
27 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Apremilast 💬 Apremilast [8] 36, 46, 50, 56, 97, 107, 162, 271 💬
28 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Bucladesine 💬 Bucladesine [1] 246 💬
29 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Roflumilast 💬 Roflumilast [4] 84, 97, 206, 299 💬
30 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Rolipram 💬 Rolipram [2]  8 , 13 💬
31 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
32 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Flavoxate hydrochloride 💬 Flavoxate [1] 226 💬
33 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Aminophylline 💬 Aminophylline [1] 63 💬
34 Morphine addiction 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
35 Parathyroid hormone synthesis, secretion and action 💬
 [1] PDE4 💬 Dipyridamole 💬 Dipyridamole [5] 46, 51, 66, 96, 224 💬
36 Parathyroid hormone synthesis, secretion and action 💬
 [1] PDE4 💬 Zatolmilast 💬 Zatolmilast [1] 206 💬
37 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Aminophylline 💬 Aminophylline [1] 63 💬
38 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
39 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Flavoxate hydrochloride 💬 Flavoxate [1] 226 💬
40 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
41 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Rolipram 💬 Rolipram [2]  8 , 13 💬
42 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Aminophylline dihydrate 💬 Aminophylline [1] 63 💬
43 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Apremilast 💬 Apremilast [8] 36, 46, 50, 56, 97, 107, 162, 271 💬
44 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
45 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Bucladesine 💬 Bucladesine [1] 246 💬
46 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Flavoxate 💬 Flavoxate [1] 226 💬
47 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
48 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine citrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
49 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
50 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Roflumilast 💬 Roflumilast [4] 84, 97, 206, 299 💬
51 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
52 Purine metabolism 💬
 [1] PDE4 💬 Dipyridamole 💬 Dipyridamole [5] 46, 51, 66, 96, 224 💬
53 Purine metabolism 💬
 [1] PDE4 💬 Zatolmilast 💬 Zatolmilast [1] 206 💬
54 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
55 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Flavoxate 💬 Flavoxate [1] 226 💬
56 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
57 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Roflumilast 💬 Roflumilast [4] 84, 97, 206, 299 💬
58 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
59 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Aminophylline dihydrate 💬 Aminophylline [1] 63 💬
60 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
61 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Apremilast 💬 Apremilast [8] 36, 46, 50, 56, 97, 107, 162, 271 💬
62 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Bucladesine 💬 Bucladesine [1] 246 💬
63 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
64 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Flavoxate hydrochloride 💬 Flavoxate [1] 226 💬
65 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Caffeine citrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
66 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
67 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Aminophylline 💬 Aminophylline [1] 63 💬
68 Purine metabolism 💬
 [4] PDE4, PDE4, PDE4, PDE4 💬 Rolipram 💬 Rolipram [2]  8 , 13 💬

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