Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Apelin signaling pathway 💬
[1] PLAT 💬 Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
2 Complement and coagulation cascades 💬
[1] PLAT 💬 Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
3 Fluid shear stress and atherosclerosis 💬
[1] PLAT 💬 Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
4 Platelet activation 💬
[1] ADAMTS13 💬 Apadamtase alfa 💬 Apadamtase alfa [1] 64 💬
5 Platelet activation 💬
[1] ADAMTS13 💬 Apadamtase alfa and cinaxadamtase alfa 💬 Apadamtase alfa [1] 64 💬
6 Platelet activation 💬
[1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬
7 Platelet activation 💬
[1] BTK 💬 Acalabrutinib maleate hydrate 💬 Acalabrutinib [2] 46, 61 💬
8 Platelet activation 💬
[1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬
9 Platelet activation 💬
[1] BTK 💬 Elsubrutinib 💬 Elsubrutinib [1] 49 💬
10 Platelet activation 💬
[1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬
11 Platelet activation 💬
[1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬
12 Platelet activation 💬
[1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬
13 Platelet activation 💬
[1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬
14 Platelet activation 💬
[1] BTK 💬 Pirtobrutinib 💬 Pirtobrutinib [1] 13 💬
15 Platelet activation 💬
[1] BTK 💬 Remibrutinib 💬 Remibrutinib [3] 11, 13, 53 💬
16 Platelet activation 💬
[1] BTK 💬 Rilzabrutinib 💬 Rilzabrutinib [5] 35, 61, 63, 222, 300 💬
17 Platelet activation 💬
[1] BTK 💬 Tirabrutinib hydrochloride 💬 Tirabrutinib [2] 46, 53 💬
18 Platelet activation 💬
[1] BTK 💬 Tirabrutinib 💬 Tirabrutinib [2] 46, 53 💬
19 Platelet activation 💬
[1] BTK 💬 Tolebrutinib 💬 Tolebrutinib [2] 11, 13 💬
20 Platelet activation 💬
[1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [6] 13, 61, 63, 222, 300, 331 💬
21 Platelet activation 💬
[1] F2 💬 Dabigatran 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
22 Platelet activation 💬
[1] F2 💬 Dabigatran etexilate mesylate 💬 Dabigatran etexilate [2] 51, 75 💬
23 Platelet activation 💬
[1] F2 💬 Dabigatran etexilate 💬 Dabigatran etexilate [2] 51, 75 💬
24 Platelet activation 💬
[1] F2 💬 Thrombomodulin alfa 💬 Thrombomodulin Alfa [1] 85 💬
25 Platelet activation 💬
[2] FYN, SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
26 Platelet activation 💬
[2] FYN, SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
27 Platelet activation 💬
[3] GUCY1A, GUCY1A, GUCY1B 💬 Amyl nitrite 💬 Amyl Nitrite [1] 58 💬
28 Platelet activation 💬
[3] GUCY1A, GUCY1A, GUCY1B 💬 Zagociguat 💬 Zagociguat [1] 21 💬
29 Platelet activation 💬
[3] GUCY1A, GUCY1A, GUCY1B 💬 Avenciguat 💬 Avenciguat [1] 51 💬
30 Platelet activation 💬
[3] GUCY1A, GUCY1A, GUCY1B 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
31 Platelet activation 💬
[3] GUCY1A, GUCY1A, GUCY1B 💬 Vericiguat 💬 Vericiguat [1] 86 💬
32 Platelet activation 💬
[1] ITGB1 💬 Bexotegrast 💬 Bexotegrast [1] 94 💬
33 Platelet activation 💬
[1] ITGB1 💬 Carotegrast methyl 💬 Carotegrast methyl [1] 97 💬
34 Platelet activation 💬
[1] NOS3 💬 Tilarginine acetate 💬 Tilarginine [1] 67 💬
35 Platelet activation 💬
[1] P2RY12 💬 Clopidogrel bisulfate 💬 Clopidogrel [4] 40, 49, 51, 86 💬
36 Platelet activation 💬
[1] P2RY12 💬 Clopidogrel 💬 Clopidogrel [4] 40, 49, 51, 86 💬
37 Platelet activation 💬
[1] P2RY12 💬 Clopidogrel hydrochloride 💬 Clopidogrel [4] 40, 49, 51, 86 💬
38 Platelet activation 💬
[1] P2RY12 💬 Clopidogrel besilate 💬 Clopidogrel [4] 40, 49, 51, 86 💬
39 Platelet activation 💬
[1] P2RY12 💬 Ticagrelor 💬 Ticagrelor [1] 46 💬
40 Platelet activation 💬
[4] P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
41 Platelet activation 💬
[4] P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
42 Platelet activation 💬
[1] PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib [4] 138, 278, 279, 280 💬
43 Platelet activation 💬
[1] PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib [2] 53, 65 💬
44 Platelet activation 💬
[1] PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
45 Platelet activation 💬
[2] PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib [1] 121 💬
46 Platelet activation 💬
[3] PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
47 Platelet activation 💬
[1] PTGIR 💬 Beraprost sodium 💬 Beraprost [1] 86 💬
48 Platelet activation 💬
[1] PTGIR 💬 Beraprost 💬 Beraprost [1] 86 💬
49 Platelet activation 💬
[1] PTGIR 💬 Epoprostenol 💬 Epoprostenol [1] 86 💬
50 Platelet activation 💬
[1] PTGIR 💬 Epoprostenol sodium 💬 Epoprostenol [1] 86 💬
51 Platelet activation 💬
[1] PTGIR 💬 Esuberaprost 💬 Esuberaprost [1] 86 💬
52 Platelet activation 💬
[1] PTGIR 💬 Esuberaprost sodium 💬 Esuberaprost [1] 86 💬
53 Platelet activation 💬
[1] PTGIR 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
54 Platelet activation 💬
[1] PTGIR 💬 Iloprost 💬 Iloprost [4] 51, 84, 85, 86 💬
55 Platelet activation 💬
[1] PTGIR 💬 Iloprost tromethamine 💬 Iloprost [4] 51, 84, 85, 86 💬
56 Platelet activation 💬
[1] PTGIR 💬 Ralinepag 💬 Ralinepag [1] 86 💬
57 Platelet activation 💬
[1] PTGIR 💬 Selexipag 💬 Selexipag [6] 47, 51, 70, 84, 86, 88 💬
58 Platelet activation 💬
[1] PTGIR 💬 Treprostinil 💬 Treprostinil [5] 51, 85, 86, 88, 210 💬
59 Platelet activation 💬
[1] PTGIR 💬 Treprostinil monosodium salt 💬 Treprostinil [5] 51, 85, 86, 88, 210 💬
60 Platelet activation 💬
[1] PTGIR 💬 Treprostinil diolamine 💬 Treprostinil [5] 51, 85, 86, 88, 210 💬
61 Platelet activation 💬
[1] PTGIR 💬 Treprostinil palmitil 💬 Treprostinil palmitil [1] 86 💬
62 Platelet activation 💬
[1] PTGS1 💬 Aceclofenac 💬 Aceclofenac [1] 46 💬
63 Platelet activation 💬
[1] PTGS1 💬 Acetaminophen 💬 Acetaminophen [18]  3 ,  6 , 11, 13, 19, 34, 35, 46, 49, 51, 70, 77, 86, 96, 222, 256, 300, 337 💬
64 Platelet activation 💬
[1] PTGS1 💬 Aspirin 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 64, 86, 96, 97, 113, 158, 210, 231, 271 💬
65 Platelet activation 💬
[1] PTGS1 💬 Diclofenac potassium 💬 Diclofenac [4] 13, 34, 46, 271 💬
66 Platelet activation 💬
[1] PTGS1 💬 Diclofenac sodium 💬 Diclofenac [4] 13, 34, 46, 271 💬
67 Platelet activation 💬
[1] PTGS1 💬 Diclofenac 💬 Diclofenac [4] 13, 34, 46, 271 💬
68 Platelet activation 💬
[1] PTGS1 💬 Diclofenac diethylamine 💬 Diclofenac [4] 13, 34, 46, 271 💬
69 Platelet activation 💬
[1] PTGS1 💬 Diclofenac epolamine 💬 Diclofenac [4] 13, 34, 46, 271 💬
70 Platelet activation 💬
[1] PTGS1 💬 Flurbiprofen 💬 Flurbiprofen [3] 13, 21, 46 💬
71 Platelet activation 💬
[1] PTGS1 💬 Flurbiprofen sodium 💬 Flurbiprofen [3] 13, 21, 46 💬
72 Platelet activation 💬
[1] PTGS1 💬 Ibuprofen 💬 Ibuprofen [6] 13, 46, 65, 113, 271, 299 💬
73 Platelet activation 💬
[1] PTGS1 💬 Ibuprofen aluminum 💬 Ibuprofen [6] 13, 46, 65, 113, 271, 299 💬
74 Platelet activation 💬
[1] PTGS1 💬 Ibuprofen lysine 💬 Ibuprofen [6] 13, 46, 65, 113, 271, 299 💬
75 Platelet activation 💬
[1] PTGS1 💬 Ibuprofen sodium 💬 Ibuprofen [6] 13, 46, 65, 113, 271, 299 💬
76 Platelet activation 💬
[1] PTGS1 💬 Ibuprofen sodium 💬 Ibuprofen [6] 13, 46, 65, 113, 271, 299 💬
77 Platelet activation 💬
[1] PTGS1 💬 Indomethacin 💬 Indomethacin [3] 225, 271, 298 💬
78 Platelet activation 💬
[1] PTGS1 💬 Indomethacin sodium 💬 Indomethacin [3] 225, 271, 298 💬
79 Platelet activation 💬
[1] PTGS1 💬 Ketoprofen 💬 Ketoprofen [2] 13, 46 💬
80 Platelet activation 💬
[1] PTGS1 💬 Ketoprofen lysine 💬 Ketoprofen [2] 13, 46 💬
81 Platelet activation 💬
[1] PTGS1 💬 Ketoprofen sodium 💬 Ketoprofen [2] 13, 46 💬
82 Platelet activation 💬
[1] PTGS1 💬 Ketorolac tromethamine 💬 Ketorolac [2] 70, 226 💬
83 Platelet activation 💬
[1] PTGS1 💬 Ketorolac 💬 Ketorolac [2] 70, 226 💬
84 Platelet activation 💬
[1] PTGS1 💬 Loxoprofen 💬 Loxoprofen [2] 46, 271 💬
85 Platelet activation 💬
[1] PTGS1 💬 Naproxen 💬 Naproxen [4] 13, 46, 107, 271 💬
86 Platelet activation 💬
[1] PTGS1 💬 Naproxen sodium 💬 Naproxen [4] 13, 46, 107, 271 💬
87 Platelet activation 💬
[1] PTGS1 💬 Salsalate 💬 Salsalate [1]  5  💬
88 Platelet activation 💬
[1] PTGS1 💬 Sulindac 💬 Sulindac [1] 206 💬
89 Platelet activation 💬
[1] PTGS1 💬 Tolfenamic acid 💬 Tolfenamic acid [1]  5  💬
90 Platelet activation 💬
[2] ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil [5]  2 ,  5 ,  6 ,  7 , 51 💬
91 Platelet activation 💬
[2] ROCK1, ROCK2 💬 Fasudil 💬 Fasudil [5]  2 ,  5 ,  6 ,  7 , 51 💬
92 Platelet activation 💬
[1] ROCK2 💬 Belumosudil 💬 Belumosudil [3] 51, 85, 228 💬
93 Platelet activation 💬
[1] ROCK2 💬 Belumosudil mesylate 💬 Belumosudil [3] 51, 85, 228 💬
94 Platelet activation 💬
[1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
95 Platelet activation 💬
[1] SRC 💬 Bosutinib hydrate 💬 Bosutinib [2]  2 , 67 💬
96 Platelet activation 💬
[1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
97 Platelet activation 💬
[1] SYK 💬 Fostamatinib 💬 Fostamatinib [5] 46, 49, 61, 63, 66 💬
98 Platelet activation 💬
[1] SYK 💬 Fostamatinib disodium 💬 Fostamatinib [5] 46, 49, 61, 63, 66 💬
99 Platelet activation 💬
[1] SYK 💬 Gusacitinib 💬 Gusacitinib [1] 49 💬
100 Platelet activation 💬
[1] TBXA2R 💬 Cilostazol 💬 Cilostazol [5]  6 , 46, 51, 70, 124 💬
101 Platelet activation 💬
[1] TBXA2R 💬 Ifetroban 💬 Ifetroban [2] 85, 113 💬
102 Platelet activation 💬
[1] TBXA2R 💬 Ifetroban sodium 💬 Ifetroban [2] 85, 113 💬
103 Platelet activation 💬
[1] TBXA2R 💬 Ramatroban 💬 Ramatroban [1] 13 💬
104 Platelet activation 💬
[1] VWF 💬 Caplacizumab 💬 Caplacizumab [2] 63, 64 💬
105 Prostate cancer 💬
[1] PLAT 💬 Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
106 Transcriptional misregulation in cancer 💬
[1] PLAT 💬 Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬